ATE346287T1 - Verfahren und vorrichtung zur zuführung von proben zu einer chemischen sensormatrix - Google Patents

Verfahren und vorrichtung zur zuführung von proben zu einer chemischen sensormatrix

Info

Publication number
ATE346287T1
ATE346287T1 AT00975164T AT00975164T ATE346287T1 AT E346287 T1 ATE346287 T1 AT E346287T1 AT 00975164 T AT00975164 T AT 00975164T AT 00975164 T AT00975164 T AT 00975164T AT E346287 T1 ATE346287 T1 AT E346287T1
Authority
AT
Austria
Prior art keywords
chemical sensor
analyte
sensor matrix
supplying samples
cavities
Prior art date
Application number
AT00975164T
Other languages
English (en)
Inventor
John T Mcdevitt
Eric V Anslyn
Jason B Shear
Dean P Neikirk
Damon V Borich
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Application granted granted Critical
Publication of ATE346287T1 publication Critical patent/ATE346287T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0668—Trapping microscopic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
AT00975164T 1999-07-16 2000-07-14 Verfahren und vorrichtung zur zuführung von proben zu einer chemischen sensormatrix ATE346287T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14412699P 1999-07-16 1999-07-16
US14443599P 1999-07-16 1999-07-16
US14443699P 1999-07-16 1999-07-16

Publications (1)

Publication Number Publication Date
ATE346287T1 true ATE346287T1 (de) 2006-12-15

Family

ID=27386038

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00975164T ATE346287T1 (de) 1999-07-16 2000-07-14 Verfahren und vorrichtung zur zuführung von proben zu einer chemischen sensormatrix

Country Status (7)

Country Link
US (2) US6589779B1 (de)
EP (1) EP1204859B1 (de)
AT (1) ATE346287T1 (de)
AU (3) AU1429701A (de)
CA (1) CA2379130A1 (de)
DE (1) DE60031988T2 (de)
WO (3) WO2001006239A2 (de)

Families Citing this family (166)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030148354A1 (en) * 1996-10-02 2003-08-07 Saftest, Inc. Devices and methods for isolating and detecting specific substances in complex matrices
US6908770B1 (en) * 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
EP1212599A2 (de) * 1999-08-30 2002-06-12 Illumina, Inc. Verfahren zur verbesserung des signals einer sensorarray
WO2001055704A1 (en) * 2000-01-31 2001-08-02 Board Of Regents, The University Of Texas System System for transferring fluid samples through a sensor array
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
JP4954415B2 (ja) * 2000-02-10 2012-06-13 イルミナ インコーポレイテッド 試料のビーズをベースとした同時プロセシングのための基材としての個々のアレイのアレイおよびその製造法
RU2278612C2 (ru) * 2000-07-14 2006-06-27 Лайфскен, Инк. Иммуносенсор
CA2437558A1 (en) * 2001-01-31 2002-08-08 The Board Of Regents Of The University Of Texas System Method and apparatus for the confinement of materials in a micromachined chemical sensor array
US7294478B1 (en) * 2001-06-06 2007-11-13 Rosetta Inpharmatics Llc Microarray reaction cartridge
WO2003031419A1 (en) * 2001-10-09 2003-04-17 3-Dimensional Pharmaceuticals, Inc. Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes
US7253003B2 (en) * 2001-10-19 2007-08-07 Wisconsin Alumni Research Foundation Method for monitoring the environment within a microfluidic device
US7304259B2 (en) 2001-11-01 2007-12-04 Siemens Energy & Automation, Inc. Mail processing system with multilevel contaminant detection and sterilization
AU2002365053A1 (en) * 2001-12-20 2003-07-09 Safetest, Inc. Devices and methods for isolating and detecting specific substances in complex matrices
KR100994306B1 (ko) * 2002-03-15 2010-11-12 소니 주식회사 바이오 어세이용 기판, 바이오 어세이 방법, 바이오 어세이 장치 및 기판 기록 정보의 판독 장치
US20060134713A1 (en) * 2002-03-21 2006-06-22 Lifescan, Inc. Biosensor apparatus and methods of use
US20030180814A1 (en) * 2002-03-21 2003-09-25 Alastair Hodges Direct immunosensor assay
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
WO2003090605A2 (en) * 2002-04-26 2003-11-06 Board Of Regents, The University Of Texas System Method and system for the detection of cardiac risk factors
WO2003096015A1 (fr) * 2002-05-08 2003-11-20 Matsushita Electric Industrial Co., Ltd. Substrat biomoleculaire, masse moleculaire d'essai ou de diagnostic utilisant ce substrat, et appareil s'y rapportant
US7390461B2 (en) * 2002-05-14 2008-06-24 Arryx, Inc. Broad spectrum optically addressed sensor
US7332273B2 (en) * 2002-06-20 2008-02-19 Affymetrix, Inc. Antireflective coatings for high-resolution photolithographic synthesis of DNA arrays
US20070275411A1 (en) 2006-05-25 2007-11-29 Mcgall Glenn H Silane mixtures
US20030003587A1 (en) * 2002-06-28 2003-01-02 Murray George M Molecularly imprinted polymer based sensors for the detection of narcotics
US7183455B2 (en) * 2002-08-27 2007-02-27 Drdc Limited Adhesive dressing
