CN108164602A - 流感病毒疫苗及其应用 - Google Patents

流感病毒疫苗及其应用 Download PDF

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Publication number
CN108164602A
CN108164602A CN201710930398.2A CN201710930398A CN108164602A CN 108164602 A CN108164602 A CN 108164602A CN 201710930398 A CN201710930398 A CN 201710930398A CN 108164602 A CN108164602 A CN 108164602A
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Prior art keywords
influenza virus
polypeptide
influenza
domain
hemagglutinin
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Chinese (zh)
Inventor
阿道夫·加西亚-塞斯特
彼得·帕雷斯
佛罗莱恩·克拉默
纳塔利·皮卡
德克·艾根克
拉法尔·A·麦迪纳-席尔瓦
海容
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Icahn School of Medicine at Mount Sinai
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Mount Sinai School of Medicine
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/521—Bacterial cells; Fungal cells; Protozoal cells inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/53—DNA (RNA) vaccination
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    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16123—Virus like particles [VLP]
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16161—Methods of inactivation or attenuation
    • C12N2760/16162—Methods of inactivation or attenuation by genetic engineering
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16171—Demonstrated in vivo effect

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
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  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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CN201710930398.2A 2011-09-20 2012-09-19 流感病毒疫苗及其应用 Pending CN108164602A (zh)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201161536924P 2011-09-20 2011-09-20
US61/536,924 2011-09-20
US201161565899P 2011-12-01 2011-12-01
US61/565,899 2011-12-01
US201261607526P 2012-03-06 2012-03-06
US61/607,526 2012-03-06
US201261648525P 2012-05-17 2012-05-17
US61/648,525 2012-05-17
US201261670108P 2012-07-10 2012-07-10
US61/670,108 2012-07-10
US201261684481P 2012-08-17 2012-08-17
US61/684,481 2012-08-17
CN201280057023.5A CN104185476A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201280057023.5A Division CN104185476A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用

Publications (1)

Publication Number Publication Date
CN108164602A true CN108164602A (zh) 2018-06-15

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CN201710930398.2A Pending CN108164602A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用
CN201280057023.5A Pending CN104185476A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用
CN202310147642.3A Pending CN116162175A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用

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CN201280057023.5A Pending CN104185476A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用
CN202310147642.3A Pending CN116162175A (zh) 2011-09-20 2012-09-19 流感病毒疫苗及其应用

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Country Link
US (3) US10131695B2 (https=)
EP (2) EP4241785B1 (https=)
JP (4) JP6498439B2 (https=)
KR (1) KR20140068205A (https=)
CN (3) CN108164602A (https=)
AR (1) AR090392A1 (https=)
AU (2) AU2012312529B2 (https=)
BR (1) BR112014006694A2 (https=)
CA (1) CA2849434A1 (https=)
EA (1) EA201490659A1 (https=)
ES (1) ES2953393T3 (https=)
HK (1) HK1200102A1 (https=)
IL (2) IL231547B (https=)
IN (1) IN2014CN02114A (https=)
MX (1) MX2014003308A (https=)
SG (1) SG11201400743VA (https=)
WO (1) WO2013043729A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
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CN109096376A (zh) * 2018-09-20 2018-12-28 扬州大学 流感病毒ha多肽、klh偶联多肽及多克隆抗体的制备方法

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