CN112262207B - 洗涤剂组合物中包含碳水化合物结合活性的多肽及其在减少纺织品或织物中的褶皱的用途 - Google Patents
洗涤剂组合物中包含碳水化合物结合活性的多肽及其在减少纺织品或织物中的褶皱的用途 Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38681—Chemically modified or immobilised enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
-
- C11D2111/12—
Abstract
披露了具有碳水化合物结合特性的多肽例如CBM用于在洗衣中减少褶皱的用途。还披露了包含CBM的洗涤剂组合物。
Description
对序列表的引用
本申请含有计算机可读形式的序列表。该计算机可读形式通过引用并入本文。
技术领域
本发明涉及用于衣物的洗涤剂。特别地,本发明涉及碳水化合物结合模块为纺织品提供抗皱效果的用途。
背景技术
纺织品的洗涤是普通家庭活动中的常见活动。使用完衣服后,通常需对其进行洗涤,以去除污垢并重新整理这些衣服,然后再次使用。最常用的洗衣过程涉及在洗涤剂水溶液中洗涤,然后进行一次或多次漂洗,并且随后进行干燥。
然而,通常还会经历衣服和纺织品在洗衣期间起皱,并且洗过的衣服看起来很皱,外观也不太吸引人。
希望减少在衣服或纺织品的洗涤期间形成的褶皱的量。
发明内容
本发明涉及具有碳水化合物结合活性的多肽在织物或纺织品的清洁过程中用于减少褶皱和/或提供增加的抗折痕特性和/或提供改进的熨烫容易性和/或提供改进的形状保持性的用途。
具有碳水化合物结合活性的多肽优选地选自被称为碳水化合物结合模块(CBM)的多肽或其混合物。
本发明还涉及洗涤剂组合物,以及包含具有碳水化合物结合活性的多肽的洗衣增效剂组合物(laundry booster composition)。
定义
如本文所用,单数形式“一个/一种(a/an)”和“该”旨在也包括复数形式,除非上下文清楚地另外指明。
抗皱和抗折痕以及减少褶皱和褶皱减少:在本发明的上下文中,术语“折痕”和“褶皱”以及相关术语,例如“抗折痕”、“抗皱”、“减少褶皱”和“褶皱减少”,是指织物(例如织物和纺织品)中的非永久性变形,其可以在升高的温度和湿度下通过展平(例如通过熨烫)去除。这些术语在本文中可互换使用。
细菌的:在本发明的上下文中,术语关于多肽或碳水化合物结合模块的“细菌的”是指由细菌基因组编码并且因此可直接从细菌基因组衍生的多肽,其中这种细菌未经过遗传修饰来编码所述多肽,例如,通过重组DNA技术将编码序列引入基因组中。因此,在本发明的上下文中,术语“细菌碳水化合物结合模块”或“获得自细菌来源的碳水化合物结合模块”或“细菌来源的多肽”是指由细菌物种的基因组编码并且因此可直接从细菌物种的基因组衍生的多肽,其中该细菌物种未经受通过引入编码所述多肽的重组DNA进行的遗传修饰。因此,编码细菌多肽的核苷酸序列是天然在细菌物种遗传背景中的序列。编码细菌多肽的序列也可以称为野生型(或亲本)。细菌多肽(例如细菌碳水化合物结合模块)还包括通过例如截短修饰以获得目的分子的一部分的天然存在的多肽。细菌多肽包括重组产生的野生型以及合成产生的肽。在另一方面,本发明提供了与细菌多肽基本上同源的多肽。在本发明的上下文中,术语“基本上同源”表示具有碳水化合物结合活性的多肽,该多肽与所选择的细菌多肽的氨基酸序列具有至少80%,优选地至少85%,更优选地至少90%,更优选地至少95%,甚至更优选地至少96%、97%、98%,以及最优选地至少99%的同一性。
碳水化合物结合模块:如本文所用,术语“碳水化合物结合模块”是指具有连续氨基酸序列的多肽的独立部分,其具有离散折叠(discreet fold)和碳水化合物结合活性。参见,例如cazy.org/Carbohydrate-Binding-Modules。尽管CBM通常天然存在于较大的酶中(典型地经由接头区域连接至一个或多个催化结构域),但如本文所用的术语是指独立模块。呈其天然存在的形式的CBM可以位于多肽的N-末端、C-末端或内部位置,并且如本文所用,可以是其天然存在的形式的截短。
根据本发明有用的示例性CBM家族是CBM家族1、4、17、28、30、44、72和79的那些。再一次,参考cazy.org/Carbohydrate-Binding-Modules,CBM家族1包括几乎仅在真菌中发现的大约40个残基的模块。在许多情况下已经证明了纤维素结合功能,并且该纤维素结合功能似乎由间隔约10.4埃且形成扁平表面的三个芳族残基介导。CBM家族4包括在细菌酶中发现的大约150个残基的模块。已经用木聚糖、β-1,3-葡聚糖、β-1,3-1,4-葡聚糖、β-1,6-葡聚糖和无定形纤维素(但不用结晶纤维素)证明了这些模块的结合。CBM家族17包括大约200个残基的模块。已经证明了与无定形纤维素、纤维寡糖和衍生纤维素的结合。关于CBM家族28,来自芽孢杆菌属物种(Bacillus sp.)1139的内切-1,4-葡聚糖酶的模块与非结晶纤维素、纤维寡糖和β-(1,3)(1,4)-葡聚糖结合。对于CBM家族30,已经证明了产琥珀酸丝状杆菌(Fibrobacter succinogenes)CelF的N-末端模块与纤维素的结合。已经证明了热纤维梭菌(Clostridium thermocellum)酶的C-末端CBM44模块可很好地结合纤维素和木葡聚糖。CBM家族72包括在来自多个家族的C-末端糖苷水解酶中发现的130-180个残基的模块,有时作为串联重复。发现CBM72(其发现于来自未培养微生物的内切葡聚糖酶上)与广谱的多糖结合,这些多糖包括可溶性和不可溶性纤维素、β-1,3/1,4-混合连接的葡聚糖、木聚糖和β-甘露聚糖。CBM家族79包括迄今为止仅在瘤胃球菌蛋白中发现的大约130个残基的模块。显示了黄色瘤胃球菌(R.flavefaciens)GH9酶与多种β-葡聚糖的结合。
在优选的实施例中,碳水化合物结合模块不与软化蛋白附接(attached to)(连接(linked to))。
如本文所用,CBM的“一种混合物(mixture)”或“多种混合物(mixtures)”包括以其他方式独立鉴定的多肽的共混物,以及多肽的天然存在的或合成的构建体。例如,可用于本文的CBM能以同源或异源的二聚体、三聚体、四聚体和其他更高阶的融合产物的形式存在,它们可以任选地进一步包含连接一个或多个CBM的一个或多个氨基酸接头序列。
洗涤剂组分:本文中将术语“洗涤剂组分”定义为意指可以用于洗涤剂组合物中的化学品的类型。洗涤剂组分的实例是碱、表面活性剂、水溶助剂、助洗剂、共助洗剂、螯合剂(chelator)或螯合试剂(chelating agent)、漂白系统或漂白组分、聚合物、织物调色剂、织物调理剂、增泡剂、抑泡剂、分散剂、染料转移抑制剂、荧光增白剂、香料、光学增亮剂、杀细菌剂、杀真菌剂、污垢悬浮剂、污垢释放聚合物、抗再沉积剂、酶抑制剂或稳定剂、酶活化剂、抗氧化剂以及增溶剂。
洗涤剂组合物:术语“洗涤剂组合物”是指用于从有待清洁的物品(如纺织品)去除不希望的化合物的组合物。该洗涤剂组合物可以用于例如清洁纺织品,用于家用清洁和工业清洁二者。这些术语涵盖选择用于希望的具体类型的清洁组合物和产品的形式(例如,液体、凝胶、粉末、颗粒、糊状、或喷雾组合物)的任何材料/化合物,并且包括但不限于洗涤剂组合物(例如,液体和/或固体衣物洗涤剂和精细织物洗涤剂;织物清新剂;织物柔软剂;以及纺织品和衣物预去污剂/预处理)。除了含有本发明的酶之外,该洗涤剂配制品还可以含有一种或多种另外的酶(如蛋白酶、淀粉酶、脂肪酶、角质酶、纤维素酶、内切葡聚糖酶、木葡聚糖酶、果胶酶、果胶裂解酶、黄原胶酶、过氧化物酶、卤代过氧合酶、过氧化氢酶、核酸酶以及甘露聚糖酶、或其任何混合物),和/或洗涤剂辅助剂成分,如表面活性剂、助洗剂、螯合剂或螯合试剂、漂白系统或漂白组分、聚合物、织物调理剂、增泡剂、抑泡剂、染料、香料、晦暗抑制剂、光学增亮剂、杀细菌剂、杀真菌剂、污垢悬浮剂、防腐蚀剂、酶抑制剂或稳定剂、酶活化剂、一种或多种转移酶、水解酶、氧化还原酶、上蓝剂和荧光染料、抗氧化剂以及增溶剂。
织物改进:术语“织物改进”或“纺织品改进”意指与催化去污或防止污垢再沉积不直接相关的益处。此类益处的实例是抗返染,抗起球,抗缩水,抗磨损,抗皱,改进的颜色外观,织物柔软性,改进的形状保持性,阻燃性或耐化学性,防臭,防紫外线,防水,抗微生物,改进非纤维素和纤维素纺织品之间的结合,改进的静电控制,改进的手感或纹理,抗化学、生物、放射性或物理性危害,和/或改进的拉伸强度。防止或减少从一个纺织品到另一个纺织品或相同纺织品的另一个部分的染料转移称为抗返染(还称为染料转移抑制)。从纺织品表面去除突出或破裂的纤维来减少起球倾向或去除已经存在的球粒或细毛称为抗起球。突出或破裂的纤维的包衣或再合并或抚平也称为抗起球。防止或减少三维尺寸的减小称为抗缩水。防止或修复磨损称为抗磨损。在家庭衣物洗涤后防止起皱,纺织品从起皱中恢复,缝合处的抚平,和/或折痕保留称为“抗皱”或抗折痕。纺织品柔软性的改进或纺织品刚度的降低称为改进的织物柔软性。纺织品的颜色澄清,或提高的耐洗涤、汗、光、氯和无氯漂白、热、高温下光的色牢度称为改进的颜色外观。抗三维尺寸变化或抗家庭衣物洗涤过程中三维尺寸变化称为改进的形状保持性。提高的燃烧温度或在高温下抗燃或抗熔化称为阻燃性。在化学溶剂、酸或碱的存在下,耐化学反应,溶解或降解称为耐化学性。气味化合物(具体地短链脂肪酸或低蒸汽压的有机化合物)的抗吸收或防止保留称为防臭。对紫外光照射的不透明度和防止或修复由紫外光照射引起的氧化性损伤称为防紫外线。降低水分保持、或抗润湿性称为防水。提高抑菌或杀菌特性称为抗微生物。增加抗纺织品的感应静电电荷、或增加纺织品中感应静电电荷的衰减率称为改进的静电控制。抗在力或破断拉力的增加下伸长称为改进的拉伸强度。
第一次洗涤:术语“第一次洗涤”意指在第一次洗涤期间或在第一次洗涤中已经显示出改进或性能益处效果,并且不依赖于一个或多个后续洗涤步骤或洗涤和干燥步骤以实现益处。
真菌的:在本发明的上下文中,术语关于多肽或碳水化合物结合模块的“真菌的”是指由真菌基因组编码并且因此可直接从真菌基因组衍生的多肽,其中这种真菌未经过遗传修饰来编码所述多肽,例如,通过重组DNA技术将编码序列引入基因组中。因此,在本发明的上下文中,术语“真菌碳水化合物结合模块”或“获得自真菌来源的碳水化合物结合模块”或“真菌来源的多肽”是指由真菌物种的基因组编码并且因此可直接从真菌物种的基因组衍生的多肽,其中该真菌物种未经受通过引入编码所述多肽的重组DNA进行的遗传修饰。因此,编码真菌多肽的核苷酸序列可以是天然在真菌物种遗传背景中的序列。编码真菌多肽的序列也可以称为野生型(或亲本)。真菌多肽(例如真菌碳水化合物结合模块)还包括通过例如截短修饰以获得目的分子的一部分的天然存在的多肽。真菌多肽包括重组产生的野生型以及合成产生的肽。在另一方面,本发明提供了与真菌多肽基本上同源的多肽。在本发明的上下文中,术语“基本上同源”表示具有碳水化合物结合活性的多肽,该多肽与所选择的真菌多肽的氨基酸序列具有至少80%,优选地至少85%,更优选地至少90%,更优选地至少95%,甚至更优选地至少96%、97%、98%,以及最优选地至少99%的同一性。
衣物洗涤:术语“衣物洗涤”涉及家用衣物洗涤和工业衣物洗涤两者并且意指用含有本发明的清洁或洗涤剂组合物的溶液处理纺织品的过程。衣物洗涤过程可以例如使用例如家用或工业洗衣机进行或可以手动进行。
洗衣增效剂:洗衣增效剂是用于增加主洗涤洗涤剂组合物的功效的添加剂。
序列同一性:两个氨基酸序列之间或两个核苷酸序列之间的关联度通过参数“序列同一性”来描述。出于本发明的目的,使用如在EMBOSS包(EMBOSS:欧洲分子生物学开放软件套件(The European Molecular Biology Open Software Suite),Rice等人,2000,Trends Genet.[遗传学趋势]16:276-277)(优选5.0.0版或更新版本)的Needle程序中所实施的Needleman-Wunsch算法(Needleman和Wunsch,1970,J.Mol.Biol.[分子生物学杂志]48:443-453)可以确定两个氨基酸序列之间的序列同一性。所使用的参数是空位开放罚分10、空位延伸罚分0.5和EBLOSUM62(BLOSUM62的EMBOSS版)取代矩阵。将标记为“最长同一性”的Needle的输出(使用非简化选项(nobrief option)获得)用作同一性百分比并且计算如下:(相同的残基x 100)/(比对长度-比对中的空位总数)
出于本发明的目的,使用如在EMBOSS包(EM-BOSS:欧洲分子生物学开放软件套件(The European Molecular Biology Open Software Suite),Rice等人,2000,同上)(优选5.0.0版或更新版本)的Needle程序中所实施的Needleman-Wunsch算法(Needleman和Wunsch,1970,同上)可以确定两个脱氧核糖核苷酸序列之间的序列同一性。所使用的参数是空位开放罚分10、空位延伸罚分0.5和EDNAFULL(NCBI NUC4.4的EMBOSS版)取代矩阵。将标记为“最长同一性”的Needle的输出(使用非简化选项获得)用作同一性百分比并且计算如下:(相同的脱氧核糖核苷酸x 100)/(比对长度-比对中的空位总数)。
纺织品:术语“纺织品”意指任何纺织品材料,该任何纺织品材料包括纱线、纱线中间体、纤维、非机织材料、天然材料、合成材料、以及任何其他纺织品材料,由这些材料制成的织物和由织物制成的产品(例如,服装和其他制品),并且旨在也包括术语“织物”。该纺织品或织物可以处于针织品、机织物(WO ven)、牛仔布(denim)、非机织物、毡、纱线、以及毛巾布的形式。该纺织品可以是基于纤维素的,如天然纤维素制品,包括棉、亚麻/亚麻布、黄麻、苎麻、剑麻或椰壳纤维,或者人造纤维素(例如,来源于木浆),包括粘胶纤维/人造丝、乙酸纤维素纤维(三胞)、莱赛尔纤维(lyocell)或其共混物。纺织品或织物也可以不基于纤维素,如天然聚酰胺,包括羊毛、驼毛、羊绒、马海毛、兔毛和蚕丝,或合成聚合物如尼龙、芳族聚酰胺、聚酯、丙烯酸、聚丙烯和氨纶/弹性纤维(spandex/elastane)、或其共混物以及基于纤维素和不基于纤维素的纤维的共混物。共混物的实例是棉和/或人造丝/粘胶纤维与一种或多种伴随材料的共混物,该伴随材料如羊毛、合成纤维(例如聚酰胺纤维、丙烯酸纤维、聚酯纤维、聚氯乙烯纤维、聚氨酯纤维、聚脲纤维、芳族聚酰胺纤维)和/或含纤维素的纤维(例如人造丝/粘胶纤维、苎麻、亚麻/亚麻布、黄麻、乙酸纤维素纤维、莱赛尔纤维)。织物可以是常规的可洗涤衣物,例如有污渍的家用衣物。当使用术语织物或服装时,旨在也包括广义术语纺织品。
洗涤周期:本文将术语“洗涤周期”定义为如下洗涤操作,其中将纺织品浸泡在洗涤液中,将某种机械作用应用于该纺织品,以释放污渍,并且协助洗涤液流进和流出该纺织品,并且最终去除多余的洗涤液。在一个或多个洗涤周期后,总体上对该纺织品进行漂洗和干燥。
洗涤液:术语“洗涤液”旨在表示任选地包括用于将纺织品洗涤、用于硬表面清洁或用于餐具洗涤的酶类的水和洗涤剂的溶液或混合物。
具体实施方式
本发明涉及具有碳水化合物结合活性的多肽用于减少织物或纺织品的清洁过程中的褶皱的用途。
碳水化合物结合活性在本申请中旨在表示所讨论的多肽具有结合碳水化合物,特别是结合碳水化合物聚合物(如纤维素、半纤维素或淀粉)的能力。在优选的实施例中,CBM是纤维素结合CBM。
碳水化合物结合活性在本领域中是众所周知的,并且已经针对碳水化合物结合模块进行了详细描述,例如在http://www.cazy.org/Carbohydrate-Binding-Modules.html中,其中基于多肽的结构披露了碳水化合物结合模块家族分类。该站点描述了超过80个CBM家族,并且在该站点使用的家族编号也将在本申请和权利要求中使用。
在一个实施例中,具有碳水化合物结合活性的多肽选自属于家族CBM1;CBM4、CBM17、CBM28、CBM30、CBM44、CBM72和CBM79的碳水化合物结合模块。
在另一个实施例中,具有碳水化合物结合活性的多肽选自与SEQ ID NO:2、4、6、8、10、12、14、16、18具有至少60%序列同一性、例如至少70%序列同一性、例如至少80%序列同一性、例如至少90%序列同一性;例如至少95%序列同一性、例如至少96%序列同一性、例如至少97%序列同一性;例如至少98%序列同一性、或至少99%序列同一性的多肽。
在另一个实施例中,具有碳水化合物结合活性的多肽选自具有SEQ ID NO:2、SEQID NO:4、SEQ ID NO:6、SEQ ID NO:8、SEQ ID NO:10、SEQ ID NO:12、SEQ ID NO:14、SEQ IDNO:16、SEQ ID NO:18的氨基酸序列,或具有偏离SEQ ID NO:2、SEQ ID NO:4、SEQ ID NO:6、SEQ ID NO:8、SEQ ID NO:10、SEQ ID NO:12、SEQ ID NO:14、SEQ ID NO:16、SEQ ID NO:18之一1、2、3、4、5、6、7、8或9个取代、插入或缺失的氨基酸序列的多肽。
在本发明的一个实施例中,可以将根据本发明的具有碳水化合物结合活性的多肽以对应于以下的量添加至洗涤剂组合物中:每升的洗涤液0.001-200mg的蛋白质,如0.005-100mg的蛋白质,优选0.01-50mg的蛋白质,更优选0.05-20mg的蛋白质,甚至更优选0.1-10mg的蛋白质。
在一个实施例中,具有碳水化合物结合活性的多肽与衣物洗涤过程中使用的另一多肽(例如酶)结合。在此实施例中,具有碳水化合物结合活性的多肽的量应基于仅具有碳水化合物结合活性的多肽的重量而不基于与其结合的多肽的重量来计算。
根据本发明,可以在洗涤过程中添加CBM,并且在此实施例中,通常将CBM掺入用于洗衣过程的洗涤剂组合物中。在替代性实施例中,在洗涤过程之后的漂洗期间添加CBM,并且在此实施例中,通常将CBM掺入漂洗助剂组合物中。
在另一个实施例中,具有碳水化合物结合活性的多肽不与任何其他多肽结合。
根据本发明,与未添加具有碳水化合物活性的多肽的类似洗涤过程相比,使用具有碳水化合物结合活性的多肽可以减少在洗衣过程中出现的褶皱。根据本发明,使用AATCC(美国纺织化学师和染色师协会(American Association of Textile Chemists andColorists))测试方法124-TM 124家庭衣物洗涤后织物的平滑度外观(TM 124SmoothnessAppearance of Fabrics after Home Laundering)(https://members.aatcc.org/store/tm124/533/)评估褶皱的数量。
根据本发明,得分提高至少0.15个单位、0.20个单位、0.25个单位、0.30个单位、0.40个单位、优选至少0.5个单位、优选至少0.75个单位、优选至少1.0个单位、优选至少1.25个单位、优选至少1.5个单位、优选至少1.75个单位、优选至少2.0个单位或甚至更高。
根据本发明,可以通过专门小组成员评估来评价织物的改进。要求专门小组成员选择最柔软的毛巾部分,并选择更少折痕的T恤部分。评价后,计算分布。柔软性和抗折痕用X:Y值表示,其中X指定优选用CBM洗涤的真实物品的专门小组成员的%,并且Y指定优选未用CBM洗涤的真实物品的%。该X值和Y值的总和为100%。
根据本发明,专门小组成员优选用CBM洗涤的织物与测试专门小组成员优选不用CBM洗涤的织物为至少60:40,优选至少70:30,优选至少80:20,或优选至少90:10。优选地,测试专门小组成员优选用CBM洗涤的织物与测试专门小组成员优选不用CBM洗涤的织物的改进的柔软性效果比为至少60:40,优选至少70:30,优选至少80:20,或优选至少90:10。
本发明不限于任何特定的衣物洗涤过程,而是可以应用于使用如本领域中已知的衣物洗涤设备的任何衣物洗涤过程,例如前装式或顶装式洗衣机,或甚至手洗。
本发明不受洗涤后干燥纺织品的方式的限制,而是本发明可以与用于干燥纺织品的任何方法组合使用,包括挂干(line drying)或使用干燥机(如滚筒干燥机)。
本发明不限于任何特定的织物或纺织品,而是可以应用于任何已知的纺织品,例如棉、PET、人造丝、粘胶羊毛和丝绸、以及这些的任何共混物。然而,优选的是,纺织品包含纤维素。
洗涤剂组合物
在一个实施例中,本发明涉及洗涤剂组合物,这些洗涤剂组合物包含与一种或多种另外的清洁组合物组分组合的本发明的多肽。另外的组分的选择处于技术人员的能力范围内并且包括常规的成分,包括下文所述的示例性非限制性组分。
对于纺织品护理,组分的选择可以包括以下考虑:有待清洁的纺织品的类型、污物的类型和/或程度、进行清洁时的温度以及洗涤剂产品的配制。尽管根据具体的功能性对以下提及的组分由通用标题进行分类,但是这并不被解释为限制,因为如将被普通技术人员所理解,组分可以包含另外的功能性。
表面活性剂
