WO2007118209A3 - Apparatus and method for rapid detection of analytes - Google Patents

Apparatus and method for rapid detection of analytes Download PDF

Info

Publication number
WO2007118209A3
WO2007118209A3 PCT/US2007/066172 US2007066172W WO2007118209A3 WO 2007118209 A3 WO2007118209 A3 WO 2007118209A3 US 2007066172 W US2007066172 W US 2007066172W WO 2007118209 A3 WO2007118209 A3 WO 2007118209A3
Authority
WO
WIPO (PCT)
Prior art keywords
sample
system
light beam
excitation light
rapid detection
Prior art date
Application number
PCT/US2007/066172
Other languages
French (fr)
Other versions
WO2007118209A2 (en
Inventor
Ikro Joe
Myung L Kim
Hoshin Park
Ryan Morlok
Alan Shinn
Chiko Fan
Elias Elias
Original Assignee
Kim Lab
Ikro Joe
Myung L Kim
Hoshin Park
Ryan Morlok
Alan Shinn
Chiko Fan
Elias Elias
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US79020606P priority Critical
Priority to US60/790,206 priority
Application filed by Kim Lab, Ikro Joe, Myung L Kim, Hoshin Park, Ryan Morlok, Alan Shinn, Chiko Fan, Elias Elias filed Critical Kim Lab
Publication of WO2007118209A2 publication Critical patent/WO2007118209A2/en
Publication of WO2007118209A3 publication Critical patent/WO2007118209A3/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00Features of devices classified in G01N21/00
    • G01N2201/02Mechanical
    • G01N2201/022Casings
    • G01N2201/0221Portable; cableless; compact; hand-held

Abstract

The system of the present disclosure is a system for real time, rapid detection of a targetanalyte in a liquid sample, the system comprising: a sample holder (30) to hold the liquid sample wherein the sample holder is adapted and disposed for rotational motion; a optical source (22) to provide an excitation light beam to excite a fluorescence marker in the sample to emit an emission light; an objective lens (35) to focus the excitation light beam in the sample wherein at least a portion of the optical source is adapted and disposed for translational motion whereby the excitation light beam translates along at least a portion of the sample holder; a detector (70) to record the intensity of the emission light over the period of time; and a member (74) to calculate the number of cells or microorganisms in the sample from the recorded intensity of the emission light over the period of time.
PCT/US2007/066172 2006-04-07 2007-04-06 Apparatus and method for rapid detection of analytes WO2007118209A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US79020606P true 2006-04-07 2006-04-07
US60/790,206 2006-04-07

Publications (2)

Publication Number Publication Date
WO2007118209A2 WO2007118209A2 (en) 2007-10-18
WO2007118209A3 true WO2007118209A3 (en) 2008-09-04

Family

ID=38581847

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/066172 WO2007118209A2 (en) 2006-04-07 2007-04-06 Apparatus and method for rapid detection of analytes

Country Status (1)

Country Link
WO (1) WO2007118209A2 (en)

Families Citing this family (21)

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GB2457481B (en) * 2008-02-14 2012-08-08 Starna Scient Ltd Fluorescence measurement cell
JP5877155B2 (en) 2010-07-26 2016-03-02 オリンパス株式会社 Method for detecting the lean particles in a solution by using a light-emitting probe
JP5945506B2 (en) 2010-11-25 2016-07-05 オリンパス株式会社 Optical analyzer and an optical analysis method using the wavelength characteristics of light of a single light emitting particles
EP2667183A4 (en) 2011-01-20 2017-05-10 Olympus Corporation Photoanalysis method and photoanalysis device using detection of light from single light-emitting particle
CN103460026B (en) 2011-03-29 2015-06-10 奥林巴斯株式会社 Photometric analysis device, photometric analysis method, and computer program for photometric analysis, using single light-emitting particle detection
CN103477210B (en) 2011-04-13 2015-09-23 奥林巴斯株式会社 Analysis by the light emitting means single particle detection, optical analysis method, and computer program for optical analysis
JP6013328B2 (en) * 2011-04-18 2016-10-25 オリンパス株式会社 Quantification method of target particles
WO2013021687A1 (en) 2011-08-11 2013-02-14 オリンパス株式会社 Method for detecting target particles
CN103733049B (en) 2011-08-15 2016-01-20 奥林巴斯株式会社 Analysis by the light emitting means single particle detection, optical analysis method, and computer program for optical analysis
EP2749868B1 (en) 2011-08-26 2019-02-27 Olympus Corporation Single-particle detector using optical analysis, single-particle detection method using same, and computer program for single-particle detection
CN103765197B (en) 2011-08-30 2016-03-02 奥林巴斯株式会社 Analysis by the light emitting means single particle detection, optical analysis method, and computer program for optical analysis
JP6010034B2 (en) 2011-08-30 2016-10-19 オリンパス株式会社 The method for detecting a target particle
WO2013069504A1 (en) 2011-11-10 2013-05-16 オリンパス株式会社 Spectroscopy device, spectroscopy method, and computer program for spectroscopy, employing individual light-emitting particle detection
JP5996625B2 (en) 2012-02-17 2016-09-21 オリンパス株式会社 Optical spectrometer using a single particle detection, photometric methods and optical analysis computer program
EP2818850B1 (en) 2012-02-22 2016-08-03 Olympus Corporation Method for detecting a target particle
EP2829614A4 (en) 2012-03-21 2016-03-16 Olympus Corp Method for detecting target nucleic acid molecule
JP6010114B2 (en) 2012-04-18 2016-10-19 オリンパス株式会社 Single particle detection apparatus using an optical analysis, a single particle detection methods and single particle detection computer program
WO2013157283A1 (en) 2012-04-18 2013-10-24 オリンパス株式会社 Method for detecting target particles
TWI619809B (en) * 2012-08-24 2018-04-01 Satake Eng Co Ltd Method and device for inspecting microorganisms
WO2015052965A1 (en) 2013-10-07 2015-04-16 オリンパス株式会社 Photometric analysis device employing single light-emitting particle detection, photometric analysis method, and computer program for photometric analysis
AU2014412513A1 (en) 2014-11-27 2017-06-15 Kimberly-Clark Worldwide, Inc. Devices and methods for detecting norovirus on surfaces

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566508B2 (en) * 2000-07-07 2003-05-20 3M Innovative Properties Company Fluorogenic compounds and uses therefor
US20040072335A1 (en) * 1999-05-17 2004-04-15 Boege Steven J. Optical instrument including excitation source
US20060068409A1 (en) * 2000-11-27 2006-03-30 Phan Brigitte C Use of restriction enzymes and other chemical methods to decrease non-specific binding in dual bead assays and related bio-discs, methods, and system apparatus for detecting medical targets

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040072335A1 (en) * 1999-05-17 2004-04-15 Boege Steven J. Optical instrument including excitation source
US6566508B2 (en) * 2000-07-07 2003-05-20 3M Innovative Properties Company Fluorogenic compounds and uses therefor
US20060068409A1 (en) * 2000-11-27 2006-03-30 Phan Brigitte C Use of restriction enzymes and other chemical methods to decrease non-specific binding in dual bead assays and related bio-discs, methods, and system apparatus for detecting medical targets

Also Published As

Publication number Publication date
WO2007118209A2 (en) 2007-10-18

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