ATE461444T1 - Vorrichtung und verfahren zur untersuchung von analyten in flüssigsuspension oder lösung - Google Patents

Vorrichtung und verfahren zur untersuchung von analyten in flüssigsuspension oder lösung

Info

Publication number
ATE461444T1
ATE461444T1 AT02783313T AT02783313T ATE461444T1 AT E461444 T1 ATE461444 T1 AT E461444T1 AT 02783313 T AT02783313 T AT 02783313T AT 02783313 T AT02783313 T AT 02783313T AT E461444 T1 ATE461444 T1 AT E461444T1
Authority
AT
Austria
Prior art keywords
analyte
solution
detector
light
analytes
Prior art date
Application number
AT02783313T
Other languages
English (en)
Inventor
Nikolai Schwabe
Original Assignee
Prolmmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prolmmune Ltd filed Critical Prolmmune Ltd
Application granted granted Critical
Publication of ATE461444T1 publication Critical patent/ATE461444T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47Scattering, i.e. diffuse reflection
    • G01N21/49Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/53Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0636Focussing flows, e.g. to laminate flows
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0654Lenses; Optical fibres
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N15/149Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT02783313T 2001-12-12 2002-12-09 Vorrichtung und verfahren zur untersuchung von analyten in flüssigsuspension oder lösung ATE461444T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0129688A GB2383127B (en) 2001-12-12 2001-12-12 Device and method for investigating analytes in liquid suspension or solution
PCT/GB2002/005567 WO2003054525A2 (en) 2001-12-12 2002-12-09 Device and method for investigating analytes in liquid suspension or solution

Publications (1)

Publication Number Publication Date
ATE461444T1 true ATE461444T1 (de) 2010-04-15

Family

ID=9927453

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02783313T ATE461444T1 (de) 2001-12-12 2002-12-09 Vorrichtung und verfahren zur untersuchung von analyten in flüssigsuspension oder lösung

Country Status (9)