洗涤剂组合物可以包含一种或多种表面活性剂,它们可以是阴离子型和/或阳离子型和/或非离子型和/或半极性型和/或兼性离子型、或其混合物。在特别的实施例中,洗涤剂组合物包括一种或多种非离子型表面活性剂和一种或多种阴离子型表面活性剂的混合物。该一种或多种表面活性剂典型地以按重量计从约0.1%至60%(如约1%至约40%、或约3%至约20%、或约3%至约10%)的水平存在。基于所希望的清洁应用来选择该一种或多种表面活性剂,并且该一种或多种表面活性剂可以包括本领域中已知的任何常规表面活性剂。
当被包括在其中时,该洗涤剂将通常含有按重量计从约1%至约40%的阴离子型表面活性剂,如从约5%至约30%,包括从约5%至约15%,或从约15%至约20%,或从约20%至约25%的阴离子型表面活性剂。阴离子型表面活性剂的非限制性实例包括硫酸盐和磺酸盐,具体地,直链烷基苯磺酸盐(LAS)、LAS的异构体、支链烷基苯磺酸盐(BABS)、苯基链烷磺酸盐、α-烯烃磺酸盐(AOS)、烯烃磺酸盐、链烯烃磺酸盐、链烷-2,3-二基双(硫酸盐)、羟基链烷磺酸盐以及二磺酸盐、烷基硫酸盐(AS)(如十二烷基硫酸钠(SDS))、脂肪醇硫酸盐(FAS)、伯醇硫酸盐(PAS)、醇醚硫酸盐(AES或AEOS或FES,也被称为醇乙氧基硫酸盐或脂肪醇醚硫酸盐)、仲链烷磺酸盐(SAS)、石蜡磺酸盐(PS)、酯磺酸盐、磺化的脂肪酸甘油酯、α-磺基脂肪酸甲酯(α-SFMe或SES)(包括甲酯磺酸盐(MES))、烷基琥珀酸或烯基琥珀酸、十二烯基/十四烯基琥珀酸(DTSA)、氨基酸的脂肪酸衍生物、磺基琥珀酸的二酯和单酯或脂肪酸盐(皂)、及其组合。
当被包括在其中时,该洗涤剂将通常含有按重量计从约1%至约40%的阳离子型表面活性剂,例如从约0.5%至约30%,特别是从约1%至约20%、从约3%至约10%,如从约3%至约5%、从约8%至约12%或从约10%至约12%。阳离子型表面活性剂的非限制性实例包括烷基二甲基乙醇季胺(ADMEAQ)、十六烷基三甲基溴化铵(CTAB)、二甲基二硬脂酰氯化铵(DSDMAC)、以及烷基苄基二甲基铵、烷基季铵化合物、烷氧基化季铵(AQA)化合物、酯季铵、及其组合。
当被包括在其中时,该洗涤剂将通常含有按重量计从约0.2%至约40%的非离子型表面活性剂,例如从约0.5%至约30%,特别是从约1%至约20%、从约3%至约10%,如从约3%至约5%、从约8%至约12%或从约10%至约12%。非离子型表面活性剂的非限制性实例包括醇乙氧基化物(AE或AEO)、醇丙氧基化物、丙氧基化的脂肪醇(PFA)、烷氧基化的脂肪酸烷基酯(如乙氧基化的和/或丙氧基化的脂肪酸烷基酯)、烷基酚乙氧基化物(APE)、壬基酚乙氧基化物(NPE)、烷基多糖苷(APG)、烷氧基化胺、脂肪酸单乙醇酰胺(FAM)、脂肪酸二乙醇酰胺(FADA)、乙氧基化的脂肪酸单乙醇酰胺(EFAM)、丙氧基化的脂肪酸单乙醇酰胺(PFAM)、多羟基烷基脂肪酸酰胺、或葡糖胺的N-酰基N-烷基衍生物(葡糖酰胺(GA)、或脂肪酸葡糖酰胺(FAGA)),以及可以商品名SPAN和TWEEN获得的产品、及其组合。
当被包括在其中时,该洗涤剂将通常含有按重量计从约0.2%至约10%的半极性型表面活性剂。半极性型表面活性剂的非限制性实例包括氧化胺(AO),如烷基二甲胺氧化物、N-(椰油基烷基)-N,N-二甲胺氧化物和N-(牛油-烷基)-N,N-双(2-羟乙基)胺氧化物、及其组合。
当被包括在其中时,该洗涤剂将通常含有按重量计从约0.2%至约10%的兼性离子型表面活性剂。兼性离子型表面活性剂的非限制性实例包括甜菜碱,如烷基二甲基甜菜碱、磺基甜菜碱、及其组合。
水溶助剂
水溶助剂是如下化合物,该化合物在水溶液中溶解疏水化合物(或相反地,在非极性环境中溶解极性物质)。典型地,水溶助剂具有亲水和疏水两种特征(所谓的两亲特性,如由表面活性剂已知的);然而,水溶助剂的分子结构一般不利于自发性自聚集,参见例如通过Hodgdon和Kaler(2007),Current Opinion in Colloid&Interface Science[胶体和界面科学新见]12:121-128的综述。水溶助剂并不显示临界浓度,高于该浓度就会发生如对表面活性剂而言所发现的自聚集以及脂质形成胶束、薄层或其他明确定义的中间相。相反,许多水溶助剂显示连续类型的聚集过程,在该过程中聚集物的大小随着浓度增加而增长。然而,许多水溶助剂改变了含有极性和非极性特征的物质的系统(包括水、油、表面活性剂、和聚合物的混合物)的相行为、稳定性、和胶体特性。水溶助剂常规地在从药学、个人护理、食品到技术应用的各个产业中应用。水溶助剂在洗涤剂组合物中的使用允许例如更浓的表面活性剂配制品(如在通过去除水而压缩液体洗涤剂的过程中)而不引起不希望的现象,例如相分离或高粘度。
洗涤剂可以含有按重量计0-10%,例如按重量计0-5%,例如约0.5%至约5%、或约3%至约5%的水溶助剂。可以利用本领域中已知的用于在洗涤剂中使用的任何水溶助剂。水溶助剂的非限制性实例包括苯磺酸钠、对甲苯磺酸钠(STS)、二甲苯磺酸钠(SXS)、枯烯磺酸钠(SCS)、伞花烃磺酸钠、氧化胺、醇和聚乙二醇醚、羟基萘甲酸钠、羟基萘磺酸钠、乙基己基磺酸钠、及其组合。
助洗剂和共助洗剂
该洗涤剂组合物可以含有按重量计约0-65%(如约5%至约50%)的洗涤剂助洗剂或共助洗剂、或其混合物。在餐具洗涤洗涤剂中,助洗剂的水平典型地是40%-65%、特别是50%-65%。助洗剂和/或共助洗剂可以特别是与Ca和Mg形成水溶性络合物的螯合试剂。可以利用本领域中已知的用于在衣物洗涤剂中使用的任何助洗剂和/或共助洗剂。助洗剂的非限制性实例包括沸石、二磷酸盐(焦磷酸盐)、三磷酸盐例如三磷酸钠(STP或STPP)、碳酸盐例如碳酸钠、可溶性硅酸盐例如偏硅酸钠、层状硅酸盐(例如,来自赫斯特公司(Hoechst)的SKS-6)、乙醇胺例如2-氨基乙-1-醇(MEA)、二乙醇胺(DEA,也称为2,2’-亚氨基二乙-1-醇)、三乙醇胺(TEA,也称为2,2’,2”-次氮基三乙-1-醇)、以及(羧甲基)菊粉(CMI)、及其组合。
该洗涤剂组合物还可以含有按重量计0-50%,如约5%至约30%的洗涤剂共助洗剂。洗涤剂组合物可以包括单独的共助洗剂,或与助洗剂(例如沸石助洗剂)组合。共助洗剂的非限制性实例包括聚丙烯酸酯的均聚物或其共聚物,例如聚(丙烯酸)(PAA)或共聚(丙烯酸/马来酸)(PAA/PMA)。另外的非限制性实例包括柠檬酸盐、螯合剂(例如氨基羧酸盐、氨基多羧酸盐和磷酸盐)、以及烷基琥珀酸或烯基琥珀酸。另外的具体实例包括2,2’,2”-次氨基三乙酸(NTA)、乙二胺四乙酸(EDTA)、二亚乙基三胺五乙酸(DTPA)、亚氨基二丁二酸(IDS)、乙二胺-N,N’-二丁二酸(EDDS)、甲基甘氨酸二乙酸(MGDA)、谷氨酸-N,N-二乙酸(GLDA)、1-羟基乙烷-1,1-二膦酸(HEDP)、乙二胺四(亚甲基膦酸)(EDTMPA)、二亚乙基三胺五(亚甲基膦酸)(DTMPA或DTPMPA)、N-(2-羟乙基)亚氨基二乙酸(EDG)、天冬氨酸-N-单乙酸(ASMA)、天冬氨酸-N,N-二乙酸(ASDA)、天冬氨酸-N-单丙酸(ASMP)、亚氨基二琥珀酸(iminodisuccinic acid)(IDA)、N-(2-磺甲基)-天冬氨酸(SMAS)、N-(2-磺乙基)-天冬氨酸(SEAS)、N-(2-磺甲基)-谷氨酸(SMGL)、N-(2-磺乙基)-谷氨酸(SEGL)、N-甲基亚氨基二乙酸(MIDA)、α-丙氨酸-N,N-二乙酸(α-ALDA)、丝氨酸-N,N-二乙酸(SEDA)、异丝氨酸-N,N-二乙酸(ISDA)、苯丙氨酸-N,N-二乙酸(PHDA)、邻氨基苯甲酸-N,N-二乙酸(ANDA)、磺胺酸-N,N-二乙酸(SLDA)、牛磺酸-N,N-二乙酸(TUDA)以及磺甲基-N,N-二乙酸(SMDA)、N-(2-羟乙基)-亚乙基二胺-N,N’,N”-三乙酸盐(HEDTA)、二乙醇甘氨酸(DEG)、二亚乙基三胺五(亚甲基膦酸)(DTPMP)、氨基三(亚甲基膦酸)(ATMP)及其组合和盐。另外的示例性助洗剂和/或共助洗剂描述于例如WO 09/102854、US 5977053中。
漂白系统
洗涤剂可以含有按重量计0-30%,如约1%至约20%的漂白系统。可以利用本领域中已知的用于在衣物洗涤剂中使用的任何漂白系统。合适的漂白系统组分包括漂白催化剂、光漂白剂、漂白活化剂、过氧化氢源如过碳酸钠、过硼酸钠和过氧化氢―脲(1:1)、预成型过酸及其混合物。合适的预成型过酸包括但不限于过氧羧酸及盐、二过氧二羧酸、过亚氨酸(perimidic acid)及盐、过氧单硫酸及盐(例如过硫酸氢钾(Oxone(R))及其混合物。漂白系统的非限制性实例包括与过酸形成漂白活化剂组合的基于过氧化物的漂白系统,其可以包含例如无机盐,包括碱金属盐例如过硼酸盐的钠盐(通常为单或四水合物)、过碳酸盐、过硫酸盐、过磷酸盐、过硅酸盐。术语漂白活化剂本文意指与过氧化氢反应以经由过水解反应形成过酸的化合物。以此方式形成的过酸构成活化的漂白剂。本文有待使用的适合的漂白活化剂包括属于酯、酰胺、酰亚胺或酸酐类别的那些。适合的实例是四乙酰乙二胺(TAED)、4-[(3,5,5-三甲基己酰基)氧基]苯-1-磺酸钠(ISONOBS)、4-(十二酰基氧基)苯-1-磺酸盐(LOBS)、4-(癸酰基氧基)苯-1-磺酸盐、4-(癸酰基氧基)苯甲酸盐(DOBS或DOBA)、4-(壬酰氧基)苯-1-磺酸盐(NOBS)和/或披露于WO98/17767中的那些。感兴趣的漂白活化剂的具体家族披露于EP624154中并且在该家族中特别优选的是乙酰柠檬酸三乙酯(ATC)。ATC或短链甘油三酸酯(像三醋汀)具有以下优点,它是环境友好的。此外,乙酰柠檬酸三乙酯和三醋汀在存储时在产品中具有良好的水解稳定性,并且是一种有效的漂白活化剂。最后,ATC是多功能的,因为在过水解反应中释放的柠檬酸盐可以作为助洗剂起作用。可替代地,漂白系统可以包含例如酰胺、酰亚胺或砜类型的过氧酸。漂白系统还可以包含过酸,例如6-(苯二甲酰亚氨基)过己酸(PAP)。漂白系统还可以包括漂白催化剂。在一些实施例中,漂白组分可以是选自下组的有机催化剂,该组由以下组成:具有下式的有机催化剂:
(iii)及其混合物;
其中每个R1独立地是含有从9至24个碳的支链烷基基团或含有从11至24个碳的直链烷基基团,优选地每个R1独立地是含有从9至18个碳的支链烷基基团或含有从11至18个碳的直链烷基基团,更优选地每个R1独立地选自下组,该组由以下组成:2-丙基庚基、2-丁基辛基、2-戊基壬基、2-己基癸基、十二烷基、十四烷基、十六烷基、十八烷基、异壬基、异癸基、异十三烷基以及异十五烷基。其他示例性漂白系统描述于例如WO 2007/087258、WO2007/087244、WO 2007/087259、EP1867708(维生素K)以及WO 2007/087242中。合适的光漂白剂可以例如是磺化的酞菁锌或酞菁铝。
优选地,除了漂白催化剂,特别是有机漂白催化剂以外,漂白组分还包含过酸源。过酸源可以选自(a)预形成的过酸;(b)过碳酸盐、过硼酸盐或过硫酸盐(过氧化氢源),优选与漂白活化剂组合;和(c)过水解酶以及酯,用于在纺织品或硬表面处理步骤中在水的存在下原位形成过酸。
聚合物
洗涤剂可以含有按重量计0%-10%(例如0.5%-5%、2%-5%、0.5%-2%或0.2%-1%)的聚合物。可以利用本领域中已知的在洗涤剂中使用的任何聚合物。该聚合物可以作为如上文提到的共助洗剂起作用,或可以提供抗再沉积、纤维保护、污垢释放、染料转移抑制、油污清洁和/或抑泡特性。一些聚合物可以具有多于一种的上文提到的特性和/或多于一种的下文提到的基序。示例性聚合物包括(羧甲基)纤维素(CMC)、聚(乙烯醇)(PVA)、聚(乙烯吡咯烷酮)(PVP)、聚(乙二醇)或聚(环氧乙烷)(PEG)、乙氧基化的聚(亚乙基亚胺)、羧甲基菊粉(CMI)、和聚羧酸酯(如PAA、PAA/PMA、聚-天冬氨酸、和甲基丙烯酸月桂酯/丙烯酸共聚物)、疏水修饰的CMC(HM-CMC)和硅酮、对苯二甲酸和低聚乙二醇的共聚物、聚(对苯二甲酸乙二酯)和聚(氧乙烯对苯二甲酸酯)的共聚物(PET-POET)、PVP、聚(乙烯基咪唑)(PVI)、聚(乙烯吡啶-N-氧化物)(PVPO或PVPNO)以及聚乙烯吡咯烷酮-乙烯基咪唑(PVPVI)。另外的示例性聚合物包括磺化的聚羧酸酯、聚环氧乙烷和聚环氧丙烷(PEO-PPO)以及乙氧基硫酸二季铵盐。其他示例性聚合物披露于例如WO 2006/130575中。还考虑了以上提到的聚合物的盐。
织物调色剂
本发明的洗涤剂组合物还可以包括织物调色剂,例如染料或色素,当配制在洗涤剂组合物中时,当所述织物与洗涤液接触时织物调色剂可以沉积在织物上,该洗涤液包含所述洗涤剂组合物,并且因此通过可见光的吸收/反射改变所述织物的色彩。荧光增白剂发射至少一些可见光。相比之下,当织物调色剂吸收至少部分可见光谱时,它们改变表面的色彩。合适的织物调色剂包括染料和染料-粘土轭合物,并且还可以包括色素。合适的染料包括小分子染料和聚合物染料。合适的小分子染料包括选自下组的小分子染料,该组由落入颜色索引(Colour Index,C.I.)分类的以下染料组成:直接蓝、直接红、直接紫、酸性蓝、酸性红、酸性紫、碱性蓝、碱性紫和碱性红、或其混合物,例如于WO 2005/03274、WO 2005/03275、WO 2005/03276和EP1876226中所描述的(将其通过引用并入本文)。洗涤剂组合物优选地包含从约0.00003wt%至约0.2wt%、从约0.00008wt%至约0.05wt%、或甚至从约0.0001wt%至约0.04wt%的织物调色剂。该组合物可以包含从0.0001wt%至0.2wt%的织物调色剂,当该组合物处于单位剂量袋的形式时,这可以是尤其优选的。合适的调色剂还披露于例如WO 2007/087257和WO 2007/087243中。
酶
洗涤剂添加剂和洗涤剂组合物可以包含一种或多种酶,如蛋白酶、脂肪酶、角质酶、淀粉酶、碳水化合物酶、纤维素酶、果胶酶、甘露聚糖酶、阿拉伯糖酶、半乳聚糖酶、木聚糖酶、氧化酶(例如,漆酶)和/或过氧化物酶。
通常,选择的一种或多种酶的特性应当与所选择的洗涤剂相容(即,最适pH,与其他酶成分或非酶成分的相容性等),并且该一种或多种酶应当以有效量存在。
纤维素酶
合适的纤维素酶包括细菌或真菌来源的那些。包括化学修饰的突变体或蛋白质工程化的突变体。合适的纤维素酶包括来自芽孢杆菌属、假单胞菌属、腐质霉属、镰孢属、梭孢壳菌属、支顶孢属的纤维素酶,例如披露于US 4,435,307、US 5,648,263、US 5,691,178、US5,776,757以及WO 89/09259中的由特异腐质霉、嗜热毁丝霉和尖孢镰孢产生的真菌纤维素酶。
特别合适的纤维素酶是具有颜色护理益处的碱性或中性纤维素酶。此类纤维素酶的实例是描述于EP 0 495 257、EP 0 531 372、WO 96/11262、WO 96/29397、WO 98/08940中的纤维素酶。其他实例是例如描述于WO 94/07998、EP 0 531 315、US 5,457,046、US 5,686,593、US 5,763,254、WO 95/24471、WO 98/12307以及WO 99/001544中的那些纤维素酶变体。
其他纤维素酶是具有以下序列的内切-β-1,4-葡聚糖酶,该序列与WO 2002/099091的SEQ ID NO:2的位置1至位置773的氨基酸序列具有至少97%同一性,或家族44木葡聚糖酶,该木葡聚糖酶具有以下序列,该序列与WO 2001/062903的SEQ ID NO:2的位置40-559具有至少60%同一性。
可商购的纤维素酶包括CelluzymeTM和CarezymeTM(诺维信公司(Novozymes A/S))、Carezyme PremiumTM(诺维信公司)、CellucleanTM(诺维信公司)、CellucleanClassicTM(诺维信公司)、CellusoftTM(诺维信公司)、WhitezymeTM(诺维信公司)、ClazinaseTM和Puradax HATM(杰能科国际有限公司(Genencor International Inc.))以及KAC-500(B)TM(花王株式会社(Kao Corporation))。
甘露聚糖酶
合适的甘露聚糖酶包括细菌或真菌来源的那些。包括化学或遗传修饰的突变体。甘露聚糖酶可以是家族5或26的碱性甘露聚糖酶。它可以是来自芽孢杆菌属或腐质霉属的野生型,特别是粘琼脂芽孢杆菌、地衣芽孢杆菌、嗜碱芽孢杆菌(B.halodurans)、克劳氏芽孢杆菌或特异腐质霉。合适的甘露聚糖酶描述于WO 1999/064619中。可商购的甘露聚糖酶是Mannaway(诺维信公司)。
纤维素酶
合适的纤维素酶包括细菌或真菌来源的完整纤维素酶或单组分内切葡聚糖酶。包括化学或遗传修饰的突变体。纤维素酶可以例如是单组分内切-1,4-β-葡聚糖酶(通常直接称为内切葡聚糖酶)或者是其混合物。合适的纤维素酶包括真菌纤维素酶,该真菌纤维素酶来自特异腐质霉(US 4,435,307)或来自木霉属,例如里氏木霉或绿色木霉。纤维素酶的实例在EP 0495 257进行了描述。其他合适的纤维素酶来自梭孢壳菌属,例如如在WO 96/29397中描述的土生梭孢壳霉或如在WO 91/17244中描述的尖孢镰孢,或者来自如在WO 02/099091和JP2000210081中所描述的芽孢杆菌属。其他实例是纤维素酶变体,例如描述于WO 94/07998、EP0 531 315、US 5,457,046、US 5,686,593、US 5,763,254、WO 95/24471、WO 98/12307中的那些。可商购的纤维素酶包括和/>(诺维信公司)、/>Puradax HA、和Puradax EG(可从杰能科公司(Genencor)获得)。
过氧化物酶/氧化酶
合适的过氧化物酶/氧化酶包括植物、细菌或真菌来源的那些。包括化学修饰的突变体或蛋白质工程化的突变体。有用的过氧化物酶的实例包括来自鬼伞属,例如来自灰盖鬼伞的过氧化物酶,及其变体,如在WO 93/24618、WO 95/10602、以及WO 98/15257中描述的那些。可商购的过氧化物酶包括GuardzymeTM(诺维信公司)。
蛋白酶
合适的蛋白酶包括细菌、真菌、植物、病毒或动物来源的那些,例如植物或微生物来源。优选微生物来源。包括化学修饰的突变体或蛋白质工程化的突变体。它可以是碱性蛋白酶,例如丝氨酸蛋白酶或金属蛋白酶。丝氨酸蛋白酶可以例如是S1家族的(如胰蛋白酶)或S8家族的(如枯草杆菌蛋白酶)。金属蛋白酶蛋白酶可以例如是来自例如M4家族的嗜热菌蛋白酶或其他金属蛋白酶,如来自M5、M7或M8家族的那些。
术语“枯草杆菌酶”是指根据Siezen等人,Protein Engng.[蛋白质工程]4(1991)719-737和Siezen等人,Protein Science[蛋白质科学]6(1997)501-523的丝氨酸蛋白酶亚组。丝氨酸蛋白酶是特征为在活性位点具有与底物形成共价加合物的丝氨酸的蛋白酶的亚组。枯草杆菌酶可以被划分为6个亚类,即,枯草杆菌蛋白酶家族、嗜热蛋白酶家族、蛋白酶K家族、羊毛硫氨酸抗生素肽酶家族、Kexin家族和Pyrolysin家族。
枯草杆菌酶的实例是来源于芽孢杆菌属的那些,例如描述于US7262042和WO 09/021867中的迟缓芽孢杆菌、嗜碱芽孢杆菌、枯草芽孢杆菌、解淀粉芽孢杆菌、短小芽孢杆菌和吉氏芽孢杆菌;和迟缓枯草杆菌蛋白酶、枯草杆菌蛋白酶Novo、枯草杆菌蛋白酶Carlsberg、地衣芽孢杆菌、枯草杆菌蛋白酶BPN’、枯草杆菌蛋白酶309、枯草杆菌蛋白酶147和枯草杆菌蛋白酶168以及例如描述于(WO 93/18140)中的蛋白酶PD138。其他有用的蛋白酶可以是描述于WO 01/016285和WO 02/016547中的那些。胰蛋白酶样蛋白酶的实例是胰蛋白酶(例如猪或牛来源的)和镰孢属蛋白酶(描述于WO 94/25583和WO 05/040372中),以及来源于纤维单胞菌(Cellumonas)的胰凝乳蛋白酶(描述于WO 05/052161和WO 05/052146中)。
进一步优选的蛋白酶是来自迟缓芽孢杆菌DSM 5483的碱性蛋白酶(如在例如WO95/23221中所述)、及其变体(在WO 92/21760、WO 95/23221、EP1921147以及EP1921148中描述的)。
金属蛋白酶的实例是如描述于WO 07/044993(宝洁公司(Procter&Gamble)/杰能科国际有限公司(Genencor Int.))中的中性金属蛋白酶,如来源于解淀粉芽孢杆菌的那些。
