DE69515750T2 - Verfahren zur Herstellung von Alpha-Tocopherol - Google Patents

Verfahren zur Herstellung von Alpha-Tocopherol

Info

Publication number
DE69515750T2
DE69515750T2 DE69515750T DE69515750T DE69515750T2 DE 69515750 T2 DE69515750 T2 DE 69515750T2 DE 69515750 T DE69515750 T DE 69515750T DE 69515750 T DE69515750 T DE 69515750T DE 69515750 T2 DE69515750 T2 DE 69515750T2
Authority
DE
Germany
Prior art keywords
tocopherol
alpha
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69515750T
Other languages
English (en)
Other versions
DE69515750D1 (de
DE69515750T3 (de
Inventor
Noriyasu Hirose
Hiroshi Inoue
Toshio Matsunami
Takashi Yoshimura
Kouzou Morita
Yuh Horikawa
Noriyoshi Iwata
Norio Minami
Kenji Hayashi
Chiaki Seki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26496517&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69515750(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of DE69515750D1 publication Critical patent/DE69515750D1/de
Publication of DE69515750T2 publication Critical patent/DE69515750T2/de
Application granted granted Critical
Publication of DE69515750T3 publication Critical patent/DE69515750T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69515750T 1994-07-27 1995-07-24 Verfahren zur Herstellung von Alpha-Tocopherol Expired - Lifetime DE69515750T3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP17516794 1994-07-27
JP17516794 1994-07-27
JP28230994 1994-11-16
JP28230994 1994-11-16

Publications (3)

Publication Number Publication Date
DE69515750D1 DE69515750D1 (de) 2000-04-27
DE69515750T2 true DE69515750T2 (de) 2000-08-10
DE69515750T3 DE69515750T3 (de) 2005-01-20

Family

ID=26496517

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69515750T Expired - Lifetime DE69515750T3 (de) 1994-07-27 1995-07-24 Verfahren zur Herstellung von Alpha-Tocopherol

Country Status (5)

Country Link
US (2) US5663376A (de)
EP (1) EP0694541B2 (de)
CN (1) CN1067066C (de)
CA (1) CA2154605C (de)
DE (1) DE69515750T3 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009051118A1 (de) * 2009-10-13 2011-04-21 Otto Bock Mobility Solutions Gmbh Elektrorollstuhl

