DE69332976D1 - Digitale analytische nachweisvorrichtung - Google Patents

Digitale analytische nachweisvorrichtung

Info

Publication number
DE69332976D1
DE69332976D1 DE69332976T DE69332976T DE69332976D1 DE 69332976 D1 DE69332976 D1 DE 69332976D1 DE 69332976 T DE69332976 T DE 69332976T DE 69332976 T DE69332976 T DE 69332976T DE 69332976 D1 DE69332976 D1 DE 69332976D1
Authority
DE
Germany
Prior art keywords
analyte
analyte particles
sample
digital
optical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69332976T
Other languages
English (en)
Other versions
DE69332976T2 (de
Inventor
Fritz Allen
Thomas Niemczyk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Acrogen Inc
Original Assignee
Acrogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acrogen Inc filed Critical Acrogen Inc
Application granted granted Critical
Publication of DE69332976D1 publication Critical patent/DE69332976D1/de
Publication of DE69332976T2 publication Critical patent/DE69332976T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/695—Preprocessing, e.g. image segmentation
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/10—Segmentation; Edge detection
    • G06T7/11—Region-based segmentation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10056—Microscopic image
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10064—Fluorescence image
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro

Landscapes

  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Radiology & Medical Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Multimedia (AREA)
  • Quality & Reliability (AREA)
  • Molecular Biology (AREA)
  • Signal Processing (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Spectrometry And Color Measurement (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE69332976T 1992-07-23 1993-07-16 Digitale analytische nachweisvorrichtung Expired - Lifetime DE69332976T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US918357 1992-07-23
US07/918,357 US5329461A (en) 1992-07-23 1992-07-23 Digital analyte detection system
PCT/US1993/006707 WO1994002831A1 (en) 1992-07-23 1993-07-16 Digital analyte detection system

Publications (2)

Publication Number Publication Date
DE69332976D1 true DE69332976D1 (de) 2003-06-18
DE69332976T2 DE69332976T2 (de) 2004-05-19

Family

ID=25440250

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69332976T Expired - Lifetime DE69332976T2 (de) 1992-07-23 1993-07-16 Digitale analytische nachweisvorrichtung

Country Status (6)

