ATE142334T1 - Hochempfindliche fluoreszierende einzelteilchen, gerät und verfahren zum nachweis einzelner moleküle - Google Patents

Hochempfindliche fluoreszierende einzelteilchen, gerät und verfahren zum nachweis einzelner moleküle

Info

Publication number
ATE142334T1
ATE142334T1 AT90908805T AT90908805T ATE142334T1 AT E142334 T1 ATE142334 T1 AT E142334T1 AT 90908805 T AT90908805 T AT 90908805T AT 90908805 T AT90908805 T AT 90908805T AT E142334 T1 ATE142334 T1 AT E142334T1
Authority
AT
Austria
Prior art keywords
fluorescent particles
particles
fluid
burst
highly sensitive
Prior art date
Application number
AT90908805T
Other languages
English (en)
Inventor
Richard A Mathies
Konan Peck
Lubert Stryer
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Application granted granted Critical
Publication of ATE142334T1 publication Critical patent/ATE142334T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G01N2015/0222—Investigating a scatter or diffraction pattern from dynamic light scattering, e.g. photon correlation spectroscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT90908805T 1989-05-26 1990-05-21 Hochempfindliche fluoreszierende einzelteilchen, gerät und verfahren zum nachweis einzelner moleküle ATE142334T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/358,782 US4979824A (en) 1989-05-26 1989-05-26 High sensitivity fluorescent single particle and single molecule detection apparatus and method

Publications (1)

Publication Number Publication Date
ATE142334T1 true ATE142334T1 (de) 1996-09-15

Family

ID=23411024

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90908805T ATE142334T1 (de) 1989-05-26 1990-05-21 Hochempfindliche fluoreszierende einzelteilchen, gerät und verfahren zum nachweis einzelner moleküle

Country Status (7)

Country Link
US (1) US4979824A (de)
EP (1) EP0426829B1 (de)
JP (1) JPH04500274A (de)
AT (1) ATE142334T1 (de)
AU (1) AU624047B2 (de)
DE (1) DE69028370T2 (de)
WO (1) WO1990014589A1 (de)