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020505A (en) * 1994-07-27 2000-02-01 Eisai Co., Ltd. Process for the preparation of α-tocopherol
WO1997028151A1 (de) * 1996-01-29 1997-08-07 Basf Aktiengesellschaft VERFAHREN ZUR HERSTELLUNG VON DL-α-TOCOPHEROL ODER DL-α-TOCOPHERYLACETAT
US6005122A (en) * 1996-12-23 1999-12-21 Basf Aktiengesellschaft Preparation of α-tocopherol or α-tocopheryl acetate by reacting trimethylhydroquinone and phytol or isophytol, with recycling of the zinc halide condensation catalyst
DE19654038A1 (de) * 1996-12-23 1998-06-25 Basf Ag Verfahren zur Herstellung von alpha-Tocopherol oder alpha-Tocopherylacetat durch Umsetzen von Trimethylhydrochinon und Phytol oder Isophytol unter Rückführung des Kondensationskatalysators Zinkchlorid
US6029415A (en) 1997-10-24 2000-02-29 Abco, Inc. Laminated vinyl siding
DE19757124A1 (de) * 1997-12-20 1999-06-24 Degussa Verfahren zur Herstellung von alpha-Tocopherolestern
ES2264230T3 (es) * 1998-04-06 2006-12-16 Dsm Ip Assets B.V. Procedimiento par ala obtencion de d,1-alfa-tocoferol, en un disolvente de carbonato y en presencia de un catalizador de acido conteniendo azufre.
IN188479B (de) 1998-07-10 2002-09-28 Hoffmann La Roche
EP0970953B1 (de) * 1998-07-10 2004-09-29 DSM IP Assets B.V. Herstellung von alpha-Tocopherol
FR2784104B1 (fr) * 1998-09-18 2002-12-27 Rhone Poulenc Nutrition Animal Procede de preparation de la vitamine e
KR100452291B1 (ko) 1999-12-14 2004-10-08 에스케이 주식회사 고수율 및 고순도로 ＤＬ-α-토코페롤를 제조하는 방법
KR20030005202A (ko) * 2000-02-21 2003-01-17 다케다 야쿠힌 고교 가부시키가이샤 환상 화합물의 제조 방법
DE102004038800A1 (de) 2003-08-13 2005-03-31 Dsm Ip Assets B.V. Herstellung von Tocol, Tocolderivaten und Tocopherolen
ATE411307T1 (de) 2003-12-05 2008-10-15 Dsm Ip Assets Bv Verfahren zur herstellung von alkenylierten hydroxylierten aromatischen verbindungen, von chromanverbindungen und deren acylierten derivaten
JP4999690B2 (ja) * 2004-06-11 2012-08-15 ディーエスエム アイピー アセッツ ビー．ブイ． クロマン誘導体、特にα−トコフェロールおよびそのアルカノエートの製造方法
WO2007129834A1 (en) 2006-05-04 2007-11-15 Lg Chem, Ltd. Organic light-emitting device having light-emitting pattern, method and apparatus for preparing the same
CN103080055A (zh) 2010-08-24 2013-05-01 帝斯曼知识产权资产管理有限公司 3,7-二甲基-1-辛烯-3-醇的制备方法
CN102964330A (zh) * 2011-08-31 2013-03-13 卫材R&D管理有限公司 α-生育酚及α-生育酚乙酸酯的制造方法
US11917753B2 (en) 2019-09-23 2024-02-27 Ticona Llc Circuit board for use at 5G frequencies
WO2021122439A1 (en) 2019-12-19 2021-06-24 Dsm Ip Assets B.V. Formation of alpha tocopherol from 2,3,6-trimethylphenol
CN116987057A (zh) * 2023-06-16 2023-11-03 江苏宏邦化工科技有限公司 一种维生素e乙酸酯的合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2411969A (en) † 1938-03-31 1946-12-03 Hoffmann La Roche Process for the preparation of synthetic dl-tocopherols
DE960720C (de) † 1954-01-25 1957-03-28 Hoffmann La Roche Verfahren zur Herstellung von ª‡-Tocopherol
DE1015446B (de) † 1956-09-01 1957-09-12 Knoll Ag Verfahren zur Herstellung von d, 1-ª‡-Tocopherol
US3459773A (en) † 1966-12-27 1969-08-05 Takasago Perfumery Co Ltd Process for producing alpha-tocopherol and its esters
US3444213A (en) † 1967-07-12 1969-05-13 Eastman Kodak Co Continuous process for producing dl alpha tocopherol
CH547278A (de) † 1971-01-11 1974-03-29 Hoffmann La Roche Verfahren zur herstellung von chromanderivaten.
US3708505A (en) † 1971-02-25 1973-01-02 Diamond Shamrock Corp Process for preparation of d,l-alpha tocopherol
JPS5124513B2 (de) * 1972-09-12 1976-07-24
US4168271A (en) * 1977-04-13 1979-09-18 Scm Corporation Unsaturated vitamin E intermediates--dehydro and didehydro α-tocopherols
US5110955A (en) * 1989-04-14 1992-05-05 Hoffmann-La Roche Inc. Tocopherol synthesis: chromane cyclization and catalysis
DE4208477A1 (de) † 1992-03-17 1993-09-23 Basf Ag Verfahren zur herstellung von vitamin e
JP3848380B2 (ja) † 1993-12-14 2006-11-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 α−トコフェロール誘導体の製造法
JP3416281B2 (ja) † 1994-04-12 2003-06-16 エーザイ株式会社 α−トコフェロール誘導体の製造方法および触媒

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009051118A1 (de) * 2009-10-13 2011-04-21 Otto Bock Mobility Solutions Gmbh Elektrorollstuhl
DE102009051118B4 (de) * 2009-10-13 2014-04-30 Otto Bock Mobility Solutions Gmbh Elektrorollstuhl

Also Published As

Publication number Publication date
CA2154605A1 (en) 1996-01-28
EP0694541A1 (de) 1996-01-31
EP0694541B2 (de) 2004-03-03
EP0694541B1 (de) 2000-03-22
US5663376A (en) 1997-09-02
US5886197A (en) 1999-03-23
CN1067066C (zh) 2001-06-13
CN1123278A (zh) 1996-05-29
DE69515750D1 (de) 2000-04-27
CA2154605C (en) 2004-10-05
DE69515750T3 (de) 2005-01-20

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings
8327 Change in the person/name/address of the patent owner

Owner name: EISAI R&D MANAGEMENT CO., LTD., TOKYO, JP