DE60235718D1 - Vorrichtung und verfahren zur untersuchung von analyten in flüssigsuspension oder lösung - Google Patents

Vorrichtung und verfahren zur untersuchung von analyten in flüssigsuspension oder lösung

Info

Publication number
DE60235718D1
DE60235718D1 DE60235718T DE60235718T DE60235718D1 DE 60235718 D1 DE60235718 D1 DE 60235718D1 DE 60235718 T DE60235718 T DE 60235718T DE 60235718 T DE60235718 T DE 60235718T DE 60235718 D1 DE60235718 D1 DE 60235718D1
Authority
DE
Germany
Prior art keywords
analyte
solution
detector
light
liquid suspension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60235718T
Other languages
English (en)
Inventor
Nikolai Franz Schwabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prolmmune Ltd
Original Assignee
Prolmmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prolmmune Ltd filed Critical Prolmmune Ltd
Application granted granted Critical
Publication of DE60235718D1 publication Critical patent/DE60235718D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
DE60235718T 2001-12-12 2002-12-09 Vorrichtung und verfahren zur untersuchung von analyten in flüssigsuspension oder lösung Expired - Lifetime DE60235718D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0129688A GB2383127B (en) 2001-12-12 2001-12-12 Device and method for investigating analytes in liquid suspension or solution
PCT/GB2002/005567 WO2003054525A2 (en) 2001-12-12 2002-12-09 Device and method for investigating analytes in liquid suspension or solution

Publications (1)

Publication Number Publication Date
DE60235718D1 true DE60235718D1 (de) 2010-04-29

Family

ID=9927453

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60235718T Expired - Lifetime DE60235718D1 (de) 2001-12-12 2002-12-09 Vorrichtung und verfahren zur untersuchung von analyten in flüssigsuspension oder lösung

Country Status (9)

