WO2002061392A3 - Method and apparatus for the confinement of materials in a micromachined chemical sensor array - Google Patents

Method and apparatus for the confinement of materials in a micromachined chemical sensor array Download PDF

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Publication number
WO2002061392A3
WO2002061392A3 PCT/US2002/003275 US0203275W WO02061392A3 WO 2002061392 A3 WO2002061392 A3 WO 2002061392A3 US 0203275 W US0203275 W US 0203275W WO 02061392 A3 WO02061392 A3 WO 02061392A3
Authority
WO
WIPO (PCT)
Prior art keywords
cavities
sensor array
particles
analyte
confinement
Prior art date
Application number
PCT/US2002/003275
Other languages
French (fr)
Other versions
WO2002061392A2 (en
WO2002061392A9 (en
Inventor
John T Mcdevitt
Eric V Anslyn
Jason B Shear
Dean P Neikirk
Byunghwa Park
Yoon Sok Park
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Priority to EP02713535A priority Critical patent/EP1373874A4/en
Priority to CA002437558A priority patent/CA2437558A1/en
Priority to JP2002561913A priority patent/JP2004529323A/en
Publication of WO2002061392A2 publication Critical patent/WO2002061392A2/en
Publication of WO2002061392A3 publication Critical patent/WO2002061392A3/en
Publication of WO2002061392A9 publication Critical patent/WO2002061392A9/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle. Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities.
PCT/US2002/003275 2001-01-31 2002-01-31 Method and apparatus for the confinement of materials in a micromachined chemical sensor array WO2002061392A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP02713535A EP1373874A4 (en) 2001-01-31 2002-01-31 Method and apparatus for the confinement of materials in a micromachined chemical sensor array
CA002437558A CA2437558A1 (en) 2001-01-31 2002-01-31 Method and apparatus for the confinement of materials in a micromachined chemical sensor array
JP2002561913A JP2004529323A (en) 2001-01-31 2002-01-31 Method and apparatus for confining material in a micromachined chemical sensor array

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26577601P 2001-01-31 2001-01-31
US60/265,776 2001-01-31

Publications (3)

Publication Number Publication Date
WO2002061392A2 WO2002061392A2 (en) 2002-08-08
WO2002061392A3 true WO2002061392A3 (en) 2003-10-16
WO2002061392A9 WO2002061392A9 (en) 2004-12-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/003275 WO2002061392A2 (en) 2001-01-31 2002-01-31 Method and apparatus for the confinement of materials in a micromachined chemical sensor array

Country Status (5)

Country Link
US (1) US20020197622A1 (en)
EP (1) EP1373874A4 (en)
JP (1) JP2004529323A (en)
CA (1) CA2437558A1 (en)
WO (1) WO2002061392A2 (en)

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