CN1103762C - 新的具有抗惊厥活性且4－位上含有二取代氨基的1－芳(烷)基咪唑啉－2－酮类化合物,以及它们的制备方法 - Google Patents

新的具有抗惊厥活性且4－位上含有二取代氨基的1－芳(烷)基咪唑啉－2－酮类化合物,以及它们的制备方法 Download PDF

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Publication number
CN1103762C
CN1103762C CN96197801A CN96197801A CN1103762C CN 1103762 C CN1103762 C CN 1103762C CN 96197801 A CN96197801 A CN 96197801A CN 96197801 A CN96197801 A CN 96197801A CN 1103762 C CN1103762 C CN 1103762C
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CN
China
Prior art keywords
ketone
tetrahydroglyoxaline
compound
phenyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CN96197801A
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English (en)
Chinese (zh)
Other versions
CN1200728A (zh
Inventor
H·J·兰考
M·门泽尔
K·翁弗尔菲尔思
K·格瓦德
H·谢费尔
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Limited liability company
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Arzneimittelwerk Dresden GmbH
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Application filed by Arzneimittelwerk Dresden GmbH filed Critical Arzneimittelwerk Dresden GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN96197801A 1995-09-05 1996-07-26 新的具有抗惊厥活性且4－位上含有二取代氨基的1－芳(烷)基咪唑啉－2－酮类化合物,以及它们的制备方法 Expired - Lifetime CN1103762C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19532668A DE19532668A1 (de) 1995-09-05 1995-09-05 Neue, antikonvulsiv wirkende 1-Ar(alk)yl-imidazolin-2-one, die in 4-Stellung einen disubstituierten Amin-Rest enthalten, und Verfahren zu deren Herstellung
DE19532668.7 1995-09-05

Publications (2)

Publication Number Publication Date
CN1200728A CN1200728A (zh) 1998-12-02
CN1103762C true CN1103762C (zh) 2003-03-26

Family

ID=7771261

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96197801A Expired - Lifetime CN1103762C (zh) 1995-09-05 1996-07-26 新的具有抗惊厥活性且4－位上含有二取代氨基的1－芳(烷)基咪唑啉－2－酮类化合物,以及它们的制备方法

Country Status (31)

Country Link
EP (1) EP0863880B1 (enExample)
JP (1) JP4030578B2 (enExample)
CN (1) CN1103762C (enExample)
AR (1) AR003502A1 (enExample)
AT (1) ATE254606T1 (enExample)
AU (1) AU700602B2 (enExample)
BG (1) BG63917B1 (enExample)
BR (1) BR9610359A (enExample)
CA (1) CA2184871C (enExample)
CZ (1) CZ291839B6 (enExample)
DE (2) DE19532668A1 (enExample)
DK (1) DK0863880T3 (enExample)
EA (1) EA000535B1 (enExample)
EE (1) EE03562B1 (enExample)
ES (1) ES2208758T3 (enExample)
FR (1) FR13C0049I2 (enExample)
GE (1) GEP20022652B (enExample)
HU (1) HU225956B1 (enExample)
IL (1) IL123333A (enExample)
LT (1) LT4482B (enExample)
LU (1) LU92263I2 (enExample)
NO (1) NO313829B1 (enExample)
NZ (1) NZ315624A (enExample)
PL (1) PL188287B1 (enExample)
PT (1) PT863880E (enExample)
SK (1) SK284868B6 (enExample)
TR (1) TR199800476T1 (enExample)
TW (1) TW422838B (enExample)
UA (1) UA46790C2 (enExample)
WO (1) WO1997009314A1 (enExample)
ZA (1) ZA967014B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19721580A1 (de) * 1997-05-23 1998-11-26 Dresden Arzneimittel Verwendung von 1-Ar(alk)yl-imidazolin-2-one zur Behandlung von Angst- und Spannungszuständen
US20050070537A1 (en) 2002-10-10 2005-03-31 Chris Rundfeldt Use of dihydroimidazolones for the treatment of dogs
AU2004255414A1 (en) * 2003-07-11 2005-01-20 Boehringer Ingelheim Vetmedica Gmbh Method of treating or preventing central nervous system disorders with compounds having selectivity for the alpha 3 subunit of the benzodiazepine receptor
EP2093218A1 (en) * 2008-02-22 2009-08-26 Ruggero Fariello Arylalkyl substituted imidazolidinones
KR20140057604A (ko) 2011-08-12 2014-05-13 베링거잉겔하임베트메디카게엠베하 고양잇과 동물의 심부전을 치료 및 예방하는 방법에 사용하기 위한 퍼니 전류 억제제
US9820988B2 (en) 2014-03-24 2017-11-21 Boehringer Ingelheim Vetmedica Gmbh Treatment of epileptic disorders in feline animals
IT202100000782A1 (it) 2021-01-18 2022-07-18 Procos Spa Processo per la sintesi di imepitoina
EP4553066A1 (en) 2023-11-10 2025-05-14 Justesa Imagen S.A.U. Improved process for the synthesis of imepitoin