US6900133B2 (en) 2002-09-18 2005-05-31 Applied Materials, Inc Method of etching variable depth features in a crystalline substrate
GB0225791D0 (en) * 2002-11-05 2002-12-11 Kratos Analytical Ltd Charged particle spectrometer and detector therefor
US7122384B2 (en) * 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
FR2846957B1 (fr) * 2002-11-13 2005-09-30 Commissariat Energie Atomique Micro-systeme a remplissage de micro-billes et procede d'obtention
AU2003302264A1 (en) 2002-12-20 2004-09-09 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
EP1590669B1 (de) * 2003-02-05 2009-11-25 The General Hospital Corporation System auf mikrochipbasis zur hiv-diagnostik
US20040241880A1 (en) * 2003-05-30 2004-12-02 Leproust Eric M. Ligand array assays having reduced fluorescent dye degradation and compositions for practicing the same
US7298478B2 (en) 2003-08-14 2007-11-20 Cytonome, Inc. Optical detector for a particle sorting system
WO2005059551A2 (en) * 2003-12-11 2005-06-30 Board Of Regents, The University Of Texas System Method and system for the analysis of saliva using a sensor array
US20060257991A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Integration of fluids and reagents into self-contained cartridges containing particle-based sensor elements and membrane-based sensor elements
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
US8105849B2 (en) 2004-02-27 2012-01-31 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements
US20060257854A1 (en) * 2004-02-27 2006-11-16 Mcdevitt John T Membrane assay system including preloaded particles
US20070178009A1 (en) * 2004-03-18 2007-08-02 Yoshiki Sakaino Analysis element for use in method of testing specimen
US7776531B1 (en) 2004-03-25 2010-08-17 Illumina, Inc. Compositions and methods for stabilizing surface bound probes
US7442339B2 (en) * 2004-03-31 2008-10-28 Intel Corporation Microfluidic apparatus, Raman spectroscopy systems, and methods for performing molecular reactions
US7692219B1 (en) 2004-06-25 2010-04-06 University Of Hawaii Ultrasensitive biosensors
US7763454B2 (en) * 2004-07-09 2010-07-27 Church & Dwight Co., Inc. Electronic analyte assaying device
US20060211126A1 (en) 2004-09-16 2006-09-21 Banks Bruce A Method for using texturing surfaces of optical fiber sensors for blood glucose monitoring
US20060229531A1 (en) * 2005-02-01 2006-10-12 Daniel Goldberger Blood monitoring system
US7608042B2 (en) * 2004-09-29 2009-10-27 Intellidx, Inc. Blood monitoring system
WO2006043899A1 (en) * 2004-10-18 2006-04-27 Nanyang Technological University A transducer
US7785785B2 (en) 2004-11-12 2010-08-31 The Board Of Trustees Of The Leland Stanford Junior University Charge perturbation detection system for DNA and other molecules
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
AU2005311631B2 (en) 2004-12-03 2012-06-07 Cytonome/St, Llc Unitary cartridge for particle processing
US20070023643A1 (en) 2005-02-01 2007-02-01 Nolte David D Differentially encoded biological analyzer planar array apparatus and methods
US7910356B2 (en) 2005-02-01 2011-03-22 Purdue Research Foundation Multiplexed biological analyzer planar array apparatus and methods
US7405831B2 (en) 2005-02-01 2008-07-29 Purdue Research Foundation Laser scanning interferometric surface metrology
DE102005013198B4 (de) * 2005-03-16 2007-07-19 BAM Bundesanstalt für Materialforschung und -prüfung Optochemische Sensormembran und Verfahren zur Herstellung
US20060228734A1 (en) * 2005-03-18 2006-10-12 Applera Corporation Fluid processing device with captured reagent beads
WO2007053186A2 (en) 2005-05-31 2007-05-10 Labnow, Inc. Methods and compositions related to determination and use of white blood cell counts
US20060275852A1 (en) * 2005-06-06 2006-12-07 Montagu Jean I Assays based on liquid flow over arrays
US9410889B2 (en) 2005-06-10 2016-08-09 Applied Biosystem, Llc Method and system for multiplex genetic analysis
CA2613078A1 (en) 2005-06-24 2007-01-04 Board Of Regents, The University Of Texas System Systems and methods including self-contained cartridges with detection systems and fluid delivery systems
US7791728B2 (en) * 2005-08-11 2010-09-07 Hewlett-Packard Development Company, L.P. System for optically analyzing a substance with a selected single-wavelength
US20070123801A1 (en) * 2005-11-28 2007-05-31 Daniel Goldberger Wearable, programmable automated blood testing system
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US20080038738A1 (en) * 2006-05-10 2008-02-14 The Board Of Regents Of The University Of Texas System Detecting tumor biomarker in oral cancer
US8092385B2 (en) 2006-05-23 2012-01-10 Intellidx, Inc. Fluid access interface