Country Link
US (8) US7245379B2 (de)
EP (1) EP1454123B1 (de)
JP (1) JP2005513476A (de)
AT (1) ATE461444T1 (de)
AU (1) AU2002347379A1 (de)
DE (1) DE60235718D1 (de)
DK (1) DK1454123T3 (de)
GB (1) GB2383127B (de)
WO (1) WO2003054525A2 (de)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2383127B (en) * 2001-12-12 2004-10-20 Proimmune Ltd Device and method for investigating analytes in liquid suspension or solution
EP2266687A3 (de) 2003-04-10 2011-06-29 The President and Fellows of Harvard College Erzeugung und Kontrolle von Fluiden
JP4228808B2 (ja) 2003-07-23 2009-02-25 株式会社日立製作所 マイクロ分光計測装置及びマイクロ化学システム
EP2662135A3 (de) * 2003-08-27 2013-12-25 President and Fellows of Harvard College Verfahren zur Mischung von Tröpfchen in einem Mikrokanal
WO2005033654A2 (en) * 2003-08-28 2005-04-14 The Regents Of The University Of Michigan Micro flow cytometer with multiangular waveguide detectors having spectral capabilities
US20050103690A1 (en) * 2003-11-19 2005-05-19 Aisin Seiki Kabushiki Kaisha Micro liquid control system
US7155082B2 (en) * 2004-04-12 2006-12-26 Colorado School Of Mines Switchable microfluidic optical waveguides
CN1973195B (zh) * 2004-04-23 2011-12-07 古河电气工业株式会社 试样的分离、识别、分注方法和其装置及解析装置
US20080213821A1 (en) * 2004-05-06 2008-09-04 Nanyang Technological University Microfluidic Cell Sorter System
JP4565205B2 (ja) * 2004-07-01 2010-10-20 タマティーエルオー株式会社 検体分析素子
JP2006029921A (ja) * 2004-07-14 2006-02-02 Institute Of Physical & Chemical Research フローサイトメーター
JP2006300564A (ja) * 2005-04-15 2006-11-02 Sumitomo Electric Ind Ltd 分析デバイス及び分析装置
US7709821B2 (en) * 2005-04-27 2010-05-04 Advanced Cytometry Instrumentation Systems, Inc. Flow cytometer acquisition and detection system
US7767444B2 (en) * 2005-05-31 2010-08-03 Nanyang Technological University Cell analysis using laser with external cavity
JP4995197B2 (ja) * 2005-07-01 2012-08-08 ハネウェル・インターナショナル・インコーポレーテッド ３ｄ流体力学的集束を有する成形カートリッジ
US8270781B2 (en) * 2005-10-28 2012-09-18 The Regents Of The University Of California Apparatus and method for improved optical detection of particles in fluid
FR2893414A1 (fr) * 2005-11-17 2007-05-18 Philippe Claude Loui Daurenjou Systeme de differenciation et de denombrement des particules suspendues dans un liquide.
US7551278B2 (en) 2006-05-12 2009-06-23 Honeywell International Inc. Fluid light guide system
CA2657970A1 (en) * 2006-05-17 2007-11-29 Luminex Corporation Chip-based flow cytometer type systems for analyzing fluorescently tagged particles
US8285150B2 (en) * 2006-10-02 2012-10-09 Futurewei Technologies, Inc. Method and system for integrated DWDM transmitters
US20090051912A1 (en) * 2006-10-02 2009-02-26 Agave Biosystems, Inc. Modular Microfluidic Flow Cytometer and Method Applications
US8285149B2 (en) * 2006-10-02 2012-10-09 Futurewei Technologies, Inc. Method and system for integrated DWDM transmitters
US8050525B2 (en) * 2006-10-11 2011-11-01 Futurewei Technologies, Inc. Method and system for grating taps for monitoring a DWDM transmitter array integrated on a PLC platform
US8285151B2 (en) 2006-10-20 2012-10-09 Futurewei Technologies, Inc. Method and system for hybrid integrated 1XN DWDM transmitter
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
US20080245960A1 (en) * 2007-04-09 2008-10-09 Baker Hughes Incorporated Method and Apparatus to Determine Characteristics of an Oil-Based Mud Downhole
US20100181472A1 (en) * 2007-04-09 2010-07-22 Baker Hughes Incorporated Method and Apparatus to Determine Characteristics of an Oil-Based Mud Downhole