Country Link
US (2) US5329461A (de)
EP (1) EP0651879B1 (de)
JP (1) JP3954089B2 (de)
AT (1) ATE240515T1 (de)
DE (1) DE69332976T2 (de)
WO (1) WO1994002831A1 (de)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3076118B2 (ja) * 1991-11-27 2000-08-14 シスメックス株式会社 粒子計数方法
US5329461A (en) * 1992-07-23 1994-07-12 Acrogen, Inc. Digital analyte detection system
US6327031B1 (en) * 1998-09-18 2001-12-04 Burstein Technologies, Inc. Apparatus and semi-reflective optical system for carrying out analysis of samples
US5722470A (en) * 1995-11-09 1998-03-03 Glaxo Group Limited Bead dispensing device and methods
US5771310A (en) * 1996-12-30 1998-06-23 Shriners Hospitals For Children Method and apparatus for recording three-dimensional topographies
EP0907889B1 (de) * 1996-04-25 2007-07-04 BioArray Solutions Ltd. Licht-regulierte, elektrokinetische zusammensetzung von partikeln an oberflächen
US20050214827A1 (en) * 1996-07-08 2005-09-29 Burstein Technologies, Inc. Assay device and method
US5978519A (en) * 1996-08-06 1999-11-02 Xerox Corporation Automatic image cropping
JP2962234B2 (ja) * 1996-08-07 1999-10-12 日本電気株式会社 半導体デバイスの寄生ＭＩＭ構造箇所解析法及びＳｉ半導体デバイスの寄生ＭＩＭ構造箇所解析法
WO1998011258A1 (en) 1996-09-16 1998-03-19 University Of Utah Research Foundation Method and apparatus for analysis of chromatographic migration patterns
WO1998012559A1 (en) 1996-09-20 1998-03-26 Demers James P Spatially addressable combinatorial chemical arrays in cd-rom format
US6449562B1 (en) * 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
DE69731629T2 (de) * 1997-09-11 2005-11-03 Randox Laboratories Ltd., Crumlin Verfahren und Gerät zur Bildanalyse
US20030153023A1 (en) * 1999-05-13 2003-08-14 Starzl Timothy W. Enumeration method of analyte detection
US6151973A (en) * 1999-01-29 2000-11-28 Glaxo Wellcome Inc. Bead picking apparatus and method
US6355934B1 (en) 1999-02-26 2002-03-12 Packard Biochip Technologies Imaging system for an optical scanner
JP2002543370A (ja) * 1999-02-26 2002-12-17 ジーエスアイ・ルモニクス，インコーポレイテッド 光学スキャナ用の画像形成システム
DE19923822A1 (de) † 1999-05-19 2000-11-23 Zeiss Carl Jena Gmbh Scannende Anordnung, vorzugsweise zur Erfassung von Fluoreszenzlicht
WO2001007896A1 (en) * 1999-07-21 2001-02-01 Tropix, Inc. Luminescence detection workstation
US6888951B1 (en) * 1999-08-23 2005-05-03 Nagaoka & Co., Ltd. Methods and apparatus for analyzing operational and analyte data acquired from optical disc
US20050069956A1 (en) * 1999-11-22 2005-03-31 Michael Seul Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
US7892854B2 (en) 2000-06-21 2011-02-22 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
WO2002008754A1 (en) * 2000-07-26 2002-01-31 Chemometec A/S Spatially resolved enzyme-linked assay
US20030045005A1 (en) * 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
WO2002084302A2 (en) * 2000-11-08 2002-10-24 Burstein Technologies, Inc. Interactive system for analyzing biological samples and processing related information and the use thereof
EP1410386A2 (de) * 2000-11-09 2004-04-21 Burstein Technologies, Inc. Plattenlaufwerkssystem und verfahren zur verwendung mit bio-platten
AU2002241602A1 (en) * 2000-11-16 2002-06-11 Burstein Technologies, Inc. Methods and apparatus for detecting and quantifying lymphocytes with optical biodiscs
EP1410045A2 (de) * 2000-11-22 2004-04-21 Burstein Technologies, Inc. Vorrichtung und verfahren zur abscheidung von agglomeraten und diversen partikeln
US6760298B2 (en) * 2000-12-08 2004-07-06 Nagaoka & Co., Ltd. Multiple data layer optical discs for detecting analytes
US6995845B2 (en) * 2000-12-08 2006-02-07 Burstein Technologies, Inc. Methods for detecting analytes using optical discs and optical disc readers
US7200088B2 (en) * 2001-01-11 2007-04-03 Burstein Technologies, Inc. System and method of detecting investigational features related to a sample
CA2439307A1 (en) * 2001-02-23 2002-09-06 Genicon Sciences Corporation Methods for providing extended dynamic range in analyte assays
WO2004010099A2 (en) * 2001-05-16 2004-01-29 Burstein Technologies, Inc. Variable sampling for rendering pixelization of analysis results in optical bio-disc assembly
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US7141416B2 (en) * 2001-07-12 2006-11-28 Burstein Technologies, Inc. Multi-purpose optical analysis optical bio-disc for conducting assays and various reporting agents for use therewith
US7221632B2 (en) * 2001-07-12 2007-05-22 Burstein Technologies, Inc. Optical disc system and related detecting methods for analysis of microscopic structures
US20040226348A1 (en) * 2001-07-24 2004-11-18 Phillip Bruce Magnetic assisted detection of magnetic beads using optical disc drives
US6750457B2 (en) * 2001-08-29 2004-06-15 Becton Dickinson And Company System for high throughput analysis
US20030129665A1 (en) * 2001-08-30 2003-07-10 Selvan Gowri Pyapali Methods for qualitative and quantitative analysis of cells and related optical bio-disc systems
US20030143637A1 (en) * 2001-08-31 2003-07-31 Selvan Gowri Pyapali Capture layer assemblies for cellular assays including related optical analysis discs and methods
AU2002335715A1 (en) * 2001-09-07 2003-03-24 Burstein Technologies, Inc. Optical bio-disc systems for nuclear morphology based identification
JP2005502369A (ja) * 2001-09-12 2005-01-27 バースタイン テクノロジーズ，インコーポレイティド 分画細胞計数方法ならびにそれを実行するための関連する装置およびソフトウェア
WO2003034029A2 (en) 2001-10-15 2003-04-24 Bioarray Solutions, Ltd. Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection
CA2464476A1 (en) * 2001-10-24 2003-05-01 Burstein Technologies, Inc. Optical biological disk analyser
US20080094974A1 (en) * 2001-11-09 2008-04-24 Burstein Technologies, Inc. Optical disc system and related detecting methods for analysis of microscopic structures