US7382944B1 (en) 2006-07-14 2008-06-03 The United States Of America As Represented By The Administration Of The National Aeronautics And Space Administration Protective coating and hyperthermal atomic oxygen texturing of optical fibers used for blood glucose monitoring
WO2008055257A2 (en) * 2006-11-02 2008-05-08 Vectrant Technologies Inc. Cartridge for conducting diagnostic assays
US7522282B2 (en) 2006-11-30 2009-04-21 Purdue Research Foundation Molecular interferometric imaging process and apparatus
EP2118653A4 (de) * 2006-12-07 2009-12-09 Univ Florida Materialien und verfahren zur effizienten und genauen detektion von analyten
EP2653861B1 (de) 2006-12-14 2014-08-13 Life Technologies Corporation Verfahren zur Nukleinsäure-Sequenzierung mittels großer FET-Arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US8262900B2 (en) * 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
WO2008089495A2 (en) * 2007-01-19 2008-07-24 Purdue Research Foundation System with extended range of molecular sensing through integrated multi-modal data acquisition
EP2120680A2 (de) 2007-02-06 2009-11-25 Glumetrics, Inc. Optische systeme und verfahren zur ratiometrischen messung der blutzuckerkonzentration
US8972196B2 (en) * 2007-02-06 2015-03-03 Medtronic Minimed, Inc. Algorithms for calibrating an analyte sensor
CA2681722A1 (en) 2007-03-26 2008-10-02 Purdue Research Foundation Method and apparatus for conjugate quadrature interferometric detection of an immunoassay
US20080268442A1 (en) * 2007-04-24 2008-10-30 Igd Intel, Llc Method and system for preparing a blood sample for a disease association gene transcript test
JP5517919B2 (ja) 2007-05-10 2014-06-11 グルメトリクス、 インク． 即時血管内グルコース測定のための平衡非消費蛍光センサー
US20080309923A1 (en) * 2007-06-14 2008-12-18 Falk R Aaron Compact chemical sensor
US20110059040A1 (en) * 2007-06-27 2011-03-10 Kiser Patrick F Compositions and methods for inhibiting viral and bacterial activity
WO2009006075A2 (en) * 2007-06-29 2009-01-08 Board Of Regents, The University Of Texas System Functionalized expanded porphyrins
CA2734029C (en) 2007-08-30 2016-03-29 The Trustees Of Tufts College Methods for determining the concentration of an analyte in solution
WO2009067626A1 (en) 2007-11-21 2009-05-28 Glumetrics, Inc. Use of an equilibrium intravascular sensor to achieve tight glycemic control
US8180421B2 (en) * 2007-12-12 2012-05-15 Kimberly-Clark Worldwide, Inc. Resonance energy transfer based detection of nosocomial infection
EP2265677B1 (de) * 2008-04-09 2019-05-15 Battelle Memorial Institute Korrosionsdetektionsprodukt und verfahren
WO2009129186A2 (en) 2008-04-17 2009-10-22 Glumetrics, Inc. Sensor for percutaneous intravascular deployment without an indwelling cannula
JP5667049B2 (ja) * 2008-06-25 2015-02-12 ライフ テクノロジーズ コーポレーション 大規模なｆｅｔアレイを用いて分析物を測定するための方法および装置
EP2331952B1 (de) * 2008-09-04 2016-06-15 The Board of Trustees of the University of Illionis Kolorimetrischer sensor basierend auf nanoporösen pigmenten
US8222047B2 (en) * 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US8385998B2 (en) * 2008-10-24 2013-02-26 Jin Zhang Contact lens integrated with a biosensor for the detection of glucose and other components in tears
US8802074B2 (en) 2008-11-26 2014-08-12 Board Of Regents, The University Of Texas System Polymers functionalized with ion-specific recognition elements
US8753290B2 (en) 2009-03-27 2014-06-17 Intellectual Inspiration, Llc Fluid transfer system and method
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US8673627B2 (en) 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
CA2766597A1 (en) * 2009-07-01 2011-01-06 Board Of Regents, The University Of Texas System Methods of determining the presence and/or concentration of an analyte in a sample
GB0913258D0 (en) * 2009-07-29 2009-09-02 Dynex Technologies Inc Reagent dispenser
US9523701B2 (en) * 2009-07-29 2016-12-20 Dynex Technologies, Inc. Sample plate systems and methods
WO2011041546A1 (en) 2009-09-30 2011-04-07 Glumetrics, Inc. Sensors with thromboresistant coating
US8467843B2 (en) 2009-11-04 2013-06-18 Glumetrics, Inc. Optical sensor configuration for ratiometric correction of blood glucose measurement
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8236574B2 (en) * 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
ES2544635T3 (es) * 2010-03-01 2015-09-02 Quanterix Corporation Métodos para extender el rango dinámico en ensayos para la detección de moléculas o partículas
WO2011113020A1 (en) * 2010-03-11 2011-09-15 Glumetrics, Inc. Measurement devices and methods for measuring analyte concentration incorporating temperature and ph correction