Families Citing this family (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5541061A (en) * 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
JP2575270B2 (ja) * 1992-11-10 1997-01-22 浜松ホトニクス株式会社 核酸の塩基配列決定方法、単一分子検出方法、その装置及び試料の作成方法
FI96638C (fi) * 1992-11-17 1996-07-25 Biohit Oy "Inner-filter"-korjaus fluorometripohjaisella monitoimintoisella laitteella
AU673245B2 (en) * 1993-02-01 1996-10-31 Seq, Ltd. Methods and apparatus for DNA sequencing
US5547849A (en) * 1993-02-17 1996-08-20 Biometric Imaging, Inc. Apparatus and method for volumetric capillary cytometry
US6864048B2 (en) * 1993-04-28 2005-03-08 Affymetrix, Inc. Factorial chemical libraries
US5439578A (en) * 1993-06-03 1995-08-08 The Governors Of The University Of Alberta Multiple capillary biochemical analyzer
JP3577317B2 (ja) * 1994-09-02 2004-10-13 ビー・ディー・バイオサイエンシーズ・システムズ・アンド・リエイジェンツ・インコーポレイテッド 光学式スキャナの校正方法と装置
DE19649048C1 (de) * 1996-11-27 1998-04-09 Evotec Biosystems Gmbh Verfahren zur Unterscheidung oder Erfassung von Partikeln in einer Probe durch Identifizierung von Signalabschnitten zeitaufgelöster, optischer Rohsignale aus der Probe auf Basis von Einzelphotonendetektion
IL156002A0 (en) 1997-02-12 2003-12-23 Eugene Y Chan Methods and products for analyzing polymers
WO1998057152A1 (en) * 1997-06-09 1998-12-17 Guava Technologies, Inc. Method and apparatus for detecting microparticles in fluid samples
US6710871B1 (en) 1997-06-09 2004-03-23 Guava Technologies, Inc. Method and apparatus for detecting microparticles in fluid samples
US6049380A (en) * 1997-11-12 2000-04-11 Regents Of The University Of California Single molecule identification using selected fluorescence characteristics
SE9800360D0 (sv) * 1998-02-06 1998-02-06 Goeteborg University Science I Method, apparatus and flow cell for high sensitivity detection of fluorescent molecules
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US20100130368A1 (en) * 1998-07-30 2010-05-27 Shankar Balasubramanian Method and system for sequencing polynucleotides
US20040106110A1 (en) * 1998-07-30 2004-06-03 Solexa, Ltd. Preparation of polynucleotide arrays
EP1105529B2 (de) * 1998-07-30 2013-05-29 Illumina Cambridge Limited Matrizen von biomolekülen und ihre verwendung in sequenzierung
US6263286B1 (en) * 1998-08-13 2001-07-17 U.S. Genomics, Inc. Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer
DE19844931C1 (de) 1998-09-30 2000-06-15 Stefan Seeger Verfahren zur DNS- oder RNS-Sequenzierung
US6232075B1 (en) 1998-12-14 2001-05-15 Li-Cor, Inc. Heterogeneous assay for pyrophosphate detection
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US6696022B1 (en) 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
US6927065B2 (en) * 1999-08-13 2005-08-09 U.S. Genomics, Inc. Methods and apparatus for characterization of single polymers
US6569685B1 (en) 1999-10-05 2003-05-27 The Molecular Sciences Institute, Inc. Protein fingerprint system and related methods
EP1254430B1 (de) * 2000-01-27 2010-07-28 Applied Precision, Inc. Vefahren zur flachfeldbildausglättung und zusamensetzung von teilbildern
JP2004516810A (ja) 2000-06-07 2004-06-10 リ−コール インコーポレーティッド 電荷スイッチヌクレオチド
US6936702B2 (en) 2000-06-07 2005-08-30 Li-Cor, Inc. Charge-switch nucleotides
US6447995B1 (en) * 2000-10-04 2002-09-10 Genvec, Inc. Utilizing intrinsic fluorescence to detect adenovirus
WO2002044425A2 (en) 2000-12-01 2002-06-06 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
WO2002061391A2 (en) * 2001-01-31 2002-08-08 The University Of Tennessee Research Corporation Methods for detecting interaction of molecules with surface-bound reagents
EP1368497A4 (de) 2001-03-12 2007-08-15 California Inst Of Techn Verfahren und vorrichtung zur analyse von polynukleotidsequenzen durch asynchrone basenverlängerung
AU2002258997A1 (en) * 2001-04-24 2002-11-05 Li-Cor, Inc. Polymerases with charge-switch activity and methods of generating such polymerases
