CN106715470B - 与pd-1和lag-3具有免疫反应性的共价结合的双抗体和其使用方法 - Google Patents

与pd-1和lag-3具有免疫反应性的共价结合的双抗体和其使用方法 Download PDF

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CN106715470B
CN106715470B CN201580034116.XA CN201580034116A CN106715470B CN 106715470 B CN106715470 B CN 106715470B CN 201580034116 A CN201580034116 A CN 201580034116A CN 106715470 B CN106715470 B CN 106715470B
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lag
tumor
leu
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CN106715470A (zh
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E·波维尼
L·S·约翰逊
K·沙哈
R·拉莫特-莫斯
P·A·摩尔
S·凯尼格
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Macrogenics Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation

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CN201580034116.XA 2014-06-26 2015-06-19 与pd-1和lag-3具有免疫反应性的共价结合的双抗体和其使用方法 Active CN106715470B (zh)

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US201462017467P 2014-06-26 2014-06-26
US62/017,467 2014-06-26
PCT/US2015/036634 WO2015200119A1 (en) 2014-06-26 2015-06-19 Covalently bonded diabodies having immunoreactivity with pd-1 and lag-3, and methods of use thereof

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