US8487238B2 (en) * 2007-11-01 2013-07-16 Baker Hughes Incorporated Method of identification of petroleum compounds using frequency mixing on surfaces
JP2009133818A (ja) * 2007-11-05 2009-06-18 Sony Corp 基板流路内における液体の送液方法及び液体送液装置
JP2010169701A (ja) * 2008-05-13 2010-08-05 Sony Corp マイクロチップ
JP4661942B2 (ja) 2008-05-13 2011-03-30 ソニー株式会社 マイクロチップとその流路構造
JP4572973B2 (ja) * 2008-06-16 2010-11-04 ソニー株式会社 マイクロチップ及びマイクロチップにおける送流方法
JP2010151777A (ja) * 2008-11-19 2010-07-08 Sony Corp 微小粒子解析装置、微小粒子解析用マイクロチップ及び微小粒子解析方法
US9678005B1 (en) * 2008-12-03 2017-06-13 Arizona Board Of Regents On Behalf Of The University Of Arizona Devices and methods for detection of microorganisms
JP5308834B2 (ja) * 2009-01-13 2013-10-09 古河電気工業株式会社 微粒子分別装置及び微粒子分別方法
JP5306835B2 (ja) * 2009-01-13 2013-10-02 古河電気工業株式会社 光計測方法
JP5487638B2 (ja) 2009-02-17 2014-05-07 ソニー株式会社 微小粒子分取のための装置及びマイクロチップ
JP2012519871A (ja) 2009-03-07 2012-08-30 ヒューレット−パッカード デベロップメント カンパニー エル．ピー． アナライザ及びアナライザを用いて検知を行うための方法
WO2010104993A2 (en) 2009-03-10 2010-09-16 The Regents Of The University Of California Fluidic flow cytometry devices and particle sensing based on signal-encoding
US9645010B2 (en) 2009-03-10 2017-05-09 The Regents Of The University Of California Fluidic flow cytometry devices and methods
PL2440941T3 (pl) * 2009-06-10 2017-10-31 Cynvenio Biosystems Inc Sposoby i urządzenia z przepływem laminarnym
JP5321260B2 (ja) * 2009-06-11 2013-10-23 ソニー株式会社 光学的測定装置、並びにフローサイトメーター及び光学的測定方法
JP5493486B2 (ja) 2009-06-16 2014-05-14 ソニー株式会社 物質混合装置と物質混合方法
CN102368945B (zh) * 2009-08-20 2014-05-21 奥林巴斯医疗株式会社 生物体测量装置及生物体测量方法
KR101712691B1 (ko) * 2010-01-28 2017-03-06 버로우 디. 아미르카니안 볼엔드 입출력 광섬유를 이용한 생체분석 장치 및 방법
ES2733548T3 (es) * 2010-02-09 2019-11-29 Cytena Gmbh Dispositivo de descarga de material líquido que contiene partículas
JP5691195B2 (ja) 2010-03-01 2015-04-01 ソニー株式会社 マイクロチップ及び微小粒子分析装置
US10024819B2 (en) 2010-10-21 2018-07-17 The Regents Of The University Of California Microfluidics with wirelessly powered electronic circuits
KR101250751B1 (ko) * 2010-10-22 2013-04-03 연세대학교 산학협력단 다중 형광 정도 이용 세포 분리 장치 및 전극구조와 다중 형광 정도 이용 세포 분리 방법
WO2012058716A1 (en) * 2010-11-02 2012-05-10 Edith Cowan University An optical sensor for measuring a property of a fluid
CN102128777A (zh) * 2010-11-24 2011-07-20 西安交通大学 一种用于细胞检测的3d微流控结构及其制备方法
KR20220023960A (ko) * 2011-03-07 2022-03-03 더 거버닝 카운실 오브 더 유니버시티 오브 토론토 미세유체기술을 이용한 휴대용 세포 검출 및 분석 방법 및 시스템
WO2013034311A1 (en) * 2011-09-09 2013-03-14 Fci Photonic integrated transmitter device, photonic integrated receiver device, and active optical cable transceiver system
JP5926810B2 (ja) 2011-11-15 2016-05-25 エンパイア テクノロジー ディベロップメント エルエルシー 組込式光学センサ
CN104769414B (zh) * 2012-09-06 2018-08-24 古河电气工业株式会社 检体识别分离提取装置及检体识别分离提取方法
JP6396911B2 (ja) 2012-10-15 2018-09-26 ナノセレクト バイオメディカル， インコーポレイテッド 粒子を選別するためのシステム、装置、および、方法
US9017537B2 (en) * 2013-03-13 2015-04-28 Eastman Kodak Company Metallic and semiconducting carbon nanotube sorting
US9372143B2 (en) * 2013-05-15 2016-06-21 Captl Llc Scanning image flow cytometer
US9453791B2 (en) * 2014-07-01 2016-09-27 Octrolix Bv Flow cytometry system and method
JP5897681B2 (ja) * 2014-10-08 2016-03-30 ソニー株式会社 マイクロチップ及び微小粒子分析装置
US10900885B2 (en) 2014-12-19 2021-01-26 Captl Llc Flow cytometry using hydrodynamically planar flow
JP6438319B2 (ja) * 2015-02-18 2018-12-12 アズビル株式会社 粒子検出装置
JP6557022B2 (ja) * 2015-02-18 2019-08-07 アズビル株式会社 粒子検出装置
US10036698B2 (en) 2015-06-19 2018-07-31 Captl Llc Time-sequential cytometry
JP6509759B2 (ja) * 2016-03-01 2019-05-08 ソニー株式会社 マイクロチップ及び微小粒子分析装置