Country Link
US (8) US7245379B2 (de)
EP (1) EP1454123B1 (de)
JP (1) JP2005513476A (de)
AT (1) ATE461444T1 (de)
AU (1) AU2002347379A1 (de)
DE (1) DE60235718D1 (de)
DK (1) DK1454123T3 (de)
GB (1) GB2383127B (de)
WO (1) WO2003054525A2 (de)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2383127B (en) * 2001-12-12 2004-10-20 Proimmune Ltd Device and method for investigating analytes in liquid suspension or solution
EP2127736A1 (de) 2003-04-10 2009-12-02 The President and Fellows of Harvard College Erzeugung und Kontrolle von Fluiden
JP4228808B2 (ja) 2003-07-23 2009-02-25 株式会社日立製作所 マイクロ分光計測装置及びマイクロ化学システム
EP1658133A1 (de) * 2003-08-27 2006-05-24 President And Fellows Of Harvard College Elektronische steuerung von fluidspezies
WO2005033654A2 (en) * 2003-08-28 2005-04-14 The Regents Of The University Of Michigan Micro flow cytometer with multiangular waveguide detectors having spectral capabilities
US20050103690A1 (en) * 2003-11-19 2005-05-19 Aisin Seiki Kabushiki Kaisha Micro liquid control system
US7155082B2 (en) * 2004-04-12 2006-12-26 Colorado School Of Mines Switchable microfluidic optical waveguides
WO2005103642A1 (ja) 2004-04-23 2005-11-03 The Furukawa Electric Co., Ltd. 検体の分離と識別と分注方法とその装置及び解析装置
US20080213821A1 (en) * 2004-05-06 2008-09-04 Nanyang Technological University Microfluidic Cell Sorter System
WO2006004176A1 (ja) * 2004-07-01 2006-01-12 Tama-Tlo Corporation 検体分析素子
JP2006029921A (ja) * 2004-07-14 2006-02-02 Institute Of Physical & Chemical Research フローサイトメーター
JP2006300564A (ja) * 2005-04-15 2006-11-02 Sumitomo Electric Ind Ltd 分析デバイス及び分析装置
US7709821B2 (en) * 2005-04-27 2010-05-04 Advanced Cytometry Instrumentation Systems, Inc. Flow cytometer acquisition and detection system
US7767444B2 (en) * 2005-05-31 2010-08-03 Nanyang Technological University Cell analysis using laser with external cavity
WO2007005907A1 (en) * 2005-07-01 2007-01-11 Honeywell International, Inc. A molded cartridge with 3-d hydrodynamic focusing
US8270781B2 (en) * 2005-10-28 2012-09-18 The Regents Of The University Of California Apparatus and method for improved optical detection of particles in fluid
FR2893414A1 (fr) * 2005-11-17 2007-05-18 Philippe Claude Loui Daurenjou Systeme de differenciation et de denombrement des particules suspendues dans un liquide.
US7551278B2 (en) 2006-05-12 2009-06-23 Honeywell International Inc. Fluid light guide system
KR20090027643A (ko) * 2006-05-17 2009-03-17 루미넥스 코포레이션 형광성 표지가 부착된 입자를 분석하기 위해 칩에 기초한 유세포분석기 시스템
US20090051912A1 (en) * 2006-10-02 2009-02-26 Agave Biosystems, Inc. Modular Microfluidic Flow Cytometer and Method Applications
US8285149B2 (en) * 2006-10-02 2012-10-09 Futurewei Technologies, Inc. Method and system for integrated DWDM transmitters
US8285150B2 (en) * 2006-10-02 2012-10-09 Futurewei Technologies, Inc. Method and system for integrated DWDM transmitters
US8050525B2 (en) * 2006-10-11 2011-11-01 Futurewei Technologies, Inc. Method and system for grating taps for monitoring a DWDM transmitter array integrated on a PLC platform
US8285151B2 (en) 2006-10-20 2012-10-09 Futurewei Technologies, Inc. Method and system for hybrid integrated 1XN DWDM transmitter
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
US20080245960A1 (en) * 2007-04-09 2008-10-09 Baker Hughes Incorporated Method and Apparatus to Determine Characteristics of an Oil-Based Mud Downhole
US20100181472A1 (en) * 2007-04-09 2010-07-22 Baker Hughes Incorporated Method and Apparatus to Determine Characteristics of an Oil-Based Mud Downhole
US8487238B2 (en) * 2007-11-01 2013-07-16 Baker Hughes Incorporated Method of identification of petroleum compounds using frequency mixing on surfaces
JP2009133818A (ja) * 2007-11-05 2009-06-18 Sony Corp 基板流路内における液体の送液方法及び液体送液装置
JP4661942B2 (ja) 2008-05-13 2011-03-30 ソニー株式会社 マイクロチップとその流路構造
JP2010169701A (ja) * 2008-05-13 2010-08-05 Sony Corp マイクロチップ
JP4572973B2 (ja) * 2008-06-16 2010-11-04 ソニー株式会社 マイクロチップ及びマイクロチップにおける送流方法
JP2010151777A (ja) * 2008-11-19 2010-07-08 Sony Corp 微小粒子解析装置、微小粒子解析用マイクロチップ及び微小粒子解析方法
US9678005B1 (en) * 2008-12-03 2017-06-13 Arizona Board Of Regents On Behalf Of The University Of Arizona Devices and methods for detection of microorganisms
JP5306835B2 (ja) * 2009-01-13 2013-10-02 古河電気工業株式会社 光計測方法
JP5308834B2 (ja) * 2009-01-13 2013-10-09 古河電気工業株式会社 微粒子分別装置及び微粒子分別方法
JP5487638B2 (ja) * 2009-02-17 2014-05-07 ソニー株式会社 微小粒子分取のための装置及びマイクロチップ
WO2010104497A1 (en) 2009-03-07 2010-09-16 Hewlett-Packard Development Company, L.P. Analyzer and method for sensing using the same
WO2010104993A2 (en) 2009-03-10 2010-09-16 The Regents Of The University Of California Fluidic flow cytometry devices and particle sensing based on signal-encoding
US9645010B2 (en) 2009-03-10 2017-05-09 The Regents Of The University Of California Fluidic flow cytometry devices and methods
DK2440941T3 (en) * 2009-06-10 2017-08-28 Cynvenio Biosystems Inc Sheath flow devices and methods
JP5321260B2 (ja) * 2009-06-11 2013-10-23 ソニー株式会社 光学的測定装置、並びにフローサイトメーター及び光学的測定方法
JP5493486B2 (ja) * 2009-06-16 2014-05-14 ソニー株式会社 物質混合装置と物質混合方法
WO2011021419A1 (ja) * 2009-08-20 2011-02-24 オリンパスメディカルシステムズ株式会社 生体測定装置及び生体測定方法
US8784626B2 (en) * 2010-01-28 2014-07-22 Bioptic, Inc. Bio-analysis using ball-ended incident and output optical fibers
DE202011111070U1 (de) * 2010-02-09 2019-05-24 Microjet Corporation Ausstoßvorrichtung für flüssiges Material mit partikelförmigen Körpern
JP5691195B2 (ja) 2010-03-01 2015-04-01 ソニー株式会社 マイクロチップ及び微小粒子分析装置
KR101885936B1 (ko) 2010-10-21 2018-09-10 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 무선 전력이 공급되는 전자 회로를 포함하는 미세 유체
KR101250751B1 (ko) * 2010-10-22 2013-04-03 연세대학교 산학협력단 다중 형광 정도 이용 세포 분리 장치 및 전극구조와 다중 형광 정도 이용 세포 분리 방법
WO2012058716A1 (en) * 2010-11-02 2012-05-10 Edith Cowan University An optical sensor for measuring a property of a fluid
CN102128777A (zh) * 2010-11-24 2011-07-20 西安交通大学 一种用于细胞检测的3d微流控结构及其制备方法
AU2012225123B2 (en) * 2011-03-07 2016-07-07 The Governing Council Of The University Of Toronto Method and system for portable cell detection and analysis using microfluidic technology
CN103931124A (zh) * 2011-09-09 2014-07-16 Fci公司 光子集成发射器装置、光子集成接收器装置、以及有源光缆收发器系统
US8958071B2 (en) 2011-11-15 2015-02-17 Empire Technology Development Llc Integrated optical sensor
WO2014038640A1 (ja) * 2012-09-06 2014-03-13 古河電気工業株式会社 検体識別分取装置および検体識別分取方法
EP2906928A4 (de) 2012-10-15 2016-11-09 Nanocellect Biomedical Inc Systeme, vorrichtungen und verfahren zum sortieren von partikeln
US9017537B2 (en) * 2013-03-13 2015-04-28 Eastman Kodak Company Metallic and semiconducting carbon nanotube sorting
US9372143B2 (en) * 2013-05-15 2016-06-21 Captl Llc Scanning image flow cytometer
US9453791B2 (en) * 2014-07-01 2016-09-27 Octrolix Bv Flow cytometry system and method
JP5897681B2 (ja) * 2014-10-08 2016-03-30 ソニー株式会社 マイクロチップ及び微小粒子分析装置
WO2016100954A1 (en) 2014-12-19 2016-06-23 Captl Llc Flow cytometry using hydrodynamically planar flow
JP6557022B2 (ja) * 2015-02-18 2019-08-07 アズビル株式会社 粒子検出装置
JP6438319B2 (ja) * 2015-02-18 2018-12-12 アズビル株式会社 粒子検出装置
US10036698B2 (en) 2015-06-19 2018-07-31 Captl Llc Time-sequential cytometry
JP6509759B2 (ja) * 2016-03-01 2019-05-08 ソニー株式会社 マイクロチップ及び微小粒子分析装置
EP3445492B1 (de) * 2016-04-20 2021-09-15 Cellix Limited Mikrofluidischer chip zum fokussieren eines stroms aus partikelhaltigem fluid
WO2017202932A2 (en) * 2016-05-24 2017-11-30 Cellix Limited An apparatus for microfluidic flow cytometry analysis of a particulate containing fluid
CN107029640B (zh) * 2017-05-23 2023-04-21 中国科学技术大学 基于液驱流动聚焦射流扰动的微液滴主动制备装置及方法
CN113725725A (zh) 2017-09-28 2021-11-30 苹果公司 使用量子阱混合技术的激光架构
CN116893160A (zh) 2017-09-29 2023-10-17 苹果公司 路径解析的光学采样架构
EP3688422B1 (de) 2017-09-29 2024-05-15 Apple Inc. Verbundene epitaktische optische abtastsysteme
TWI647430B (zh) * 2017-10-12 2019-01-11 致茂電子股份有限公司 光學量測裝置
US11035707B2 (en) * 2017-10-25 2021-06-15 Government Of The United States Of America, As Represented By The Secretary Of Commerce Optical flow meter for determining a flow rate of a liquid
JP6708978B2 (ja) * 2017-12-28 2020-06-10 ソニー株式会社 マイクロチップ及び微小粒子分析装置
US11226459B2 (en) 2018-02-13 2022-01-18 Apple Inc. Integrated photonics device having integrated edge outcouplers
JP2019184337A (ja) * 2018-04-05 2019-10-24 ソニー株式会社 マイクロチップ、微小粒子測定装置、及び微小粒子測定方法
US11022538B2 (en) 2018-05-15 2021-06-01 Government Of The United States Of America, As Represented By The Secretary Of Commerce Quantum flow cytometer
US11644618B2 (en) 2018-06-22 2023-05-09 Apple Inc. Discrete optical unit on a substrate of an integrated photonics chip
EP3821227B1 (de) * 2018-07-10 2024-03-13 Gerrit Jan Van Den Engh System, vorrichtung und verfahren zur ausseraxialen beleuchtung in der durchflusszytometrie
US11525967B1 (en) * 2018-09-28 2022-12-13 Apple Inc. Photonics integrated circuit architecture
US10458909B1 (en) 2018-10-24 2019-10-29 International Business Machines Corporation MEMS optical sensor
US11171464B1 (en) 2018-12-14 2021-11-09 Apple Inc. Laser integration techniques
US11881678B1 (en) 2019-09-09 2024-01-23 Apple Inc. Photonics assembly with a photonics die stack
US11525958B1 (en) 2019-09-09 2022-12-13 Apple Inc. Off-cut wafer with a supported outcoupler
US11835836B1 (en) 2019-09-09 2023-12-05 Apple Inc. Mach-Zehnder interferometer device for wavelength locking
US11231319B1 (en) 2019-09-09 2022-01-25 Apple Inc. Athermal wavelength stability monitor using a detraction grating
US11506535B1 (en) 2019-09-09 2022-11-22 Apple Inc. Diffraction grating design
US11320718B1 (en) 2019-09-26 2022-05-03 Apple Inc. Cantilever beam waveguide for silicon photonics device
US11500154B1 (en) 2019-10-18 2022-11-15 Apple Inc. Asymmetric optical power splitting system and method
EP4162253A1 (de) * 2020-06-09 2023-04-12 Particle Measuring Systems, Inc. Partikeldetektion über streulicht in kombination mit einfallendem licht
KR20230043191A (ko) 2020-09-09 2023-03-30 애플 인크. 노이즈 완화를 위한 광학 시스템
US11561346B2 (en) 2020-09-24 2023-01-24 Apple Inc. Tunable echelle grating
US11852865B2 (en) 2020-09-24 2023-12-26 Apple Inc. Optical system with phase shifting elements
US11815719B2 (en) 2020-09-25 2023-11-14 Apple Inc. Wavelength agile multiplexing
US11906778B2 (en) 2020-09-25 2024-02-20 Apple Inc. Achromatic light splitting device with a high V number and a low V number waveguide
US20220228984A1 (en) * 2021-01-20 2022-07-21 Electronics And Telecommunications Research Institute Fluorescence generating device and digital polymerase chain reaction analysis system including the same
US11914201B2 (en) 2021-09-23 2024-02-27 Apple Inc. Mechanisms that transfer light between layers of multi-chip photonic assemblies
CN114486823A (zh) * 2021-12-24 2022-05-13 广东唯实生物技术有限公司 用于侧向免疫层析仪器的光路系统和手持设备

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5558820A (en) 1978-10-27 1980-05-01 Fujitsu Ltd Data detection system
US4801205A (en) 1984-06-30 1989-01-31 Kabushiki Kaisha Toshiba Particle size measuring apparatus
JPS6114543A (ja) * 1984-06-30 1986-01-22 Toshiba Corp 粒径測定装置
JPS61110033A (ja) * 1984-11-02 1986-05-28 Toray Ind Inc 凝集反応の測定装置
JPS61145928A (ja) 1984-12-19 1986-07-03 Mitsubishi Electric Corp 位相比較器
US4936465A (en) * 1987-12-07 1990-06-26 Zoeld Tibor Method and apparatus for fast, reliable, and environmentally safe dispensing of fluids, gases and individual particles of a suspension through pressure control at well defined parts of a closed flow-through system
US4945400A (en) * 1988-03-03 1990-07-31 At&T Bell Laboratories Subassembly for optoelectronic devices
DD271953A1 (de) * 1988-05-09 1989-09-20 Zeiss Jena Veb Carl Einrichtung zur automatischen photometrischen analyse kleinster probenmengen
FR2638847B1 (fr) * 1988-11-04 1990-12-14 Commissariat Energie Atomique Dispositif optique integre pour la mesure d'indice de refraction d'un fluide
JPH02285830A (ja) 1989-04-27 1990-11-26 Nec Corp 同期切替装置
US4942305A (en) * 1989-05-12 1990-07-17 Pacific Scientific Company Integrating sphere aerosol particle detector
JPH0228538A (ja) * 1989-05-26 1990-01-30 Hitachi Ltd 蒸気湿り度測定装置
US5010346A (en) * 1989-10-27 1991-04-23 The Boeing Company Electro-optical analog-to-digital converter and method for digitizing an analog signal
US5377008A (en) * 1990-09-20 1994-12-27 Battelle Memorial Institute Integrated optical compensating refractometer apparatus
US5269937A (en) * 1990-10-23 1993-12-14 Cetus Corporation HPLC light scattering detector for biopolymers
US5250186A (en) 1990-10-23 1993-10-05 Cetus Corporation HPLC light scattering detector for biopolymers
EP0535861B1 (de) 1991-09-30 1998-02-18 AT&T Corp. Verfahren zur Herstellung von planaren optischen Wellenleitern
US5959738A (en) * 1994-07-25 1999-09-28 Molecular Devices Corporation Determination of light absorption pathlength in a vertical-beam photometer
DE4438391C2 (de) * 1994-10-27 1997-07-03 Evotec Biosystems Gmbh Vorrichtung zur Bestimmung stoffspezifischer Parameter eines oder weniger Moleküle mittels Korrelations-Spektroskopie
AU719048B2 (en) 1995-04-06 2000-05-04 Alfa Laval Agri Ab Method and apparatus for quantitative particle determination in fluids
AU6354796A (en) * 1995-06-23 1997-01-22 Novartis Ag Flow cell
US5726751A (en) * 1995-09-27 1998-03-10 University Of Washington Silicon microchannel optical flow cytometer
JPH09145928A (ja) * 1995-11-22 1997-06-06 Matsushita Electric Ind Co Ltd 光減衰器
US5991493A (en) * 1996-12-13 1999-11-23 Corning Incorporated Optically transmissive bonding material
US6144795A (en) 1996-12-13 2000-11-07 Corning Incorporated Hybrid organic-inorganic planar optical waveguide device
NL1008934C2 (nl) * 1998-04-20 1999-10-21 Univ Twente Geïntegreerde optische lichtgeleider inrichting.
FR2783919A1 (fr) * 1998-09-25 2000-03-31 Suisse Electronique Microtech Capteur optique integre pour detecter les composants d'un fluide
US6496260B1 (en) * 1998-12-23 2002-12-17 Molecular Devices Corp. Vertical-beam photometer for determination of light absorption pathlength
JP2001337030A (ja) * 2000-05-29 2001-12-07 Yokogawa Electric Corp 微粒子成分分析装置
DE10029946A1 (de) 2000-06-17 2001-12-20 Merck Patent Gmbh Integrierte optische Wellenleiter für mikrofluidische Analysensysteme
US20020028434A1 (en) * 2000-09-06 2002-03-07 Guava Technologies, Inc. Particle or cell analyzer and method
JP2002221485A (ja) * 2000-11-22 2002-08-09 Minolta Co Ltd マイクロチップ
AU2002318269A1 (en) * 2001-07-18 2003-03-03 The Regents Of The University Of Michigan Gas-focusing flow cytometer cell and flow cytometer detection system with waveguide optics
US20030038237A1 (en) * 2001-08-21 2003-02-27 Pranalytica, Inc. Amplifier-enhanced optical analysis system and method
GB2383127B (en) * 2001-12-12 2004-10-20 Proimmune Ltd Device and method for investigating analytes in liquid suspension or solution

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US20050068536A1 (en) 2005-03-31
US20140146315A1 (en) 2014-05-29
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AU2002347379A1 (en) 2003-07-09
US7245379B2 (en) 2007-07-17
GB0129688D0 (en) 2002-01-30
US20130271762A1 (en) 2013-10-17
EP1454123A2 (de) 2004-09-08
DK1454123T3 (da) 2010-06-28
WO2003054525A2 (en) 2003-07-03
GB2383127B (en) 2004-10-20
US20160178518A1 (en) 2016-06-23
GB2383127A (en) 2003-06-18
US20120307245A1 (en) 2012-12-06
WO2003054525A3 (en) 2003-11-20
US20070268489A1 (en) 2007-11-22
JP2005513476A (ja) 2005-05-12
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US7477384B2 (en) 2009-01-13
EP1454123B1 (de) 2010-03-17

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