CA2184871A1 - Anticonvulsive 1-ar(alk)ylimidazolin-2-ones, and process for making - Google Patents
Anticonvulsive 1-ar(alk)ylimidazolin-2-ones, and process for makingInfo
- Publication number
- CA2184871A1 CA2184871A1 CA002184871A CA2184871A CA2184871A1 CA 2184871 A1 CA2184871 A1 CA 2184871A1 CA 002184871 A CA002184871 A CA 002184871A CA 2184871 A CA2184871 A CA 2184871A CA 2184871 A1 CA2184871 A1 CA 2184871A1
- Authority
- CA
- Canada
- Prior art keywords
- making
- ylimidazolin
- anticonvulsive
- alk
- ones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002082 anti-convulsion Effects 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compounds having anticonsulive activity, of the formula 1 (I) in which X is hydrogen, a C1-4-alkyl, C1-4 alkoxy, trifluoromethyl, or halogen residue, R1 and R2 are independently of each other C1-4-alkyl, cycloalkyl or heteroalkyl, or R1 and R2 are together a C2-6 alkylene reside in which a-CH2-group is optionally replaced by oxygen, nitrogen or sulfur, m is 0 or 1, and n is 0 or a cardinal number from 1 to 5.
The application also relates to a process for making the compound of formula (I).
The application also relates to a process for making the compound of formula (I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19532668A DE19532668A1 (en) | 1995-09-05 | 1995-09-05 | Novel, anticonvulsant 1-ar (alk) yl-imidazolin-2-ones which contain a disubstituted amine radical in the 4-position, and process for their preparation |
| DE19532668.7 | 1995-09-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2184871A1 true CA2184871A1 (en) | 1997-03-06 |
| CA2184871C CA2184871C (en) | 2001-08-21 |
Family
ID=7771261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002184871A Expired - Lifetime CA2184871C (en) | 1995-09-05 | 1996-09-05 | Anticonvulsive 1-ar(alk)ylimidazolin-2-ones, and process for making |
Country Status (32)
| Country | Link |
|---|---|
| EP (1) | EP0863880B1 (en) |
| JP (1) | JP4030578B2 (en) |
| CN (1) | CN1103762C (en) |
| AR (1) | AR003502A1 (en) |
| AT (1) | ATE254606T1 (en) |
| AU (1) | AU700602B2 (en) |
| BG (1) | BG63917B1 (en) |
| BR (1) | BR9610359A (en) |
| CA (1) | CA2184871C (en) |
| CZ (1) | CZ291839B6 (en) |
| DE (2) | DE19532668A1 (en) |
| DK (1) | DK0863880T3 (en) |
| EA (1) | EA000535B1 (en) |
| EE (1) | EE03562B1 (en) |
| ES (1) | ES2208758T3 (en) |
| FR (1) | FR13C0049I2 (en) |
| GE (1) | GEP20022652B (en) |
| HK (1) | HK1015776A1 (en) |
| HU (1) | HU225956B1 (en) |
| IL (1) | IL123333A (en) |
| LT (1) | LT4482B (en) |
| LU (1) | LU92263I2 (en) |
| NO (1) | NO313829B1 (en) |
| NZ (1) | NZ315624A (en) |
| PL (1) | PL188287B1 (en) |
| PT (1) | PT863880E (en) |
| SK (1) | SK284868B6 (en) |
| TR (1) | TR199800476T1 (en) |
| TW (1) | TW422838B (en) |
| UA (1) | UA46790C2 (en) |
| WO (1) | WO1997009314A1 (en) |
| ZA (1) | ZA967014B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19721580A1 (en) * | 1997-05-23 | 1998-11-26 | Dresden Arzneimittel | Use of 1-ar (alk) yl-imidazolin-2-one for the treatment of anxiety and tension |
| US20050070537A1 (en) | 2002-10-10 | 2005-03-31 | Chris Rundfeldt | Use of dihydroimidazolones for the treatment of dogs |
| JP2009513539A (en) * | 2003-07-11 | 2009-04-02 | ベーリンガー・インゲルハイム・フエトメデイカ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | Methods for treating or preventing central nervous system disorders using compounds having selectivity for the alpha 3 subunit of a benzodiazepine receptor |
| EP2093218A1 (en) * | 2008-02-22 | 2009-08-26 | Ruggero Fariello | Arylalkyl substituted imidazolidinones |
| MX2014001556A (en) | 2011-08-12 | 2014-03-31 | Boehringer Ingelheim Vetmed | Taste masked pharmaceutical composition. |
| US9820988B2 (en) | 2014-03-24 | 2017-11-21 | Boehringer Ingelheim Vetmedica Gmbh | Treatment of epileptic disorders in feline animals |
| IT202100000782A1 (en) | 2021-01-18 | 2022-07-18 | Procos Spa | PROCESS FOR THE SYNTHESIS OF IMEPITOIN |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE790380A (en) | 1971-10-21 | 1973-04-20 | American Cyanamid Co | NEW (P-CHLORO) PHENYL-1 METHYL-3 IMIDAZOLIDINES, 2,4-DISUBSTITUTIONS USEFUL IN PARTICULAR AS ANTIALDOSTERONE DIURETIC AGENTS AND THEIR PREPARATION PROCESS |
| US4044021A (en) * | 1971-10-21 | 1977-08-23 | American Cyanamid Company | Tetrasubstituted imidazolidine diuretics useful in the treatment of hyperaldosteronism |