US7118907B2 (en) * 2001-06-06 2006-10-10 Li-Cor, Inc. Single molecule detection systems and methods
US7076092B2 (en) * 2001-06-14 2006-07-11 The United States Of America As Represented By The United States Department Of Energy High-throughput, dual probe biological assays based on single molecule detection
US7695926B2 (en) 2001-07-10 2010-04-13 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for detecting receptor-ligand interactions in single cells
US7393656B2 (en) * 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
US7381535B2 (en) 2002-07-10 2008-06-03 The Board Of Trustees Of The Leland Stanford Junior Methods and compositions for detecting receptor-ligand interactions in single cells
WO2003067210A2 (en) 2001-07-10 2003-08-14 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for detecting the activation state of the multiple proteins in single cells
US20030110840A1 (en) * 2001-07-24 2003-06-19 Arriaga Edgar A. Systems and methods for detecting a particle
US7016087B2 (en) * 2001-08-08 2006-03-21 Becton Dickinson And Company Photon efficient scanner
US6750457B2 (en) * 2001-08-29 2004-06-15 Becton Dickinson And Company System for high throughput analysis
US7371520B2 (en) * 2002-05-28 2008-05-13 U.S. Genomics, Inc. Methods and apparati using single polymer analysis
KR100473360B1 (ko) * 2002-07-31 2005-03-08 주식회사 디지탈바이오테크놀러지 레이저 반사를 이용한 미세 채널 위치 및 치수의 자동측정방법, 그 측정방법을 이용한 측정장치 및 그측정방법을 이용한 미세 채널 검사장치
AU2003298672A1 (en) * 2002-11-19 2005-01-28 Singulex, Inc. Detection of target molecules through interaction with probes
US7745116B2 (en) * 2003-04-08 2010-06-29 Pacific Biosciences Of California, Inc. Composition and method for nucleic acid sequencing
WO2005019419A2 (en) * 2003-07-31 2005-03-03 Singulex, Inc. Co-detection of single polypeptide and polynucleotide molecules
US7317521B2 (en) * 2003-09-18 2008-01-08 Micron Technology, Inc. Particle detection method
US20080021674A1 (en) * 2003-09-30 2008-01-24 Robert Puskas Methods for Enhancing the Analysis of Particle Detection
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
ATE463584T1 (de) 2004-02-19 2010-04-15 Helicos Biosciences Corp Verfahren zur analyse von polynukleotidsequenzen
US7476734B2 (en) 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
US7635562B2 (en) 2004-05-25 2009-12-22 Helicos Biosciences Corporation Methods and devices for nucleic acid sequence determination
US7340957B2 (en) 2004-07-29 2008-03-11 Los Alamos National Security, Llc Ultrasonic analyte concentration and application in flow cytometry
US9040305B2 (en) * 2004-09-28 2015-05-26 Singulex, Inc. Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry
US8685711B2 (en) 2004-09-28 2014-04-01 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
EP1805500A4 (de) * 2004-09-28 2008-05-07 Singulex Inc System und verfahren zur spektroskopischen analyse einzelner partikel
US7572640B2 (en) * 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
US7220549B2 (en) * 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
US20070009923A1 (en) * 2005-01-24 2007-01-11 Massachusetts Institute Of Technology Use of bayesian networks for modeling cell signaling systems
US7482120B2 (en) 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
CA2543521C (en) * 2005-04-13 2014-05-27 Frederick David King Particle imaging system with a varying flow rate
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
US7998717B2 (en) * 2005-12-02 2011-08-16 Pacific Biosciences Of California, Inc. Mitigation of photodamage in analytical reactions
CA3086149A1 (en) 2006-04-04 2007-10-11 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
EP3156799B1 (de) 2006-04-04 2024-01-24 Novilux, LLC Analysator und verfahren zur hochempfindlichen detektion von analyten
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