BR112018071562A2 (pt) * 2016-04-20 2019-02-12 Cellix Limited chip de microfluídica para focalização de uma corrente de particulado contendo fluido
US11839876B2 (en) 2016-05-24 2023-12-12 Cellix Limited Apparatus for microfluidic flow cytometry analysis of a particulate containing fluid
CN107029640B (zh) * 2017-05-23 2023-04-21 中国科学技术大学 基于液驱流动聚焦射流扰动的微液滴主动制备装置及方法
WO2019067455A1 (en) 2017-09-28 2019-04-04 Masseta Technologies Llc LASER ARCHITECTURES USING QUANTUM WELL MIX TECHNIQUES
CN111164393A (zh) 2017-09-29 2020-05-15 苹果公司 连接的外延光学感测系统
CN116893160A (zh) 2017-09-29 2023-10-17 苹果公司 路径解析的光学采样架构
TWI647430B (zh) * 2017-10-12 2019-01-11 致茂電子股份有限公司 光學量測裝置
US11035707B2 (en) * 2017-10-25 2021-06-15 Government Of The United States Of America, As Represented By The Secretary Of Commerce Optical flow meter for determining a flow rate of a liquid
JP6708978B2 (ja) * 2017-12-28 2020-06-10 ソニー株式会社 マイクロチップ及び微小粒子分析装置
EP3752873A1 (de) 2018-02-13 2020-12-23 Apple Inc. Integrierte photonikvorrichtung mit integrierten kantenauskopplern
JP2019184337A (ja) * 2018-04-05 2019-10-24 ソニー株式会社 マイクロチップ、微小粒子測定装置、及び微小粒子測定方法
US11022538B2 (en) 2018-05-15 2021-06-01 Government Of The United States Of America, As Represented By The Secretary Of Commerce Quantum flow cytometer
WO2019246594A1 (en) 2018-06-22 2019-12-26 Masseta Technologies Llc Discrete optical unit on a substrate of an integrated photonics chip
CA3106121A1 (en) * 2018-07-10 2020-01-16 Gerrit Jan Van Den Engh System, apparatus and method for off-axis illumination in flow cytometry
US11525967B1 (en) * 2018-09-28 2022-12-13 Apple Inc. Photonics integrated circuit architecture
US10458909B1 (en) 2018-10-24 2019-10-29 International Business Machines Corporation MEMS optical sensor
US11171464B1 (en) 2018-12-14 2021-11-09 Apple Inc. Laser integration techniques
US11881678B1 (en) 2019-09-09 2024-01-23 Apple Inc. Photonics assembly with a photonics die stack
US11525958B1 (en) 2019-09-09 2022-12-13 Apple Inc. Off-cut wafer with a supported outcoupler
US11231319B1 (en) 2019-09-09 2022-01-25 Apple Inc. Athermal wavelength stability monitor using a detraction grating
US11506535B1 (en) 2019-09-09 2022-11-22 Apple Inc. Diffraction grating design
US11835836B1 (en) 2019-09-09 2023-12-05 Apple Inc. Mach-Zehnder interferometer device for wavelength locking
US11320718B1 (en) 2019-09-26 2022-05-03 Apple Inc. Cantilever beam waveguide for silicon photonics device
US11500154B1 (en) 2019-10-18 2022-11-15 Apple Inc. Asymmetric optical power splitting system and method
JP2023529813A (ja) * 2020-06-09 2023-07-12 パーティクル・メージャーリング・システムズ・インコーポレーテッド 散乱光と入射光との組み合わせによる粒子検出
EP4176304A1 (de) 2020-09-09 2023-05-10 Apple Inc. Optisches system zur rauschminderung
US11852865B2 (en) 2020-09-24 2023-12-26 Apple Inc. Optical system with phase shifting elements
US11561346B2 (en) 2020-09-24 2023-01-24 Apple Inc. Tunable echelle grating
US11815719B2 (en) 2020-09-25 2023-11-14 Apple Inc. Wavelength agile multiplexing
US11906778B2 (en) 2020-09-25 2024-02-20 Apple Inc. Achromatic light splitting device with a high V number and a low V number waveguide
US20220228984A1 (en) * 2021-01-20 2022-07-21 Electronics And Telecommunications Research Institute Fluorescence generating device and digital polymerase chain reaction analysis system including the same
US11914201B2 (en) 2021-09-23 2024-02-27 Apple Inc. Mechanisms that transfer light between layers of multi-chip photonic assemblies
CN114486823A (zh) * 2021-12-24 2022-05-13 广东唯实生物技术有限公司 用于侧向免疫层析仪器的光路系统和手持设备