有用的蛋白酶的实例是描述于以下中的变体:WO 89/06279、WO 92/19729、WO 96/034946、WO 98/20115、WO 98/20116、WO 99/011768、WO 01/44452、WO 03/006602、WO 04/03186、WO 04/041979、WO 07/006305、WO 11/036263、WO 11/036264,尤其是在以下位置中的一个或多个处具有取代的变体:3、4、9、15、24、27、42、55、59、60、66、74、85、96、97、98、99、100、101、102、104、116、118、121、126、127、128、154、156、157、158、161、164、176、179、182、185、188、189、193、198、199、200、203、206、211、212、216、218、226、229、230、239、246、255、256、268和269,其中这些位置对应于WO 2016/001449的SEQ ID NO1中示出的迟缓芽孢杆菌蛋白酶的位置。更优选的蛋白酶变体可以包含选自下组的一种或多种突变,该组由以下组成:S3T、V4I、S9R、S9E、A15T、S24G、S24R、K27R、N42R、S55P、G59E、G59D、N60D、N60E、V66A、N74D、S85R、A96S、S97G、S97D、S97A、S97SD、S99E、S99D、S99G、S99M、S99N、S99R、S99H、S101A、V102I、V102Y、V102N、S104A、G116V、G116R、H118D、H118N、A120S、S126L、P127Q、S128A、S154D、A156E、G157D、G157P、S158E、Y161A、R164S、Q176E、N179E、S182E、Q185N、A188P、G189E、V193M、N198D、V199I、Y203W、S206G、L211Q、L211D、N212D、N212S、M216S、A226V、K229L、Q230H、Q239R、N246K、N255W、N255D、N255E、L256E、L256D、T268A以及R269H。这些蛋白酶变体优选地是在WO 2016/001449的SEQ ID NO 1中示出的迟缓芽孢杆菌蛋白酶的变体、在WO 2016/001449的SEQ ID NO 2中示出的解淀粉芽孢杆菌蛋白酶(BPN’)的变体。这些蛋白酶变体与WO 2016/001449的SEQ ID NO 1或SEQ ID NO 2优选地具有至少80%序列同一性。
蛋白酶变体在对应于WO 2004/067737的SEQ ID NO:1的位置171、173、175、179或180的一个或多个位置处包含取代,其中所述蛋白酶变体与WO 2004/067737的SEQ ID NO:1具有至少75%但小于100%的序列同一性。
合适的可商购蛋白酶包括以下列商品名出售的那些:DuralaseTm、DurazymTm、/>Ultra、Ultra、NovozymesNovozymes/>Uno、Novozymes/>Excell、Ultra、/>Blaze/>100T、Blaze125T、Blaze/>150T、/>and/>(诺维信公司),在以下商品名下出售的那些:/>PurafectPurafect/>ExcellenzP1000TM、Excellenz P1250TM、/>Preferenz P100TM、Purafect/>PreferenzP110TM、Effectenz P1000TM、/>EffectenzP1050TM、Purafect/>Effectenz P2000TM、/> 和/>(丹斯尼克公司(Danisco)/杜邦公司(DuPont))、AxapemTM(吉斯特布罗卡德斯公司(Gist-BrocasesN.V.))、BLAP(在US5352604的图29中显示的序列)及其变体(汉高公司(Henkel AG))和来自花王株式会社(Kao)的KAP(嗜碱芽孢杆菌枯草杆菌蛋白酶)。
脂肪酶和角质酶:
合适的脂肪酶和角质酶包括细菌或真菌来源的那些。包括化学修饰的突变体酶或蛋白质工程化的突变体酶。实例包括来自嗜热真菌属的脂肪酶,例如如描述于EP258068和EP305216中的来自疏绵状嗜热丝孢菌(早先命名为疏棉状腐质霉);来自腐质霉属的角质酶,例如特异腐质霉(WO 96/13580);来自假单胞菌属的菌株的脂肪酶(这些中的一些现在改名为伯克霍尔德菌属),例如产碱假单胞菌或类产碱假单胞菌(EP218272)、洋葱假单胞菌(EP331376)、假单胞菌属菌株SD705(WO 95/06720和WO 96/27002)、威斯康星假单胞菌(P.wisconsinensis)(WO 96/12012);GDSL-型链霉菌属脂肪酶(WO 10/065455);来自稻瘟病菌的角质酶(WO 10/107560);来自门多萨假单胞菌的角质酶(US5,389,536);来自褐色嗜热裂孢菌(Thermobifida fusca)的脂肪酶(WO 11/084412);嗜热脂肪土芽孢杆菌脂肪酶(WO 11/084417);来自枯草芽孢杆菌的脂肪酶(WO 11/084599);以及来自灰色链霉菌(WO11/150157)和始旋链霉菌(S.pristinaespiralis)的脂肪酶(WO 12/137147)。
其他实例是脂肪酶变体,例如在EP407225、WO 92/05249、WO 94/01541、WO 94/25578、WO 95/14783、WO 95/30744、WO 95/35381、WO 95/22615、WO 96/00292、WO 97/04079、WO 97/07202、WO 00/34450、WO 00/60063、WO 01/92502、WO 07/87508以及WO 09/109500中所述的那些。
优选的商业化脂肪酶产品包括LipolaseTM、LipexTM;LipolexTM和LipocleanTM(诺维信公司),Lumafast(来自杰能科公司)以及Lipomax(来自吉斯特布罗卡德斯公司)。
仍其他实例是有时称为酰基转移酶或过水解酶的脂肪酶,例如与南极假丝酵母(Candida antarctica)脂肪酶A具有同源性的酰基转移酶(WO 10/111143)、来自耻垢分枝杆菌(Mycobacterium smegmatis)的酰基转移酶(WO 05/56782)、来自CE 7家族的过水解酶(WO 09/67279)以及耻垢分枝杆菌过水解酶的变体(特别是来自亨斯迈纺织品染化有限公司(Huntsman Textile Effects Pte Ltd)的商业产品Gentle Power Bleach中所用的S54V变体)(WO 10/100028)。
淀粉酶:
能与本发明的多肽一起使用的合适的淀粉酶可以是α淀粉酶或葡糖淀粉酶并且可以是细菌来源的或真菌来源的。包括化学修饰的突变体或蛋白质工程化的突变体。淀粉酶包括例如从芽孢杆菌属、例如地衣芽孢杆菌的特定菌株(更详细地描述于GB 1,296,839中)获得的α-淀粉酶。
合适的淀粉酶包括具有WO 95/10603中的SEQ ID NO:2的淀粉酶或其与SEQ IDNO:3具有90%序列同一性的变体。优选的变体描述于WO 94/02597、WO 94/18314、WO 97/43424中以及WO 99/019467的SEQ ID NO:4中,例如在一个或多个以下位置中具有取代的变体:15、23、105、106、124、128、133、154、156、178、179、181、188、190、197、201、202、207、208、209、211、243、264、304、305、391、408和444。
不同的合适的淀粉酶包括具有WO 02/010355中的SEQ ID NO:6的淀粉酶或其与SEQ ID NO:6具有90%序列同一性的变体。SEQ ID NO:6的优选的变体是在位置181和182中具有缺失并且在位置193中具有取代的那些。
其他合适的淀粉酶是包含示于WO 2006/066594的SEQ ID NO:6中的来源于解淀粉芽孢杆菌的α-淀粉酶的残基1-33和示于WO 2006/066594的SEQ ID NO:4中的地衣芽孢杆菌α-淀粉酶的残基36-483的杂合α-淀粉酶或其具有90%序列同一性的变体。此杂合α-淀粉酶的优选的变体是在以下位置的一个或多个中具有取代、缺失或插入的那些:G48、T49、G107、H156、A181、N190、M197、I201、A209和Q264。包含示于WO 2006/066594的SEQ ID NO:6中的来源于解淀粉芽孢杆菌的α-淀粉酶的残基1-33和SEQ ID NO:4的残基36-483的杂合α-淀粉酶的最优选的变体是具有以下取代的那些:M197T;
H156Y+A181T+N190F+A209V+Q264S;或
G48A+T49I+G107A+H156Y+A181T+N190F+I201F+A209V+Q264S。
另外的合适的淀粉酶是具有WO 99/019467中的SEQ ID NO:6的淀粉酶或其与SEQID NO:6具有90%序列同一性的变体。SEQ ID NO:6的优选的变体是在以下位置中的一个或多个中具有取代、缺失或插入的那些:R181、G182、H183、G184、N195、I206、E212、E216和K269。特别优选的淀粉酶是在位置R181和G182、或位置H183和G184中具有缺失的那些。
可以使用的另外的淀粉酶是具有WO 96/023873的SEQ ID NO:1、SEQ ID NO:3、SEQID NO:2或SEQ ID NO:7的那些或其与SEQ ID NO:1、SEQ ID NO:2、SEQ ID NO:3或SEQ IDNO:7具有90%序列同一性的变体。SEQ ID NO:1、SEQ ID NO:2、SEQ ID NO:3或SEQ ID NO:7的优选的变体是在以下位置中的一个或多个中具有取代、缺失或插入的那些:140、181、182、183、184、195、206、212、243、260、269、304和476,使用WO 96/023873的SEQ ID 2用于编号。更优选的变体是在选自181、182、183和184的两个位置(例如181和182、182和183、或位置183和184)中具有缺失的那些。SEQ ID NO:1、SEQ ID NO:2或SEQ ID NO:7的最优选的淀粉酶变体是在位置183和184中具有缺失并且在位置140、195、206、243、260、304和476中的一个或多个中具有取代的那些。
可以使用的其他淀粉酶是具有WO 08/153815的SEQ ID NO:2、WO 01/66712中的SEQ ID NO:10的淀粉酶或其与WO 08/153815的SEQ ID NO:2具有90%序列同一性或与WO01/66712中的SEQ ID NO:10具有90%序列同一性的变体。WO 01/66712中的SEQ ID NO:10的优选的变体是在以下位置的一个或多个中具有取代、缺失或插入的那些:176、177、178、179、190、201、207、211和264。
另外的适合的淀粉酶是具有WO 09/061380的SEQ ID NO:2的淀粉酶或其与SEQ IDNO:2具有90%序列同一性的变体。SEQ ID NO:2的优选的变体是在以下位置的一个或多个中具有C-末端截短和/或取代、缺失或插入的那些:Q87、Q98、S125、N128、T131、T165、K178、R180、S181、T182、G183、M201、F202、N225、S243、N272、N282、Y305、R309、D319、Q320、Q359、K444和G475。SEQ ID NO:2的更优选的变体是在以下位置的一个或多个处具有取代的那些:Q87E,R、Q98R、S125A、N128C、T131I、T165I、K178L、T182G、M201L、F202Y、N225E,R、N272E,R、S243Q,A,E,D、Y305R、R309A、Q320R、Q359E、K444E以及G475K,和/或在位置R180和/或S181或T182和/或G183处具有缺失的那些。SEQ ID NO:2的最优选的淀粉酶变体是具有以下取代的那些:N128C+K178L+T182G+Y305R+G475K;
N128C+K178L+T182G+F202Y+Y305R+D319T+G475K;
S125A+N128C+K178L+T182G+Y305R+G475K;或
S125A+N128C+T131I+T165I+K178L+T182G+Y305R+G475K,其中这些变体是C-末端截短的,并且任选地进一步包含在位置243处的取代和/或在位置180和/或位置181处的缺失。
另外的合适的淀粉酶是具有WO 13184577的SEQ ID NO:1的淀粉酶或其与SEQ IDNO:1具有90%序列同一性的变体。SEQ ID NO:1的优选的变体是在以下位置的一个或多个中具有取代、缺失或插入的那些:K176、R178、G179、T180、G181、E187、N192、M199、I203、S241、R458、T459、D460、G476和G477。SEQ ID NO:1的更优选的变体是在以下位置的一个或多个中具有取代的那些:K176L、E187P、N192FYH、M199L、I203YF、S241QADN、R458N、T459S、D460T、G476K、以及G477K,和/或在位置R178和/或S179或T180和/或G181中具有缺失的那些。SEQ ID NO:1的最优选的淀粉酶变体是具有以下取代的那些:E187P+I203Y+G476K
E187P+I203Y+R458N+T459S+D460T+G476K
其中这些变体任选地进一步包含在位置241处的取代和/或在位置178和/或位置179处的缺失。
另外的合适的淀粉酶是具有WO 10104675的SEQ ID NO:1的淀粉酶或其与SEQ IDNO:1具有90%序列同一性的变体。SEQ ID NO:1的优选的变体是在以下位置的一个或多个中具有取代、缺失或插入的那些:N21、D97、V128、K177、R179、S180、I181、G182、M200、L204、E242、G477和G478。SEQ ID NO:1的更优选的变体是在以下位置的一个或多个中具有取代的那些:N21D、D97N、V128I、K177L、M200L、L204YF、E242QA、G477K、以及G478K,和/或在位置R179和/或S180或I181和/或G182中具有缺失的那些。SEQ ID NO:1的最优选的淀粉酶变体是具有以下取代的那些:N21D+D97N+V128I
其中变体任选地进一步包含在位置200处的取代和/或在位置180和/或位置181处的缺失。
其他合适的淀粉酶是具有WO 01/66712中的SEQ ID NO:12的α-淀粉酶或与SEQ IDNO:12具有至少90%序列同一性的变体。优选的淀粉酶变体是在WO 01/66712中的SEQ IDNO:12的以下位置的一个或多个中具有取代、缺失或插入的那些:R28、R118、N174;R181、G182、D183、G184、G186、W189、N195、M202、Y298、N299、K302、S303、N306、R310、N314;R320、H324、E345、Y396、R400、W439、R444、N445、K446、Q449、R458、N471、N484。特别优选的淀粉酶包括具有D183和G184的缺失并且具有取代R118K、N195F、R320K和R458K的变体,以及另外在一个或多个选自下组的位置中具有取代的变体:M9、G149、G182、G186、M202、T257、Y295、N299、M323、E345和A339,最优选的是另外在所有这些位置中具有取代的变体。
其他实例是淀粉酶变体,如在WO 2011/098531、WO 2013/001078和WO 2013/001087中描述的那些。
可商购的淀粉酶是DuramylTM、TermamylTM、FungamylTM、Stainzyme TM、StainzymePlusTM、NatalaseTM、Liquozyme X和BANTM(来自诺维信公司)、以及RapidaseTM、PurastarTM/EffectenzTM、Powerase、Preferenz S1000、Preferenz S100和Preferenz S110(来自杰能科国际有限公司/杜邦公司)。
过氧化物酶/氧化酶
根据本发明的过氧化物酶是由酶分类EC 1.11.1.7囊括的由国际生物化学和分子生物学联盟命名委员会(IUBMB)规定的酶,或来源于其中的展示出过氧化物酶活性的任何片段。
合适的过氧化物酶包括植物、细菌或真菌来源的那些。包括化学修饰的突变体或蛋白质工程化的突变体。有用的过氧化物酶的实例包括来自拟鬼伞属,例如来自灰盖拟鬼伞(C.cinerea)的过氧化物酶(EP 179,486),及其变体,如在WO 93/24618、WO 95/10602以及WO 98/15257中所描述的那些。
根据本发明的过氧化物酶还包括卤代过氧化物酶,例如氯过氧化物酶、溴过氧化物酶以及展示出氯过氧化物酶或溴过氧化物酶活性的化合物。根据其对卤素离子的特异性将卤代过氧化物酶进行分类。氯过氧化物酶(E.C.1.11.1.10)催化从氯离子形成次氯酸盐。
在实施例中,本发明的卤代过氧化物酶是氯过氧化物酶。优选地,该卤代过氧化物酶是钒卤代过氧化物酶,即含钒酸盐的卤代过氧化物酶。在本发明的优选的方法中,将含钒酸盐的卤代过氧化物酶与氯离子来源组合。
已从许多不同真菌,特别是从暗色丝孢菌(dematiaceous hyphomycete)真菌组中分离出了卤代过氧化物酶,例如卡尔黑霉属(Caldariomyces)(例如,煤卡尔黑霉(C.fumago))、链格孢属、弯孢属(例如,疣枝弯孢(C.verruculosa)和不等弯孢(C.inaequalis))、内脐蠕孢属、细基格孢属以及葡萄孢属。
还已从细菌,例如假单胞菌属(例如吡咯假单胞菌(P.pyrrocinia))和链霉菌属(例如,金色链霉菌(S.aureofaciens))中分离出了卤代过氧化物酶。
在优选的实施例中,卤代过氧化物酶可来源于弯孢属,特别是疣枝弯孢(Curvularia verruculosa)或不等弯孢,如描述于WO 95/27046中的不等弯孢CBS 102.42;或描述于WO 97/04102中的疣枝弯孢CBS 147.63或疣枝弯孢CBS 444.70;或来源于如描述于WO 01/79459中的Drechslera hartlebii、如描述于WO 01/79458中的盐沼小树状霉(Dendryphiella salina)、如描述于WO 01/79461中的Phaeotrichoconis crotalarie、或如描述于WO 01/79460中的Geniculosporium属物种。
根据本发明的氧化酶特别包括由酶分类EC 1.10.3.2囊括的任何漆酶或来源于其中的展示出漆酶活性的片段、或展示出类似活性的化合物,例如儿茶酚氧化酶(EC1.10.3.1)、邻氨基苯酚氧化酶(EC 1.10.3.4)或胆红素氧化酶(EC 1.3.3.5)。
优选的漆酶是微生物来源的酶。这些酶可以来源于植物、细菌或真菌(包括丝状真菌和酵母)。
来自真菌的合适实例包括可来源于以下的菌株的漆酶:曲霉属,脉孢菌属(例如,粗糙脉孢菌),柄孢壳菌属,葡萄孢属,金钱菌属(Collybia),层孔菌属(Fomes),香菇属,侧耳属,栓菌属(例如,长绒毛栓菌和变色栓菌),丝核菌属(例如,立枯丝核菌(R.solani)),拟鬼伞属(例如,灰盖拟鬼伞、毛头拟鬼伞(C.comatus)、弗瑞氏拟鬼伞(C.friesii)及C.plicatilis),小脆柄菇属(Psathyrella)(例如,白黄小脆柄菇(P.condelleana)),斑褶菇属(例如,蝶形斑褶菇(P.papilionaceus)),毁丝霉属(例如,嗜热毁丝霉),Schytalidium(例如,S.thermophilum),多孔菌属(例如,P.pinsitus),射脉菌属(例如,射脉侧菌(P.radiata))(WO 92/01046)或革盖菌属(例如,毛革盖菌(C.hirsutus))(JP 2238885)。
来自细菌的合适的实例包括可来源于芽孢杆菌属的菌株的漆酶。
优选的是来源于拟鬼伞属或毁丝霉属的漆酶;特别是来源于灰盖拟鬼伞的漆酶,如披露于WO 97/08325中;或来源于嗜热毁丝霉,如披露于WO 95/33836中。
核酸酶
合适的核酸酶包括脱氧核糖核酸酶(DNA酶)以及核糖核酸酶。DNA酶是催化DNA骨架中的磷酸二酯键的水解切割从而降解DNA的任何酶。根据本发明,可获得自细菌的DNA酶是优选的;特别地,可获得自芽孢杆菌属的DNA酶是优选的;特别地,可获得自枯草芽孢杆菌或地衣芽孢杆菌的DNA酶是优选的。此类DNA酶的实例描述于专利申请WO 2011/098579或PCT/EP2013/075922中。
可以通过添加含有一种或多种酶的单独添加剂、或通过添加含有所有这些酶的组合添加剂而将一种或多种洗涤剂酶包含于洗涤剂组合物中。本发明的洗涤剂添加剂,即单独的或组合的添加剂,可以配制成例如颗粒、液体、浆液等。优选的洗涤剂添加剂配制品是颗粒,特别是无粉尘颗粒;液体,特别是稳定化液体;或浆液。
无粉尘颗粒例如可以如在US 4,106,991和4,661,452中所披露地产生并且可以任选地通过本领域已知的方法包衣。蜡状包衣材料的实例是平均分子量为1000至20000的聚乙二醇(PEG);具有16至50个环氧乙烷单元的乙氧基化壬基酚;乙氧基化脂肪醇,其中醇含有12至20个碳原子,并且其中存在15至80个环氧乙烷单元;脂肪醇;脂肪酸;以及脂肪酸的甘油单酯、和甘油二酯、和甘油三酯。适合用于通过流化床技术应用的成膜包衣材料的实例在GB 1483591中给出。液体酶制剂可以例如通过根据已确立的方法添加多元醇(如丙二醇)、糖或糖醇、乳酸或硼酸而稳定化。受保护的酶可以根据EP 238,216中披露的方法来制备。