WO2011124945A1 (en) * 2010-04-07 2011-10-13 Empire Technology Development Llc. Detector for detecting contaminants in water or aqueous solutions
EP2388592A1 (de) * 2010-05-19 2011-11-23 Stichting Dutch Polymer Institute Kügelchen und Verfahren zu deren Herstellung und Sensorvorrichtung
EP2588838B1 (de) * 2010-06-29 2018-03-21 Life Technologies Corporation Ph-messvorrichtung mit partikeln mit immobilisiertem puffer
US20110318820A1 (en) 2010-06-29 2011-12-29 Life Technologies Corporation Immobilized Buffer Particles and Uses Thereof
TWI569025B (zh) 2010-06-30 2017-02-01 生命技術公司 用於測試離子感測場效電晶體（ｉｓｆｅｔ）陣列之裝置及方法
EP2598804B1 (de) 2010-06-30 2021-10-20 Life Technologies Corporation Verfahren zur erzeugung eines ausgangssignals in einem isfet-array
WO2012003363A1 (en) 2010-06-30 2012-01-05 Life Technologies Corporation Ion-sensing charge-accumulation circuits and methods
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
US8653567B2 (en) 2010-07-03 2014-02-18 Life Technologies Corporation Chemically sensitive sensor with lightly doped drains
US9618475B2 (en) 2010-09-15 2017-04-11 Life Technologies Corporation Methods and apparatus for measuring analytes
EP2619564B1 (de) 2010-09-24 2016-03-16 Life Technologies Corporation Transistorschaltungen mit zusammengehörigen paaren
WO2012065117A2 (en) 2010-11-12 2012-05-18 William Marsh Rice University Oral cancer point of care diagnostics
US9671413B2 (en) 2010-11-12 2017-06-06 William Marsh Rice University Prostate cancer point of care diagnostics
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US8735175B2 (en) * 2011-03-18 2014-05-27 Chris D. Geddes Multicolor microwave-accelerated metal-enhanced fluorescence (M-MAMEF)
US20120264202A1 (en) * 2011-03-23 2012-10-18 Walker Christopher I System for performing polymerase chain reaction nucleic acid amplification
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
SG194892A1 (en) 2011-05-12 2013-12-30 Univ Rice William M Bio-nano-chips for on-site drug screening
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
CN104011197B (zh) * 2011-12-19 2016-08-24 雅马哈发动机株式会社 对象物分选装置以及对象物分选方法
US8747748B2 (en) 2012-01-19 2014-06-10 Life Technologies Corporation Chemical sensor with conductive cup-shaped sensor surface
US8821798B2 (en) 2012-01-19 2014-09-02 Life Technologies Corporation Titanium nitride as sensing layer for microwell structure
US9533308B2 (en) 2012-02-10 2017-01-03 California Institute Of Technology PC board-based polymerase chain reaction systems, methods and materials
US8860579B1 (en) * 2012-03-06 2014-10-14 Ali T. Alouani Illegal drug detector and method of its use
WO2013176767A1 (en) 2012-05-25 2013-11-28 The University Of North Carolina At Chapel Hill Microfluidic devices, solid supports for reagents and related methods
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
EP2908140B1 (de) * 2012-10-15 2019-08-14 National University Corporation Nagoya University Mikrokanalchip zur mikropartikeltrennung, mikropartikeltrennverfahren und system zur mikropartikeltrennung mithilfe des chips
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
WO2014113502A1 (en) 2013-01-15 2014-07-24 Quanterix Corporation Detection of dna or rna using single molecule arrays and other techniques
US8962366B2 (en) 2013-01-28 2015-02-24 Life Technologies Corporation Self-aligned well structures for low-noise chemical sensors
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
US8841217B1 (en) 2013-03-13 2014-09-23 Life Technologies Corporation Chemical sensor with protruded sensor surface
WO2014149779A1 (en) 2013-03-15 2014-09-25 Life Technologies Corporation Chemical device with thin conductive element
EP4036579A1 (de) 2013-03-15 2022-08-03 Arizona Board of Regents on behalf of Arizona State University Biosensor-mikroarrayzusammensetzungen und verfahren
WO2014149780A1 (en) 2013-03-15 2014-09-25 Life Technologies Corporation Chemical sensor with consistent sensor surface areas
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
US9116117B2 (en) 2013-03-15 2015-08-25 Life Technologies Corporation Chemical sensor with sidewall sensor surface
JP6581074B2 (ja) 2013-03-15 2019-09-25 ライフ テクノロジーズ コーポレーション 一貫性のあるセンサ表面積を有する化学センサ
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
US9028772B2 (en) 2013-06-28 2015-05-12 Google Inc. Methods for forming a channel through a polymer layer using one or more photoresist layers
US8816278B1 (en) * 2013-09-05 2014-08-26 Globalfoundries Singapore Pte. Ltd. Imaging methods
US20150111778A1 (en) * 2013-10-21 2015-04-23 William Marsh Rice University Bio-nano-chip for anticonvulsant drug salivary assay
US10241099B2 (en) 2014-03-20 2019-03-26 Agency For Science, Technology And Research Film sensor