US8124943B1 (en) * 2006-04-06 2012-02-28 Lugade Ananda G Methods and systems for altering fluorescent intensities of a plurality of particles
WO2008019448A1 (en) * 2006-08-18 2008-02-21 Macquarie University Time gated fluorescent flow cytometer
US7835000B2 (en) 2006-11-03 2010-11-16 Los Alamos National Security, Llc System and method for measuring particles in a sample stream of a flow cytometer or the like
US7804594B2 (en) 2006-12-29 2010-09-28 Abbott Laboratories, Inc. Method and apparatus for rapidly counting and identifying biological particles in a flow stream
EP2664916B1 (de) 2007-04-02 2017-02-08 Acoustic Cytometry Systems, Inc. Verfahren zum Manipulieren einer Flüssigkeit in einer Durchflusszelle unter Anwendung von akustischer Fokussierung
US7837040B2 (en) 2007-04-09 2010-11-23 Los Alamos National Security, Llc Acoustic concentration of particles in fluid flow
US8083068B2 (en) 2007-04-09 2011-12-27 Los Alamos National Security, Llc Apparatus for separating particles utilizing engineered acoustic contrast capture particles
FR2917842A1 (fr) * 2007-06-19 2008-12-26 Commissariat Energie Atomique Dispositif et methode de comptage de particules elementaires emises par un fluide dans un conduit.
WO2009029550A2 (en) * 2007-08-24 2009-03-05 Singulex, Inc. Highly sensitive system and methods for analysis of prostate specific antigen (psa)
US8263407B2 (en) 2007-10-24 2012-09-11 Los Alamos National Security, Llc Method for non-contact particle manipulation and control of particle spacing along an axis
US8528406B2 (en) 2007-10-24 2013-09-10 Los Alamos National Security, LLP Method for non-contact particle manipulation and control of particle spacing along an axis
US8159670B2 (en) 2007-11-05 2012-04-17 Abbott Laboratories Method and apparatus for rapidly counting and identifying biological particles in a flow stream
CN103543094B (zh) 2007-12-19 2017-06-09 神谷来克斯公司 单分子检测用扫描分析器和使用方法
US8266950B2 (en) 2007-12-19 2012-09-18 Los Alamos National Security, LLP Particle analysis in an acoustic cytometer
US8714014B2 (en) 2008-01-16 2014-05-06 Life Technologies Corporation System and method for acoustic focusing hardware and implementations
AU2009234106A1 (en) * 2008-03-05 2009-10-15 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
US20090291458A1 (en) * 2008-05-22 2009-11-26 Nodality, Inc. Method for Determining the Status of an Individual
US8399206B2 (en) 2008-07-10 2013-03-19 Nodality, Inc. Methods for diagnosis, prognosis and methods of treatment
WO2010006291A1 (en) 2008-07-10 2010-01-14 Nodality, Inc. Methods for diagnosis, prognosis and treatment
GB2464183A (en) * 2008-09-19 2010-04-14 Singulex Inc Sandwich assay
AU2010259022B2 (en) 2009-06-08 2016-05-12 Singulex, Inc. Highly sensitive biomarker panels
CN102782480B (zh) * 2010-03-01 2013-09-11 奥林巴斯株式会社 光学分析装置、光学分析方法和用于光学分析的计算机程序
US20110301053A1 (en) 2010-05-06 2011-12-08 Singulex, Inc. Methods for Diagnosing, Staging, Predicting Risk for Developing and Identifying Treatment Responders for Rheumatoid Arthritis
US8834847B2 (en) 2010-08-12 2014-09-16 Pacific Biosciences Of California, Inc. Photodamage mitigation compounds and systems
JP5856983B2 (ja) 2011-01-20 2016-02-10 オリンパス株式会社 単一発光粒子からの光の検出を用いた光分析方法及び光分析装置
JP5391336B2 (ja) * 2011-06-29 2014-01-15 パナソニック株式会社 発光素子の製造方法、及び、発光素子の製造装置
CN103765196B (zh) 2011-08-26 2016-03-02 奥林巴斯株式会社 利用单个发光粒子检测的光分析装置及光分析方法
EP2752655A4 (de) 2011-08-30 2015-06-17 Olympus Corp Verfahren zum nachweis von zielpartikeln
EP2790008B1 (de) 2011-12-05 2017-11-15 Rion Co., Ltd. Biopartikelzähler, biopartikelzählverfahren, dialysatüberwachungssystem und wasserreinigungsüberwachungssystem
US9028776B2 (en) 2012-04-18 2015-05-12 Toxic Report Llc Device for stretching a polymer in a fluid sample
JP6360481B2 (ja) 2013-07-31 2018-07-18 オリンパス株式会社 単一発光粒子検出技術を用いた光学顕微鏡装置、顕微鏡観察法及び顕微鏡観察のためのコンピュータプログラム
WO2017098597A1 (ja) 2015-12-09 2017-06-15 オリンパス株式会社 単一発光粒子検出を用いた光分析方法及び光分析装置

