CN1123278A - α-生育酚的制备方法 - Google Patents
α-生育酚的制备方法 Download PDFInfo
- Publication number
- CN1123278A CN1123278A CN95109665A CN95109665A CN1123278A CN 1123278 A CN1123278 A CN 1123278A CN 95109665 A CN95109665 A CN 95109665A CN 95109665 A CN95109665 A CN 95109665A CN 1123278 A CN1123278 A CN 1123278A
- Authority
- CN
- China
- Prior art keywords
- acetate
- solvent
- alpha
- tocopherol
- alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrane Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (5)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP175167/94 | 1994-07-27 | ||
JP17516794 | 1994-07-27 | ||
JP175167/1994 | 1994-07-27 | ||
JP282309/94 | 1994-11-16 | ||
JP282309/1994 | 1994-11-16 | ||
JP28230994 | 1994-11-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1123278A true CN1123278A (zh) | 1996-05-29 |
CN1067066C CN1067066C (zh) | 2001-06-13 |
Family
ID=26496517
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN95109665A Expired - Lifetime CN1067066C (zh) | 1994-07-27 | 1995-07-27 | α-生育酚的制备方法 |
Country Status (5)
Country | Link |
---|---|
US (2) | US5663376A (zh) |
EP (1) | EP0694541B2 (zh) |
CN (1) | CN1067066C (zh) |
CA (1) | CA2154605C (zh) |
DE (1) | DE69515750T3 (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100374430C (zh) * | 1996-12-23 | 2008-03-12 | 巴斯福股份公司 | α-生育酚或乙酸α-生育酯的催化制备 |
CN101704809B (zh) * | 2003-12-05 | 2012-11-07 | 帝斯曼知识产权资产管理有限公司 | 用于制备链烯基化的羟化芳族化合物、苯并二氢吡喃化合物和其酰化衍生物的方法 |
CN102964330A (zh) * | 2011-08-31 | 2013-03-13 | 卫材R&D管理有限公司 | α-生育酚及α-生育酚乙酸酯的制造方法 |
US9028975B2 (en) | 2006-05-04 | 2015-05-12 | Lg Chem, Ltd. | Organic light-emitting device having light-emitting pattern, method and apparatus for preparing the same |
CN114901650A (zh) * | 2019-12-19 | 2022-08-12 | 帝斯曼知识产权资产管理有限公司 | 由2,3,6-三甲基苯酚形成α-生育酚 |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6020505A (en) * | 1994-07-27 | 2000-02-01 | Eisai Co., Ltd. | Process for the preparation of α-tocopherol |
WO1997028151A1 (de) * | 1996-01-29 | 1997-08-07 | Basf Aktiengesellschaft | VERFAHREN ZUR HERSTELLUNG VON DL-α-TOCOPHEROL ODER DL-α-TOCOPHERYLACETAT |
US6005122A (en) * | 1996-12-23 | 1999-12-21 | Basf Aktiengesellschaft | Preparation of α-tocopherol or α-tocopheryl acetate by reacting trimethylhydroquinone and phytol or isophytol, with recycling of the zinc halide condensation catalyst |
US6029415A (en) | 1997-10-24 | 2000-02-29 | Abco, Inc. | Laminated vinyl siding |
DE19757124A1 (de) * | 1997-12-20 | 1999-06-24 | Degussa | Verfahren zur Herstellung von alpha-Tocopherolestern |
ES2264230T3 (es) * | 1998-04-06 | 2006-12-16 | Dsm Ip Assets B.V. | Procedimiento par ala obtencion de d,1-alfa-tocoferol, en un disolvente de carbonato y en presencia de un catalizador de acido conteniendo azufre. |
IN188479B (zh) | 1998-07-10 | 2002-09-28 | Hoffmann La Roche | |
EP0970953B1 (en) * | 1998-07-10 | 2004-09-29 | DSM IP Assets B.V. | Manufacture of d,1-alpha-tocopherol |
FR2784104B1 (fr) * | 1998-09-18 | 2002-12-27 | Rhone Poulenc Nutrition Animal | Procede de preparation de la vitamine e |
KR100452291B1 (ko) | 1999-12-14 | 2004-10-08 | 에스케이 주식회사 | 고수율 및 고순도로 DL-α-토코페롤를 제조하는 방법 |
KR20030005202A (ko) * | 2000-02-21 | 2003-01-17 | 다케다 야쿠힌 고교 가부시키가이샤 | 환상 화합물의 제조 방법 |
DE102004038800A1 (de) | 2003-08-13 | 2005-03-31 | Dsm Ip Assets B.V. | Herstellung von Tocol, Tocolderivaten und Tocopherolen |
JP4999690B2 (ja) * | 2004-06-11 | 2012-08-15 | ディーエスエム アイピー アセッツ ビー.ブイ. | クロマン誘導体、特にα−トコフェロールおよびそのアルカノエートの製造方法 |
DE102009051118B4 (de) * | 2009-10-13 | 2014-04-30 | Otto Bock Mobility Solutions Gmbh | Elektrorollstuhl |
CN103080055A (zh) | 2010-08-24 | 2013-05-01 | 帝斯曼知识产权资产管理有限公司 | 3,7-二甲基-1-辛烯-3-醇的制备方法 |
US11917753B2 (en) | 2019-09-23 | 2024-02-27 | Ticona Llc | Circuit board for use at 5G frequencies |
CN116987057A (zh) * | 2023-06-16 | 2023-11-03 | 江苏宏邦化工科技有限公司 | 一种维生素e乙酸酯的合成方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2411969A (en) † | 1938-03-31 | 1946-12-03 | Hoffmann La Roche | Process for the preparation of synthetic dl-tocopherols |
DE960720C (de) † | 1954-01-25 | 1957-03-28 | Hoffmann La Roche | Verfahren zur Herstellung von ª‡-Tocopherol |
DE1015446B (de) † | 1956-09-01 | 1957-09-12 | Knoll Ag | Verfahren zur Herstellung von d, 1-ª‡-Tocopherol |