GB2524541A (en) * 2014-03-26 2015-09-30 Ibm Microfluidic chip with conic bead trapping cavities and fabrication thereof
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
KR102593647B1 (ko) 2014-12-18 2023-10-26 라이프 테크놀로지스 코포레이션 트랜스미터 구성을 갖춘 높은 데이터율 집적 회로
EP3234575B1 (de) 2014-12-18 2023-01-25 Life Technologies Corporation Vorrichtung zur messung von analyten unter verwendung von grossflächigen fet-arrays
GB201501012D0 (en) * 2015-01-21 2015-03-04 Base4 Innovation Ltd Improved droplet sequencing apparatus and method
US10870111B2 (en) 2015-07-22 2020-12-22 The University Of North Carolina At Chapel Hill Fluidic devices with bead well geometries with spatially separated bead retention and signal detection segments and related methods
WO2017132727A1 (en) * 2016-02-02 2017-08-10 The University Of Adelaide Apparatus, method and system for detecting a chemical driving property using a fluorophore
DE102016117919A1 (de) 2016-09-22 2018-03-22 Endress+Hauser Messtechnik GmbH+Co.KG Dosiervorrichtung einer Prozessanlage
US11243192B2 (en) * 2016-09-27 2022-02-08 Vaon, Llc 3-D glass printable hand-held gas chromatograph for biomedical and environmental applications
JP7025141B2 (ja) * 2017-06-21 2022-02-24 シンロイヒ株式会社 蛍光検出方法、インク組成物、塗装体、及び対象物の識別方法
DE102017114537A1 (de) * 2017-06-29 2019-01-03 Endress+Hauser Conducta Gmbh+Co. Kg Sensormembran, Sensorkappe und optischer Sensor
US11383236B2 (en) 2017-11-10 2022-07-12 Christopher Walker Polymerase chain reaction using a microfluidic chip fabricated with printed circuit board techniques
CN112912725A (zh) * 2018-10-25 2021-06-04 Tl基因体科技株式会社 使用微通道对血液进行预处理以对血细胞进行分级
JP6912140B2 (ja) * 2019-03-28 2021-07-28 国立大学法人愛媛大学 分光分析用チップ

Family Cites Families (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3696932A (en) 1970-09-30 1972-10-10 Pall Corp Disposable filter assembly
US3701433A (en) 1970-11-10 1972-10-31 Pall Corp Filter for use in the filtration of blood
US3709868A (en) 1971-03-08 1973-01-09 Hoffmann La Roche Opium alkaloid antigens and antibodies specific therefor
US3843696A (en) 1972-09-05 1974-10-22 Syva Co Methadone analog compounds
CS164231B2 (de) 1972-09-28 1975-11-07
US3856469A (en) 1973-01-02 1974-12-24 Syva Corp Interferant removal from amphetamine immunoassay
US3954623A (en) 1974-05-28 1976-05-04 Johnson & Johnson Blood filtration unit
US3876504A (en) 1974-06-10 1975-04-08 Early Warning Co Procedure for determination of antigens and antibodies and articles for use therewith
US4189382A (en) 1974-11-07 1980-02-19 Sherwood Medical Industries Inc. Blood coagulation and separation
US4036946A (en) 1975-10-20 1977-07-19 Marcos Kleinerman Immunofluorometric method for measuring minute quantities of antigens, antibodies and other substances
US4050898A (en) 1976-04-26 1977-09-27 Eastman Kodak Company Integral analytical element
US4069017A (en) 1977-01-14 1978-01-17 Eastman Kodak Company Colorimetric assay for bilirubin
US4200613A (en) 1977-06-03 1980-04-29 Ramco Laboratories Inc. Radioimmunoassay apparatus
US4115277A (en) 1977-06-17 1978-09-19 Pioneer Filters, Inc. Blood filtering apparatus of graduated fiber density
US4294817A (en) 1977-11-25 1981-10-13 International Diagnostic Technology, Inc. Method of fluoro immunoassay
US4245041A (en) 1977-12-07 1981-01-13 American Monitor Corporation Triglycerides assay and reagents therefor
US4246107A (en) 1978-03-06 1981-01-20 Asahi Kasei Kogyo Kabushiki Kaisha Separation of lymphocytes from lymphocyte-containing suspension by filtration
US4378429A (en) 1979-08-23 1983-03-29 Modrovich Ivan Endre Enzymatic method and stabilized solutions for determining total cholesterol in human serum
US4344743A (en) 1979-12-04 1982-08-17 Bessman Samuel P Piezoelectric driven diaphragm micro-pump
DE3029579C2 (de) 1980-08-05 1985-12-12 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und Mittel zur Abtrennung von Plasma oder Serum aus Vollblut
US4596657A (en) 1982-06-04 1986-06-24 Miles Laboratories, Inc. Blood bag system with integral filtering means
US4567149A (en) 1983-03-17 1986-01-28 Mast Immunosystems, Ltd. Binding assay system and method of making and using same
US4922591A (en) * 1984-03-20 1990-05-08 Carboloy Inc. Tool storage and changing system
US4672028A (en) 1984-05-23 1987-06-09 Icn Micromedic Systems, Inc. Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels
IL77144A (en) 1984-11-27 1991-04-15 Orgenics Ltd Method and apparatus for performing solid phase immuno-assay on test card in a plurality of samples
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5354825A (en) 1985-04-08 1994-10-11 Klainer Stanley M Surface-bound fluorescent polymers and related methods of synthesis and use
