CN1104432C - 吡咯并三嗪和嘧啶化合物 - Google Patents

吡咯并三嗪和嘧啶化合物 Download PDF

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Publication number
CN1104432C
CN1104432C CN97196525A CN97196525A CN1104432C CN 1104432 C CN1104432 C CN 1104432C CN 97196525 A CN97196525 A CN 97196525A CN 97196525 A CN97196525 A CN 97196525A CN 1104432 C CN1104432 C CN 1104432C
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China
Prior art keywords
compound
ome
formula
preferred
alkyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CN97196525A
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English (en)
Chinese (zh)
Other versions
CN1225637A (zh
Inventor
A·G·阿范尼蒂斯
R·J·乔尔瓦特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
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Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Priority claimed from US08/899,242 external-priority patent/US6124289A/en
Publication of CN1225637A publication Critical patent/CN1225637A/zh
Application granted granted Critical
Publication of CN1104432C publication Critical patent/CN1104432C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Coloring (AREA)
CN97196525A 1996-07-24 1997-07-23 吡咯并三嗪和嘧啶化合物 Expired - Lifetime CN1104432C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US68604796A 1996-07-24 1996-07-24
US2329096P 1996-07-24 1996-07-24
US60/023,290 1996-07-24
US08/686,047 1996-07-24
US08/899,242 1997-07-23
US08/899,242 US6124289A (en) 1996-07-24 1997-07-23 Azolo triazines and pyrimidines

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN 01120849 Division CN1250223C (zh) 1996-07-24 2001-05-30 吡咯并三嗪和嘧啶化合物
CN 02118589 Division CN1388126A (zh) 1996-07-24 2002-04-25 吡咯并三嗪和嘧啶化合物

Publications (2)

Publication Number Publication Date
CN1225637A CN1225637A (zh) 1999-08-11
CN1104432C true CN1104432C (zh) 2003-04-02

Family

ID=27362048

Family Applications (3)

Application Number Title Priority Date Filing Date
CN97196525A Expired - Lifetime CN1104432C (zh) 1996-07-24 1997-07-23 吡咯并三嗪和嘧啶化合物
CN 01120849 Expired - Lifetime CN1250223C (zh) 1996-07-24 2001-05-30 吡咯并三嗪和嘧啶化合物
CN 02118589 Pending CN1388126A (zh) 1996-07-24 2002-04-25 吡咯并三嗪和嘧啶化合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN 01120849 Expired - Lifetime CN1250223C (zh) 1996-07-24 2001-05-30 吡咯并三嗪和嘧啶化合物
CN 02118589 Pending CN1388126A (zh) 1996-07-24 2002-04-25 吡咯并三嗪和嘧啶化合物

Country Status (15)

Country Link
JP (2) JP4704521B2 (pt)
CN (3) CN1104432C (pt)
AR (1) AR049583A2 (pt)
BR (1) BR9710544A (pt)
CA (1) CA2259583C (pt)
CZ (1) CZ299451B6 (pt)
EA (1) EA004403B1 (pt)
EE (1) EE04316B1 (pt)
HR (1) HRP970413A2 (pt)
IL (4) IL127871A0 (pt)
NO (1) NO315610B1 (pt)
NZ (1) NZ333777A (pt)
PL (1) PL195762B1 (pt)
SI (1) SI9720045B (pt)
SK (1) SK286461B6 (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103694242A (zh) * 2013-12-10 2014-04-02 中国科学院昆明植物研究所 吡唑并嘧啶类化合物及其药物组合物和其在制药中的应用