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932452A (en) * 1975-02-07 1976-01-13 Morton-Norwich Products, Inc. 1-Arylmethyl-2-imidazolidinones

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE790380A (fr) 1971-10-21 1973-04-20 American Cyanamid Co Nouvelles (p-chloro) phenyl-1 methyl-3 imidazolidines, 2,4-disubstituees utiles notamment comme agents diuretiques antialdosterone et leur procede de preparation
US4044021A (en) * 1971-10-21 1977-08-23 American Cyanamid Company Tetrasubstituted imidazolidine diuretics useful in the treatment of hyperaldosteronism

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932452A (en) * 1975-02-07 1976-01-13 Morton-Norwich Products, Inc. 1-Arylmethyl-2-imidazolidinones

Also Published As

Publication number Publication date
TR199800476T1 (xx) 1998-06-22
BG63917B1 (bg) 2003-06-30
EE03562B1 (et) 2001-12-17
ATE254606T1 (de) 2003-12-15
MX9801742A (es) 1998-08-30
LU92263I2 (fr) 2013-10-07
JP4030578B2 (ja) 2008-01-09
TW422838B (en) 2001-02-21
DE19532668A1 (de) 1997-03-06
HUP9802941A3 (en) 1999-10-28
EP0863880B1 (de) 2003-11-19
SK284868B6 (sk) 2006-01-05
EA199800271A1 (ru) 1998-10-29
BG102287A (en) 1998-09-30
NO980906L (no) 1998-03-02
GEP20022652B (en) 2002-03-25
EP0863880A1 (de) 1998-09-16
UA46790C2 (uk) 2002-06-17
HUP9802941A2 (hu) 1999-09-28
AR003502A1 (es) 1998-08-05
HK1015776A1 (en) 1999-10-22
LT98047A (en) 1998-10-26
CA2184871A1 (en) 1997-03-06
EE9800063A (et) 1998-08-17
AU6737596A (en) 1997-03-27
CZ66198A3 (cs) 1998-07-15
PT863880E (pt) 2004-04-30
DE59610827D1 (de) 2003-12-24
FR13C0049I2 (fr) 2014-03-28
JPH11512101A (ja) 1999-10-19
BR9610359A (pt) 1999-07-06
AU700602B2 (en) 1999-01-07
CA2184871C (en) 2001-08-21
HU225956B1 (en) 2008-01-28
EA000535B1 (ru) 1999-10-28
ZA967014B (en) 1997-08-18
SK21698A3 (en) 1998-10-07
LT4482B (lt) 1999-03-25
NO980906D0 (no) 1998-03-02
FR13C0049I1 (enExample) 2013-09-27
NO313829B1 (no) 2002-12-09
PL188287B1 (pl) 2005-01-31
ES2208758T3 (es) 2004-06-16
CN1200728A (zh) 1998-12-02
IL123333A0 (en) 1998-09-24
WO1997009314A1 (de) 1997-03-13
DK0863880T3 (da) 2004-03-22
NZ315624A (en) 1998-11-25
CZ291839B6 (cs) 2003-06-18
PL325413A1 (en) 1998-07-20
IL123333A (en) 2001-10-31

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