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5558820A (en) 1978-10-27 1980-05-01 Fujitsu Ltd Data detection system
EP0167272B1 (de) * 1984-06-30 1991-01-16 Kabushiki Kaisha Toshiba Apparat zur Messung der Abmessungen von Teilchen
JPS6114543A (ja) * 1984-06-30 1986-01-22 Toshiba Corp 粒径測定装置
JPS61110033A (ja) * 1984-11-02 1986-05-28 Toray Ind Inc 凝集反応の測定装置
JPS61145928A (ja) 1984-12-19 1986-07-03 Mitsubishi Electric Corp 位相比較器
US4936465A (en) * 1987-12-07 1990-06-26 Zoeld Tibor Method and apparatus for fast, reliable, and environmentally safe dispensing of fluids, gases and individual particles of a suspension through pressure control at well defined parts of a closed flow-through system
US4945400A (en) * 1988-03-03 1990-07-31 At&T Bell Laboratories Subassembly for optoelectronic devices
DD271953A1 (de) * 1988-05-09 1989-09-20 Zeiss Jena Veb Carl Einrichtung zur automatischen photometrischen analyse kleinster probenmengen
FR2638847B1 (fr) * 1988-11-04 1990-12-14 Commissariat Energie Atomique Dispositif optique integre pour la mesure d'indice de refraction d'un fluide
JPH02285830A (ja) 1989-04-27 1990-11-26 Nec Corp 同期切替装置
US4942305A (en) * 1989-05-12 1990-07-17 Pacific Scientific Company Integrating sphere aerosol particle detector
JPH0228538A (ja) * 1989-05-26 1990-01-30 Hitachi Ltd 蒸気湿り度測定装置
US5010346A (en) * 1989-10-27 1991-04-23 The Boeing Company Electro-optical analog-to-digital converter and method for digitizing an analog signal
US5377008A (en) * 1990-09-20 1994-12-27 Battelle Memorial Institute Integrated optical compensating refractometer apparatus
US5250186A (en) * 1990-10-23 1993-10-05 Cetus Corporation HPLC light scattering detector for biopolymers
US5269937A (en) * 1990-10-23 1993-12-14 Cetus Corporation HPLC light scattering detector for biopolymers
DE69224454T2 (de) 1991-09-30 1998-07-30 At & T Corp Verfahren zur Herstellung von planaren optischen Wellenleitern
US5959738A (en) * 1994-07-25 1999-09-28 Molecular Devices Corporation Determination of light absorption pathlength in a vertical-beam photometer
DE4438391C2 (de) * 1994-10-27 1997-07-03 Evotec Biosystems Gmbh Vorrichtung zur Bestimmung stoffspezifischer Parameter eines oder weniger Moleküle mittels Korrelations-Spektroskopie
ATE339680T1 (de) * 1995-04-06 2006-10-15 Delaval Holding Ab Verfahren und vorrichtung zur quantitativen bestimmung von teilchen in flüssigkeiten
AU6354796A (en) * 1995-06-23 1997-01-22 Novartis Ag Flow cell
US5726751A (en) * 1995-09-27 1998-03-10 University Of Washington Silicon microchannel optical flow cytometer
JPH09145928A (ja) * 1995-11-22 1997-06-06 Matsushita Electric Ind Co Ltd 光減衰器
US6144795A (en) * 1996-12-13 2000-11-07 Corning Incorporated Hybrid organic-inorganic planar optical waveguide device
US5991493A (en) * 1996-12-13 1999-11-23 Corning Incorporated Optically transmissive bonding material
NL1008934C2 (nl) * 1998-04-20 1999-10-21 Univ Twente Geïntegreerde optische lichtgeleider inrichting.
FR2783919A1 (fr) * 1998-09-25 2000-03-31 Suisse Electronique Microtech Capteur optique integre pour detecter les composants d'un fluide
US6496260B1 (en) * 1998-12-23 2002-12-17 Molecular Devices Corp. Vertical-beam photometer for determination of light absorption pathlength
JP2001337030A (ja) * 2000-05-29 2001-12-07 Yokogawa Electric Corp 微粒子成分分析装置
DE10029946A1 (de) 2000-06-17 2001-12-20 Merck Patent Gmbh Integrierte optische Wellenleiter für mikrofluidische Analysensysteme
US20020028434A1 (en) * 2000-09-06 2002-03-07 Guava Technologies, Inc. Particle or cell analyzer and method
JP2002221485A (ja) * 2000-11-22 2002-08-09 Minolta Co Ltd マイクロチップ
US7105355B2 (en) 2001-07-18 2006-09-12 The Regents Of The University Of Michigan Flow cytometers and detection system of lesser size
US20030038237A1 (en) * 2001-08-21 2003-02-27 Pranalytica, Inc. Amplifier-enhanced optical analysis system and method
GB2383127B (en) * 2001-12-12 2004-10-20 Proimmune Ltd Device and method for investigating analytes in liquid suspension or solution