微生物
该洗涤剂添加剂以及洗涤剂组合物还可以包含一种或多种微生物,如一种或多种真菌、酵母、或细菌。
在实施例中,该一种或多种微生物是脱水(例如通过冻干)的细菌或酵母,例如乳酸杆菌菌株。
在另一个实施例中,微生物是一种或多种微生物孢子(与营养细胞相对),例如细菌孢子;或真菌孢子、分生孢子、菌丝。优选地,该一种或多种孢子是芽孢杆菌芽孢;甚至更优选地,该一种或多种孢子是枯草芽孢杆菌、地衣芽孢杆菌、解淀粉芽孢杆菌、或巨大芽孢杆菌的内生孢子。
微生物可以按与酶相同的方式包含在洗涤剂组合物或添加剂中(见上文)。
辅料
还可以利用本领域中已知的用于在衣物洗涤剂中使用的任何洗涤剂组分。其他任选的洗涤剂组分包括防腐蚀剂、防缩剂、抗污垢再沉积剂、抗皱剂、杀细菌剂、粘合剂、腐蚀抑制剂、崩解剂(disintegrant)/崩解试剂(disintegration agent)、染料、酶稳定剂(包括硼酸、硼酸盐、CMC和/或多元醇,例如丙二醇)、织物调理剂(包括粘土)、填料/加工助剂、荧光增白剂/光学增亮剂、增泡剂、泡沫(泡)调节剂、香料、污垢悬浮剂、柔软剂、抑泡剂、晦暗抑制剂以及芯吸剂,单独或组合使用。可以利用本领域中已知的用于在衣物洗涤剂中使用的任何成分。此类成分的选择完全在技术人员的技术范围内。
分散剂
本发明的洗涤剂组合物还可以包含分散剂。具体地,粉末洗涤剂可以包含分散剂。合适的水溶性有机材料包括均聚合或共聚合的酸或其盐,其中聚羧酸包含被不多于两个碳原子彼此分开的至少两个羧基。合适的分散剂例如描述于Powdered Detergents[粉末洗涤剂],Surfactant science series[表面活性剂科学系列],第71卷,马塞尔德克尔公司(Marcel Dekker,Inc.)中。
染料转移抑制剂
本发明的洗涤剂组合物还可以包括一种或多种染料转移抑制剂。合适的聚合物染料转移抑制剂包括但不局限于聚乙烯吡咯烷酮聚合物、多胺N-氧化物聚合物、N-乙烯吡咯烷酮和N-乙烯基咪唑的共聚物、聚乙烯噁唑烷酮和聚乙烯咪唑或其混合物。当在主题组合物中存在时,染料转移抑制剂可以按该组合物的重量计以从约0.0001%至约10%、从约0.01%至约5%或甚至从约0.1%至约3%的水平存在。
荧光增白剂
本发明的洗涤剂组合物将优选地还包含另外的组分,这些组分可以给正在清洁的物品着色,例如荧光增白剂或光学增亮剂。当存在时,该增亮剂优选地以约0.01%至约0.5%的水平存在。在本发明的组合物中可以使用合适用于在衣物洗涤剂组合物中使用的任何荧光增白剂。最常用的荧光增白剂是属于以下类别的那些:二氨基芪-磺酸衍生物、二芳基吡唑啉衍生物和二苯基-联苯乙烯基衍生物。荧光增白剂的二氨基芪-磺酸衍生物型的实例包括以下的钠盐:4,4’-双-(2-二乙醇氨基-4-苯胺-s-三嗪-6-基氨基)芪-2,2’-二磺酸盐、4,4’-双-(2,4-二苯胺基-s-三嗪-6-基氨基)芪-2.2’-二磺酸盐、4,4’-双-(2-苯胺基-4-(N-甲基-N-2-羟基-乙基氨基)-s-三嗪-6-基氨基)芪-2,2’-二磺酸盐、4,4’-双-(4-苯基-1,2,3-三唑-2-基)芪-2,2’-二磺酸盐以及5-(2H-萘并[1,2-d][1,2,3]三唑-2-基)-2-[(E)-2-苯基乙烯基]苯磺酸钠。优选的荧光增白剂是可从汽巴–嘉基股份有限公司(Ciba-Geigy AG)(巴塞尔,瑞士)获得的天来宝(Tinopal)DMS和天来宝CBS。天来宝DMS是4,4’-双-(2-吗啉代-4-苯胺基-s-三嗪-6-基氨基)芪-2,2’-二磺酸盐的二钠盐。天来宝CBS是2,2’-双-(苯基-苯乙烯基)-二磺酸盐的二钠盐。还优选的是荧光增白剂是可商购的Parawhite KX,由印度孟买的派拉蒙矿物与化学品公司(Paramount Minerals andChemicals)供应。合适用于本发明中使用的其他荧光剂包括1-3-二芳基吡唑啉和7-氨烷基香豆素。
合适的荧光增亮剂水平包括从约0.01wt%、从0.05wt%、从约0.1wt%或甚至从约0.2wt%的较低水平至0.5wt%或甚至0.75wt%的较高水平。
污垢释放聚合物
本发明的洗涤剂组合物还可以包括一种或多种污垢释放聚合物,这些聚合物帮助从织物(如棉和基于聚酯的织物)去除污垢,特别是从基于聚酯的织物去除疏水性污垢。污垢释放聚合物可以例如是非离子型或阴离子型对苯二甲酸基的聚合物、聚乙烯基己内酰胺和相关共聚物、乙烯基接枝共聚物、聚酯聚酰胺,参见例如Powdered Detergents[粉末洗涤剂],Surfactant science series[表面活性剂科学系列],第71卷,第7章,马塞尔德克尔公司。另一种类型的污垢释放聚合物是包含核心结构和附接至该核心结构的多个烷氧基化基团的两亲性烷氧基化油污清洁聚合物。核心结构可以包含聚烷基亚胺结构或聚烷醇胺结构,如在WO 2009/087523中详细描述的(通过引用并入本文)。此外,随机接枝共聚物是合适的污垢释放聚合物。合适的接枝共聚物更详细地描述于WO 2007/138054、WO 2006/108856以及WO 2006/113314中(通过引用并入本文)。其他污垢释放聚合物是取代的多糖结构,尤其是取代的纤维素结构,如修饰的纤维素衍生物,如EP 1867808或WO 2003/040279中所描述的那些(将二者都通过引用并入本文)。合适的纤维素聚合物包括纤维素、纤维素醚、纤维素酯、纤维素酰胺以及其混合物。合适的纤维素聚合物包括阴离子修饰的纤维素、非离子修饰的纤维素、阳离子修饰的纤维素、兼性离子修饰的纤维素及其混合物。合适的纤维素聚合物包括甲基纤维素、羧甲基纤维素、乙基纤维素、羟乙基纤维素、羟丙基甲基纤维素、酯羧甲基纤维素及其混合物。
抗再沉积剂
本发明的洗涤剂组合物还可以包括一种或多种抗再沉积剂,如羧甲基纤维素(CMC)、聚乙烯醇(PVA)、聚乙烯吡咯烷酮(PVP)、聚氧乙烯和/或聚乙二醇(PEG)、丙烯酸的均聚物、丙烯酸和马来酸的共聚物、和乙氧基化的聚乙亚胺。以上在污垢释放聚合物下所描述的基于纤维素的聚合物还可以作为抗再沉积剂起作用。
流变改性剂
本发明的洗涤剂组合物还可以包括一种或多种流变改性剂、结构剂或增稠剂,不同于降粘剂。流变改性剂选自下组,该组由以下组成:非聚合物结晶、羟基功能材料、聚合物流变改性剂,它们为液体洗涤剂组合物的水性液相基质赋予剪切稀化特征。可以通过本领域已知的方法修饰和调整洗涤剂的流变学和粘度,例如,如在EP 2169040中所示。
其他合适的辅料包括但不限于防缩剂、抗皱剂、杀细菌剂、粘合剂、载体、染料、酶稳定剂、织物柔软剂、填料、泡沫调节剂、水溶助剂、香料、色素、抑泡剂、溶剂以及用于液体洗涤剂的结构剂和/或结构弹性剂。
洗涤剂产品的配制品
本发明的洗涤剂组合物可以处于任何常规形式,例如条,均匀的片剂,具有两层或更多层的片剂,具有一个或多个室的袋,规则的或压缩的粉末,颗粒,膏,凝胶,或规则的、压缩的或浓缩的液体。
袋可以被配置为单一室或多室。它可以具有适合用于容持该组合物的任何形式、形状和材料,例如在与水接触之前,不允许该组合物从袋中释放出来。袋由水溶性膜制成,它包含了一个内部体积。可以将所述内部体积分成袋的室。优选的膜是聚合物材料,优选地形成膜或薄片的聚合物。优选的聚合物、共聚物或其衍生物选自聚丙烯酸酯、和水溶性丙烯酸酯共聚物、甲基纤维素、羧甲基纤维素、糊精钠、乙基纤维素、羟乙基纤维素、羟丙基甲基纤维素、麦芽糊精、聚甲基丙烯酸酯,最优选地是聚乙烯醇共聚物以及羟丙基甲基纤维素(HPMC)。优选地,聚合物在膜例如PVA中的水平是至少约60%。优选的平均分子量将典型地是约20,000至约150,000。膜还可以是共混组合物,这些共混组合物包含可水解降解并且可水溶的聚合物共混物,如聚乳酸和聚乙烯醇(已知在贸易参考号M8630下,如由美国印第安纳州的MonoSol有限责任公司(MonoSol LLC)销售)加增塑剂,像甘油、乙二醇、丙二醇、山梨醇及其混合物。这些袋可以包含固体洗衣清洁组合物或部分组分和/或液体清洁组合物或由水溶性膜分开的部分组分。可用于液体组分的室在组成上可以与含有固体的室不同:US2009/0011970A1。
可以由水溶性袋中的或片剂的不同层中的室来将洗涤剂成分彼此物理分开。因此,可以避免组分间的不良的储存相互作用。在洗涤溶液中,每个室的不同溶解曲线还可以引起选择的组分的延迟溶解。
非单位剂量的液体或凝胶洗涤剂可以是水性的,典型地含有按重量计至少20%并且最高达95%的水,例如高达约70%的水、高达约65%的水、高达约55%的水、高达约45%的水、高达约35%的水。包括但不限于链烷醇、胺、二醇、醚以及多元醇的其他类型的液体可以被包括在水性液体或凝胶中。水性液体或凝胶洗涤剂可以含有从0-30%的有机溶剂。
液体或凝胶洗涤剂可以是非水性的。
洗衣皂条
本发明的多肽可以被添加至洗衣皂条中并且用于手洗洗衣、织物和/或纺织品。术语洗衣皂条包括洗衣条、皂条、组合条(combo bar)、合成洗涤剂条以及洗涤剂条。条的类型通常区别在于他们包含的表面活性剂的类型,并且术语洗衣皂条包括包含来自脂肪酸的皂和/或合成皂的那些。洗衣皂条具有在室温下为固体而非液体、凝胶或粉末的物理形式。术语固体被定义为不随时间显著变化的物理形式,即如果固体物体(例如洗衣皂条)被放置在容器里,该固体物体不会为了填充其被放置的容器而发生改变。该条是固体时典型地是条的形式但也可能是其他的固体形状如圆形或椭圆。
该洗衣皂条可以包含一个或多个另外的酶、蛋白酶抑制剂如肽醛类(或次硫酸盐加合物或半缩醛加合物)、硼酸、硼酸盐、硼砂和/或苯基硼酸衍生物如4-甲酸基苯硼酸、一个或多个皂或合成的表面活性剂、多元醇如甘油、pH控制化合物如脂肪酸、柠檬酸、乙酸和/或甲酸、和/或一价阳离子和有机阴离子的盐,其中该一价阳离子可以是例如Na+、K+或NH4 +并且该有机阴离子可以是例如甲酸盐、乙酸盐、柠檬酸盐或乳酸盐,这样使得一价阳离子和有机阴离子的盐可以是例如甲酸钠。
洗衣皂条还可以包含络合剂像EDTA和HEDP、香料和/或不同类型的填充剂、表面活性剂例如阴离子型合成表面活性剂、助洗剂、聚合的污垢释放剂、洗涤剂螯合剂、稳定试剂、填料、染料、着色剂、染料转移抑制剂、烷氧基化的聚碳酸酯、抑泡剂、结构剂、粘合剂、浸出剂、漂白活化剂、黏土去污剂、抗再沉积剂、聚合分散剂、增亮剂、织物柔软剂、香料和/或本领域已知的其他化合物。
洗衣皂条可以在常规的洗衣皂条制造设备中进行加工,该设备例如但不限于:混合器、压条机(例如两级真空压条机)、挤出机、切割机、标识压模、冷却隧道以及包装机。本发明不局限于通过任何单一方法制备洗衣皂条。可以在过程的不同阶段向皂中添加本发明的预混料。例如,可以制备含有皂、本发明的多肽、任选地一种或多种另外的酶、蛋白酶抑制剂以及一价阳离子和有机阴离子的盐的预混料并且然后将该混合物压条。可以同时添加作为例如处于液态的蛋白酶抑制剂的本发明的多肽以及任选的另外的酶。除了混合步骤和压条步骤以外,该过程还可以进一步包含研磨、挤出、切割、压模、冷却和/或包装的步骤。
颗粒洗涤剂配制品
可以如描述于WO 09/092699、EP 1705241、EP 1382668、WO 07/001262、US6472364、WO 04/074419或WO 09/102854中的配制颗粒洗涤剂。其他有用的洗涤剂配制品描述于以下中:WO 09/124162、WO 09/124163、WO 09/117340、WO 09/117341、WO 09/117342、WO 09/072069、WO 09/063355、WO 09/132870、WO 09/121757、WO 09/112296、WO 09/112298、WO 09/103822、WO 09/087033、WO 09/050026、WO 09/047125、WO 09/047126、WO09/047127、WO 09/047128、WO 09/021784、WO 09/010375、WO 09/000605、WO 09/122125、WO09/095645、WO 09/040544、WO 09/040545、WO 09/024780、WO 09/004295、WO 09/004294、WO09/121725、WO 09/115391、WO 09/115392、WO 09/074398、WO 09/074403、WO 09/068501、WO09/065770、WO 09/021813、WO 09/030632以及WO 09/015951。
WO 2011025615、WO 2011016958、WO 2011005803、WO 2011005623、WO2011005730、WO 2011005844、WO 2011005904、WO 2011005630、WO 2011005830、WO2011005912、WO 2011005905、WO 2011005910、WO 2011005813、WO 2010135238、WO2010120863、WO 2010108002、WO 2010111365、WO 2010108000、WO 2010107635、WO2010090915、WO 2010033976、WO 2010033746、WO 2010033747、WO 2010033897、WO2010033979、WO 2010030540、WO 2010030541、WO 2010030539、WO 2010024467、WO2010024469、WO 2010024470、WO 2010025161、WO 2010014395、WO 2010044905、
WO 2010145887、WO 2010142503、WO 2010122051、WO 2010102861、WO2010099997、WO 2010084039、WO 2010076292、WO 2010069742、WO 2010069718、WO2010069957、WO 2010057784、WO 2010054986、WO 2010018043、WO 2010003783、WO2010003792、
WO 2011023716、WO 2010142539、WO 2010118959、WO 2010115813、WO2010105942、WO 2010105961、WO 2010105962、WO 2010094356、WO 2010084203、WO2010078979、WO 2010072456、WO 2010069905、WO 2010076165、WO 2010072603、WO2010066486、WO 2010066631、WO 2010066632、WO 2010063689、WO 2010060821、WO2010049187、WO 2010031607、WO 2010000636。
共颗粒中酶的配制品
本发明的酶可以被配制为颗粒,例如,配制为结合一种或多种酶的共颗粒。然后,每种酶将存在于多种颗粒中,这些颗粒确保酶在洗涤剂中的分布更均匀。这还减少了由于不同的粒度,不同酶的物理隔离。用于生产针对洗涤剂工业的多酶共颗粒的方法披露于IP.com披露内容IPCOM000200739D中。
通过使用共颗粒的酶的配制品的另一个实例披露于WO 2013/188331中,其涉及包含以下的洗涤剂组合物:(a)多酶共颗粒;(b)少于10wt沸石(无水的基础上);和(c)少于10wt磷酸盐(无水的基础上),其中所述酶共颗粒包含从10wt%至98wt%的水分汇组分(sink component),并且该组合物另外还包含从20wt%至80wt%的洗涤剂水分汇组分。
WO 2013/188331还涉及处理和/或清洁表面(优选地织物表面)的方法,该方法包括以下步骤:(i)使所述表面在含水洗涤液中与如在本文要求保护的并且描述的洗涤剂组合物接触,(ii)漂洗和/或干燥该表面。
该多酶共颗粒可以包含本发明的酶和(a)一种或多种选自下组的酶,该组由以下组成:第一次洗涤脂肪酶、清洁纤维素酶、木葡聚糖酶、过水解酶、过氧化物酶、脂加氧酶、漆酶及其混合物;和(b)一种或多种选自下组的酶,该组由以下组成:半纤维素酶、蛋白酶、护理纤维素酶、纤维二糖脱氢酶、木聚糖酶、磷脂酶、酯酶、角质酶、果胶酶、甘露聚糖酶、果胶裂解酶、角蛋白酶、还原酶、氧化酶、酚氧化酶、木质酶、普鲁兰酶、鞣酸酶、戊聚糖酶、地衣聚糖酶、葡聚糖酶、阿拉伯糖苷酶、玻璃酸酶、软骨素酶、淀粉酶、核酸酶、及其混合物。在另一个实施例中,该多酶共颗粒不包含纤维素酶。
在洗涤剂中的用途。
可以将本发明的多肽被添加至洗涤剂组合物中并且因此变成洗涤剂组合物的组分。
例如,本发明的洗涤剂组合物可以被配制为手洗或机洗衣物洗涤剂组合物,包括适用于预处理有污渍的织物的衣物洗涤添加剂组合物和漂洗添加型织物柔软剂组合物,或被配制为用于一般家用硬表面清洁操作的洗涤剂组合物,或被配制以用于手洗或机洗餐具洗涤操作。
在具体的方面,本发明提供了包含如本文所述的本发明多肽的洗涤剂添加剂。
实例
材料与方法
褶皱的评估:AATCC(美国纺织化学师和染色师协会)测试方法124-TM124家庭衣物洗涤后织物的平滑度外观(可在members.aatcc.org/store/tm124/533/处获得)(AATCC测试方法TM124-2018)。
静电的评估:AATCC测试方法115-织物的静电粘合:织物到金属的测试(可在members.aatcc.org/store/tm115/525/处获得)。
通过专门小组成员偏好进行评估:
要求专门小组成员选择更少折痕的T恤部分。评价后,计算分布。
柔软性和抗折痕用X:Y值表示,其中X指定优选用CBM洗涤的真实物品的专门小组成员的%,并且Y指定优选未用CBM洗涤的真实物品的%。该X值和Y值的总和为100%。
洗涤剂组合物
以下提及的洗涤剂组合物可以与本文所述的碳水化合物结合模块组合使用,用于防止或减少衣物中的折痕和褶皱。
标准洗涤剂B组合物(液体):
用NaOH或柠檬酸进行最后调节至指定pH(在标准洗涤剂B的情况下,pH为8)。通过将CaCl2和MgCl2(Ca2+:Mg2+=4:1)添加到测试系统中,将水硬度调节至15°dH。
碧浪灵敏性白色与彩色组合物、液体洗涤剂组合物:水、酒精乙氧基硫酸盐、醇乙氧基化物、氨基氧化物、柠檬酸、C12-18拔顶棕榈仁脂肪酸、蛋白酶、糖苷酶、淀粉酶、乙醇、1,2丙二醇、甲酸钠、氯化钙、氢氧化钠、有机硅乳液、跨硫酸EHDQ(这些成分以递减次序列出)。
WFK IEC-A标准洗涤剂组合物(粉末)成分:直链烷基苯磺酸钠8.8%、乙氧基化的脂肪醇C12-18(7EO)4.7%、钠皂3.2%、消泡剂DC2-4248S3.9%、硅酸铝钠沸石4A 28.3%、碳酸钠11.6%、丙烯酸和马来酸的共聚物的钠盐(Sokalan CP5)2.4%、硅酸钠3.0%、羧甲基纤维素1.2%、Dequest 20662.8%,光学增白剂0.2%、硫酸钠6.5%、蛋白酶0.4%。
标准洗涤剂A组合物(液体):成分:12%LAS、11%AEO Biosoft N25-7(NI)、7%AEOS(SLES)、6%MPG(丙二醇)、3%乙醇、3%TEA、2.75%可可皂、2.75%大豆皂、2%甘油、2%氢氧化钠、2%柠檬酸钠、1%甲酸钠、0.2%DTMPA和0.2%PCA(所有的百分数都是w/w)
碧浪Actilift组合物(液体)成分:5%-15%阴离子型表面活性剂;<5%非离子型表面活性剂、磷酸盐、皂;酶、光学增亮剂、苯并异噻唑啉酮、甲基异噻唑啉酮、香料、α-异甲基紫罗兰酮、香茅醇、香叶醇、芳樟醇。
碧浪Actilift彩色与风格组合物(碧浪彩色与风格):水、十二烷基苯磺酸钠、C14-C15 Pareth-7、柠檬酸钠、丙二醇、棕榈仁油酸钠、月桂醇醚硫酸钠、MEA十二烷基苯磺酸、季铵化的硫酸化乙氧基化的六亚甲基二胺、枯烯磺酸钠、香料、PEG/乙酸乙烯酯的共聚物、甲酸钠、氢化蓖麻油、二亚乙基三胺五亚甲基磷酸钠、PEG/PPG-10/2丙基庚基醚、丁苯基甲基丙醛、聚乙烯吡啶-N-氧化物、山梨醇、甘油、乙醇胺、氢氧化钠、α-异甲基紫罗兰酮、蛋白酶、氯化钙、香叶醇、芳樟醇、香茅醇、三丙二醇、糖苷酶、苯并异噻唑啉酮、二甲硅油、糖苷酶、乙酸钠、纤维素酶、着色剂、甘油硬脂酸酯、羟乙基纤维素、二氧化硅。
碧浪Actilift彩色与风格组合物,新包装:成分:水、月桂醇聚醚硫酸钠、丙二醇、C14-C15 Pareth-7、柠檬酸钠、棕榈仁酸钠、醇、甲酸钠、硫酸化乙氧基化六亚甲基二胺季铵化物、氢氧化钠、香料、聚乙烯基吡啶-N-氧化物、山梨醇、氯化钙、蛋白酶、甘油、葡糖苷酶、糖苷酶、乙酸钠、着色剂、纤维素酶。
碧浪Actilift白色与彩色酷洁组合物,新包装:成分:水、月桂醇聚醚硫酸钠、丙二醇、C14-C15 Pareth-7、柠檬酸钠、棕榈仁酸钠、醇、甲酸钠、硫酸化乙氧基化六亚甲基二胺季铵化物、氢氧化钠、香料、山梨醇、氯化钙、蛋白酶、甘油、葡糖苷酶、糖苷酶、乙酸钠、着色剂、纤维素酶。
碧浪灵敏性白色与彩色组合物:成分:水、月桂醇聚醚硫酸钠、丙二醇、C14-C15Pareth-7、柠檬酸钠、棕榈仁酸钠、醇、甲酸钠、硫酸化乙氧基化六亚甲基二胺季铵化物、氢氧化钠、山梨醇、氯化钙、蛋白酶、甘油、糖苷酶、乙酸钠、着色剂、纤维素酶、二氧化硅。