US4661445A (en) 1985-05-24 1987-04-28 Saxinger W Carl Competitive ELISA for the detection of HTLV-III antibodies
US4623461A (en) 1985-05-31 1986-11-18 Murex Corporation Transverse flow diagnostic device
US4795698A (en) 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
US4855225A (en) 1986-02-07 1989-08-08 Applied Biosystems, Inc. Method of detecting electrophoretically separated oligonucleotides
US4810378A (en) 1986-04-21 1989-03-07 Miles Laboratories, Inc. Red blood cell filtering system
US4777021A (en) * 1986-04-25 1988-10-11 Richard K. Wertz Manifold vacuum device for biochemical and immunological uses
US5143853A (en) 1986-06-25 1992-09-01 Trustees Of Tufts College Absorbance modulated fluorescence detection methods and sensors
US5252494A (en) 1986-06-25 1993-10-12 Trustees Of Tufts College Fiber optic sensors, apparatus, and detection methods using controlled release polymers and reagent formulations held within a polymeric reaction matrix
US4812293A (en) * 1986-06-30 1989-03-14 Becton, Dickinson And Company Vacuum actuated assay device and method of using same
US4935346A (en) 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
US4753776A (en) 1986-10-29 1988-06-28 Biotrack, Inc. Blood separation device comprising a filter and a capillary flow pathway exiting the filter
US4925800A (en) 1986-12-04 1990-05-15 The United States Of America As Represented By The Department Of Health And Human Services Monoclonal antibody against human pneumocystis carinii
US4813277A (en) 1987-03-30 1989-03-21 Amoco Corporation Method for collecting magnetizable particles in an above ground storage tank
US4828386A (en) 1987-06-19 1989-05-09 Pall Corporation Multiwell plates containing membrane inserts
US5209904A (en) 1987-12-23 1993-05-11 Abbott Laboratories Agglutination reaction device utilizing selectively impregnated porous material
US4938742A (en) 1988-02-04 1990-07-03 Smits Johannes G Piezoelectric micropump with microvalves
US5162863A (en) 1988-02-15 1992-11-10 Canon Kabushiki Kaisha Method and apparatus for inspecting a specimen by optical detection of antibody/antigen sensitized carriers
DE68911359T2 (de) * 1988-04-26 1994-05-11 Nippon Telegraph & Telephone Lasermagnetisches Immuntestverfahren und Gerät dazu.
US4874499A (en) 1988-05-23 1989-10-17 Massachusetts Institute Of Technology Electrochemical microsensors and method of making such sensors
US5252294A (en) * 1988-06-01 1993-10-12 Messerschmitt-Bolkow-Blohm Gmbh Micromechanical structure
US4908112A (en) 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
JP2955759B2 (ja) 1988-07-20 1999-10-04 セゲブ・ダイアグノスティックス・インコーポレイテッド 核酸配列を増幅及び検出する方法
IT1226712B (it) 1988-08-05 1991-02-05 Eniricerche Spa Metodo immunoenzimatico elisa monopiastra con inibizione competitiva per la rivelazione di anticorpi antisporozoitari di plasmodium falciparum.
US5108933A (en) 1988-09-16 1992-04-28 Immunicon Corporation Manipulation of colloids for facilitating magnetic separations
FR2638848B1 (fr) 1988-11-04 1993-01-22 Chemunex Sa Procede de detection et/ou de dosage dans un milieu liquide ou semi-liquide d'au moins une substance organique, biologique ou medicamenteuse soluble, par une methode d'agglutination
IE67038B1 (en) 1988-12-22 1996-02-21 Patrick Joseph Joyce Immunodiagnostic assays for use in the detection and determination of mastitis
US6008031A (en) 1989-05-12 1999-12-28 Duke University Method of analysis and manipulation of DNA utilizing mismatch repair systems
US5156810A (en) 1989-06-15 1992-10-20 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
US5491097A (en) 1989-06-15 1996-02-13 Biocircuits Corporation Analyte detection with multilayered bioelectronic conductivity sensors
US5053197A (en) 1989-07-19 1991-10-01 Pb Diagnostic Systems, Inc. Diagnostic assay module
JP3127449B2 (ja) 1989-07-28 2001-01-22 三菱化学株式会社 抗体の測定法
CA2024548C (en) 1989-09-05 2002-05-28 David Issachar Analyte specific chemical sensor
US5137833A (en) 1989-09-21 1992-08-11 Russell Anthony P Method for detecting polyhydroxyl compounds
US5366860A (en) 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
US5188934A (en) 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
US4997577A (en) 1989-12-20 1991-03-05 Baxter International Inc. Systems and methods for removing undesired matter from blood cells
CA2035010C (en) 1990-01-26 1996-12-10 Keith C. Backman Method of amplifying target nucleic acids applicable to both polymerase and ligase chain reactions
US5183740A (en) 1990-02-23 1993-02-02 The United States Of America As Represented By The Secretary Of The Navy Flow immunosensor method and apparatus
US5965695A (en) 1990-05-15 1999-10-12 Chiron Corporation Modified peptide and peptide libraries with protease resistance, derivatives thereof and methods of producing and screening such