Also Published As

Publication number Publication date
EP1454123A2 (de) 2004-09-08
JP2005513476A (ja) 2005-05-12
US7477384B2 (en) 2009-01-13
US20140146315A1 (en) 2014-05-29
AU2002347379A1 (en) 2003-07-09
US7245379B2 (en) 2007-07-17
US20070268489A1 (en) 2007-11-22
GB2383127A (en) 2003-06-18
US20110216319A1 (en) 2011-09-08
GB2383127B (en) 2004-10-20
WO2003054525A2 (en) 2003-07-03
EP1454123B1 (de) 2010-03-17
US20130271762A1 (en) 2013-10-17
GB0129688D0 (en) 2002-01-30
US20100079756A1 (en) 2010-04-01
US20050068536A1 (en) 2005-03-31
ATE461444T1 (de) 2010-04-15
US20120307245A1 (en) 2012-12-06
WO2003054525A3 (en) 2003-11-20
DK1454123T3 (da) 2010-06-28
US20160178518A1 (en) 2016-06-23

Similar Documents

Publication Publication Date Title
DE60235718D1 (de) Vorrichtung und verfahren zur untersuchung von analyten in flüssigsuspension oder lösung
EP1873512A3 (de) Vorrichtung und Verfahren zur Erkennung von Fluoreszenzen in biologischen Proben
WO2016124083A1 (zh) 一种超小型化多通道实时荧光光谱检测装置
DE69942697D1 (de) Vorrichtung zur Mikrotestdurchführung
EP0902271A3 (de) Vorrichtung und Verfahren zur Analyse von Proben
DE60109128D1 (de) Vorrichtung zur bestimmung des Volumens einer einzigen roten Blutzelle
ATE346287T1 (de) Verfahren und vorrichtung zur zuführung von proben zu einer chemischen sensormatrix
ATE377752T1 (de) Lesevorrichtung, verfahren und system für lateralfluss-assayteststreifen
NO20044590L (no) Fremgansmate og anordning for optisk deteksjon og analyse av partikler
DE60309476D1 (de) Optische vorrichtung und verfahren zur messung von lichttransmission
WO2001090726A3 (en) Optical alignment in capillary detection using capillary wall scatter
DE60141517D1 (de) Abtastvorrichtung und verfahren zum abtasten von mehreren proben
DK252188A (da) Detektorindretning til analyseinstrument
ATE319078T1 (de) Dataträger für testvorrichtung
WO1998010122A1 (en) Microfabricated hybrid capillary array and multichannel detection assembly
EP1406088A3 (de) Reagenzsatz und Verfahren zum Nachweis von Malariaparasiten, wobei eine Hämolyse in zwei Schritten mittels Tensiden durchgeführt wird
WO2009014844A3 (en) Method and device for identifying an unknown biological substance
ATE483964T1 (de) Analyseverfahren und analyseeinrichtung
ATE393389T1 (de) Verfahren zur detektion von fluoreszenzlicht
US20230118814A1 (en) Metabolite detection apparatus and method of detecting metabolites
ATE387625T1 (de) Vorrichtung zur messung von durch licht angeregter fluoreszenz und deren verwendung
DE60109261D1 (de) Vorrichtung zur Bestimmung des Volumens einer einzigen roten Blutzelle
CN104949928A (zh) 一种新型在线检测光度计
CN211741155U (zh) 基于嵌入式芯片结构的电泳分离及紫外吸收检测系统
KR101926828B1 (ko) 라만 또는 형광 기반의 고감도 고효율 진단을 위한 바이오 센서

Legal Events

Date Code Title Description
8364 No opposition during term of opposition