碧浪Actilif组合物,普通:水、十二烷基苯磺酸钠、C14-C15 Pareth-7、柠檬酸钠、丙二醇、棕榈仁酸钠、月桂醇醚硫酸钠、MEA十二烷基苯磺酸盐、硫酸化乙氧基化六亚甲基二胺季铵化物、枯烯磺酸钠、香料、PEG/乙酸乙烯酯共聚物、甲酸钠、C12-C14 Pareth-7、氢化蓖麻油、二亚乙基三胺五亚甲基膦酸钠、PEG/PPG-10/2丙基庚基醚、丁苯基甲基丙醛、荧光增亮剂9、山梨醇、甘油、乙醇胺、氢氧化钠、α-异甲基紫罗兰酮、蛋白酶、氯化钙、香叶醇、芳樟醇、香茅醇、三丙二醇、氯化钠、糖苷酶、苯并异噻唑啉酮、二甲硅油、糖苷酶、乙酸钠、纤维素酶、着色剂、硬脂酸甘油酯、羟乙基纤维素、二氧化硅。
宝莹小与强大(Small&Mighty)组合物(液体):成分:15%-30%阴离子型表面活性剂、非离子型表面活性剂、5%-15%皂、<5%聚羧酸盐、香料、磷酸盐、光学增亮剂
Fairy非生物制品组合物(液体):成分:15%-30%阴离子型表面活性剂、5%-15%非离子型表面活性剂、皂、苯并异噻唑啉酮、甲基异噻唑啉酮、香料
标准洗涤剂T组合物(粉末):成分:11%LAS、2%AS/AEOS、2%皂、3%AEO、15.15%碳酸钠、3%硅酸钠、18.75%沸石、0.15%螯合剂、2%柠檬酸钠、1.65%AA/MA共聚物、2.5%CMC和0.5%SRP(所有的百分数都是w/w)。
标准洗涤剂X组合物(粉末):成分:16.5%LAS、15%沸石、12%二硅酸钠、20%碳酸钠、1%sokalan、35.5%硫酸钠(所有的百分数都是w/w)。
碧浪Actilift组合物(粉末):成分:15%-30%阴离子型表面活性剂、<5%非离子型表面活性剂、磷酸盐、聚羧酸盐、沸石;酶、香料、己基肉桂醛。
宝莹Megaperls组合物(粉末):成分:以下的15%-30%:阴离子型表面活性剂、基于氧的漂白剂和沸石,以下的少于5%:非离子型表面活性剂、磷酸盐、聚羧酸盐、皂,另外的成分:香料、己基肉桂醛、水杨酸苄酯、芳樟醇、光学增亮剂、酶和香茅醇。
嘉盛液体,原版:成分:水、醇乙氧基硫酸盐、二乙二醇、醇乙氧化物、乙醇胺、直链烷基苯磺酸盐、脂肪酸钠、聚乙烯亚胺乙氧基化物、柠檬酸、硼砂、枯烯磺酸钠、丙二醇、DTPA、二氨基二苯乙烯二磺酸钠、二丙乙基四氨、氢氧化钠、甲酸钠、甲酸钙、二甲硅油、淀粉酶、蛋白酶、LiquitintTM、氢化蓖麻油、香味
汰渍液体,原版:成分:直链烷基苯磺酸酯、丙二醇、柠檬酸、氢氧化钠、硼砂、乙醇胺、乙醇、醇硫酸盐、聚乙烯亚胺乙氧基化物、脂肪酸钠、乙氧基硫酸二季铵盐、蛋白酶、二乙二醇、月桂醇聚醚-9、烷基二甲胺氧化物、香味、淀粉酶、二氨基二苯乙烯二磺酸钠、DTPA、甲酸钠、甲酸钙、聚乙二醇4000、甘露聚糖酶、LiquitintTM蓝、二甲硅油。
液体汰渍,自由和温和型:水、醇乙氧基硫酸钠、丙二醇、硼砂、乙醇、直链烷基苯磺酸钠、盐、聚乙烯亚胺乙氧基化物、二乙二醇、反式硫酸化和乙氧基化的六亚甲基二胺、醇乙氧化物、直链烷基苯磺酸酯、MEA盐、甲酸钠、烷基硫酸钠、DTPA、氧化胺、甲酸钙、二氨基二苯乙烯二钠、二磺酸盐、淀粉酶、蛋白酶、二甲硅油、苯并异噻唑啉酮
汰渍冷水液体,清香型:水、醇乙氧基硫酸酯、直链烷基苯磺酸酯、二乙二醇、丙二醇、乙醇胺、柠檬酸、硼砂、醇硫酸盐、氢氧化钠、聚乙烯亚胺、乙氧基化物、脂肪酸钠、乙醇、蛋白酶、月桂醇聚醚-9、乙氧基硫酸二季铵盐、月桂基胺氧化物、异丙苯钠、磺酸盐、香味、DTPA、淀粉酶、二钠、二氨基二苯乙烯、二磺酸盐、甲酸钠、二苯乙烯基联苯基二磺酸二钠、甲酸钙、聚乙二醇4000、甘露聚糖酶、果胶酶、LiquitintTM蓝、二甲硅油
汰渍TOTALCARETM液体,冷棉:水、醇乙氧基硫酸酯、丙二醇、脂肪酸钠、月桂基三甲基氯化铵、乙醇、氢氧化钠、异丙基苯磺酸钠、柠檬酸、乙醇胺、二甘醇、聚醚硅氧烷、硼砂、香味、聚乙烯亚胺、乙氧基化物、蛋白酶、月桂醇聚醚-9、DTPA、聚丙烯酰胺季铵盐氯化物、二氨基二苯乙烯二磺酸钠、甲酸钠、LiquitintTM橙、二丙基乙四胺、二甲硅油、纤维素酶,
液体汰渍加漂白剂AlternativeTM,生动白与鲜艳、原版以及清洁微风(CleanBreeze):水、醇乙氧基硫酸钠、烷基硫酸钠、MEA柠檬酸、直链烷基苯磺酸酯、MEA盐、丙二醇、二乙二醇、聚乙烯亚胺乙氧基化物、乙醇、脂肪酸钠、乙醇胺、月桂基胺氧化物、硼砂、月桂醇聚醚-9、DTPA、枯烯磺酸钠、甲酸钠、甲酸钙、直链烷基苯磺酸酯、钠盐、醇硫酸盐、氢氧化钠、乙氧基硫酸二季铵盐、香味、淀粉酶、蛋白酶、甘露聚糖酶、果胶酶、二氨基二苯乙烯二磺酸钠、苯并异噻唑啉酮、LiquitintTM蓝、二甲硅油、二丙基乙四胺。
液体汰渍HE,原味:水、醇乙氧基硫酸钠、MEA柠檬酸、烷基硫酸钠、醇乙氧化物、直链烷基苯磺酸酯、MEA盐、脂肪酸钠、聚乙烯亚胺乙氧基化物、二乙二醇、丙二醇、乙氧基硫酸二季铵盐、硼砂、聚乙烯亚胺、乙氧基化物丙氧基化物、乙醇、枯烯磺酸钠、香味、DTPA、二氨基二苯乙烯二磺酸钠、甘露聚糖酶、纤维素酶、淀粉酶、甲酸钠、甲酸钙、月桂基胺氧化物、LiquitintTM蓝、二甲硅油/聚二甲基硅酮。
汰渍TOTALCARE HE液体,新生雨润(renewing Rain):水、醇乙氧基硫酸酯、直链烷基苯磺酸酯、醇乙氧化物、柠檬酸、乙醇胺、脂肪酸钠、二乙二醇、丙二醇、氢氧化钠、硼砂、聚乙烯亚胺乙氧基化物、聚醚硅氧烷、乙醇、蛋白酶、枯烯磺酸钠、乙氧基硫酸二季铵盐、月桂醇聚醚-9、香味、淀粉酶、DTPA、二氨基二苯乙烯二磺酸钠、二苯乙烯基联苯基二磺酸二钠、甲酸钠、甲酸钙、甘露聚糖酶、LiquitintTM橙、二甲硅油、聚丙烯酰胺季铵盐氯化物、纤维素酶、二丙基乙四胺。
汰渍液体HE自由:水、醇乙氧基硫酸酯、二乙二醇、单乙醇胺柠檬酸、甲酸钠、丙二醇、直链烷基苯磺酸酯、乙醇胺、乙醇、聚乙烯亚胺乙氧基化物、淀粉酶、苯并异噻唑啉、硼砂、甲酸钙、柠檬酸、乙二烯三胺五乙酸钠、二甲硅油、乙氧基硫酸二季铵盐、二氨基二苯乙烯二磺酸钠、月桂醇聚醚-9、甘露聚糖酶、蛋白酶、枯烯磺酸钠、脂肪酸钠。
汰渍冷水HE液体,清香型:水、醇乙氧基硫酸酯、MEA柠檬酸、醇硫酸盐、醇乙氧化物、直链烷基苯磺酸酯MEA、脂肪酸钠、聚乙烯亚胺乙氧基化物、二乙二醇、丙二醇、乙氧基硫酸二季铵盐、硼砂、聚乙烯亚胺乙氧基化物丙氧基化物、乙醇、枯烯磺酸钠、香味、DTPA、二氨基二苯乙烯二磺酸钠、蛋白酶、甘露聚糖酶、纤维素酶、淀粉酶、甲酸钠、甲酸钙、月桂基胺氧化物、LiquitintTM蓝、二甲硅油。
汰渍冷水HE自由液体:水、醇乙氧基硫酸钠、MEA柠檬酸、直链烷基苯磺酸酯:钠盐、醇乙氧化物、直链烷基苯磺酸酯:MEA盐、脂肪酸钠、聚乙烯亚胺乙氧基化物、二乙二醇、丙二醇、乙氧基硫酸二季铵盐、硼砂、蛋白酶、聚乙烯亚胺乙氧基化物丙氧基化物、乙醇、枯烯磺酸钠、淀粉酶、柠檬酸、DTPA、二氨基二苯乙烯二磺酸钠、甲酸钠、甲酸钙、二甲硅油。
汰渍简单洁净与清新(Clean&Fresh):水、醇乙氧化物硫酸盐、直链烷基苯磺酸钠/Mea盐、丙二醇、二乙二醇、甲酸钠、乙醇、硼砂、脂肪酸钠、香味、月桂基胺氧化物、DTPA、聚乙烯胺乙氧基化物、甲酸钙、二氨基二苯乙烯二磺酸钠、二甲硅油、四胺、LiquitintTM蓝。
汰渍舱(Tide Pods),海雾(Ocean Mist),神秘森林(Mystic Forest),春天牧场(Spring Meadow):直链烷基苯磺酸酯、C12-16 Pareth-9、丙二醇、醇乙氧基硫酸酯、水、聚乙烯亚胺乙氧基化物、甘油、脂肪酸盐、PEG-136聚乙酸乙烯酯、乙二胺琥珀酸盐、单乙醇胺柠檬酸、亚硫酸氢钠、乙二烯三胺五乙酸钠、二苯乙烯基联苯基二磺酸二钠、甲酸钙、甘露聚糖酶、木葡聚糖酶、甲酸钠、氢化蓖麻油、natalase、染料、termamyl、枯草杆菌蛋白酶、苯并异噻唑啉、香料。
汰渍去污笔(Tide to Go):去离子水、二丙二醇丁基醚、烷基硫酸钠、过氧化氢、乙醇、硫酸镁、烷基二甲基氧化胺、柠檬酸、氢氧化钠、三甲氧基苯甲酸、香味。
汰渍污渍释放液体:水、烷基乙氧基化物、直链烷基苯磺酸盐、过氧化氢、乙氧基硫酸二季铵盐、乙醇胺、二苯乙烯基联苯基二磺酸二钠、四丁基乙叉基双酚、F&DC黄3、香味。
汰渍污渍释放粉末:过碳酸钠、硫酸钠、碳酸钠、铝硅酸钠、壬酰氧基苯磺酸盐、聚丙烯酸钠、水、烷基苯磺酸钠、DTPA、聚乙二醇、棕榈酸钠、淀粉酶、蛋白酶、修饰的淀粉、FD&C蓝1、香味。
汰渍污渍释放,预处理器喷雾:水、烷基乙氧基化物、MEA硼酸盐、直链烷基苯磺酸盐、丙二醇、乙氧基硫酸二季铵盐、氯化钙酶、蛋白酶、乙醇胺、苯并异噻唑啉酮、淀粉酶、柠檬酸钠、氢氧化钠、香味。
汰渍去污渍橡皮擦:水、烷基氧化胺、二丙二醇苯基醚、过氧化氢、柠檬酸、乙二胺二琥珀酸钠盐、烷基硫酸钠、香味。
汰渍氧化加强:碳酸氢钠、碳酸钠、过碳酸钠、醇乙氧化物、氯化钠、马来酸/丙烯酸共聚物、壬酰氧基苯磺酸盐、硫酸钠、着色剂、乙二烯三胺五乙酸钠盐、水合硅铝酸盐(沸石)、聚乙二醇、烷基苯磺酸钠、棕榈酸钠、淀粉、水、香味。
汰渍污渍释放加强双重Pac:聚乙烯醇袋膜,其中有被包装的液体部分和粉末部分:液体成分:二丙二醇、乙氧基硫酸二季铵盐、水、甘油、LiquitintTM橙,粉末成分:过碳酸钠、壬酰氧基苯磺酸盐、碳酸钠、硫酸钠、铝硅酸钠、聚丙烯酸钠、烷基苯磺酸钠、马来酸/丙烯酸共聚物、水、淀粉酶、聚乙二醇、棕榈酸钠、修饰的淀粉、蛋白酶、甘油、DTPA、香味。
汰渍超级污渍释放:水、醇乙氧基硫酸钠、直链烷基苯磺酸盐、钠/MEA盐、MEA柠檬酸、丙二醇、聚乙烯亚胺乙氧基化物、乙醇、二乙二醇、聚乙烯亚胺丙氧基乙氧基化物、脂肪酸钠、蛋白酶、硼砂、枯烯磺酸钠、DTPA、香味、淀粉酶、二氨基二苯乙烯二磺酸钠、甲酸钙、甲酸钠、葡聚糖酶、二甲硅油、LiquitintTM蓝、甘露聚糖酶。
具有少许粉状洗涤剂的超级汰渍,四月清新(April Fresh)/清洁微风(Clean Breeze)/四月精华(April Essence):碳酸钠、铝硅酸钠、硫酸钠、直链烷基苯磺酸酯、膨润土、水、过碳酸钠、聚丙烯酸钠、硅酸盐、烷基硫酸盐、壬酰氧基苯酚酯磺酸、DTPA、聚乙二醇4000、硅胶、乙氧基化物、香味、聚氧化乙烯、棕榈酸、二氨基二苯乙烯二磺酸钠、蛋白酶、LiquitintTM红、FD&C蓝1、纤维素酶。
具有少许Downy清洁微风(Clean Breeze)的超级汰渍:水、醇乙氧基硫酸钠、MEA柠檬酸、直链烷基苯磺酸盐:钠/MEA盐、丙二醇、聚乙烯亚胺乙氧基化物、乙醇、二乙二醇、聚乙烯亚胺、丙氧基乙氧基化物、乙氧基硫酸二季铵盐、醇硫酸盐、二甲硅油、香味、硼砂、脂肪酸钠、DTPA、蛋白酶、亚硫酸氢钠、二氨基二苯乙烯二磺酸钠、淀粉酶、葡聚糖酶、蓖麻油、甲酸钙、MEA、苯乙烯丙烯酯共聚物、甲酸钠、LiquitintTM蓝。
具有Downy太阳花(Downy Sun Blossom)的超级汰渍:水、醇乙氧基硫酸钠、MEA柠檬酸、直链烷基苯磺酸盐:钠/MEA盐、丙二醇、乙醇、二乙二醇、聚乙烯亚胺丙氧基乙氧基化物、聚乙烯亚胺乙氧基化物、醇硫酸盐、二甲硅油、香味、硼砂、脂肪酸钠、DTPA、蛋白酶、亚硫酸氢钠、二氨基二苯乙烯二磺酸钠、淀粉酶、蓖麻油、甲酸钙、MEA、苯乙烯丙烯酯共聚物、丙铵丙酰胺、葡聚糖酶、甲酸钠、LiquitintTM蓝。
具有Downy四月清新(April Fresh)/甜蜜梦境(Sweet Dreams)的超级汰渍:水、醇乙氧基硫酸钠、MEA柠檬酸、直链烷基苯磺酸盐:钠/MEA盐、丙二醇、聚乙烯亚胺乙氧基化物、乙醇、二乙二醇、聚亚乙基亚胺丙氧基乙氧基化物、乙氧基硫酸二季铵盐、醇硫酸盐、二甲硅油、香味、硼砂、脂肪酸钠、DTPA、蛋白酶、亚硫酸氢钠、二氨基二苯乙烯二磺酸钠、淀粉酶、葡聚糖酶、
蓖麻油、甲酸钙、MEA、苯乙烯丙烯酯共聚物、丙铵丙酰胺、甲酸钠、LiquitintTM蓝。
超级汰渍自由粉状洗涤剂:碳酸钠、铝硅酸钠、烷基硫酸盐、硫酸钠、直链烷基苯磺酸酯、水、聚丙烯酸钠、硅酸盐、乙氧基化物、过碳酸钠、聚乙二醇4000、蛋白酶、二氨基二苯乙烯二磺酸钠、硅胶、纤维素酶。
超级汰渍粉状洗涤剂,清洁微风(Clean Breeze)/春日薰衣草(SpringLavender)/森林泉(mountain Spring):碳酸钠、铝硅酸钠、硫酸钠、直链烷基苯磺酸酯、烷基硫酸盐、过碳酸钠、水、聚丙烯酸钠、硅酸盐、壬酰氧基苯酚酯磺酸、乙氧基化物、聚乙二醇4000、香味、DTPA、二氨基二苯乙烯二磺酸钠、棕榈酸、蛋白酶、硅胶、纤维素酶。
超级汰渍HE(高效率)粉状洗涤剂,清洁微风(Clean Breeze):碳酸钠、铝硅酸钠、硫酸钠、线形烷基苯磺酸酯、水、
壬酰氧基苯酚酯磺酸、烷基硫酸盐、聚丙烯酸钠、硅酸盐、过碳酸钠、乙氧基化物、聚乙二醇4000、香味、DTPA、棕榈酸、二氨基二苯乙烯二磺酸钠、蛋白酶、硅胶、纤维素酶。
超级汰渍冷水粉状洗涤剂,清香型:碳酸钠、铝硅酸钠、硫酸钠、过碳酸钠、烷基硫酸盐、线形烷基苯磺酸酯、水、壬酰氧基苯酚酯磺酸、聚丙烯酸钠、硅酸盐、乙氧基化物、聚乙二醇4000、DTPA、香味、Natalase、棕榈酸、蛋白酶、二钠、二氨基二苯乙烯二磺酸盐、FD&C蓝1、硅胶、纤维素酶、烷基醚硫酸盐。
具有漂白剂粉状洗涤剂的超级汰渍,清洁微风(Clean Breeze):碳酸钠、铝硅酸钠、硫酸钠、线形烷基苯磺酸酯、过碳酸钠、壬酰氧基苯酚酯磺酸、烷基硫酸盐、水、硅酸盐、聚丙烯酸钠、乙氧基化物、聚乙二醇4000、香味、DTPA、棕榈酸、蛋白酶、二氨基二苯乙烯二磺酸钠、硅胶、FD&C蓝1、纤维素酶、烷基醚硫酸盐。
具有Febreeze FreshnessTM粉状洗涤剂的超级汰渍,春日新生(Spring Renewal):碳酸钠、铝硅酸钠、硫酸钠、线形烷基苯磺酸酯、过碳酸钠、烷基硫酸盐、水、聚丙烯酸钠、硅酸盐、壬酰氧基苯酚酯磺酸、乙氧基化物、聚乙二醇4000、DTPA、香味、纤维素酶、蛋白酶、二氨基二苯乙烯二磺酸钠、硅胶、FD&C蓝1。
具有Febreeze Freshness的液体汰渍加–运动HE活跃新鲜(Sport HE ActiveFresh):水、醇乙氧基硫酸钠、MEA柠檬酸、直链烷基苯磺酸酯、钠盐、直链烷基苯磺酸酯:MEA盐、醇乙氧化物、脂肪酸钠、丙二醇、二乙二醇、聚乙烯亚胺乙氧基化物丙氧基化物、乙氧基硫酸二季铵盐、
乙醇、枯烯磺酸钠、硼砂、香味、DTPA、硫酸氢钠、二氨基二苯乙烯二磺酸钠、甘露聚糖酶、纤维素酶、淀粉酶、甲酸钠、甲酸钙、
月桂基胺氧化物、LiquitintTM蓝、二甲硅油/聚二甲基硅酮。
汰渍加Febreeze春日新生(Spring&Renewal):水、醇乙氧基硫酸钠、直链烷基苯磺酸盐:钠/MEA盐、MEA柠檬酸、丙二醇、聚乙烯亚胺乙氧基化物、香味、乙醇、二乙二醇、聚乙烯亚胺丙氧基乙氧基化物、蛋白酶、醇硫酸盐、硼砂、脂肪酸钠、DTPA、二氨基二苯乙烯二磺酸钠、MEA、甘露聚糖酶、葡聚糖酶、甲酸钠、二甲硅油、LiquitintTM蓝、四胺。
具有Febreeze Freshness的液体汰渍加,运动HE胜利新鲜(Sport HE VictoryFresh):水、醇乙氧基硫酸钠、MEA柠檬酸、线形烷基苯磺酸酯、钠盐、线形烷基苯磺酸酯:MEA盐、醇乙氧化物、脂肪酸钠、丙二醇、二乙二醇、聚乙烯亚胺乙氧基化物丙氧基化物、乙氧基硫酸二季铵盐、乙醇、枯烯磺酸钠、硼砂、香味、DTPA、硫酸氢钠、二氨基二苯乙烯二磺酸钠、甘露聚糖酶、纤维素酶、淀粉酶、甲酸钠、甲酸钙、月桂基胺氧化物、LiquitintTM蓝、二甲硅油/聚二甲基硅酮。
汰渍生动白+鲜艳,原版:碳酸钠、铝硅酸钠、硫酸钠、直链烷基苯磺酸酯、过碳酸钠、壬酰氧基苯酚酯磺酸、烷基硫酸盐、水、硅酸盐、聚丙烯酸钠、
乙氧基化物、聚乙二醇4000、香味、DTPA、棕榈酸、蛋白酶、二氨基二苯乙烯二磺酸钠、硅胶、FD&C蓝1、纤维素酶、烷基醚硫酸盐。
Hey Sport纺织品洗涤剂:水、十二烷基苯磺酸、月桂醇聚醚-11、peg-75羊毛脂、丙二醇、改性醇、大豆油酸钾、氢氧化钾、椰油两性二乙酸二钠、乙二胺三乙椰子烷基酰胺、香精、蓖麻醇酸锌、氯化钠、苯并异噻唑啉酮、甲基异噻唑啉酮、ci 16255、苯甲醇。
命名为汰渍、碧浪、嘉盛和Fairy的产品是由宝洁公司(Procter&Gamble)提供的可商购产品。命名为宝莹的产品是由联合利华和汉高公司(Unilever and Henkel)提供的可商购产品。命名为Hey Sport的产品是由Hey Sport提供的可商购产品。
表1.
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所有酶水平表达为rug活性酶蛋白/100g洗涤剂组合物。
表面活性剂成分可以获得自巴斯夫公司(BASF)、路德维希港、德国(Lutensol(R));壳牌化学公司(Shell Chemicals),伦敦,英国;斯泰潘公司(Stepan),诺思菲尔德,III,美国;亨斯曼公司(Huntsman),盐湖城,犹他州,美国;科莱恩公司(Clariant),苏尔茨巴赫市,德国(Praepagen(R))。
三聚磷酸钠可以获得自罗地亚公司(Rhodia)、巴黎、法国。
沸石可以获得自工业沸石(英国)有限公司,格雷士,艾塞克斯,英国。
柠檬酸和柠檬酸钠可以获得自永本兹劳尔公司(Jungbunzlauer),巴塞尔,瑞士。
NOBS是壬酰基羟苯磺酸钠,由伊士曼公司(Eastman),贝茨维尔,阿肯色州,美国提供。
TAED是四乙酰乙二胺,在科莱恩有限公司(Clariant GmbH),祖尔茨巴赫,德国的Peractive(R)品牌下提供。
碳酸钠和碳酸氢钠可以获得自索尔维公司(Solvay),布鲁塞尔,比利时。
聚丙烯酸酯、聚丙烯酸酯/马来酸酯共聚物可以获得自巴斯夫公司、路德维希港、德国。
Repel-O-Tex(R)可以获得自罗地亚公司(Rhodia)、巴黎、法国。
Texcare(R)可以获得自科莱恩公司,祖尔茨巴赫,德国。过碳酸钠和碳酸钠可以获得自索尔维公司,休斯顿,德克萨斯州,美国。
乙二胺-N,N’-二琥珀酸的Na盐,(S,S)异构体(EDDS)是通过联合奥泰公司(Octel),埃尔斯米尔港,英国提供。
羟基乙醇二磷酸盐(HEDP)是由美国陶氏化学公司(Dow Chemical),米德兰,密歇根州,美国提供。
酶Savinase(R)、Savinase(R)Ultra、Stainzyme(R)Plus、Lipex(R)、Lipolex(R)、Lipoclean(R)、Celluclean(R)、Carezyme(R)、Natalase(R)、Stainzyme(R)、Stainzyme(R)Plus、Termamyl(R)、Termamyl(R)ultra、和Mannaway(R)可以获得自诺维信公司(Novozymes),巴格斯瓦德,丹麦。
酶Purafect(R)、FN3和FN4可以获得自杜邦国际公司(DuPont InternationalInc.)
帕洛阿尔托,加利福尼亚州,美国。直接紫9和99可以获得自巴斯夫公司、路德维希港、德国。溶剂紫13可以获得自宁波立兴化工有限公司(Ningbo Lixing Chemical Co.,Ltd.),宁波,浙江,中国。增亮剂可以获得自汽巴精化有限公司,巴塞尔,瑞士。除非另外指明,所有百分比和比率都是按重量计算。除非另外指明,所有百分比和比率都是基于总组合物计算。
应当理解的是贯穿本说明书给出的每一最大数值限度包括每一较低的数值限度,如同此类较低数值限度在此被明确写出。贯穿本说明书给出的每一最小数值限度将包括每一较高的数值限度,如同此类较高数值限度本文被明确写出。本说明书中所给出的每个数值范围将包括落入在这样更宽泛数值范围内的每一狭小的范围,如同此类狭小的数值范围都在本文被明确写出。
洗涤测定
Launder-O-Meter(LOM)模式洗涤系统
Launder-O-Meter(LOM)是中等规模标准洗涤系统,它可以应用于同时测试多达20种不同洗涤条件。LOM基本上是大型的具有20个封闭金属烧杯在其中旋转的温度受控的水浴。每个烧杯构成一个小的洗衣机并且在一次实验过程中,每个试管将包含一种具有特定的有待测试的洗涤剂/酶系统连同在关于其进行测试的弄脏的和未弄脏的织物。机械压力由在水浴中旋转的烧杯并且由包括在烧杯中的金属球实现。
LOM标准洗涤系统主要用于洗涤剂和酶的中等规模测试,在例如欧洲洗涤条件下。在LOM实验中,因素如压载物与污垢的比率和织物与洗涤液的比率可以变化。因此,LOM提供了在小规模实验(如AMSA和微型洗涤)与在前装式洗衣机中的更费时的全规模实验之间的联系。
迷你Launder-O-Meter(迷你LOM)标准洗涤系统
迷你LOM是Launder-O-Meter(LOM)的修饰的迷你洗涤系统,其是中等规模标准洗涤系统,它可以应用于同时测试多达20种不同洗涤条件。LOM或基本上是大型的具有20个封闭金属烧杯在其中旋转的温度受控的水浴。每个烧杯构成一个小的洗衣机并且在一次实验过程中,每个试管将包含一种具有特定的有待测试的洗涤剂/酶系统连同在关于其进行测试的弄脏的和未弄脏的织物。机械压力由在水浴中旋转的烧杯并且由包括在烧杯中的金属球实现。