US3459773A (en) † | 1966-12-27 | 1969-08-05 | Takasago Perfumery Co Ltd | Process for producing alpha-tocopherol and its esters |
US3444213A (en) † | 1967-07-12 | 1969-05-13 | Eastman Kodak Co | Continuous process for producing dl alpha tocopherol |
CH547278A (de) † | 1971-01-11 | 1974-03-29 | Hoffmann La Roche | Verfahren zur herstellung von chromanderivaten. |
US3708505A (en) † | 1971-02-25 | 1973-01-02 | Diamond Shamrock Corp | Process for preparation of d,l-alpha tocopherol |
JPS5124513B2 (zh) * | 1972-09-12 | 1976-07-24 | ||
US4168271A (en) * | 1977-04-13 | 1979-09-18 | Scm Corporation | Unsaturated vitamin E intermediates--dehydro and didehydro α-tocopherols |
US5110955A (en) * | 1989-04-14 | 1992-05-05 | Hoffmann-La Roche Inc. | Tocopherol synthesis: chromane cyclization and catalysis |
DE4208477A1 (de) † | 1992-03-17 | 1993-09-23 | Basf Ag | Verfahren zur herstellung von vitamin e |
JP3848380B2 (ja) † | 1993-12-14 | 2006-11-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | α−トコフェロール誘導体の製造法 |
JP3416281B2 (ja) † | 1994-04-12 | 2003-06-16 | エーザイ株式会社 | α−トコフェロール誘導体の製造方法および触媒 |
-
1995
- 1995-06-02 US US08/460,667 patent/US5663376A/en not_active Expired - Lifetime
- 1995-07-24 DE DE69515750T patent/DE69515750T3/de not_active Expired - Lifetime
- 1995-07-24 EP EP95111601A patent/EP0694541B2/en not_active Expired - Lifetime
- 1995-07-25 CA CA002154605A patent/CA2154605C/en not_active Expired - Lifetime
- 1995-07-27 CN CN95109665A patent/CN1067066C/zh not_active Expired - Lifetime
-
1997
- 1997-04-03 US US08/826,504 patent/US5886197A/en not_active Expired - Fee Related
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100374430C (zh) * | 1996-12-23 | 2008-03-12 | 巴斯福股份公司 | α-生育酚或乙酸α-生育酯的催化制备 |
CN101704809B (zh) * | 2003-12-05 | 2012-11-07 | 帝斯曼知识产权资产管理有限公司 | 用于制备链烯基化的羟化芳族化合物、苯并二氢吡喃化合物和其酰化衍生物的方法 |
US9028975B2 (en) | 2006-05-04 | 2015-05-12 | Lg Chem, Ltd. | Organic light-emitting device having light-emitting pattern, method and apparatus for preparing the same |
CN102964330A (zh) * | 2011-08-31 | 2013-03-13 | 卫材R&D管理有限公司 | α-生育酚及α-生育酚乙酸酯的制造方法 |
CN114901650A (zh) * | 2019-12-19 | 2022-08-12 | 帝斯曼知识产权资产管理有限公司 | 由2,3,6-三甲基苯酚形成α-生育酚 |
Also Published As
Publication number | Publication date |
---|---|
CA2154605A1 (en) | 1996-01-28 |
EP0694541A1 (en) | 1996-01-31 |
DE69515750T2 (de) | 2000-08-10 |
EP0694541B2 (en) | 2004-03-03 |
EP0694541B1 (en) | 2000-03-22 |
US5663376A (en) | 1997-09-02 |
US5886197A (en) | 1999-03-23 |
CN1067066C (zh) | 2001-06-13 |
DE69515750D1 (de) | 2000-04-27 |
CA2154605C (en) | 2004-10-05 |
DE69515750T3 (de) | 2005-01-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: WEI CAI & D MANAGEMENT CO., LTD. Free format text: FORMER OWNER: EISAI CO., LTD. Effective date: 20070518 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20070518 Address after: Tokyo, Japan, Japan Patentee after: Eisai R. & D. Man Co., Ltd. Address before: Tokyo, Japan Patentee before: Eisai co., Ltd. |
|
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 19960529 Assignee: Eisai co., Ltd. Assignor: Eisai R. & D. Man Co., Ltd. Contract record no.: 2013990000017 Denomination of invention: Process for manufacturing d, 1-alpha-tocopherol Granted publication date: 20010613 License type: Common License Record date: 20130115 Application publication date: 19960529 Assignee: Wei foods Chemical Co Ltd Assignor: Eisai co., Ltd. Contract record no.: 2013990000018 Denomination of invention: Process for manufacturing d, 1-alpha-tocopherol Granted publication date: 20010613 License type: Common License Record date: 20130115 |
|
LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 19960529 Assignee: Eisai co., Ltd. Assignor: Guardian Management Company Limited Contract record no.: 2013990000017 Denomination of invention: Process for manufacturing d, 1-alpha-tocopherol Granted publication date: 20010613 License type: Common License Record date: 20130115 |
|
LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
CX01 | Expiry of patent term |
Expiration termination date: 20150727 Granted publication date: 20010613 |
|
EXPY | Termination of patent right or utility model |