CA2468041A1 (en) * 2001-11-20 2003-05-30 Burstein Technologies, Inc. Optical bio-discs and microfluidic devices for analysis of cells
US7365849B2 (en) * 2001-12-27 2008-04-29 Taiwan Unison Biotechnology, Inc. Portable, scanning and analyzing apparatus
US20040246252A1 (en) * 2002-01-14 2004-12-09 Morrow Jesse James Method and apparatus for visualizing data
CA2471018A1 (en) * 2002-01-28 2003-08-07 Burstein Technologies, Inc. Methods and apparatus for logical triggering of an optical bio-disc
US20050003459A1 (en) * 2002-01-30 2005-01-06 Krutzik Siegfried Richard Multi-purpose optical analysis disc for conducting assays and related methods for attaching capture agents
EP1470424A2 (de) * 2002-01-31 2004-10-27 Burstein Technologies, Inc. Verfahren zum auslösen mittels platterillen und entsprechende optische analyse-platten
WO2004047007A1 (en) 2002-11-15 2004-06-03 Bioarray Solutions, Ltd. Analysis, secure access to, and transmission of array images
EP1648286B1 (de) * 2003-07-12 2017-12-20 Accelerate Diagnostics, Inc. Empfindliche und schnelle biodetektion
US7341841B2 (en) * 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
WO2005029705A2 (en) 2003-09-18 2005-03-31 Bioarray Solutions, Ltd. Number coding for identification of subtypes of coded types of solid phase carriers
NZ546072A (en) 2003-09-22 2009-08-28 Bioarray Solutions Ltd Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
AU2004286252A1 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Optimization of gene expression analysis using immobilized capture probes
US20050089916A1 (en) * 2003-10-28 2005-04-28 Xiongwu Xia Allele assignment and probe selection in multiplexed assays of polymorphic targets
AU2004287069B2 (en) 2003-10-29 2009-07-16 Bioarray Solutions, Ltd. Multiplexed nucleic acid analysis by fragmentation of double-stranded DNA
US7363170B2 (en) * 2004-07-09 2008-04-22 Bio Array Solutions Ltd. Transfusion registry network providing real-time interaction between users and providers of genetically characterized blood products
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
US8486629B2 (en) 2005-06-01 2013-07-16 Bioarray Solutions, Ltd. Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation
US8492098B2 (en) * 2006-02-21 2013-07-23 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of reaction components that affect a reaction
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
EP2061901A2 (de) * 2006-10-31 2009-05-27 Noxxon Pharma AG Verfahren zum nachweis eines einzel- oder doppelsträngigen nukleinsäuremoleküls
US8244021B2 (en) * 2006-12-20 2012-08-14 Ventana Medical Systems, Inc. Quantitative, multispectral image analysis of tissue specimens stained with quantum dots
US20080243865A1 (en) * 2007-03-28 2008-10-02 Oracle International Corporation Maintaining global state of distributed transaction managed by an external transaction manager for clustered database systems
ES2556627T3 (es) * 2007-08-30 2016-01-19 Trustees Of Tufts College Métodos para determinar la concentración de un analito en solución
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US20100075862A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
US20100075439A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of molecules by capture-and-release using reducing agents followed by quantification
US8581927B2 (en) * 2008-11-04 2013-11-12 Beckman Coulter, Inc. Multidimensional particle analysis data cluster reconstruction
DK200801722A (en) 2008-12-05 2010-06-06 Unisensor As Optical sectioning of a sample and detection of particles in a sample
CN102782561B (zh) 2009-12-04 2016-10-05 皇家飞利浦有限公司 对生物有机体进行时间相关的显微镜检查的系统和方法
US9678068B2 (en) * 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
WO2011109379A1 (en) 2010-03-01 2011-09-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US8415171B2 (en) * 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
EP2542878B1 (de) 2010-03-04 2016-09-14 Koninklijke Philips N.V. Flexibler probenbehälter
US8767069B2 (en) * 2010-06-30 2014-07-01 Luminex Corporation Apparatus, system, and method for increasing measurement accuracy in a particle imaging device using light distribution
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
EP2683831B1 (de) 2011-03-07 2015-09-23 Accelerate Diagnostics, Inc. Schnelle zellreinigungssysteme
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
WO2014113502A1 (en) 2013-01-15 2014-07-24 Quanterix Corporation Detection of dna or rna using single molecule arrays and other techniques
US10656149B2 (en) * 2013-03-15 2020-05-19 The Trustees Of Princeton University Analyte detection enhancement by targeted immobilization, surface amplification, and pixelated reading and analysis
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
CN105229467A (zh) * 2013-03-15 2016-01-06 普林斯顿大学理事会 快速且灵敏的分析物测量测定法
EP3063527B1 (de) 2013-10-29 2020-12-02 IDEXX Laboratories, Inc. Verfahren und vorrichtung für den nachweis von bakterien und zur bestimmung der konzentration davon in einer flüssigen probe
WO2015080964A1 (en) * 2013-11-27 2015-06-04 Cirtemo, Lld Optical analysis system and process
KR102136645B1 (ko) * 2014-03-04 2020-07-22 삼성전자주식회사 검사장치 및 그 제어방법
WO2016142785A1 (en) * 2015-03-10 2016-09-15 Microbix Biosystems Inc. Methods, systems and apparatus for sorting and processing analytes
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
US10023895B2 (en) 2015-03-30 2018-07-17 Accelerate Diagnostics, Inc. Instrument and system for rapid microogranism identification and antimicrobial agent susceptibility testing
US10718003B2 (en) * 2015-12-31 2020-07-21 Roche Molecular Systems, Inc. Detecting an analyte in a flash and glow reaction
WO2019036479A1 (en) * 2017-08-14 2019-02-21 Senseonics, Incorporated SYSTEM, APPARATUS AND METHODS FOR DISCTINCTING OPTICAL SIGNALS
WO2021014682A1 (ja) * 2019-07-19 2021-01-28 株式会社日立ハイテク 粒子定量装置

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853987A (en) * 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US4201763A (en) * 1975-10-09 1980-05-06 Bio-Rad Laboratories, Inc. Solid phase immunofluorescent assay method
US4271123A (en) * 1979-10-22 1981-06-02 Bio-Rad Laboratories, Inc. Automated system for performing fluorescent immunoassays
US4295199A (en) * 1979-10-22 1981-10-13 Bio-Rad Laboratories, Inc. Automatic fluorometer and data processor for performing fluorescent immunoassays
US4393466A (en) * 1980-09-12 1983-07-12 International Remote Imaging Systems Method of analyzing particles in a dilute fluid sample
US4612614A (en) * 1980-09-12 1986-09-16 International Remote Imaging Systems, Inc. Method of analyzing particles in a fluid sample
US4720804A (en) * 1984-08-08 1988-01-19 Moore Sidney D Electrically addressable opto-electronic indicator for making dynamic evaluations of microscopic or larger subjects
CA1228811A (en) * 1983-05-05 1987-11-03 Robert G. Pergolizzi Assay method utilizing polynucleotide sequences
US4672040A (en) * 1983-05-12 1987-06-09 Advanced Magnetics, Inc. Magnetic particles for use in separations
US4704255A (en) * 1983-07-15 1987-11-03 Pandex Laboratories, Inc. Assay cartridge
FR2558172B1 (fr) * 1984-01-16 1986-06-13 Inst Nat Sante Rech Med Sonde contenant un acide nucleique modifie et reconnaissance par des anticorps specifiques et utilisation de cette sonde et de ces anticorps specifiques pour detecter et caracteriser une sequence d'adn homologue
AU3844485A (en) * 1984-02-09 1985-08-15 Enzo Biochem Inc. Heterologous detection of cabeled dna
CA1260372A (en) * 1984-04-27 1989-09-26 Elazar Rabbani Hybridization method for the detection of genetic materials
US4722840A (en) * 1984-09-12 1988-02-02 Chiron Corporation Hybrid particle immunogens
FI844027A (fi) * 1984-10-12 1986-04-13 Labsystems Oy Immunologiskt bestaemningsfoerfarande.
US4775619A (en) * 1984-10-16 1988-10-04 Chiron Corporation Polynucleotide determination with selectable cleavage sites
GB8507706D0 (en) * 1985-03-25 1985-05-01 Genetics Int Inc Magnetic nucleic acid sequences
US4824776A (en) * 1985-07-25 1989-04-25 Molecular Biosystems, Inc. Method for increasing the sensitivity of nucleic acid hybridization assays
US4769776A (en) * 1985-08-30 1988-09-06 Hitachi, Ltd. Apparatus for measuring the concentration of filamentous microorganisms in a mixture including microorganisms
US4868105A (en) * 1985-12-11 1989-09-19 Chiron Corporation Solution phase nucleic acid sandwich assay
US4882269A (en) * 1985-12-13 1989-11-21 Princeton University Amplified hybridization assay
US4758727A (en) * 1986-02-12 1988-07-19 Ohio State University Research Foundation Method and apparatus for the measurement of low-level laser-induced fluorescence
US4968602A (en) * 1986-03-05 1990-11-06 Molecular Diagnostics, Inc. Solution-phase single hybridization assay for detecting polynucleotide sequences
US4925785A (en) * 1986-03-07 1990-05-15 Biotechnica Diagnostics, Inc. Nucleic acid hybridization assays
NO162946C (no) * 1987-08-21 1990-03-14 Otto Soerensen Anordning for magnetisk separasjon av celler.
US4855930A (en) * 1987-03-27 1989-08-08 Chimerix Corporation Method and appartatus for improved time-resolved fluorescence spectroscopy
IL85551A0 (en) * 1987-04-01 1988-08-31 Miles Inc Rapid hybridization assay and reagent system used therein
US4988618A (en) * 1987-11-16 1991-01-29 Gene-Trak Systems Magnetic separation device and methods for use in heterogeneous assays
NO164622C (no) * 1988-05-11 1990-10-24 Tore Lindmo Binaer immunometrisk partikkelbasert metode for maaling av spesifikke serum-antigener ved hjelp av vaeskestroemsmikrofotometri og et ferdigpreparert maaloppsett derav.
WO1990002205A1 (en) * 1988-08-25 1990-03-08 Angenics, Inc. Detection of nucleic acid sequences using particle agglutination
CA2049042A1 (en) * 1989-03-10 1990-09-11 Mark L. Collins Preventing interference with affinity capture schemes
US5162990A (en) * 1990-06-15 1992-11-10 The United States Of America As Represented By The United States Navy System and method for quantifying macrophage phagocytosis by computer image analysis
USH1183H (en) * 1991-12-19 1993-05-04 Laser scanner method for determining number and size of particles
US5329461A (en) * 1992-07-23 1994-07-12 Acrogen, Inc. Digital analyte detection system

Also Published As

Publication number Publication date
EP0651879A4 (de) 1995-08-23
JP3954089B2 (ja) 2007-08-08
US5329461A (en) 1994-07-12
WO1994002831A1 (en) 1994-02-03
EP0651879A1 (de) 1995-05-10
DE69332976T2 (de) 2004-05-19
US5488567A (en) 1996-01-30
ATE240515T1 (de) 2003-05-15
JPH07509314A (ja) 1995-10-12
EP0651879B1 (de) 2003-05-14

Similar Documents

Publication Publication Date Title
DE69332976D1 (de) Digitale analytische nachweisvorrichtung
EP0284630B1 (de) Verfahren zur Erfassung von Fehlern in Oberflächen
DK0941465T3 (da) Fremgangsmåde til at skelne og detektere partikler i en sonde ved identifikation af tidsopløste signalafsnit,optiske råsignaler fra en sonde på basis af detektion af enkeltfotoner
DE69331188D1 (de) Vorrichtung und verfahren zur molekularen charakterisierung
NO974597D0 (no) Fremgangsmåte og apparat for kvantitativ partikkelbestemmelse i fluider
DE59310263D1 (de) Verfahren zur Bestimmung von Stoffen und/oder deren Eigenschaften und Gerät hierfür
EP0360126A3 (de) Verfahren zum Betrieb eines optischen Rauchmelders sowie Rauchmelder zur Durchführung des Verfahrens
ATE215694T1 (de) Verfahren zur charakterisierung von proben unter verwendung statistischer zwischendaten
EP0903572A3 (de) Vorrichtung zur Detektion der Verschmutzung eines Fensters
ATE357663T1 (de) Teilchenförmiges markierungsmittel verwendendes analytassay
ATE292316T1 (de) Selbstansaugende brandmeldeeinrichtung
EP0760477A3 (de) Vorrichtung und Verfahren zur Messung eines streuenden Mediums
EP0046058A2 (de) Einrichtung zur Kontrolle einer Materialbahn
FR2433179A1 (fr) Systeme de detection et de classification des criques de surfaces metalliques
SE9400849L (sv) Anordning och förfarande för detektering av defekter i virke
GB2338299A (en) Improved Rayleigh backscatter control apparatus and method
DE58909246D1 (de) Vorrichtung und Verfahren zur Bewegungsdetektion in einem Videosignal.
JP2995124B2 (ja) 寸法測定装置
ATE195806T1 (de) Detektion von verunreinigungen in metallagglomeraten
JPS57164657A (en) Image analyzing method and device
DE3889190D1 (de) Vorrichtung zur Prüfung von Münzen.
KR910010155A (ko) 폭 측정장치
FR2652896B1 (fr) Procede et dispositif de detection de cliquetis.
JPS59105543A (ja) 抗原抗体反応検出器
SU871041A1 (ru) Автоматический оптико-электронный анализатор дл определени качества сырь ,полупродуктов и готовой продукции

Legal Events

Date Code Title Description
8364 No opposition during term of opposition