LOM标准洗涤系统主要用于洗涤剂和酶的中等规模测试,在例如欧洲洗涤条件下。在LOM实验中,因素如压载物与污垢的比率和织物与洗涤液的比率可以变化。因此,LOM提供了在小规模实验(如AMSA和微型洗涤)与在前装式洗衣机中的更费时的全规模实验之间的联系。
在迷你LOM中,洗涤是在置于斯图尔特(Stuart)旋转器中的50ml试管中进行的。
Terg-O-Tometer(TOM)洗涤测定
Terg-O-tometer(TOM)是一种中等规模标准洗涤系统,它可以应用于同时测试12种不同的洗涤条件。TOM基本上是一个大型温控水浴,最多可浸入12个开口金属烧杯。每个烧杯构成一个小的顶装式洗衣机并且在实验期间,它们中的每一者将含有特定洗涤剂/酶系统的溶液并且对弄脏的和未弄脏的织物测试其性能。通过旋转搅拌臂获得机械应力,该旋转搅拌臂搅拌在每个烧杯内的液体。因为TOM杯子不含盖子,所以能够在TOM实验期间收回样品并且在洗涤期间在线分析信息。
TOM标准洗涤系统主要用于在US或LA/AP洗涤条件,以及用于EU条件下进行洗涤剂和酶的中等规模测试。在TOM实验中,因素(如压载物与污垢的比率和织物与洗涤液的比率)可以变化。因此,TOM提供了在小规模实验与在顶装式洗衣机中的更费时的全规模实验之间的联系。
CBM的生产
通过制备穿梭质粒来构建表达构建体,该穿梭质粒包含编码与曲霉属启动子、信号序列以及Kex切割位点和终止子操作连接的CBM的核苷酸序列,并且进一步包含用于在曲霉属中进行amdS选择的amdS基因。用于CBM生产的启动子进一步描述于WO 2003/008575中。通过测序确认构建体的正确性。
曲霉属转化:用表达构建体转化米曲霉实验室菌株,并使其在诱导条件下生长以表达CBM。
CBM的回收在转化的曲霉属生长之后,使用标准色谱方法从上清液中纯化CBM。
实例1
CBM的制备
如方法与材料中所述,制备了三个属于CBM1家族的CBM。
CBM1-1来源于长柄镰孢GH10多肽,并由以下核苷酸序列编码:
并具有以下氨基酸序列:
CBM1-2来源于长柄镰孢GH6多肽,并由以下核苷酸序列编码:
并具有以下氨基酸序列:
CBM1-3来源于棒曲霉碳水化合物酯酶CE1多肽,并由以下核苷酸序列编码:
并具有以下氨基酸序列:
制备了多种CBM家族的另外的CBM。总体克隆和转化方法与“材料与方法”部分中的相同,但是编码重组CBM的基因针对米曲霉进行了密码子优化,并由GeneArt公司合成。信号肽序列MKLSWLVAAALTAASVVSA(SEQ ID NO:21)用于分泌重组CBM。
CBM79来源于黄色瘤胃球菌GH9内切葡聚糖酶多肽,并由SEQ ID NO:7的核苷酸序列编码,并具有以下氨基酸序列:
CBM72来源于未鉴定的微生物GH5内切葡聚糖酶多肽,并由SEQ ID NO:9的核苷酸序列编码,并具有以下氨基酸序列:
CBM44来源于亨氏热纤维梭菌(Hungateiclostridium thermocellum)GH9内切葡聚糖酶多肽,并由SEQ ID NO:11的核苷酸序列编码,并具有以下氨基酸序列:
产生的蛋白质含有19.9%具有SEQ ID NO:12的序列的蛋白质和80.1%具有突变G134S的蛋白质。
CBM30来源于嗜纤维梭菌(Clostridium cellulovorans)GH9内切葡聚糖酶多肽,并由SEQ ID NO:13的核苷酸序列编码,并具有以下氨基酸序列:
包含CBM17和CBM28的异源二聚体来源于嗜纤维梭菌GH5内切葡聚糖酶多肽,并由SEQ ID NO:15的核苷酸序列编码,并具有以下氨基酸序列:
产生的蛋白质还包括具有突变V174M的蛋白质。
分别对应于CBM17和CBM28部分。
CBM4来源于粪碱纤维单胞菌(Cellulomonas fimi)GH9内切葡聚糖酶多肽,并由SEQ ID NO:19的核苷酸序列编码,并具有以下氨基酸序列:
实例2
在棉T恤上评估了来自污垢压载物的混合污垢的CBM抗折痕特性
从中国ZARA公司购买了孟加拉国生产的儿童蓝色T恤。T恤用作褶皱计数的示踪物。将4片大小为40x 20cm2的污垢压载物(SBL-CFT)(等量化8g污垢)添加至各欧洲前装式全规模洗衣(FSW)机中。对于FSW,使用Miele Softtronic W5841洗衣机(程序:棉;附加程序:短;温度:30℃;离心机:1600rpm;压载物:600-700g 100%棉T恤)。商业洗涤剂组合物碧浪彩色与风格(Ariel Color&Style)以5g/L给予。将实例1中制备的、以0.5ppm给予的三个碳结合模块添加至单独的洗衣机中,并如所描述的进行洗涤。对各FSW进行4次独立重复。将来自各机器的T恤在室温下挂干(line-dried)持续24h。将织物片根据标准AATCC三维平滑度外观重复(Standard AATCC Three-Dimensional Smoothness Appearance Replicas)由7名专门小组成员组成的小组通过评分来评价(小组设置尽可能接近AATCC方法124)。要求专门小组成员将每个小块布样与AATCC平滑度标准等级进行比较,该等级包括从SA值=1(非常褶皱的标准)到SA值=5(完全平滑的标准)。评估后,计算每个条件的小组评分的平均值和标准误差。
这些值指定根据AATCC平滑度标准+/-StE由小组给出的平均SA值等级。
实例3
在棉T恤上评估了来自污垢压载物的混合污垢的、具有抗折痕特性的两种CBM类别
的混合物
从法国迪卡侬公司(Decathlon)购买了印度生产的女生粉色T恤(100%棉)。4件T恤/机器用作褶皱计数的示踪物。将4片大小为40x 20cm2的污垢压载物(SBL-CFT)(等量化8g污垢)添加至各欧洲前装式全规模洗衣(FSW)机中。使用Miele Softtronic W5841洗衣机进行洗涤(程序:棉;附加程序:短;温度:30℃;离心机:800rpm;压载物:600g-700g 100%棉T恤)。标准洗涤剂B以3,3g/L给予。如下给予两种碳结合模块(分别为SEQ ID NO:17和SEQID NO:18,CBM17和CBM28)的混合物。将来自各机器的T恤在室温下挂干(line-dried)持续24h。将织物片根据标准AATCC三维平滑度外观重复由4名经培训的专门小组成员组成的小组通过评分来评价(小组设置尽可能接近AATCC方法124)。要求专门小组成员将每个小块布样与AATCC平滑度标准等级进行比较,该等级包括从SA值=1(非常褶皱的标准)到SA值=5(完全平滑的标准)。评估后,计算每个条件的小组评分的平均值和标准误差。
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这些值指定根据AATCC平滑度标准+/-StE由小组给出的平均SA值等级。
实例4
在棉T恤上评估了来自污垢压载物的混合污垢的、具有抗折痕特性的CBM44类别
CBM
从德国迪卡侬公司购买了印度生产的女生粉色T恤(100%棉)。4件T恤/机器用作褶皱计数的示踪物。将4片大小为40x 20cm2的污垢压载物(SBL-CFT)(等量化8g污垢)添加至各欧洲前装式全规模洗衣(FSW)机中。使用Miele Softtronic W5841洗衣机进行洗涤(程序:棉;附加程序:短;温度:30℃;离心机:800rpm;压载物:4kg 100%棉T恤)。标准洗涤剂B以3,3g/L给予。测试了分别以0.25ppm、0.5ppm和2ppm给予的CBM44碳结合模块(SEQ ID NO:12)。将来自各机器的T恤在室温下挂干(line-dried)持续24h。将织物片根据标准AATCC三维平滑度外观重复由4名经培训的专门小组成员组成的小组通过评分来评价(小组设置尽可能接近AATCC方法124)。要求专门小组成员将每个小块布样与AATCC平滑度标准等级进行比较,该等级包括从SA值=1(非常褶皱的标准)到SA值=5(完全平滑的标准)。评估后,计算每个条件的小组评分的平均值和标准误差。
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这些值指定根据AATCC平滑度标准+/-StE由小组给出的平均SA值等级。
实例5
在棉T恤上评估了来自污垢压载物的混合污垢的、在第一次洗涤内给出形状保持
性特性的三种CBM1单体的混合物
从法国迪卡侬公司购买了印度生产的女生粉色T恤(100%棉)。4件T恤/机器用作由小组评估的形状保持性的示踪物。将4片大小为40x 20cm2的污垢压载物(SBL-CFT)(等量化8g污垢)添加至各欧洲前装式全规模洗衣(FSW)机中。使用Miele Softtronic W5841洗衣机进行洗涤(程序:棉;附加程序:短;温度:30℃;离心机:800rpm;压载物:600g-700g 100%棉T恤)。标准洗涤剂B以3,3g/L给予。以如下总剂量测试了三种碳结合模块(单体CBM1-1、CBM1-2和CBM1-3(分别为SEQ ID NO:2;4;6))的混合物。将来自各机器的T恤在室温下挂干(line-dried)持续24h。在相同小组评分期间对来自3个单独试验的T恤组进行了评分。由24名未经培训的专门小组成员组成的小组通过偏好评分对织物片进行评估(每种处理对之间的随机偏好测试)。要求专门小组成员根据原始形状指出偏好的形状。评估后,计算每个偏好的百分比。
实例6
CBM4和CBM72-在棉T恤上评估了来自污垢压载物的混合污垢的两种不同CBM类别
的抗折痕特性
从法国迪卡侬公司购买了孟加拉国生产的儿童粉色T恤。T恤用作褶皱计数的示踪物。将4片大小为40x 20cm2的污垢压载物(SBL-CFT)(等量化8g污垢)添加至各欧洲前装式全规模洗衣(FSW)机中。使用Miele Softtronic W5841洗衣机进行洗涤(程序:棉;附加程序:短;温度:30℃;离心机:1600rpm;压载物:600g-700g 100%棉T恤)。碧浪彩色与风格以5g/L给予。来自两种不同CBM类别(CBM4和CBM72,分别为SEQ ID NO:18和10)的碳结合模块的两个代表以0.5ppm给予。对各FSW进行4次独立重复。将来自各机器的T恤在室温下挂干(line-dried)持续24h。将织物片根据标准AATCC三维平滑度外观重复由3名专门小组成员组成的小组通过评分来评价(小组设置尽可能接近AATCC方法124)。要求专门小组成员将每个小块布样与AATCC平滑度标准等级进行比较,该等级包括从SA值=1(非常褶皱的标准)到SA值=5(完全平滑的标准)。评估后,计算每个条件的小组评分的平均值和标准误差。
这些值指定根据AATCC平滑度标准+/-StE由小组给出的平均SA值等级。
实例7
CBM79-在CS-10小块布样上评估了抗折痕特性
在Terg-o-Tometer 1L烧杯中洗涤八片大小为5x 5cm2的CS-10小块布样(CFT),洗涤20min,并在流动的自来水中漂洗10min。碧浪彩色与风格以5g/L给予。测试了以0.5ppm给予的、来自CBM79类别的纯化的碳结合模块(SEQ ID NO:8)。对各烧杯进行2次独立重复。将来自各烧杯的CS-10小块布样在滤纸上在室温下水平干燥16h。由14名未经培训的专门小组成员组成的小组通过随机对的偏好测试对织物片进行评估。要求专门小组成员优选褶皱最少的小块布样。评估后,计算每个条件的小组评分的平均值。
/>
序列表
<110> 诺维信公司(Novozymes A/S)
<120> 多肽的用途
<130> 14716-WO-PCT
<160> 21
<170> PatentIn 3.5版
<210> 1
<211> 114
<212> DNA
<213> 长柄镰孢
<220>
<221> CDS
<222> (1)..(111)
<400> 1
cag tcc ccc atc tgg gga cag tgt ggt gga aac gga tgg act ggt gca 48
Gln Ser Pro Ile Trp Gly Gln Cys Gly Gly Asn Gly Trp Thr Gly Ala
1 5 10 15
aca aca tgt cag tcc gga ctc aag tgt gag aaa gtg aac gat tgg tac 96
Thr Thr Cys Gln Ser Gly Leu Lys Cys Glu Lys Val Asn Asp Trp Tyr
20 25 30
tac cag tgt gtc ccc taa 114
Tyr Gln Cys Val Pro
35
<210> 2
<211> 37
<212> PRT
<213> 长柄镰孢
<400> 2
Gln Ser Pro Ile Trp Gly Gln Cys Gly Gly Asn Gly Trp Thr Gly Ala
1 5 10 15
Thr Thr Cys Gln Ser Gly Leu Lys Cys Glu Lys Val Asn Asp Trp Tyr
20 25 30
Tyr Gln Cys Val Pro
35
<210> 3
<211> 144
<212> DNA
<213> 长柄镰孢
<220>
<221> CDS
<222> (1)..(141)
<400> 3
gca ccg gtc gaa gaa cga cag tcg tgt tcg aac gga gtc tgg gca cag 48
Ala Pro Val Glu Glu Arg Gln Ser Cys Ser Asn Gly Val Trp Ala Gln
1 5 10 15
tgt ggt ggt cag aac tgg tcg ggt aca ccc tgt tgt aca tcc ggc aac 96
Cys Gly Gly Gln Asn Trp Ser Gly Thr Pro Cys Cys Thr Ser Gly Asn
20 25 30
aca tgt gtc aaa atc aac gac ttc tac tcg cag tgt cag cct ggc taa 144
Thr Cys Val Lys Ile Asn Asp Phe Tyr Ser Gln Cys Gln Pro Gly
35 40 45
<210> 4
<211> 47
<212> PRT
<213> 长柄镰孢
<400> 4
Ala Pro Val Glu Glu Arg Gln Ser Cys Ser Asn Gly Val Trp Ala Gln
1 5 10 15
Cys Gly Gly Gln Asn Trp Ser Gly Thr Pro Cys Cys Thr Ser Gly Asn
20 25 30
Thr Cys Val Lys Ile Asn Asp Phe Tyr Ser Gln Cys Gln Pro Gly
35 40 45
<210> 5
<211> 123
<212> DNA
<213> 棒曲霉
<220>
<221> CDS
<222> (1)..(120)
<400> 5
cag cag tcc ctc tat ggc cag tgt gga ggt aac ggc tgg tcc gga ccc 48
Gln Gln Ser Leu Tyr Gly Gln Cys Gly Gly Asn Gly Trp Ser Gly Pro
1 5 10 15
aca gag tgt aca gca gga gca tgt tgt cag gtc cag aac ccg tgg tat 96
Thr Glu Cys Thr Ala Gly Ala Cys Cys Gln Val Gln Asn Pro Trp Tyr
20 25 30
tcc cag tgt ctc cct ggc gat tgt taa 123
Ser Gln Cys Leu Pro Gly Asp Cys
35 40
<210> 6
<211> 40
<212> PRT
<213> 棒曲霉
<400> 6
Gln Gln Ser Leu Tyr Gly Gln Cys Gly Gly Asn Gly Trp Ser Gly Pro
1 5 10 15
Thr Glu Cys Thr Ala Gly Ala Cys Cys Gln Val Gln Asn Pro Trp Tyr
20 25 30
Ser Gln Cys Leu Pro Gly Asp Cys
35 40
<210> 7
<211> 381
<212> DNA
<213> 黄色瘤胃球菌
<220>
<221> CDS
<222> (1)..(381)
<400> 7
gat ggt tac acc att aag ccc aac aag aaa gtc act tac tcg gca ctc 48
Asp Gly Tyr Thr Ile Lys Pro Asn Lys Lys Val Thr Tyr Ser Ala Leu
1 5 10 15
ggc gaa gat gaa cgg atg att ggc ttc tcg tac aag gac ttc ggc atc 96
Gly Glu Asp Glu Arg Met Ile Gly Phe Ser Tyr Lys Asp Phe Gly Ile
20 25 30
tcc tcg tcg gaa aag atc aca gag gtc cag gtc aac att tcg gcc aac 144
Ser Ser Ser Glu Lys Ile Thr Glu Val Gln Val Asn Ile Ser Ala Asn
35 40 45
aag aac att ggt aag tac gtc ggc cag ttc ggc acg tcc aca acc gac 192
Lys Asn Ile Gly Lys Tyr Val Gly Gln Phe Gly Thr Ser Thr Thr Asp
50 55 60
tcg gca aac gga tac tgg gcc atg ggc gac gag atc act cag tcc atc 240
Ser Ala Asn Gly Tyr Trp Ala Met Gly Asp Glu Ile Thr Gln Ser Ile
65 70 75 80
tcg ggt aac tcc ggc acg atc aca tgg aag gtc ccc tcg gat atc tcg 288
Ser Gly Asn Ser Gly Thr Ile Thr Trp Lys Val Pro Ser Asp Ile Ser
85 90 95
tcg atc atc cag acg cag tat ggc gga gaa atc aaa ttc gga gtg tgg 336
Ser Ile Ile Gln Thr Gln Tyr Gly Gly Glu Ile Lys Phe Gly Val Trp
100 105 110
tgg atc gat tgt gat gag ttc aca atc gat tcg gtg gtc ctc aaa 381
Trp Ile Asp Cys Asp Glu Phe Thr Ile Asp Ser Val Val Leu Lys
115 120 125
<210> 8
<211> 127
<212> PRT
<213> 黄色瘤胃球菌
<400> 8
Asp Gly Tyr Thr Ile Lys Pro Asn Lys Lys Val Thr Tyr Ser Ala Leu
1 5 10 15
Gly Glu Asp Glu Arg Met Ile Gly Phe Ser Tyr Lys Asp Phe Gly Ile
20 25 30
Ser Ser Ser Glu Lys Ile Thr Glu Val Gln Val Asn Ile Ser Ala Asn
35 40 45
Lys Asn Ile Gly Lys Tyr Val Gly Gln Phe Gly Thr Ser Thr Thr Asp
50 55 60
Ser Ala Asn Gly Tyr Trp Ala Met Gly Asp Glu Ile Thr Gln Ser Ile
65 70 75 80
Ser Gly Asn Ser Gly Thr Ile Thr Trp Lys Val Pro Ser Asp Ile Ser
85 90 95
Ser Ile Ile Gln Thr Gln Tyr Gly Gly Glu Ile Lys Phe Gly Val Trp
100 105 110
Trp Ile Asp Cys Asp Glu Phe Thr Ile Asp Ser Val Val Leu Lys
115 120 125
<210> 9
<211> 567
<212> DNA
<213> 人工序列
<220>
<223> 未鉴定的微生物
<220>
<221> CDS
<222> (1)..(567)
<400> 9
ggc tac aag tac ccg aca gcc gac gat ttc gaa atc gtg tat gac atc 48
Gly Tyr Lys Tyr Pro Thr Ala Asp Asp Phe Glu Ile Val Tyr Asp Ile
1 5 10 15