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB696675A (en) * 1950-02-17 1953-09-09 Ici Ltd Improvements in and relating to methods of, and apparatus for, determining the concentration of particulate matter contained in liquid suspensions or colloidal solutionsor of solutes in true solutions
US3536898A (en) * 1967-12-04 1970-10-27 Us Navy Detection device
US4021117A (en) * 1975-08-07 1977-05-03 Hildegard Gohde Process for automatic counting and measurement of particles
US4573798A (en) * 1981-09-16 1986-03-04 Toshiba Kikai Kabushiki Kaisha Method and apparatus for measuring pattern area percentage for engraving films
JPS59174742A (ja) * 1983-03-25 1984-10-03 Agency Of Ind Science & Technol 微小粒子を区分又は選別する方法及びその装置
US4573796A (en) * 1984-01-06 1986-03-04 The United States Of America As Represented By The United States Department Of Energy Apparatus for eliminating background interference in fluorescence measurements
US4793705A (en) * 1987-10-07 1988-12-27 The United States Of America As Represented By The United States Department Of Energy Single molecule tracking
FR2628530B1 (fr) * 1988-03-08 1994-01-28 Chemunex Sa Appareil et procede de detection et de numeration de particules fluorescentes, portees par un support solide

Also Published As

Publication number Publication date
DE69028370D1 (de) 1996-10-10
JPH04500274A (ja) 1992-01-16
AU5677690A (en) 1990-12-18
EP0426829A4 (en) 1992-05-06
DE69028370T2 (de) 1997-03-13
WO1990014589A1 (en) 1990-11-29
AU624047B2 (en) 1992-05-28
EP0426829A1 (de) 1991-05-15
EP0426829B1 (de) 1996-09-04
US4979824A (en) 1990-12-25

Similar Documents

Publication Publication Date Title
DE69028370D1 (de) Hochempfindliche fluoreszierende einzelteilchen, gerät und verfahren zum nachweis einzelner moleküle
DE69915481D1 (de) Versuchsanordnung und methode zum screenen eines immuntests
DE69233703D1 (de) Verfahren und Vorrichtung für verbesserte Lumineszenztests
CA2294966A1 (en) Method and apparatus for marking and identifying liquids
ATE542128T1 (de) Verfahren zur erkennung von fehlern in transparentem material
DE3586380D1 (de) Verfahren zur messung von strahlungsschwankungen und anwendung desselben zum nachweis eines analyten.
DE60031988D1 (de) Verfahren und vorrichtung zur zuführung von proben zu einer chemischen sensormatrix
CA2111552A1 (en) Luminometer
ATE16642T1 (de) Untersuchungsverfahren und -vorrichtung.
ATE101739T1 (de) Verfahren zum betrieb eines optischen rauchmelders sowie rauchmelder zur durchfuehrung des verfahrens.
AU560701B2 (en) Photomultiplier testing for defects
DE69930451D1 (de) Spektrophotometrische Vorrichtung mit Nachweis eines Reagenzstreifens
KR970705750A (ko) 다이아몬드 시험 장치 및 방법(examining a diamond)
NO20003709L (no) Fremgangsmate for detektering av en analytt, og omsluttingsmiddel og kit for anvendelse deri
ATE259503T1 (de) Verfahren zur messung der konzentration eines spezifischen bestandteils
NO973853L (no) Fremgangsmåte for kontroll av en glassbeholder
US5354999A (en) Leak detection achieved by detection of light transmitted through an opaque layer interrupted by a passing bubble
NO983126L (no) Fremgangsmåte og anordning for å måle farge og/eller partikler i et fluid
ATE302406T1 (de) Verfahren und vorrichtung zum analytischen nachweis von spuren
DE69911219D1 (de) Verfahren zur messung der spektralen absorption eines körpers und vorrichtung zur durchführung des verfahrens
ATE17531T1 (de) Vorrichtung zum automatischen erkennen und auswerten der merkmale von druckschriften.
JPS5536733A (en) Method of detecting oil polluted bottle
DE69435159D1 (de) Vorrichtung und verfahren zur durchführung von testmessungen zur elektrochemilumineszenz
KR970053221A (ko) 디벨로프 파티클 검출장치

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties