CN1071334C - 糖肽抗生素衍生物 - Google Patents

糖肽抗生素衍生物 Download PDF

Info

Publication number
CN1071334C
CN1071334C CN95100041A CN95100041A CN1071334C CN 1071334 C CN1071334 C CN 1071334C CN 95100041 A CN95100041 A CN 95100041A CN 95100041 A CN95100041 A CN 95100041A CN 1071334 C CN1071334 C CN 1071334C
Authority
CN
China
Prior art keywords
benzyl
phenyl
alkyl
compound
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN95100041A
Other languages
English (en)
Chinese (zh)
Other versions
CN1119649A (zh
Inventor
R·D·G·库帕
T·I·尼卡斯
M·J·罗德里奎斯
N·J·施奈德
R·C·汤普森
M·J·赛费尔
B·E·哈夫
J·T·夸特罗切
M·A·施塔斯扎克
S·C·韦尔基
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CN1119649A publication Critical patent/CN1119649A/zh
Application granted granted Critical
Publication of CN1071334C publication Critical patent/CN1071334C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN95100041A 1994-01-28 1995-01-27 糖肽抗生素衍生物 Expired - Lifetime CN1071334C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US356413 1989-05-25
US18939394A 1994-01-28 1994-01-28
US189,393 1994-01-28
US35641394A 1994-12-15 1994-12-15
US356,413 1994-12-15
US189393 1998-11-10

Publications (2)

Publication Number Publication Date
CN1119649A CN1119649A (zh) 1996-04-03
CN1071334C true CN1071334C (zh) 2001-09-19

Family

ID=26885101

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95100041A Expired - Lifetime CN1071334C (zh) 1994-01-28 1995-01-27 糖肽抗生素衍生物

Country Status (30)

Country Link
US (1) US5843889A (da)
EP (3) EP1031576B1 (da)
JP (1) JP3756539B2 (da)
KR (1) KR100388867B1 (da)
CN (1) CN1071334C (da)
AT (3) ATE248856T1 (da)
AU (1) AU703106B2 (da)
BR (1) BR9500365A (da)
CA (3) CA2546910C (da)
CO (1) CO4600679A1 (da)
CZ (2) CZ292895B6 (da)
DE (3) DE69532013T2 (da)
DK (3) DK1016670T3 (da)
EG (1) EG25884A (da)
ES (3) ES2204444T3 (da)
FI (3) FI117095B (da)
HU (1) HU225164B1 (da)
IL (1) IL112457A (da)
MY (1) MY128335A (da)
NO (1) NO323103B1 (da)
NZ (1) NZ270387A (da)
PE (1) PE40996A1 (da)
PL (1) PL180961B1 (da)
PT (3) PT667353E (da)
RU (1) RU2145609C1 (da)
SG (1) SG52719A1 (da)
SI (2) SI0667353T1 (da)
TW (1) TW457248B (da)
UA (1) UA43323C2 (da)
YU (1) YU4995A (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101343313B (zh) * 2008-09-03 2011-11-16 南京农业大学 一种葡萄糖二肽类化合物及其制备方法和用途

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
US5919756A (en) * 1996-06-28 1999-07-06 Eli Lilly And Company Amides
ID18900A (id) * 1996-11-21 1998-05-20 Lilly Co Eli Alkilasi menurun dari gliko peptida anti biotik
US5939382A (en) * 1996-11-21 1999-08-17 Eli Lilly And Company Reducing agent for reductive alkylation of glycopeptide antibiotics
US5952466A (en) * 1997-11-12 1999-09-14 Eli Lilly And Company Reductive alkylation of glycopeptide antibiotics
US5919771A (en) * 1997-05-20 1999-07-06 Eli Lilly And Company Urea and thiourea derivatives of glycopeptides
US5977063A (en) * 1997-05-20 1999-11-02 Eli Lilly And Company Alkylated hexapeptides
US5952310A (en) * 1997-05-20 1999-09-14 Eli Lilly And Company Glycopeptide hexapeptides
US5994297A (en) * 1997-08-22 1999-11-30 Eli Lilly And Company Therapy for Staphylococcus aureus
US6518242B1 (en) 1998-02-20 2003-02-11 Theravance, Inc. Derivatives of glycopeptide antibacterial agents
EP1073447B1 (en) 1998-05-01 2007-05-09 Eli Lilly And Company N1-modified glycopeptides
US6710168B1 (en) * 1999-05-19 2004-03-23 The Trustees Of The University Of Princeton Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same
JP2002520422A (ja) * 1998-07-14 2002-07-09 プリンストン ユニバーシティ グリコペプチド抗生物質、グリコペプチド抗生物質のコンビナトリアルライブラリーおよびその作成方法
CZ301184B6 (cs) 1998-12-23 2009-12-02 Theravance, Inc. Glykopeptidový derivát a farmaceutické prostredky, které jej obsahují
WO2001081373A2 (en) * 2000-04-25 2001-11-01 Merck & Co., Inc. Glycopeptide antibacterial compounds and methods of using same
AU2001259306A1 (en) 2000-05-02 2001-11-12 Advanced Medicine, Inc. Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin
US6770621B2 (en) 2000-05-02 2004-08-03 Theravance, Inc. Polyacid glycopeptide derivatives
CN100532392C (zh) * 2000-05-02 2009-08-26 施万制药 还原性烷基化方法
US6872804B2 (en) 2000-06-22 2005-03-29 Theravance, Inc. Glycopeptide disulfide and thioester derivatives
EP1292611B1 (en) 2000-06-22 2008-03-12 Theravance, Inc. Glycopeptide carboxy-saccharide derivatives
UA75083C2 (uk) * 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
US6828299B2 (en) 2000-06-22 2004-12-07 Theravance, Inc. Polyhydroxy glycopeptide derivatives
TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
TWI312785B (en) 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
TWI233932B (en) * 2001-08-24 2005-06-11 Theravance Inc Process for purifying glycopeptide phosphonate derivatives
JP2006503015A (ja) * 2002-08-30 2006-01-26 カー・イュー・ルーベン・リサーチ・アンド・ディベロップメント グリコペプチド抗生物質誘導体
EP1624858B1 (en) 2003-04-09 2018-06-06 Rutgers, the State University of New Jersey Novel encochleation methods
JP2006528704A (ja) 2003-05-27 2006-12-21 セラヴァンス インコーポレーテッド グリコペプチド抗細菌剤と組み合わせたポリエンマクロライド抗真菌剤の使用
DE602004010915T2 (de) 2003-07-22 2008-12-11 Theravance, Inc., South San Francisco Verwendung eines antimykotischen echinocandin-mittels in kombination mit einem antibakteriellen glycopeptid-mittel
EP1818340A4 (en) 2004-11-29 2009-02-25 Univ Nagoya Nat Univ Corp MONOMERIC ANTIBIOTIC DERIVATIVES OF GLYCOPEPTIDES
US7632918B2 (en) 2005-02-28 2009-12-15 Novartis Vaccines And Diagnostics, Inc. Semi-synthetic glycopeptides with antibiotic activity
KR101474818B1 (ko) 2005-04-01 2014-12-19 부케예 테크놀로지스 인코포레이티드 방음용 부직포 재료 및 제조방법
CA2623239C (en) 2005-09-22 2016-07-12 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
CA2623198C (en) 2005-09-22 2014-08-05 Medivas, Llc Bis-(a-amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
TW200808818A (en) 2006-05-26 2008-02-16 Shionogi & Co Glycopeptide antibiotic derivatives
CA2710417A1 (en) 2007-12-26 2009-07-02 Shionogi & Co., Ltd. Glycosylated glycopeptide antibiotic derivatives
EP2260060A4 (en) 2008-04-01 2013-01-16 Univ Cornell ORGANIC SOLUBLE CHITOSA SALT AND CHITOSAN DERIVED BIOMATERIALS MANUFACTURED THEREFROM
WO2012151517A1 (en) 2011-05-05 2012-11-08 Coordinated Program Development, Llc Cochleate compositions and methods of making and using same
CN104418941B (zh) 2013-08-19 2017-11-07 爱斯医药科技(南京)有限公司 万古霉素衍生物、制备方法及其应用
US20160303184A1 (en) 2013-09-23 2016-10-20 Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) Vancomycin-sugar conjugates and uses thereof
MX2017000676A (es) * 2014-07-17 2018-01-11 The Medicines Co Oritavancina de alta pureza y metodo para producir la misma.
RS59851B1 (sr) 2014-11-06 2020-02-28 Xellia Pharmaceuticals Aps Kompozicije glikopeptida
EP3240574A1 (en) * 2014-12-25 2017-11-08 Jawaharlal Nehru Centre For Advanced Scientific Research Glycopeptides and uses thereof
CN106188243B (zh) * 2015-05-05 2020-06-26 博瑞生物医药（苏州）股份有限公司 一种奥利万星的制备方法
CN106467570B (zh) * 2015-08-14 2020-04-07 正大天晴药业集团股份有限公司 糖肽类抗生素的还原烷基化方法
CN107434823B (zh) * 2016-05-26 2021-11-16 江苏恒瑞医药股份有限公司 一种奥利万星中间体a82846b的纯化方法
CN108409837B (zh) * 2018-03-06 2021-09-24 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用
CN109053864B (zh) * 2018-07-10 2021-08-24 丽珠集团新北江制药股份有限公司 一种制备奥利万星的方法
CN109053865B (zh) * 2018-07-20 2021-04-13 丽珠集团新北江制药股份有限公司 一种羧基保护制备奥利万星的方法
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0201251A2 (en) * 1985-04-25 1986-11-12 Eli Lilly And Company Novel glycopeptide derivatives

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3067099A (en) * 1955-09-16 1962-12-04 Lilly Co Eli Vancomycin and method for its preparation
US3338786A (en) * 1966-07-29 1967-08-29 American Cyanamid Co Antibiotic av290 and production thereof
US4552886A (en) * 1982-06-07 1985-11-12 Eli Lilly And Company Fungicidal pyridylmethyl-amines
IT1173329B (it) * 1984-02-21 1987-06-24 Lepetit Spa Procedimento per la trasformazione quantitativa di teicoplanina a2 fattore 1 in teicoplanina a2 fattore 3
GB8415093D0 (en) * 1984-06-13 1984-07-18 Lepetit Spa Antibiotic l 17392
US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
US4643987A (en) * 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
US4639433A (en) * 1985-08-14 1987-01-27 Eli Lilly And Company Glycopeptide derivatives
US4946941A (en) * 1986-01-24 1990-08-07 Shionogi & Co., Ltd. Novel glycopeptide antibiotics
EG18377A (en) * 1986-09-19 1993-04-30 Lilly Co Eli Process for preparing glycopeptide antibiotics
GB8701872D0 (en) * 1987-01-28 1987-03-04 Lepetit Spa N15-alkyl & n15,n15-dialkyl derivatives
US5071749A (en) * 1987-04-16 1991-12-10 Shionogi & Co., Ltd. Glycopetide antibiotic pa-45052-b
GB8726859D0 (en) * 1987-11-17 1987-12-23 Lepetit Spa 22-dechlorotei-coplanins
PT90366A (pt) * 1988-04-28 1989-11-10 Beecham Group Plc Processo para a producao de compostos glicopeptidicos
CA1339808C (en) * 1988-10-19 1998-04-07 Manuel Debono Glycopeptide antibiotics
US5194424A (en) * 1988-12-27 1993-03-16 Gruppo Lepetit Spa C63 -amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-teicoplanin and their use as medicaments against bacteria resistant to glycopeptide antibiotics
US5185320A (en) * 1989-04-03 1993-02-09 Gruppo Lepetit S.P.A. O56 -alkyl derivatives of aglycone and pseudo aglycones of teicoplanin
ATE87502T1 (de) * 1989-12-11 1993-04-15 De Beers Ind Diamond Schleifprodukte.
NZ236393A (en) * 1989-12-13 1992-05-26 Lilly Co Eli N-alkylated glycopeptide derivatives prepared from antibiotics a82846 series and pa-42867-a; pharmaceutical compositions
US5187082A (en) * 1990-08-16 1993-02-16 Eli Lilly And Company Process for producing A83850 antibiotics
WO1993003060A1 (en) * 1991-07-29 1993-02-18 Gruppo Lepetit S.P.A. Amide derivatives of antibiotic a 40926

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0201251A2 (en) * 1985-04-25 1986-11-12 Eli Lilly And Company Novel glycopeptide derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101343313B (zh) * 2008-09-03 2011-11-16 南京农业大学 一种葡萄糖二肽类化合物及其制备方法和用途

