AR003502A1 - Compuestos de 1-aril (alquil)-4-aminosustituido -imidazolin-2-ona; procedimiento para prepararlos; composiciones farmaceuticas que los contienen como agente activo y el uso de dichos compuestos para preparar medicamentos antiepilepticos - Google Patents
Compuestos de 1-aril (alquil)-4-aminosustituido -imidazolin-2-ona; procedimiento para prepararlos; composiciones farmaceuticas que los contienen como agente activo y el uso de dichos compuestos para preparar medicamentos antiepilepticosInfo
- Publication number
- AR003502A1 AR003502A1 ARP960104226A AR10422696A AR003502A1 AR 003502 A1 AR003502 A1 AR 003502A1 AR P960104226 A ARP960104226 A AR P960104226A AR 10422696 A AR10422696 A AR 10422696A AR 003502 A1 AR003502 A1 AR 003502A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- prepare
- alkyl
- imidazolin
- contain
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000013543 active substance Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 SUBSTITUTED Chemical class 0.000 title 1
- 230000003556 anti-epileptic effect Effects 0.000 title 1
- 239000001961 anticonvulsive agent Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001037 epileptic effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Nuevos compuestos de 1-ar(alquil)-imidazolin-2-ona, caracterizados porque tienen la fórmula general (I), en la que X = hidrógeno, C1-C4-alquilo, C1-C4-alcoxi, trifluormetilo, halógeno; R1 o, en su caso, R2 = C1-C4-alquilo, cicloalquilo,hete roalquilo o bien R1 y R2 significan en conjunto un grupoalquileno de 2-6 átomos de carbono, en el que un grupo CH2 puede ser sustituido por oxígeno, nitrógeno o azufre. También se propone la preparación de dichoscompuestos, composicionesfarmacéutica s que los contienen como agente activo para el tratamiento de enfermedades epilépticas y la aplicación de dichosderivados en la preparación de las composiciones mencionadas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19532668A DE19532668A1 (de) | 1995-09-05 | 1995-09-05 | Neue, antikonvulsiv wirkende 1-Ar(alk)yl-imidazolin-2-one, die in 4-Stellung einen disubstituierten Amin-Rest enthalten, und Verfahren zu deren Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR003502A1 true AR003502A1 (es) | 1998-08-05 |
Family
ID=7771261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960104226A AR003502A1 (es) | 1995-09-05 | 1996-09-04 | Compuestos de 1-aril (alquil)-4-aminosustituido -imidazolin-2-ona; procedimiento para prepararlos; composiciones farmaceuticas que los contienen como agente activo y el uso de dichos compuestos para preparar medicamentos antiepilepticos |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP0863880B1 (es) |
| JP (1) | JP4030578B2 (es) |
| CN (1) | CN1103762C (es) |
| AR (1) | AR003502A1 (es) |
| AT (1) | ATE254606T1 (es) |
| AU (1) | AU700602B2 (es) |
| BG (1) | BG63917B1 (es) |
| BR (1) | BR9610359A (es) |
| CA (1) | CA2184871C (es) |
| CZ (1) | CZ291839B6 (es) |
| DE (2) | DE19532668A1 (es) |
| DK (1) | DK0863880T3 (es) |
| EA (1) | EA000535B1 (es) |
| EE (1) | EE03562B1 (es) |
| ES (1) | ES2208758T3 (es) |
| FR (1) | FR13C0049I2 (es) |
| GE (1) | GEP20022652B (es) |
| HK (1) | HK1015776A1 (es) |
| HU (1) | HU225956B1 (es) |
| IL (1) | IL123333A (es) |
| LT (1) | LT4482B (es) |
| LU (1) | LU92263I2 (es) |
| NO (1) | NO313829B1 (es) |
| NZ (1) | NZ315624A (es) |
| PL (1) | PL188287B1 (es) |
| PT (1) | PT863880E (es) |
| SK (1) | SK284868B6 (es) |
| TR (1) | TR199800476T1 (es) |
| TW (1) | TW422838B (es) |
| UA (1) | UA46790C2 (es) |
| WO (1) | WO1997009314A1 (es) |
| ZA (1) | ZA967014B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19721580A1 (de) * | 1997-05-23 | 1998-11-26 | Dresden Arzneimittel | Verwendung von 1-Ar(alk)yl-imidazolin-2-one zur Behandlung von Angst- und Spannungszuständen |