tcg tac aac gac gag tgg tcc gaa ttg ttc ttg ttc ggc tcg tgg gac 96
Ser Tyr Asn Asp Glu Trp Ser Glu Leu Phe Leu Phe Gly Ser Trp Asp
20 25 30
agg act gcc gtc aac ttg tcg gga tac aag ggc atc cgc gtg gag atg 144
Arg Thr Ala Val Asn Leu Ser Gly Tyr Lys Gly Ile Arg Val Glu Met
35 40 45
gac aag gcc tat ggc aac aaa ctc cag atc aag gtg tac ggc gac aag 192
Asp Lys Ala Tyr Gly Asn Lys Leu Gln Ile Lys Val Tyr Gly Asp Lys
50 55 60
aag tcc ggt acc gat ttc aac gaa cag tat gcc cct ctc tcc gat aca 240
Lys Ser Gly Thr Asp Phe Asn Glu Gln Tyr Ala Pro Leu Ser Asp Thr
65 70 75 80
tcg gcc tcc acg acg gtc gat ttc gac acc tcg att ttg ggc tcg acg 288
Ser Ala Ser Thr Thr Val Asp Phe Asp Thr Ser Ile Leu Gly Ser Thr
85 90 95
ttc tgg ggt gtc acg ttg cag acg aac tcc ggt gca ttg acc gcg aca 336
Phe Trp Gly Val Thr Leu Gln Thr Asn Ser Gly Ala Leu Thr Ala Thr
100 105 110
ctc aaa gag gcc aag ttg atc aag gcc gac gga acc gag gaa cct gcc 384
Leu Lys Glu Ala Lys Leu Ile Lys Ala Asp Gly Thr Glu Glu Pro Ala
115 120 125
tcg gtg acc gca gca tgg gga tgt aca gtg act gcc aag tcg acc ccg 432
Ser Val Thr Ala Ala Trp Gly Cys Thr Val Thr Ala Lys Ser Thr Pro
130 135 140
aaa cct acc ggc atc cac gcc atc cag ttg atc aaa acc gaa gca gat 480
Lys Pro Thr Gly Ile His Ala Ile Gln Leu Ile Lys Thr Glu Ala Asp
145 150 155 160
ggt gcc atc tat aac ctc cag ggc cag agg gtg cag aac ccc cag aag 528
Gly Ala Ile Tyr Asn Leu Gln Gly Gln Arg Val Gln Asn Pro Gln Lys
165 170 175
ggt atc tac att cag aac ggc aag aaa tac gtg atg aaa 567
Gly Ile Tyr Ile Gln Asn Gly Lys Lys Tyr Val Met Lys
180 185
<210> 10
<211> 189
<212> PRT
<213> 人工序列
<220>
<223> 合成的构建体
<400> 10
Gly Tyr Lys Tyr Pro Thr Ala Asp Asp Phe Glu Ile Val Tyr Asp Ile
1 5 10 15
Ser Tyr Asn Asp Glu Trp Ser Glu Leu Phe Leu Phe Gly Ser Trp Asp
20 25 30
Arg Thr Ala Val Asn Leu Ser Gly Tyr Lys Gly Ile Arg Val Glu Met
35 40 45
Asp Lys Ala Tyr Gly Asn Lys Leu Gln Ile Lys Val Tyr Gly Asp Lys
50 55 60
Lys Ser Gly Thr Asp Phe Asn Glu Gln Tyr Ala Pro Leu Ser Asp Thr
65 70 75 80
Ser Ala Ser Thr Thr Val Asp Phe Asp Thr Ser Ile Leu Gly Ser Thr
85 90 95
Phe Trp Gly Val Thr Leu Gln Thr Asn Ser Gly Ala Leu Thr Ala Thr
100 105 110
Leu Lys Glu Ala Lys Leu Ile Lys Ala Asp Gly Thr Glu Glu Pro Ala
115 120 125
Ser Val Thr Ala Ala Trp Gly Cys Thr Val Thr Ala Lys Ser Thr Pro
130 135 140
Lys Pro Thr Gly Ile His Ala Ile Gln Leu Ile Lys Thr Glu Ala Asp
145 150 155 160
Gly Ala Ile Tyr Asn Leu Gln Gly Gln Arg Val Gln Asn Pro Gln Lys
165 170 175
Gly Ile Tyr Ile Gln Asn Gly Lys Lys Tyr Val Met Lys
180 185
<210> 11
<211> 435
<212> DNA
<213> 亨氏热纤维梭菌
<220>
<221> CDS
<222> (1)..(435)
<400> 11
ggc act ctc gga gga ttc act acc tcc ggc acc aac gcc aca gga gtg 48
Gly Thr Leu Gly Gly Phe Thr Thr Ser Gly Thr Asn Ala Thr Gly Val
1 5 10 15
gtg gtg aac acg acc gag aag gca ttc aag gga gag agg gga ctc aag 96
Val Val Asn Thr Thr Glu Lys Ala Phe Lys Gly Glu Arg Gly Leu Lys
20 25 30
tgg aca gtc aca tcg gag ggt gag ggt act gcc gag ttg aag ttg gat 144
Trp Thr Val Thr Ser Glu Gly Glu Gly Thr Ala Glu Leu Lys Leu Asp
35 40 45
gga ggc aca atc gtc gtc cct ggc acg act atg act ttc cgg atc tgg 192
Gly Gly Thr Ile Val Val Pro Gly Thr Thr Met Thr Phe Arg Ile Trp
50 55 60
att ccc tcg ggt gca cct att gca gcc atc cag cct tac atc atg cct 240
Ile Pro Ser Gly Ala Pro Ile Ala Ala Ile Gln Pro Tyr Ile Met Pro
65 70 75 80
cat aca ccg gat tgg tcg gag gtc ctc tgg aac tcg acc tgg aag gga 288
His Thr Pro Asp Trp Ser Glu Val Leu Trp Asn Ser Thr Trp Lys Gly
85 90 95
tac acg atg gtc aag acg gat gat tgg aac gag att acc ctc act ctc 336
Tyr Thr Met Val Lys Thr Asp Asp Trp Asn Glu Ile Thr Leu Thr Leu
100 105 110
ccg gaa gac gtg gac ccc act tgg cct cag cag atg gga att cag gtc 384
Pro Glu Asp Val Asp Pro Thr Trp Pro Gln Gln Met Gly Ile Gln Val
115 120 125
cag acc atc gac gaa ggc gaa ttc aca atc tac gtg gat gcg atc gat 432
Gln Thr Ile Asp Glu Gly Glu Phe Thr Ile Tyr Val Asp Ala Ile Asp
130 135 140
tgg 435
Trp
145
<210> 12
<211> 145
<212> PRT
<213> 亨氏热纤维梭菌
<400> 12
Gly Thr Leu Gly Gly Phe Thr Thr Ser Gly Thr Asn Ala Thr Gly Val
1 5 10 15
Val Val Asn Thr Thr Glu Lys Ala Phe Lys Gly Glu Arg Gly Leu Lys
20 25 30
Trp Thr Val Thr Ser Glu Gly Glu Gly Thr Ala Glu Leu Lys Leu Asp
35 40 45
Gly Gly Thr Ile Val Val Pro Gly Thr Thr Met Thr Phe Arg Ile Trp
50 55 60
Ile Pro Ser Gly Ala Pro Ile Ala Ala Ile Gln Pro Tyr Ile Met Pro
65 70 75 80
His Thr Pro Asp Trp Ser Glu Val Leu Trp Asn Ser Thr Trp Lys Gly
85 90 95
Tyr Thr Met Val Lys Thr Asp Asp Trp Asn Glu Ile Thr Leu Thr Leu
100 105 110
Pro Glu Asp Val Asp Pro Thr Trp Pro Gln Gln Met Gly Ile Gln Val
115 120 125
Gln Thr Ile Asp Glu Gly Glu Phe Thr Ile Tyr Val Asp Ala Ile Asp
130 135 140
Trp
145
<210> 13
<211> 552
<212> DNA
<213> 嗜纤维梭菌
<220>
<221> CDS
<222> (1)..(552)
<400> 13
gat acc aca gtg tcc agg aag ctc atg gat ctc gag gtg ttc aag tcc 48
Asp Thr Thr Val Ser Arg Lys Leu Met Asp Leu Glu Val Phe Lys Ser
1 5 10 15
gca tcc att acc ggc tgg tcc gga tcg gca gga ggc gaa ctc gag gtg 96
Ala Ser Ile Thr Gly Trp Ser Gly Ser Ala Gly Gly Glu Leu Glu Val
20 25 30
gca tcc gat tcg aac ttg ccc atc gac aca tcc gca acc tac aac ggc 144
Ala Ser Asp Ser Asn Leu Pro Ile Asp Thr Ser Ala Thr Tyr Asn Gly
35 40 45
ttg cct tcc ttg agg ttg aac gtc aca aag gcc tcc gca cag tgg tgg 192
Leu Pro Ser Leu Arg Leu Asn Val Thr Lys Ala Ser Ala Gln Trp Trp
50 55 60
tcc tcg ctc ctc aca ctc agg gga tgg tgt act cag gac ttg aca cag 240
Ser Ser Leu Leu Thr Leu Arg Gly Trp Cys Thr Gln Asp Leu Thr Gln
65 70 75 80
tac ctc gcc aac ggc tat ttg gag ttc aac gtg aaa ggt aag gtc gga 288
Tyr Leu Ala Asn Gly Tyr Leu Glu Phe Asn Val Lys Gly Lys Val Gly
85 90 95
ggc gag gac ttc cag att gga ctc cag gac cag act cat gaa cga gca 336
Gly Glu Asp Phe Gln Ile Gly Leu Gln Asp Gln Thr His Glu Arg Ala
100 105 110
gcc gga gac tcg gtc acc tcc gtg aag tcg atc aag aac tat gtc aac 384
Ala Gly Asp Ser Val Thr Ser Val Lys Ser Ile Lys Asn Tyr Val Asn
115 120 125
atc tcg acc aac tgg cag cac gtg aag atc ccc ttg aag gac att atg 432
Ile Ser Thr Asn Trp Gln His Val Lys Ile Pro Leu Lys Asp Ile Met
130 135 140
gga ccc tcc act gga ttc gac ccg act aca gcc cga tgt atc aac atc 480
Gly Pro Ser Thr Gly Phe Asp Pro Thr Thr Ala Arg Cys Ile Asn Ile
145 150 155 160
gtg aag ggc tcc tcg gag atc ttc acg gca tgg atc aac gac ctc aag 528
Val Lys Gly Ser Ser Glu Ile Phe Thr Ala Trp Ile Asn Asp Leu Lys
165 170 175
atc acg tcg acg gac aac gag aag 552
Ile Thr Ser Thr Asp Asn Glu Lys
180
<210> 14
<211> 184
<212> PRT
<213> 嗜纤维梭菌
<400> 14
Asp Thr Thr Val Ser Arg Lys Leu Met Asp Leu Glu Val Phe Lys Ser
1 5 10 15
Ala Ser Ile Thr Gly Trp Ser Gly Ser Ala Gly Gly Glu Leu Glu Val
20 25 30
Ala Ser Asp Ser Asn Leu Pro Ile Asp Thr Ser Ala Thr Tyr Asn Gly
35 40 45
Leu Pro Ser Leu Arg Leu Asn Val Thr Lys Ala Ser Ala Gln Trp Trp
50 55 60
Ser Ser Leu Leu Thr Leu Arg Gly Trp Cys Thr Gln Asp Leu Thr Gln
65 70 75 80
Tyr Leu Ala Asn Gly Tyr Leu Glu Phe Asn Val Lys Gly Lys Val Gly
85 90 95
Gly Glu Asp Phe Gln Ile Gly Leu Gln Asp Gln Thr His Glu Arg Ala
100 105 110
Ala Gly Asp Ser Val Thr Ser Val Lys Ser Ile Lys Asn Tyr Val Asn
115 120 125
Ile Ser Thr Asn Trp Gln His Val Lys Ile Pro Leu Lys Asp Ile Met
130 135 140
Gly Pro Ser Thr Gly Phe Asp Pro Thr Thr Ala Arg Cys Ile Asn Ile
145 150 155 160
Val Lys Gly Ser Ser Glu Ile Phe Thr Ala Trp Ile Asn Asp Leu Lys
165 170 175
Ile Thr Ser Thr Asp Asn Glu Lys
180
<210> 15
<211> 1083
<212> DNA
<213> 嗜纤维梭菌
<220>
<221> CDS
<222> (1)..(1083)
<400> 15
ttg tgg gat ttc aac gac ggc acc aag cag ggc ttc ggc gtc aac ggc 48
Leu Trp Asp Phe Asn Asp Gly Thr Lys Gln Gly Phe Gly Val Asn Gly
1 5 10 15
gat tcc cct gtc gaa gat gtg gtc atc gag aac gag gca ggt gcc ttg 96
Asp Ser Pro Val Glu Asp Val Val Ile Glu Asn Glu Ala Gly Ala Leu
20 25 30
aag ctc tcc ggc ttg gat gcc tcc aac gac gtc tcg gag gga aac tac 144
Lys Leu Ser Gly Leu Asp Ala Ser Asn Asp Val Ser Glu Gly Asn Tyr
35 40 45
tgg gca aac gcg agg ctc tcg gca gat gga tgg ggc aaa tcg gtg gac 192
Trp Ala Asn Ala Arg Leu Ser Ala Asp Gly Trp Gly Lys Ser Val Asp
50 55 60
att ttg ggt gca gag aaa ctc acc atg gat gtc atc gtg gac gaa ccg 240
Ile Leu Gly Ala Glu Lys Leu Thr Met Asp Val Ile Val Asp Glu Pro
65 70 75 80
acg acc gtc tcc att gca gcc atc cct cag ggt cct tcc gcg aac tgg 288
Thr Thr Val Ser Ile Ala Ala Ile Pro Gln Gly Pro Ser Ala Asn Trp
85 90 95
gtg aac ccc aac cgt gcc att aag gtc gag ccc acc aac ttc gtg ccc 336
Val Asn Pro Asn Arg Ala Ile Lys Val Glu Pro Thr Asn Phe Val Pro
100 105 110
ttg ggc gat aag ttc aag gcg gaa ctc aca atc acg tcc gca gac tcg 384
Leu Gly Asp Lys Phe Lys Ala Glu Leu Thr Ile Thr Ser Ala Asp Ser
115 120 125
cct tcc ctc gaa gca att gcc atg cac gca gag aac aac aac atc aac 432
Pro Ser Leu Glu Ala Ile Ala Met His Ala Glu Asn Asn Asn Ile Asn
130 135 140
aac atc atc ctc ttc gtg gga acg gaa ggt gcc gac gtc att tac ctc 480
Asn Ile Ile Leu Phe Val Gly Thr Glu Gly Ala Asp Val Ile Tyr Leu
145 150 155 160
gat aac atc aaa gtg atc ggt aca gaa gtg gaa att ccc gtg gtc cac 528
Asp Asn Ile Lys Val Ile Gly Thr Glu Val Glu Ile Pro Val Val His
165 170 175
gat ccc aag ggc gag gcc gtg ctc ccc tcg gtc ttc gaa gat ggt acc 576
Asp Pro Lys Gly Glu Ala Val Leu Pro Ser Val Phe Glu Asp Gly Thr
180 185 190