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4549630B2 (ja) * 2001-03-13 2010-09-22 ブリストル−マイヤーズ スクイブ ファーマ カンパニー コルチコトロピン放出因子受容体リガンドとしての、４−（２−ブチルアミノ）−２，７−ジメチル−８−（２−メチル−６−メトキシピリド−３−イル）ピラゾロ−［１，５−ａ］−１，３，５−トリアジン、その鏡像異性体および薬学的に許容できる塩類
WO2004110454A1 (ja) * 2003-06-13 2004-12-23 Ishihara Sangyo Kaisha, Ltd. アデノシンＡ2ａ受容体アゴニストの投与が必要な疾患を治療又は予防するための組成物
US7329662B2 (en) * 2003-10-03 2008-02-12 Hoffmann-La Roche Inc. Pyrazolo-pyridine
GB0519957D0 (en) * 2005-09-30 2005-11-09 Sb Pharmco Inc Chemical compound
CA2663511C (en) * 2006-09-20 2012-12-04 Eli Lilly And Company Thiazole pyrazolopyrimidines as crf1 receptor antagonists
CN112608316B (zh) * 2019-07-30 2022-10-21 厦门宝太生物科技股份有限公司 一种吡唑并三嗪类腺苷受体拮抗剂
AU2021324839B2 (en) 2020-08-12 2024-02-29 Spruce Biosciences, Inc. Methods and compositions for treating polycystic ovary syndrome
US11708372B2 (en) 2021-11-19 2023-07-25 Spruce Biosciences, Inc. Crystalline composition of tildacerfont and methods of use and preparation thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3995039A (en) * 1975-05-27 1976-11-30 Merck & Co., Inc. Pyrazolo [1,5-a] [1,3,5] triazines
US4824834A (en) * 1986-10-31 1989-04-25 Otsuka Pharmaceutical Company, Limited Pyrazolotriazine compounds
EP0414200A2 (en) * 1989-08-25 1991-02-27 Otsuka Pharmaceutical Factory, Inc. Salts of optically active 4-hydroxy-8-(3-lower alkoxy-4-phenylsulfinylphenyl)pyrazolo [1,5-a]-1,3,5-triazines and a process for production thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6157587A (ja) * 1984-08-29 1986-03-24 Shionogi & Co Ltd 縮合複素環誘導体および抗潰瘍剤
AU639615B2 (en) * 1990-10-09 1993-07-29 Otsuka Pharmaceutical Co., Ltd. Pyrimidine derivative, production thereof, and androgen inhibitor
CA2107479C (en) * 1991-04-22 1997-12-16 Makoto Inoue Pyrazolo[1,5-a]pyrimidine derivatives and anti-inflammatory agent containing the same
US5356897A (en) * 1991-09-09 1994-10-18 Fujisawa Pharmaceutical Co., Ltd. 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3995039A (en) * 1975-05-27 1976-11-30 Merck & Co., Inc. Pyrazolo [1,5-a] [1,3,5] triazines
US4824834A (en) * 1986-10-31 1989-04-25 Otsuka Pharmaceutical Company, Limited Pyrazolotriazine compounds
EP0414200A2 (en) * 1989-08-25 1991-02-27 Otsuka Pharmaceutical Factory, Inc. Salts of optically active 4-hydroxy-8-(3-lower alkoxy-4-phenylsulfinylphenyl)pyrazolo [1,5-a]-1,3,5-triazines and a process for production thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103694242A (zh) * 2013-12-10 2014-04-02 中国科学院昆明植物研究所 吡唑并嘧啶类化合物及其药物组合物和其在制药中的应用
CN103694242B (zh) * 2013-12-10 2016-01-06 昆明翔昊科技有限公司 吡唑并嘧啶类化合物及其药物组合物和其在制药中的应用

Also Published As

Publication number Publication date
JP2002513382A (ja) 2002-05-08
SI9720045A (sl) 1999-10-31
CN1250223C (zh) 2006-04-12
EE9900019A (et) 1999-08-16
JP4704521B2 (ja) 2011-06-15
JP4194539B2 (ja) 2008-12-10
SI9720045B (sl) 2008-02-29
PL195762B1 (pl) 2007-10-31
CZ299451B6 (cs) 2008-07-30
NZ333777A (en) 2000-07-28
CN1388126A (zh) 2003-01-01
NO315610B3 (no) 2003-09-29
EA004403B1 (ru) 2004-04-29
CN1225637A (zh) 1999-08-11
IL164513A (en) 2010-04-29
HRP970413A2 (en) 1998-10-31
PL331523A1 (en) 1999-07-19
IL164513A0 (en) 2005-12-18
SK286461B6 (sk) 2008-10-07
IL127871A0 (en) 1999-10-28
CA2259583C (en) 2009-11-17
NO990264L (no) 1999-03-10
NO315610B1 (no) 2003-09-29
EE04316B1 (et) 2004-06-15
EA199900158A1 (ru) 1999-10-28
CZ18499A3 (cs) 1999-11-17
BR9710544A (pt) 1999-08-17
NO990264D0 (no) 1999-01-21
CA2259583A1 (en) 1998-01-29
AR049583A2 (es) 2006-08-16
IL150163A (en) 2010-12-30
IL127871A (en) 2010-04-29
SK9799A3 (sk) 2005-04-01
CN1327793A (zh) 2001-12-26
JP2005097257A (ja) 2005-04-14

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