Also Published As

Publication number Publication date
SG52719A1 (en) 1998-09-28
YU4995A (sh) 1998-07-10
MY128335A (en) 2007-01-31
FI950374A0 (fi) 1995-01-27
KR100388867B1 (ko) 2003-10-08
CA2141106C (en) 2007-01-23
DE69533004D1 (de) 2004-06-09
CZ292921B6 (cs) 2004-01-14
DE69531709T2 (de) 2004-07-15
FI20050513A (fi) 2005-05-13
RU95101039A (ru) 1996-10-27
CZ292895B6 (cs) 2003-12-17
ES2220335T3 (es) 2004-12-16
NO950298L (no) 1995-07-31
UA43323C2 (uk) 2001-12-17
US5843889A (en) 1998-12-01
DE69531709D1 (de) 2003-10-09
CA2546625C (en) 2008-09-09
EP1031576A2 (en) 2000-08-30
NO950298D0 (no) 1995-01-26
PT1031576E (pt) 2004-08-31
EP1031576B1 (en) 2004-05-06
PT1016670E (pt) 2003-12-31
AU703106B2 (en) 1999-03-18
RU2145609C1 (ru) 2000-02-20
IL112457A (en) 2004-06-20
EP0667353A1 (en) 1995-08-16
CA2141106A1 (en) 1995-07-29
EP1016670B1 (en) 2003-09-03
TW457248B (en) 2001-10-01
DE69532013T2 (de) 2004-07-08
CA2546910C (en) 2010-09-14
AU1138995A (en) 1995-08-10
EG25884A (en) 2012-09-24
FI117096B (fi) 2006-06-15
JPH07258289A (ja) 1995-10-09
BR9500365A (pt) 1995-10-17
CO4600679A1 (es) 1998-05-08
FI950374A (fi) 1995-07-29
PL306976A1 (en) 1995-08-07
ATE266042T1 (de) 2004-05-15
EP1031576A3 (en) 2000-12-27
SI1016670T1 (en) 2004-02-29
DK1016670T3 (da) 2004-01-05
FI117097B (fi) 2006-06-15
EP1016670A1 (en) 2000-07-05
NO323103B1 (no) 2007-01-02
PE40996A1 (es) 1996-10-14
FI20050512A (fi) 2005-05-13
EP0667353B1 (en) 2003-10-29
DK0667353T3 (da) 2004-03-22
HU9500230D0 (en) 1995-03-28
DE69532013D1 (de) 2003-12-04
JP3756539B2 (ja) 2006-03-15
SI0667353T1 (en) 2004-04-30
KR950032274A (ko) 1995-12-20
CA2546910A1 (en) 1995-07-29
HUT68715A (en) 1995-07-28
ES2210274T3 (es) 2004-07-01
CZ18495A3 (en) 1995-08-16
FI117095B (fi) 2006-06-15
ES2204444T3 (es) 2004-05-01
PL180961B1 (pl) 2001-05-31
CA2546625A1 (en) 1995-07-29
CN1119649A (zh) 1996-04-03
PT667353E (pt) 2004-03-31
ATE253077T1 (de) 2003-11-15
NZ270387A (en) 1996-11-26
ATE248856T1 (de) 2003-09-15
HU225164B1 (en) 2006-07-28
DE69533004T2 (de) 2005-04-07
DK1031576T3 (da) 2004-08-16
IL112457A0 (en) 1995-03-30

Similar Documents

Publication Publication Date Title
CN1071334C (zh) 糖肽抗生素衍生物
CN1034506C (zh) 含糖肽衍生物的药物组合物的制备方法
CN1034934C (zh) 血管紧张素ii拮抗性吡啶衍生物的制备方法
CN1249081C (zh) 糖肽衍生物或含有它们的药物组合物
CN1094937C (zh) 具抑制法呢基转化酶作用的喹唑啉酮类
CN1033087C (zh) 新颖的7-(取代)-8-(取代)-9-[(取代的甘氨酰)酰氨基]-6-去甲基-6-去氧四环素
CN1454211A (zh) 作为Xa因子抑制剂的含氮杂双环化合物
CN1104427C (zh) 法呢基蛋白转移酶的三环抑制剂
CN1071415A (zh) 新颖的9-氨基-7-(取代)-6-脱甲基-6-脱氧四环素
CN1336919A (zh) 具有pde－iv抑制活性的苯基菲啶类化合物
CN1270585A (zh) 取代的1,2,3,4－四氢化萘衍生物
CN1476434A (zh) 新化合物
CN1437611A (zh) 糖肽膦酸盐衍生物
CN1339038A (zh) 作为血管升压素受体拮抗剂的三环苯并二氮杂䓬类
CN86107491A (zh) 新的喹啉衍生物及其制备方法
CN1047078A (zh) 用作兴奋性基酸神经递质拮抗物和/或钙通道阻滞剂的聚胺和多肽
CN1863795A (zh) P－糖蛋白抑制剂,其制备方法和包括该抑制剂的药物组合物
CN1250544C (zh) 吡啶并芳基苯基噁唑烷酮抗菌剂和相关组合物及方法
CN1150189C (zh) 用作整联蛋白抑制剂的苯并吡喃酮和苯并二氢吡喃酮衍生物
CN1708507A (zh) 具有抗炎活性的9a－氮杂内酯类
CN1045976A (zh) 新的取代的替考拉宁的烷基酰胺衍生物
CN1805749A (zh) 星孢素衍生物的新药物用途
CN1297440A (zh) 哌啶基和n－脒基哌啶基衍生物
CN1220603A (zh) 抗病毒化合物
CN1890217A (zh) 作为载脂蛋白b抑制剂的n－芳基哌啶取代的联苯基甲酰胺

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CX01 Expiry of patent term

Expiration termination date: 20150127

Granted publication date: 20010919