US5182366A (en) 1990-05-15 1993-01-26 Huebner Verena D Controlled synthesis of peptide mixtures using mixed resins
US5223393A (en) 1990-06-12 1993-06-29 Microgenics Corporation Detection of analytes having binding sites for at least two binding moieties
JPH06501225A (ja) 1990-07-09 1994-02-10 ジェイ　ガズデン　ピーティーワイ　リミテッド 改良型容器
US5147606A (en) 1990-08-06 1992-09-15 Miles Inc. Self-metering fluid analysis device
US5071076A (en) 1990-08-10 1991-12-10 Omni Quest Corporation Method for producing magnetic microparticles from metallocenes
US5235028A (en) 1990-08-31 1993-08-10 University Of Minnesota Polyethylene glycol derivatives for solid-phase applications
US5244813A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample
US5244636A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample
US5250264A (en) 1991-01-25 1993-10-05 Trustees Of Tufts College Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample
US5235039A (en) * 1991-06-10 1993-08-10 Eli Lilly And Company Substrates for hiv protease
US5578444A (en) 1991-06-27 1996-11-26 Genelabs Technologies, Inc. Sequence-directed DNA-binding molecules compositions and methods
DE69227112D1 (de) 1991-07-16 1998-10-29 Transmed Biotech Inc Verfahren und zusammensetzungen für die gleichzeitige analyse einer vielzahl von analyten
US5211850A (en) 1991-07-26 1993-05-18 Research Medical, Inc. Plasma filter sorbent system for removal of components from blood
US5288214A (en) 1991-09-30 1994-02-22 Toshio Fukuda Micropump
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
JPH05157684A (ja) 1991-12-02 1993-06-25 Seikagaku Kogyo Co Ltd 吸光光度計
US6063581A (en) 1992-01-22 2000-05-16 Axis-Shield Asa Immunoassay for homocysteine
US5262127A (en) 1992-02-12 1993-11-16 The Regents Of The University Of Michigan Solid state chemical micro-reservoirs
US5654497A (en) 1992-03-03 1997-08-05 Lockheed Martin Energy Systems, Inc. Motor vehicle fuel analyzer
US5391272A (en) 1992-03-06 1995-02-21 Andcare, Inc. Electrochemical immunoassay methods
US5518887A (en) 1992-03-30 1996-05-21 Abbott Laboratories Immunoassays empolying generic anti-hapten antibodies and materials for use therein
US5248742A (en) 1992-04-27 1993-09-28 Gencorp Inc. Unsaturated polyester-epoxy resin network composition
US5278303A (en) 1992-06-12 1994-01-11 University Of Toronto Innovations Foundation Polymer-supported solution synthesis of oligosaccharides
US5674698A (en) 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5503985A (en) 1993-02-18 1996-04-02 Cathey; Cheryl A. Disposable device for diagnostic assays
US5677196A (en) 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
GB9311988D0 (en) 1993-06-10 1993-07-28 Pall Corp Device and method for separating plasma from a blood product
US5382512A (en) 1993-08-23 1995-01-17 Chiron Corporation Assay device with captured particle reagent
FR2710410B1 (fr) 1993-09-20 1995-10-20 Bio Merieux Procédé et dispositif pour la détermination d'un analyte dans un échantillon .
JP3488465B2 (ja) * 1993-10-28 2004-01-19 ヒューストン・アドバンスド・リサーチ・センター 結合反応を別々に検出する微細加工フロースルー多孔性装置
US5499909A (en) 1993-11-17 1996-03-19 Aisin Seiki Kabushiki Kaisha Of Kariya Pneumatically driven micro-pump
WO1995018307A1 (fr) 1993-12-28 1995-07-06 Westonbridge International Limited Micropompe
US5616698A (en) 1994-01-10 1997-04-01 University Of Toronto Innovations Foundation Polymer-supported solution synthesis of oligosaccharides
US5631130A (en) 1994-05-13 1997-05-20 Abbott Laboratories Materials and methods for the detection of Mycobacterium tuberculosis
US5583162A (en) 1994-06-06 1996-12-10 Biopore Corporation Polymeric microbeads and method of preparation
JPH0842457A (ja) 1994-07-27 1996-02-13 Aisin Seiki Co Ltd マイクロポンプ
US5512490A (en) 1994-08-11 1996-04-30 Trustees Of Tufts College Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns
US5965590A (en) 1994-09-08 1999-10-12 Romark Lab Lc Method for treatment of opportunistic infections with pharmaceutical compositions of tizoxanide and nitazoxanide
US5603351A (en) 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5632876A (en) 1995-06-06 1997-05-27 David Sarnoff Research Center, Inc. Apparatus and methods for controlling fluid flow in microchannels
CA2204912C (en) * 1994-11-10 2005-01-04 David Sarnoff Research Center, Inc. Liquid distribution system
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5616790A (en) 1994-11-18 1997-04-01 California Institute Of Technology Lipid-based metal sensor
US5550373A (en) 1994-12-30 1996-08-27 Honeywell Inc. Fabry-Perot micro filter-detector
US5571401A (en) 1995-03-27 1996-11-05 California Institute Of Technology Sensor arrays for detecting analytes in fluids