| US3932452A (en) * | 1975-02-07 | 1976-01-13 | Morton-Norwich Products, Inc. | 1-Arylmethyl-2-imidazolidinones |
-
1995
- 1995-09-05 DE DE19532668A patent/DE19532668A1/en not_active Ceased
-
1996
- 1996-07-26 CZ CZ1998661A patent/CZ291839B6/en not_active IP Right Cessation
- 1996-07-26 PL PL96325413A patent/PL188287B1/en unknown
- 1996-07-26 JP JP51080097A patent/JP4030578B2/en not_active Expired - Lifetime
- 1996-07-26 AT AT96927607T patent/ATE254606T1/en active
- 1996-07-26 UA UA98041717A patent/UA46790C2/en unknown
- 1996-07-26 GE GEAP19964221A patent/GEP20022652B/en unknown
- 1996-07-26 IL IL12333396A patent/IL123333A/en not_active IP Right Cessation
- 1996-07-26 WO PCT/EP1996/003295 patent/WO1997009314A1/en active IP Right Grant
- 1996-07-26 EE EE9800063A patent/EE03562B1/en unknown
- 1996-07-26 HU HU9802941A patent/HU225956B1/en unknown
- 1996-07-26 SK SK216-98A patent/SK284868B6/en not_active IP Right Cessation
- 1996-07-26 PT PT96927607T patent/PT863880E/en unknown
- 1996-07-26 CN CN96197801A patent/CN1103762C/en not_active Expired - Lifetime
- 1996-07-26 DK DK96927607T patent/DK0863880T3/en active
- 1996-07-26 EA EA199800271A patent/EA000535B1/en not_active IP Right Cessation
- 1996-07-26 NZ NZ315624A patent/NZ315624A/en not_active IP Right Cessation
- 1996-07-26 DE DE59610827T patent/DE59610827D1/en not_active Expired - Lifetime
- 1996-07-26 EP EP96927607A patent/EP0863880B1/en not_active Expired - Lifetime
- 1996-07-26 AU AU67375/96A patent/AU700602B2/en not_active Expired
- 1996-07-26 TR TR1998/00476T patent/TR199800476T1/en unknown
- 1996-07-26 BR BR9610359A patent/BR9610359A/en active IP Right Grant
- 1996-07-26 ES ES96927607T patent/ES2208758T3/en not_active Expired - Lifetime
- 1996-08-19 ZA ZA967014A patent/ZA967014B/en unknown
- 1996-09-03 TW TW085110749A patent/TW422838B/en not_active IP Right Cessation
- 1996-09-04 AR ARP960104226A patent/AR003502A1/en active IP Right Grant
- 1996-09-05 CA CA002184871A patent/CA2184871C/en not_active Expired - Lifetime
-
1998
- 1998-02-27 BG BG102287A patent/BG63917B1/en unknown
- 1998-03-02 NO NO19980906A patent/NO313829B1/en not_active IP Right Cessation
- 1998-04-03 LT LT98-047A patent/LT4482B/en not_active IP Right Cessation
-
1999
- 1999-03-01 HK HK99100827A patent/HK1015776A1/en not_active IP Right Cessation
-
2013
- 2013-08-07 LU LU92263C patent/LU92263I2/en unknown
- 2013-08-13 FR FR13C0049C patent/FR13C0049I2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8702926A1 (en) | Novel cyclosporins | |
| ATE37375T1 (en) | PHOSPHONYL HYDROXYACYL AMINO ACID DERIVATIVES AND THEIR USE AS ANTIHYPERTENSIVES. | |
| CA2284468A1 (en) | Anti-inflammatory compounds | |
| AU5448586A (en) | Improvements in or relating to organic compounds | |
| EP1126836A4 (en) | Benzamide potassium channel inhibitors | |
| ATE287759T1 (en) | MEMBRANE AND THEIR USE | |
| CA2276455A1 (en) | Phthalazinones | |
| GB9929552D0 (en) | Compounds | |
| EA199800768A1 (en) | NEW ERYTHROMYCIN DERIVATIVES, METHOD OF THEIR PRODUCTION AND THEIR APPLICATION AS MEDICAL DOCUMENTS | |
| GB0114185D0 (en) | Compounds | |
| CA2184871A1 (en) | Anticonvulsive 1-ar(alk)ylimidazolin-2-ones, and process for making | |
| DE69504353T2 (en) | REMOVAL OF HYDROGEN SULFIDE FROM FERMENTATION GAS | |
| HUP0002442A2 (en) | N-linked ureas and carbamates of heterocyclic thioesters and pharmaceutical compositions containing them | |
| AU1321697A (en) | Dispersing agent | |
| CA2336129A1 (en) | Ectoparasiticide agents | |
| MXPA04004802A (en) | 1,2,4-triazole derivatives containing a sulphamate group as aromatase inhibitors. | |
| EA199900790A1 (en) | METHODS OF OBTAINING PESTICIDAL INTERMEDIATE COMPOUNDS | |
| ES2010036A6 (en) | Electrochemical cells. | |
| CA2239282A1 (en) | Fused isoindolones as inhibitors of protein kinase c | |
| DE69529680D1 (en) | 2 ', 5'-PHOSPHORTHIOAT / PHOSPHODIESTER OLIGOADENYLATE AND THEIR ANTIVIRAL USE | |
| NO983527D0 (en) | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents | |
| DK0971907T3 (en) | Process for the preparation of 1,3-disubstituted 2-nitroguanidines | |
| NO980309L (en) | Novel, anti-convulsive imidazoline-2,4-dione with an ortho-substituted ar (alk) yl residue at the 1-position, and their preparation | |
| DE69810294D1 (en) | CALIXAREN TUBES AS CATION RECEPTORS | |
| EP1321606A3 (en) | Cylinder lock |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20160906 |