HK1091904A1 - Imaging fluorescence signals using telecentric optics - Google Patents

Imaging fluorescence signals using telecentric optics

Info

Publication number
HK1091904A1
HK1091904A1 HK06112436.1A HK06112436A HK1091904A1 HK 1091904 A1 HK1091904 A1 HK 1091904A1 HK 06112436 A HK06112436 A HK 06112436A HK 1091904 A1 HK1091904 A1 HK 1091904A1
Authority
HK
Hong Kong
Prior art keywords
sites
imaging
present
excitation
fluorescence signals
Prior art date
Application number
HK06112436.1A
Other languages
English (en)
Inventor
Martin Gutekunst
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1091904A1 publication Critical patent/HK1091904A1/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6463—Optics
    • G01N2021/6478—Special lenses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates

Landscapes

  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Microscoopes, Condenser (AREA)
HK06112436.1A 2005-01-18 2006-11-10 Imaging fluorescence signals using telecentric optics HK1091904A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05000862A EP1681555B1 (en) 2005-01-18 2005-01-18 Imaging of fluorescence signals using telecentric excitation and imaging optics

Publications (1)

Publication Number Publication Date
HK1091904A1 true HK1091904A1 (en) 2007-01-26

Family

ID=34933340

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06112436.1A HK1091904A1 (en) 2005-01-18 2006-11-10 Imaging fluorescence signals using telecentric optics

Country Status (10)

Country Link
US (1) US7687260B2 (zh)
EP (2) EP1681555B1 (zh)
JP (1) JP4980622B2 (zh)
CN (1) CN100543512C (zh)
AT (2) ATE357653T1 (zh)
CA (1) CA2533079C (zh)
DE (2) DE602005000749T2 (zh)
DK (2) DK1681555T3 (zh)
ES (2) ES2284087T3 (zh)
HK (1) HK1091904A1 (zh)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2285578T3 (es) * 2005-01-18 2007-11-16 F. Hoffmann-La Roche Ag Visualizacion de señales de fluorescencia utilizando telecentricidad.
US7858382B2 (en) * 2005-05-27 2010-12-28 Vidar Systems Corporation Sensing apparatus having rotating optical assembly
US7528374B2 (en) * 2006-03-03 2009-05-05 Vidar Systems Corporation Sensing apparatus having optical assembly that collimates emitted light for detection
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
KR101089045B1 (ko) * 2007-06-28 2011-12-02 (주)바이오니아 핵산증폭반응 산물의 실시간 모니터링장치
EP2148187A1 (de) * 2008-07-25 2010-01-27 Roche Diagnostics GmbH Anregungs- und Abbildungsoptik für die Fluoreszenzdetektion
JP2010032400A (ja) * 2008-07-30 2010-02-12 Yokogawa Electric Corp バイオチップ読取装置
JP5339838B2 (ja) * 2008-10-01 2013-11-13 キヤノン株式会社 遺伝子検査装置
WO2010065779A2 (en) * 2008-12-03 2010-06-10 Helixis, Inc. Optical system for multiple reactions
KR20100072528A (ko) * 2008-12-22 2010-07-01 한국전자통신연구원 바이오 칩 및 바이오 물질 검출 장치
US20100267092A1 (en) 2009-02-09 2010-10-21 Frederic Zenhausern Components
GB201005704D0 (en) * 2010-04-06 2010-05-19 It Is Internat Ltd Improvements in systems for chemical and/or biochemical reactions
CN102329725A (zh) * 2010-06-16 2012-01-25 三星泰科威株式会社 光透射温度控制装置、生物诊断设备和方法
DE102010035003B4 (de) * 2010-08-20 2015-08-06 PicoQuant GmbH. Unternehmen für optoelektronische Forschung und Entwicklung Räumlich und zeitlich hochauflösende Mikroskopie
EP2511693A1 (en) 2011-04-13 2012-10-17 F. Hoffmann-La Roche AG Analysis System with a spectrally controlled light source
EP2525211B1 (en) 2011-05-16 2018-01-03 F. Hoffmann-La Roche AG Instrument and method for detecting analytes
KR101776776B1 (ko) 2011-05-31 2017-09-11 삼성전자주식회사 형광 검출 광학계 및 이를 포함하는 다채널 형광 검출 장치
BR112014007789A2 (pt) * 2011-09-30 2017-04-11 Life Technologies Corp sistemas e métodos para análise biológica
DE202012104237U1 (de) * 2011-11-04 2013-05-22 Dynex Technologies Inc. Multiplex-Optikanordnung
EP2608088B1 (en) 2011-12-20 2018-12-12 F. Hoffmann-La Roche AG Improved method for nucleic acid analysis
CN102719357B (zh) * 2012-05-31 2014-07-09 博奥生物集团有限公司 一种实时监控微阵列芯片分析过程的杂交系统
US10101274B2 (en) 2012-12-05 2018-10-16 Genepoc Inc. Optical interrogation device
CN103033493B (zh) * 2012-12-10 2015-08-05 厦门大学 一种可调谐荧光定量pcr检测系统
CN103091298A (zh) * 2013-02-01 2013-05-08 厦门大学 一种实时荧光定量pcr检测系统
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
KR101414248B1 (ko) * 2013-03-27 2014-07-01 (주)로고스바이오시스템스 형광 이미징 장치
JP6449591B2 (ja) * 2013-09-02 2019-01-09 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 生物学的液体の光測定装置
US9541750B2 (en) 2014-06-23 2017-01-10 Li-Cor, Inc. Telecentric, wide-field fluorescence scanning systems and methods
EP3271770B1 (en) * 2015-03-18 2023-09-27 Opto Engineering S.p.A. Telecentric lens
ITUB20155808A1 (it) * 2015-11-23 2017-05-23 Istituto Naz Di Astrofisica Apparato e metodo per l'ispezione non invasiva di corpi solidi mediante imaging muonico
EP3208604B1 (en) * 2016-02-22 2019-07-10 F. Hoffmann-La Roche AG Optics for analysis of microwells
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
US10450603B2 (en) 2016-09-12 2019-10-22 Delta Electronics Int'l (Singapore) Pte Ltd Fluorescence detection device
EP3312593A1 (de) * 2016-10-20 2018-04-25 Hain Lifescience GmbH Verfahren und vorrichtung zur optischen anregung einer mehrzahl von analyten in einem array von reaktionsgefässen und zur erfassung von fluoreszenzlicht aus dem analyten
SG10201609334WA (en) 2016-11-08 2018-06-28 Delta Electronics Intl Singapore Pte Ltd Multi-Channel Fluorescence Detection Device
CN110184175A (zh) * 2018-02-22 2019-08-30 致茂电子(苏州)有限公司 自动化荧光检测系统
SG10201801853WA (en) 2018-03-02 2019-10-30 Delta Electronics Int’L Singapore Pte Ltd Portable multi-color fluorescence detection device
CN113924041A (zh) 2019-03-14 2022-01-11 因斯利克萨公司 基于时间门控的荧光检测的方法和系统
CN110763657B (zh) * 2019-11-20 2022-05-13 江苏赛诺格兰医疗科技有限公司 用于反射材料反射率测试系统的光电数字转换系统
TWI722785B (zh) 2020-01-31 2021-03-21 台達電子工業股份有限公司 光學校正工具
DE102020108432A1 (de) 2020-03-25 2021-09-30 Jenoptik Optical Systems Gmbh Vorrichtung und Verfahren zur Lumineszenzanalyse mehrerer Proben
CN111551531B (zh) * 2020-05-19 2023-04-18 北京金诺美科技股份有限公司 一种荧光激发系统及实时荧光定量pcr仪

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1991866A (en) * 1933-08-31 1935-02-19 Ben Kapner Light projection lamp
DE3717274A1 (de) * 1987-05-22 1988-12-01 Sick Erwin Gmbh Optische fehlerinspektionsvorrichtung
US5118801A (en) 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
ATE295427T1 (de) 1996-06-04 2005-05-15 Univ Utah Res Found Überwachung der hybridisierung während pcr
JP4281877B2 (ja) 1996-06-04 2009-06-17 ユニバーシティ オブ ユタ リサーチ ファウンデーション 生物学的プロセスを実行し且つモニタリングするためのシステムと方法
CN1609593B (zh) 1996-08-16 2012-04-25 Ge保健尼亚加拉公司 用于分析井板、凝胶和斑点的数字成像系统
DE19748211A1 (de) 1997-10-31 1999-05-06 Zeiss Carl Fa Optisches Array-System und Reader für Mikrotiterplatten
US6198577B1 (en) * 1998-03-10 2001-03-06 Glaxo Wellcome, Inc. Doubly telecentric lens and imaging system for multiwell plates
CA2328609A1 (en) 1998-05-16 1999-11-25 Pe Corporation (Ny) Instrument for monitoring polymerase chain reaction of dna
US6818437B1 (en) * 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
US7498164B2 (en) * 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
JP2000074837A (ja) 1998-08-31 2000-03-14 Fuji Photo Film Co Ltd 撮影装置
FI982005A (fi) * 1998-09-17 2000-03-18 Wallac Oy Näytteiden kuvantamislaite
GB9905954D0 (en) * 1999-03-16 1999-05-05 Cambridge Imaging Ltd Sample imaging
DE19919092A1 (de) 1999-04-27 2000-11-02 Zeiss Carl Jena Gmbh Anordnung zur optischen Auswertung eines Gegenstandsarrays
US7387891B2 (en) * 1999-05-17 2008-06-17 Applera Corporation Optical instrument including excitation source
US7410793B2 (en) * 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
DE20004826U1 (de) * 2000-03-16 2000-06-15 Schaefter & Kirchhoff Vorrichtung zur optischen Prüfung einer Münze
US20020005493A1 (en) 2000-04-04 2002-01-17 Reese Steven A. Optical components for microarray analysis
JP2002014044A (ja) * 2000-06-29 2002-01-18 Nikon Corp 蛍光測定装置
KR100418549B1 (ko) * 2000-07-31 2004-02-11 가부시끼가이샤 도시바 컬러음극선관
CA2417986C (en) 2000-08-11 2013-11-26 University Of Utah Research Foundation Single-labeled oligonucleotide probes
US6650411B2 (en) 2001-04-26 2003-11-18 Affymetrix, Inc. System, method, and product for pixel clocking in scanning of biological materials
JP4834242B2 (ja) * 2001-05-30 2011-12-14 オリンパス株式会社 蛍光読み取り装置
DE10131687A1 (de) 2001-06-29 2003-01-16 Eppendorf Ag Vorrichtung zur Durchführung von Nukleinsäure-Amplifikationsreaktionen bei gleichzeitiger Verfolgung der Bildung von Amplifikationsprodukten
JP3999479B2 (ja) 2001-07-10 2007-10-31 オリンパス株式会社 光学装置
JP2003028797A (ja) 2001-07-11 2003-01-29 Hitachi Software Eng Co Ltd 蛍光読み取り装置
DE10155142C2 (de) 2001-11-12 2003-09-04 Friz Biochem Gmbh Dunkelfeld-Abbildungsvorrichtung zur ortsaufgelösten Dunkelfeldabbildung einer flächigen Probe
DE10200499A1 (de) 2002-01-03 2003-07-10 Zeiss Carl Jena Gmbh Verfahren und/oder Anordnung zur Identifikation von fluoreszierenden, lumineszierenden und/oder absorbierenden Substanzen auf und/oder in Probenträgern
DE10206004A1 (de) 2002-02-14 2003-08-28 Zeiss Carl Jena Gmbh Vorrichtung zur konfokalen optischen Mikroanalyse
EP1511990B1 (en) 2002-05-17 2015-03-25 Life Technologies Corporation Instrument for detecting and measuring fluorescence including an excitation source

Also Published As

Publication number Publication date
DK1681557T3 (da) 2008-10-27
US7687260B2 (en) 2010-03-30
DE602006001593D1 (de) 2008-08-14
US20060166355A1 (en) 2006-07-27
ES2284087T3 (es) 2007-11-01
CN100543512C (zh) 2009-09-23
CN1808204A (zh) 2006-07-26
ATE357653T1 (de) 2007-04-15
DK1681555T3 (da) 2007-07-02
CA2533079C (en) 2011-03-22
JP2006226998A (ja) 2006-08-31
EP1681555A1 (en) 2006-07-19
EP1681555B1 (en) 2007-03-21
CA2533079A1 (en) 2006-07-18
ATE399991T1 (de) 2008-07-15
EP1681557A1 (en) 2006-07-19
DE602005000749D1 (de) 2007-05-03
JP4980622B2 (ja) 2012-07-18
EP1681557B1 (en) 2008-07-02
DE602005000749T2 (de) 2007-12-06
ES2309835T3 (es) 2008-12-16

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