US5834318A (en) 1995-05-10 1998-11-10 Bayer Corporation Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5690807A (en) 1995-08-03 1997-11-25 Massachusetts Institute Of Technology Method for producing semiconductor particles
US5843655A (en) 1995-09-18 1998-12-01 Affymetrix, Inc. Methods for testing oligonucleotide arrays
US5714122A (en) 1995-11-22 1998-02-03 Minnesota Mining And Manufacturing Company Emulsion for robust sensing
US5705018A (en) 1995-12-13 1998-01-06 Hartley; Frank T. Micromachined peristaltic pump
US5814524A (en) 1995-12-14 1998-09-29 Trustees Of Tufts College Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations
US6127139A (en) 1996-01-04 2000-10-03 Nederlands Organisatle Voor Toegepast-Natuurwetenschappelijk Onderzoek (Tno) Method for assaying proteolytic enzymes using fluorescence-quenched substrates
JP3664328B2 (ja) 1996-01-19 2005-06-22 富士写真フイルム株式会社 血漿または血清試料の調製方法
US6013440A (en) 1996-03-11 2000-01-11 Affymetrix, Inc. Nucleic acid affinity columns
US5747349A (en) * 1996-03-20 1998-05-05 University Of Washington Fluorescent reporter beads for fluid analysis
CA2250212C (en) * 1996-04-03 2010-02-09 The Perkin-Elmer Corporation Device and method for multiple analyte detection
US5840256A (en) 1996-04-09 1998-11-24 David Sarnoff Research Center Inc. Plate for reaction system
US5788814A (en) 1996-04-09 1998-08-04 David Sarnoff Research Center Chucks and methods for positioning multiple objects on a substrate
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
JP3950493B2 (ja) 1996-04-26 2007-08-01 東レ・ダウコーニング株式会社 導電性シリコーンゴム組成物、半導体装置の製造方法およびその半導体装置
US6103479A (en) 1996-05-30 2000-08-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
US5866430A (en) 1996-06-13 1999-02-02 Grow; Ann E. Raman optrode processes and devices for detection of chemicals and microorganisms
US5770370A (en) * 1996-06-14 1998-06-23 David Sarnoff Research Center, Inc. Nuclease protection assays
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
GB2315131B (en) 1996-07-10 2000-11-29 Cambridge Imaging Ltd Improvements in and relating to imaging
US5707502A (en) 1996-07-12 1998-01-13 Chiron Diagnostics Corporation Sensors for measuring analyte concentrations and methods of making same
US5854684A (en) * 1996-09-26 1998-12-29 Sarnoff Corporation Massively parallel detection
US5872623A (en) 1996-09-26 1999-02-16 Sarnoff Corporation Massively parallel detection
US5861658A (en) 1996-10-03 1999-01-19 International Business Machines Corporation Inorganic seal for encapsulation of an organic layer and method for making the same
US5748091A (en) 1996-10-04 1998-05-05 Mcdonnell Douglas Corporation Fiber optic ice detector
US6048732A (en) 1996-10-16 2000-04-11 Board Of Regents, The University Of Texas System Receptor and method for citrate determination
EP0946278A1 (de) * 1996-10-21 1999-10-06 Smithkline Beecham Plc Vorrichtung und verfahren zur verteilung von kügelschen
US6083761A (en) * 1996-12-02 2000-07-04 Glaxo Wellcome Inc. Method and apparatus for transferring and combining reagents
CA2276462C (en) 1996-12-31 2007-06-12 Genometrix Incorporated Multiplexed molecular analysis system apparatus and method
US5827748A (en) 1997-01-24 1998-10-27 The United States Of America As Represented By The Secretary Of The Navy Chemical sensor using two-dimensional lens array
US5981297A (en) 1997-02-05 1999-11-09 The United States Of America As Represented By The Secretary Of The Navy Biosensor using magnetically-detected label
US6037137A (en) 1997-02-20 2000-03-14 Oncoimmunin, Inc. Fluorogenic peptides for the detection of protease activity
US6023540A (en) * 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US6045579A (en) 1997-05-01 2000-04-04 Spinal Concepts, Inc. Adjustable height fusion device
US6171780B1 (en) 1997-06-02 2001-01-09 Aurora Biosciences Corporation Low fluorescence assay platforms and related methods for drug discovery
CA2291180A1 (en) * 1997-05-23 1998-11-26 Lynx Therapeutics, Inc. System and apparatus for sequential processing of analytes
US7115884B1 (en) * 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
US5922617A (en) 1997-11-12 1999-07-13 Functional Genetics, Inc. Rapid screening assay methods and devices
US5992820A (en) 1997-11-19 1999-11-30 Sarnoff Corporation Flow control in microfluidics devices by controlled bubble formation
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
JP3944996B2 (ja) * 1998-03-05 2007-07-18 株式会社日立製作所 Ｄｎａプローブアレー
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6151973A (en) 1999-01-29 2000-11-28 Glaxo Wellcome Inc. Bead picking apparatus and method

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