agg cag gga tgg gat tgg gca ggt gag tcg ggt gtg aag act gcc ctc 624
Arg Gln Gly Trp Asp Trp Ala Gly Glu Ser Gly Val Lys Thr Ala Leu
195 200 205
aca atc gag gaa gcc aac gga tcg aac gcg ctc tcc tgg gaa ttc ggc 672
Thr Ile Glu Glu Ala Asn Gly Ser Asn Ala Leu Ser Trp Glu Phe Gly
210 215 220
tac ccc gaa gtc aaa ccg tcg gac aac tgg gca aca gca ccg agg ctc 720
Tyr Pro Glu Val Lys Pro Ser Asp Asn Trp Ala Thr Ala Pro Arg Leu
225 230 235 240
gac ttc tgg aag tcg gac ttg gtg agg gga gag aac gac tac gtg act 768
Asp Phe Trp Lys Ser Asp Leu Val Arg Gly Glu Asn Asp Tyr Val Thr
245 250 255
ttc gac ttc tat ctc gat cct gtg agg gca acc gaa ggc gca atg aac 816
Phe Asp Phe Tyr Leu Asp Pro Val Arg Ala Thr Glu Gly Ala Met Asn
260 265 270
att aac ctc gtc ttc cag cct ccc acg aac gga tac tgg gtg cag gca 864
Ile Asn Leu Val Phe Gln Pro Pro Thr Asn Gly Tyr Trp Val Gln Ala
275 280 285
cct aaa act tac acc atc aac ttc gat gag ctc gaa gag gcc aac cag 912
Pro Lys Thr Tyr Thr Ile Asn Phe Asp Glu Leu Glu Glu Ala Asn Gln
290 295 300
gtg aac ggc ttg tat cac tac gag gtc aag att aac gtc cgc gat atc 960
Val Asn Gly Leu Tyr His Tyr Glu Val Lys Ile Asn Val Arg Asp Ile
305 310 315 320
aca aac atc cag gac gac aca ctc ttg agg aac atg atg atc atc ttc 1008
Thr Asn Ile Gln Asp Asp Thr Leu Leu Arg Asn Met Met Ile Ile Phe
325 330 335
gcc gac gtc gaa tcg gat ttc gca gga cgc gtc ttc gtg gac aac gtc 1056
Ala Asp Val Glu Ser Asp Phe Ala Gly Arg Val Phe Val Asp Asn Val
340 345 350
cgg ttc gag gga gca gcg acc act gag 1083
Arg Phe Glu Gly Ala Ala Thr Thr Glu
355 360
<210> 16
<211> 361
<212> PRT
<213> 嗜纤维梭菌
<400> 16
Leu Trp Asp Phe Asn Asp Gly Thr Lys Gln Gly Phe Gly Val Asn Gly
1 5 10 15
Asp Ser Pro Val Glu Asp Val Val Ile Glu Asn Glu Ala Gly Ala Leu
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Lys Leu Ser Gly Leu Asp Ala Ser Asn Asp Val Ser Glu Gly Asn Tyr
35 40 45
Trp Ala Asn Ala Arg Leu Ser Ala Asp Gly Trp Gly Lys Ser Val Asp
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Ile Leu Gly Ala Glu Lys Leu Thr Met Asp Val Ile Val Asp Glu Pro
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Thr Thr Val Ser Ile Ala Ala Ile Pro Gln Gly Pro Ser Ala Asn Trp
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Val Asn Pro Asn Arg Ala Ile Lys Val Glu Pro Thr Asn Phe Val Pro
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Leu Gly Asp Lys Phe Lys Ala Glu Leu Thr Ile Thr Ser Ala Asp Ser
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Pro Ser Leu Glu Ala Ile Ala Met His Ala Glu Asn Asn Asn Ile Asn
130 135 140
Asn Ile Ile Leu Phe Val Gly Thr Glu Gly Ala Asp Val Ile Tyr Leu
145 150 155 160
Asp Asn Ile Lys Val Ile Gly Thr Glu Val Glu Ile Pro Val Val His
165 170 175
Asp Pro Lys Gly Glu Ala Val Leu Pro Ser Val Phe Glu Asp Gly Thr
180 185 190
Arg Gln Gly Trp Asp Trp Ala Gly Glu Ser Gly Val Lys Thr Ala Leu
195 200 205
Thr Ile Glu Glu Ala Asn Gly Ser Asn Ala Leu Ser Trp Glu Phe Gly
210 215 220
Tyr Pro Glu Val Lys Pro Ser Asp Asn Trp Ala Thr Ala Pro Arg Leu
225 230 235 240
Asp Phe Trp Lys Ser Asp Leu Val Arg Gly Glu Asn Asp Tyr Val Thr
245 250 255
Phe Asp Phe Tyr Leu Asp Pro Val Arg Ala Thr Glu Gly Ala Met Asn
260 265 270
Ile Asn Leu Val Phe Gln Pro Pro Thr Asn Gly Tyr Trp Val Gln Ala
275 280 285
Pro Lys Thr Tyr Thr Ile Asn Phe Asp Glu Leu Glu Glu Ala Asn Gln
290 295 300
Val Asn Gly Leu Tyr His Tyr Glu Val Lys Ile Asn Val Arg Asp Ile
305 310 315 320
Thr Asn Ile Gln Asp Asp Thr Leu Leu Arg Asn Met Met Ile Ile Phe
325 330 335
Ala Asp Val Glu Ser Asp Phe Ala Gly Arg Val Phe Val Asp Asn Val
340 345 350
Arg Phe Glu Gly Ala Ala Thr Thr Glu
355 360
<210> 17
<211> 166
<212> PRT
<213> 嗜纤维梭菌
<400> 17
Leu Trp Asp Phe Asn Asp Gly Thr Lys Gln Gly Phe Gly Val Asn Gly
1 5 10 15
Asp Ser Pro Val Glu Asp Val Val Ile Glu Asn Glu Ala Gly Ala Leu
20 25 30
Lys Leu Ser Gly Leu Asp Ala Ser Asn Asp Val Ser Glu Gly Asn Tyr
35 40 45
Trp Ala Asn Ala Arg Leu Ser Ala Asp Gly Trp Gly Lys Ser Val Asp
50 55 60
Ile Leu Gly Ala Glu Lys Leu Thr Met Asp Val Ile Val Asp Glu Pro
65 70 75 80
Thr Thr Val Ser Ile Ala Ala Ile Pro Gln Gly Pro Ser Ala Asn Trp
85 90 95
Val Asn Pro Asn Arg Ala Ile Lys Val Glu Pro Thr Asn Phe Val Pro
100 105 110
Leu Gly Asp Lys Phe Lys Ala Glu Leu Thr Ile Thr Ser Ala Asp Ser
115 120 125
Pro Ser Leu Glu Ala Ile Ala Met His Ala Glu Asn Asn Asn Ile Asn
130 135 140
Asn Ile Ile Leu Phe Val Gly Thr Glu Gly Ala Asp Val Ile Tyr Leu
145 150 155 160
Asp Asn Ile Lys Val Ile
165
<210> 18
<211> 195
<212> PRT
<213> 嗜纤维梭菌
<400> 18
Gly Thr Glu Val Glu Ile Pro Val Val His Asp Pro Lys Gly Glu Ala
1 5 10 15
Val Leu Pro Ser Val Phe Glu Asp Gly Thr Arg Gln Gly Trp Asp Trp
20 25 30
Ala Gly Glu Ser Gly Val Lys Thr Ala Leu Thr Ile Glu Glu Ala Asn
35 40 45
Gly Ser Asn Ala Leu Ser Trp Glu Phe Gly Tyr Pro Glu Val Lys Pro
50 55 60
Ser Asp Asn Trp Ala Thr Ala Pro Arg Leu Asp Phe Trp Lys Ser Asp
65 70 75 80
Leu Val Arg Gly Glu Asn Asp Tyr Val Thr Phe Asp Phe Tyr Leu Asp
85 90 95
Pro Val Arg Ala Thr Glu Gly Ala Met Asn Ile Asn Leu Val Phe Gln
100 105 110
Pro Pro Thr Asn Gly Tyr Trp Val Gln Ala Pro Lys Thr Tyr Thr Ile
115 120 125
Asn Phe Asp Glu Leu Glu Glu Ala Asn Gln Val Asn Gly Leu Tyr His
130 135 140
Tyr Glu Val Lys Ile Asn Val Arg Asp Ile Thr Asn Ile Gln Asp Asp
145 150 155 160
Thr Leu Leu Arg Asn Met Met Ile Ile Phe Ala Asp Val Glu Ser Asp
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Phe Ala Gly Arg Val Phe Val Asp Asn Val Arg Phe Glu Gly Ala Ala
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Thr Thr Glu
195
<210> 19
<211> 456
<212> DNA
<213> 粪碱纤维单胞菌
<220>
<221> CDS
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<400> 19
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20 25 30
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Cys Val Ala Val Pro Ala Gly Ser Ala Gln Tyr Gly Val Gly Val Val
35 40 45
ttg aac gga gtc gca atc gag gag ggt acc acg tat acg ctc cgt tat 192
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50 55 60
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Thr Ala Thr Ala Ser Thr Asp Val Thr Val Arg Ala Leu Val Gly Gln
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Asn Gly Ala Pro Tyr Gly Thr Val Leu Asp Thr Ser Pro Ala Leu Thr
85 90 95
tcc gaa cct cga cag gtc acc gaa acc ttc aca gca tcg gca act tat 336
Ser Glu Pro Arg Gln Val Thr Glu Thr Phe Thr Ala Ser Ala Thr Tyr
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cct gca acg cct gca gca gat gat cct gag ggt cag atc gca ttc cag 384
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ttg gga ggc ttc tcg gca gat gca tgg acc ttc tgt ttg gat gat gtc 432
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<210> 20
<211> 152
<212> PRT
<213> 粪碱纤维单胞菌
<400> 20
Ala Ser Pro Ile Gly Glu Gly Thr Phe Asp Asp Gly Pro Glu Gly Trp
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Val Ala Tyr Gly Thr Asp Gly Pro Leu Asp Thr Ser Thr Gly Ala Leu
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Pro Ala Thr Pro Ala Ala Asp Asp Pro Glu Gly Gln Ile Ala Phe Gln
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Ala Leu Asp Ser Glu Val Glu Leu
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<210> 21
<211> 19
<212> PRT
<213> 人工序列
<220>
<223> 信号肽序列
<400> 21
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1 5 10 15
Val Ser Ala
Claims (18)
1.CBM家族1碳水化合物结合模块在织物或纺织品的清洁过程中用于减少褶皱和/或提供增加的抗折痕特性和/或提供改进的熨烫容易性和/或提供改进的形状保持性的用途,其中该CBM家族1碳水化合物结合模块是SEQ ID NO:2、SEQ ID NO:4、SEQ ID NO:6之一所示的多肽,其中该CBM家族1碳水化合物结合模块不与酶附接,其中使该织物或纺织品与包含所述CBM家族1的碳水化合物结合模块的液体溶液接触。
2.如权利要求1所述的用途,其中该液体溶液为洗涤液。
3.如权利要求1或2所述的用途,作为洗衣增效剂提供。
4.如权利要求1或2所述的用途,其中该碳水化合物结合模块是细菌或真菌来源的。
5.如权利要求1或2所述的用途,其中该碳水化合物结合模块来源于具有糖苷水解酶、木聚糖酶、内切葡聚糖酶活性的多肽。
6.如权利要求2所述的用途,其中所述液体溶液进一步含有选自CBM家族4、17、28、30、44、72、79及其混合物的碳水化合物结合模块。
7.如权利要求1或2所述的用途,其中当根据AATCC的AATCC平滑度标准平均SA值评估纺织品时,这些褶皱减少至少0.20个单位。
8.如权利要求1或2所述的用途,其中测试专门小组成员优选用碳水化合物结合模块洗涤的织物与测试专门小组成员优选不用碳水化合物结合模块洗涤的织物的抗折痕效果比为至少60:40。
9.如权利要求1或2所述的用途,其中测试专门小组成员优选用碳水化合物结合模块洗涤的织物与测试专门小组成员优选不用碳水化合物结合模块洗涤的织物的改进的柔软性效果比为至少60:40。
10.如权利要求1或2所述的用途,其中这些织物或纺织品选自含棉纺织品。
11.一种洗涤剂组合物,其包含CBM家族1碳水化合物结合模块,其中该CBM家族1碳水化合物结合模块不与酶附接,其中该CBM家族1碳水化合物结合模块是SEQ ID NO:2、SEQ IDNO:4、SEQ ID NO:6之一所示的多肽。
12.如权利要求11所述的洗涤剂组合物,其中该组合物还包含选自CBM家族4、17、28、30、44、72、79或其混合物的碳水化合物结合模块。
13.如权利要求11或12所述的洗涤剂组合物,其进一步包含选自以下的一种或多种酶:蛋白酶、脂肪酶、角质酶、淀粉酶、碳水化合物酶、纤维素酶、果胶酶、甘露聚糖酶、阿拉伯糖酶、半乳聚糖酶、木聚糖酶、氧化酶、核酸酶。
14.如权利要求11或12所述的洗涤剂组合物,其进一步包含一种或多种清洁组合物组分。
15.一种洗衣增效剂组合物,用于与洗涤剂组合物结合使用,该洗衣增效剂组合物包含CBM家族1碳水化合物结合模块,其中该CBM家族1碳水化合物结合模块不与酶附接,其中该CBM家族1碳水化合物结合模块是SEQ ID NO:2、SEQ ID NO:4、SEQ ID NO:6之一所示的多肽。
16.如权利要求15所述的洗衣增效剂组合物,其中该组合物还包含选自CBM家族4、17、28、30、44、72、79或其混合物的碳水化合物结合模块。
17.如权利要求11-14中任一项所述的洗涤剂组合物或如权利要求15-16中任一项所述的洗衣增效剂组合物用于洗涤纺织品的用途。
18.如权利要求17所述的用途,其中与使用不含所述碳水化合物结合模块的相同洗涤剂组合物相比,纺织品的褶皱减少。
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PCT/EP2019/059510 WO2019201793A1 (en) | 2018-04-17 | 2019-04-12 | Polypeptides comprising carbohydrate binding activity in detergent compositions and their use in reducing wrinkles in textile or fabric. |
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US20210009927A1 (en) | 2021-01-14 |
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CN112262207A (zh) | 2021-01-22 |
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