| US20050070537A1 (en) * | 2002-10-10 | 2005-03-31 | Chris Rundfeldt | Use of dihydroimidazolones for the treatment of dogs |
| CN101254189A (zh) * | 2003-07-11 | 2008-09-03 | 埃尔比昂股份公司 | 用对苯并二氮杂䓬受体的α3亚基具有选择性的化合物治疗或预防中枢神经系统病症的方法 |
| EP2093218A1 (en) * | 2008-02-22 | 2009-08-26 | Ruggero Fariello | Arylalkyl substituted imidazolidinones |
| BR112014003117A2 (pt) | 2011-08-12 | 2017-06-13 | Boehringer Ingelheim Vetmedica Gmbh | inibidores da corrente funny (if) para uso em um método de tratamento e prevenção de insuficiência cardíaca em felino |
| US9820988B2 (en) | 2014-03-24 | 2017-11-21 | Boehringer Ingelheim Vetmedica Gmbh | Treatment of epileptic disorders in feline animals |
| IT202100000782A1 (it) | 2021-01-18 | 2022-07-18 | Procos Spa | Processo per la sintesi di imepitoina |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE790380A (fr) | 1971-10-21 | 1973-04-20 | American Cyanamid Co | Nouvelles (p-chloro) phenyl-1 methyl-3 imidazolidines, 2,4-disubstituees utiles notamment comme agents diuretiques antialdosterone et leur procede de preparation |
| US4044021A (en) * | 1971-10-21 | 1977-08-23 | American Cyanamid Company | Tetrasubstituted imidazolidine diuretics useful in the treatment of hyperaldosteronism |
| US3932452A (en) * | 1975-02-07 | 1976-01-13 | Morton-Norwich Products, Inc. | 1-Arylmethyl-2-imidazolidinones |
-
1995
- 1995-09-05 DE DE19532668A patent/DE19532668A1/de not_active Ceased
-
1996
- 1996-07-26 JP JP51080097A patent/JP4030578B2/ja not_active Expired - Lifetime
- 1996-07-26 CN CN96197801A patent/CN1103762C/zh not_active Expired - Lifetime
- 1996-07-26 TR TR1998/00476T patent/TR199800476T1/xx unknown
- 1996-07-26 PT PT96927607T patent/PT863880E/pt unknown
- 1996-07-26 UA UA98041717A patent/UA46790C2/uk unknown
- 1996-07-26 GE GEAP19964221A patent/GEP20022652B/en unknown
- 1996-07-26 BR BR9610359A patent/BR9610359A/pt active IP Right Grant
- 1996-07-26 EA EA199800271A patent/EA000535B1/ru not_active IP Right Cessation
- 1996-07-26 CZ CZ1998661A patent/CZ291839B6/cs not_active IP Right Cessation
- 1996-07-26 DK DK96927607T patent/DK0863880T3/da active
- 1996-07-26 PL PL96325413A patent/PL188287B1/pl unknown
- 1996-07-26 WO PCT/EP1996/003295 patent/WO1997009314A1/de active IP Right Grant
- 1996-07-26 NZ NZ315624A patent/NZ315624A/en not_active IP Right Cessation
- 1996-07-26 IL IL12333396A patent/IL123333A/en not_active IP Right Cessation
- 1996-07-26 ES ES96927607T patent/ES2208758T3/es not_active Expired - Lifetime
- 1996-07-26 DE DE59610827T patent/DE59610827D1/de not_active Expired - Lifetime
- 1996-07-26 AU AU67375/96A patent/AU700602B2/en not_active Expired
- 1996-07-26 AT AT96927607T patent/ATE254606T1/de active
- 1996-07-26 EP EP96927607A patent/EP0863880B1/de not_active Expired - Lifetime
- 1996-07-26 EE EE9800063A patent/EE03562B1/xx unknown
- 1996-07-26 SK SK216-98A patent/SK284868B6/sk not_active IP Right Cessation
- 1996-07-26 HU HU9802941A patent/HU225956B1/hu unknown
- 1996-08-19 ZA ZA967014A patent/ZA967014B/xx unknown
- 1996-09-03 TW TW085110749A patent/TW422838B/zh not_active IP Right Cessation
- 1996-09-04 AR ARP960104226A patent/AR003502A1/es active IP Right Grant
- 1996-09-05 CA CA002184871A patent/CA2184871C/en not_active Expired - Lifetime
-
1998
- 1998-02-27 BG BG102287A patent/BG63917B1/bg unknown
- 1998-03-02 NO NO19980906A patent/NO313829B1/no not_active IP Right Cessation
- 1998-04-03 LT LT98-047A patent/LT4482B/lt not_active IP Right Cessation
-
1999
- 1999-03-01 HK HK99100827A patent/HK1015776A1/xx not_active IP Right Cessation
-
2013
- 2013-08-07 LU LU92263C patent/LU92263I2/fr unknown
- 2013-08-13 FR FR13C0049C patent/FR13C0049I2/fr active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |