CN108137639B - 烟酰胺单核苷酸衍生物及其用途 - Google Patents

烟酰胺单核苷酸衍生物及其用途 Download PDF

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CN108137639B
CN108137639B CN201680059161.5A CN201680059161A CN108137639B CN 108137639 B CN108137639 B CN 108137639B CN 201680059161 A CN201680059161 A CN 201680059161A CN 108137639 B CN108137639 B CN 108137639B
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CN108137639A (zh
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K·D·诺明顿
D·A·辛克莱
D·利文斯顿
J·M·麦克瑞
B·斯潘肯维斯
J·N·克里姆斯基
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Metro International Biotech LLC
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    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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  • Bioinformatics & Cheminformatics (AREA)
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  • Biomedical Technology (AREA)
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  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
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  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
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  • Heart & Thoracic Surgery (AREA)
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CN201680059161.5A 2015-08-05 2016-08-05 烟酰胺单核苷酸衍生物及其用途 Active CN108137639B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562201447P 2015-08-05 2015-08-05
US62/201,447 2015-08-05
PCT/US2016/045855 WO2017024255A1 (en) 2015-08-05 2016-08-05 Nicotinamide mononucleotide derivatives and their uses

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CN108137639A CN108137639A (zh) 2018-06-08
CN108137639B true CN108137639B (zh) 2021-10-08

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US (6) US9855289B2 (https=)
EP (1) EP3331894B1 (https=)
JP (1) JP6949002B6 (https=)
KR (1) KR102354784B1 (https=)
CN (1) CN108137639B (https=)
AU (1) AU2016302005B2 (https=)
BR (1) BR112018002168B1 (https=)
CA (1) CA2994553C (https=)
DK (1) DK3331894T3 (https=)
EA (1) EA035664B1 (https=)
ES (1) ES2862170T3 (https=)
IL (1) IL257327B (https=)
MX (1) MX2018001363A (https=)
PL (1) PL3331894T3 (https=)
PT (1) PT3331894T (https=)
WO (1) WO2017024255A1 (https=)
ZA (1) ZA201801196B (https=)

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CN113817009A (zh) * 2021-11-23 2021-12-21 中立安(北京)医药科技有限公司 烟酰胺单核苷类衍生物及其制备方法和应用

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GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
US10611790B2 (en) 2015-11-02 2020-04-07 Mitobridge, Inc. Nicotinamide riboside and nicotinamide mononucleotide derivatives for use in the treatments of mitochondrial-related diseases
US10183036B2 (en) 2016-04-20 2019-01-22 ChromaDex Inc. Use of nicotinic acid riboside or nicotinamide riboside derivatives, and reduced derivatives thereof, as NAD+ increasing precursors
US20200009170A1 (en) * 2016-09-13 2020-01-09 Megumi Tanaka Sleep display agent property and method for improving sleep disorders
EP3642214A2 (en) * 2017-06-19 2020-04-29 Gangadhara Ganapati Nicotinamide riboside derivatives and their uses
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JP7287948B2 (ja) * 2018-03-22 2023-06-06 オリエンタル酵母工業株式会社 多分化能性幹細胞分化促進剤
US10654883B2 (en) 2018-05-15 2020-05-19 Jumpstart Fertility Pty Ltd Inorganic salts of nicotinic acid mononucleotide as anti-aging agents
EP3897666A2 (en) 2018-12-17 2021-10-27 Mitopower LLC Nicotinyl riboside compounds and their uses
WO2020174492A1 (en) 2019-02-25 2020-09-03 Celagenex Research (India) Pvt. Ltd. Synergistic bioactive compositions for enhancing cellular energy
US11939348B2 (en) 2019-03-22 2024-03-26 Metro International Biotech, Llc Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide
US10618927B1 (en) 2019-03-22 2020-04-14 Metro International Biotech, Llc Compositions and methods for modulation of nicotinamide adenine dinucleotide
CA3139615A1 (en) * 2019-06-05 2020-12-10 Societe Des Produits Nestle S.A. Reduced nicotinamideribosides for the treatment/prevention of liver disease
EP3999518A2 (en) 2019-07-19 2022-05-25 Biosynth AG Method of making nicotinamide ribofuranoside salts, nicotinamide ribofuranoside salts as such, and uses thereof
RS65256B1 (sr) 2019-09-09 2024-03-29 Nuvamid Sa Upotreba nmn za prevenciju i/ili lečenje bola i odgovarajuće kompozicije
FR3100449B1 (fr) 2019-09-09 2022-08-26 Nuvamid Sa Utilisation de NMN pour la prévention et/ou le traitement de la douleur et compositions correspondantes
FR3102058A1 (fr) * 2019-10-18 2021-04-23 Nuvamid Sa Utilisation de NMN pour la prévention et/ou le traitement de la polyarthrite rhumatoïde et compositions correspondantes
CN112823778B (zh) * 2019-11-21 2024-06-14 百瑞全球有限公司 毛发护理组合物及其制备方法
FR3103702B1 (fr) 2019-11-28 2022-02-11 Nuvamid Sa Utilisation de NMN pour la prévention et/ou le traitement de la spondylarthrite ankylosante et compositions correspondantes
FR3106056B1 (fr) 2020-01-13 2021-12-17 Nuvamid Utilisation de NMN pour la prévention et/ou le traitement d’une douleur articulaire induite par l’activité physique et compositions correspondantes
FR3107897B1 (fr) * 2020-03-06 2023-05-26 Nuvamid Sa Dérivés de nicotinamide mononucléotides
FR3108031B1 (fr) 2020-03-12 2024-02-16 Nuvamid Sa Utilisation de NMN pour la prévention et/ou le traitement d’une douleur dorsale et compositions correspondantes
FR3108032B1 (fr) * 2020-03-12 2024-02-16 Nuvamid Sa Utilisation de NMN pour la prévention et/ou le traitement d’une douleur musculaire, ligamentaire ou tendineuse induite par l’activité physique et compositions correspondantes
AU2021247767A1 (en) * 2020-03-30 2022-10-20 Oriental Yeast Co., Ltd. Chromosome-stabilizing agent for stem cells
EP3901160A1 (en) * 2020-04-25 2021-10-27 Nuvamid SA Nicotinamide mononucleotide and nicotinamide riboside derivatives and use thereof in the treatment of viral infections and respiratory complications, in particular caused by influenzavirus or coronavirus
JP2023522383A (ja) * 2020-04-24 2023-05-30 ヌヴァミド エスアー ニコチンアミドモノヌクレオチド及びニコチンアミドリボシド誘導体、並びに特にインフルエンザウィルス又はコロナウィルスによって引き起こされるウィルス感染症及び呼吸器合併症の治療におけるそれらの使用
KR20230006803A (ko) * 2020-05-05 2023-01-11 코나겐 인크. 미생물 공정을 통한 nmn 및 이의 유도체 생산
FR3110410A1 (fr) 2020-05-20 2021-11-26 Nuvamid Sa Compositions cosmétiques anti-âge comprenant de la NMN
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