CN1056883C - 产生除虫菌素ｂ及其培养物的方法 - Google Patents
产生除虫菌素ｂ及其培养物的方法 Download PDFInfo
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- CN1056883C CN1056883C CN88100649A CN88100649A CN1056883C CN 1056883 C CN1056883 C CN 1056883C CN 88100649 A CN88100649 A CN 88100649A CN 88100649 A CN88100649 A CN 88100649A CN 1056883 C CN1056883 C CN 1056883C
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- Prior art keywords
- avermectin
- acid
- compound
- sec
- mutant strain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
- C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Fodder In General (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Enzymes And Modification Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US651287A | 1987-01-23 | 1987-01-23 | |
| US006,512 | 1987-01-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN88100649A CN88100649A (zh) | 1988-10-26 |
| CN1056883C true CN1056883C (zh) | 2000-09-27 |
Family
ID=21721247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN88100649A Expired - Lifetime CN1056883C (zh) | 1987-01-23 | 1988-01-22 | 产生除虫菌素ｂ及其培养物的方法 |
Country Status (30)
| Country | Link |
|---|---|
| EP (2) | EP0276103B1 (enExample) |
| JP (2) | JPH0681757B2 (enExample) |
| KR (2) | KR900004419B1 (enExample) |
| CN (1) | CN1056883C (enExample) |
| AR (1) | AR241798A1 (enExample) |
| AT (2) | ATE96174T1 (enExample) |
| AU (2) | AU595673B2 (enExample) |
| BG (1) | BG51051A3 (enExample) |
| BR (1) | BR8800271A (enExample) |
| CZ (1) | CZ279782B6 (enExample) |
| DD (2) | DD290214A5 (enExample) |
| DE (2) | DE3884973T2 (enExample) |
| DK (2) | DK28988A (enExample) |
| EG (1) | EG18797A (enExample) |
| ES (2) | ES2059498T3 (enExample) |
| FI (2) | FI90088C (enExample) |
| GR (1) | GR3007586T3 (enExample) |
| HU (2) | HU200487B (enExample) |
| IE (2) | IE61066B1 (enExample) |
| IL (2) | IL85118A (enExample) |
| IN (1) | IN167980B (enExample) |
| MA (1) | MA21160A1 (enExample) |
| MY (1) | MY103514A (enExample) |
| NZ (2) | NZ223271A (enExample) |
| PL (2) | PL156764B1 (enExample) |
| PT (2) | PT86584B (enExample) |
| RU (1) | RU1806198C (enExample) |
| SK (1) | SK279351B6 (enExample) |
| YU (1) | YU47878B (enExample) |
| ZA (3) | ZA88449B (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4806527A (en) * | 1987-03-16 | 1989-02-21 | Merck & Co., Inc. | Avermectin derivatives |
| US4874749A (en) * | 1987-07-31 | 1989-10-17 | Merck & Co., Inc. | 4"-Deoxy-4-N-methylamino avermectin Bla/Blb |
| EP0313297B1 (en) * | 1987-10-23 | 1993-05-19 | Pfizer Inc. | Process for production of avermectin aglycones and cultures therefor |
| GB8807280D0 (en) * | 1988-03-26 | 1988-04-27 | Pfizer Ltd | Antiparasitic agents |
| GB8811036D0 (en) * | 1988-05-10 | 1988-06-15 | Glaxo Group Ltd | Chemical compounds |
| GB8813760D0 (en) * | 1988-06-10 | 1988-07-13 | American Cyanamid Co | Chemical process |
| GB8815967D0 (en) * | 1988-07-05 | 1988-08-10 | Pfizer Ltd | Antiparasitic agents |
| NZ231772A (en) * | 1988-12-23 | 1992-11-25 | Merck & Co Inc | Avermectin derivatives, preparation and parasiticidal compositions thereof |
| NZ231773A (en) * | 1988-12-23 | 1992-09-25 | Merck & Co Inc | Avermectin derivatives, preparation and parasiticidal pharmaceutical compositions thereof |
| US5015630A (en) * | 1989-01-19 | 1991-05-14 | Merck & Co., Inc. | 5-oxime avermectin derivatives |
| US4897383A (en) * | 1989-02-13 | 1990-01-30 | Merck & Co., Inc. | Avermectin derivatives |
| US5252474A (en) * | 1989-03-31 | 1993-10-12 | Merck & Co., Inc. | Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use |
| US5057499A (en) * | 1989-06-02 | 1991-10-15 | Merck & Co. Inc. | Avermectin derivatives |
| US5030622A (en) * | 1989-06-02 | 1991-07-09 | Merck & Co., Inc. | Avermectin derivatives |
| US5023241A (en) * | 1989-07-31 | 1991-06-11 | Merck & Co., Inc. | Avermectin derivatives |
| US5830875A (en) * | 1989-10-30 | 1998-11-03 | Merck & Co., Inc. | 24-and 25-substituted avermectin and milbemycin derivatives |
| JP2888586B2 (ja) * | 1990-03-05 | 1999-05-10 | 社団法人北里研究所 | エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法 |
| US5169839A (en) * | 1990-05-11 | 1992-12-08 | Merck & Co., Inc. | Derivatives of 3'- and 3"-o-desmethyl avermectin compounds, compositions and methods of treating melmintic and parasitic infections |
| US5208222A (en) * | 1991-03-28 | 1993-05-04 | Merck & Co., Inc. | 4"-and 4'-alkylthio avermectin derivatives |
| US5240915A (en) * | 1991-10-15 | 1993-08-31 | Merck & Co., Inc. | Avermectin derivatives |
| US6103504A (en) * | 1992-03-25 | 2000-08-15 | Pfizer Inc. | Process for production of avermectins and cultures therefor |
| US5292647A (en) * | 1992-11-30 | 1994-03-08 | Eli Lilly And Company | Strain of streptomyces for producing avermectins and processes therewith |
| CN1038330C (zh) * | 1993-07-05 | 1998-05-13 | 塞泰克斯公司 | 阿弗麦菌素的生产与分离 |
| AU6657294A (en) * | 1993-07-30 | 1995-02-28 | Pfizer Inc. | Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis |
| RU2120943C1 (ru) * | 1993-10-05 | 1998-10-27 | Пфайзер Инк. | Производные дорамектина, способы их получения, способы лечения |
| FI942725L (fi) * | 1993-12-16 | 1995-06-17 | Pfizer | Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta |
| US5701591A (en) * | 1995-04-07 | 1997-12-23 | Telecommunications Equipment Corporation | Multi-function interactive communications system with circularly/elliptically polarized signal transmission and reception |
| PL194270B1 (pl) * | 1998-02-13 | 2007-05-31 | Pfizer Prod Inc | Wyizolowana cząsteczka polinukleotydowa, cząsteczka oligonukleotydowa, zrekombinowany wektor, komórka gospodarza, wyizolowany produkt genu AveC S. avermitilis, wyizolowany produkt homologu genu AveC S. hygroscopicus, sposób wytwarzania zrekombinowanego produktu genu AveC, sposób wytwarzania zrekombinowanego produktu homologu genu AveC, cząsteczka polinukleotydowa, wektor do zastępowania genu, sposób identyfikowania mutacji otwartej ramki odczytuAveC, sposób wytwarzania nowych szczepów S. avermitilis, szczep S. avermitilis i sposób wytwarzaniaawermektyn |
| CN1186446C (zh) * | 1999-08-12 | 2005-01-26 | 辉瑞产品公司 | 介导除虫菌素b2:b1比例的除虫链霉茵基因 |
| KR100415395B1 (ko) * | 2000-08-02 | 2004-01-16 | 한국생명공학연구원 | 에버멕틴 ｂｃ-5-ｏ-메칠트랜스퍼라제의 유전자가 파괴된 스트렙토마이세스 에버미티리스 변이균주 및 그의 제조 방법 |
| EP2050815B1 (en) | 2002-02-12 | 2011-10-26 | Pfizer Products Inc. | Streptomyces Avermitilis gene directing the ratio of B2:B1 avermectins |
| WO2023203038A1 (en) | 2022-04-19 | 2023-10-26 | Syngenta Crop Protection Ag | Insect, acarina and nematode pest control |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE434277B (sv) * | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
| NZ188459A (en) * | 1977-10-03 | 1982-09-07 | Merck & Co Inc | Derivatives of c-076 compounds and pesticidal compositions |
| US4429042A (en) * | 1978-09-08 | 1984-01-31 | Merck & Co., Inc. | Strain of Streptomyces for producing antiparasitic compounds |
| ES8800986A1 (es) * | 1985-07-27 | 1987-12-01 | Pfizer | Un procedimiento para la produccion de un nuevo derivado de avermectina |
| GB8606120D0 (en) * | 1986-03-12 | 1986-04-16 | Glaxo Group Ltd | Process |
-
1987
- 1987-12-10 IN IN1059/DEL/87A patent/IN167980B/en unknown
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1988
- 1988-01-18 BG BG082657A patent/BG51051A3/bg unknown
- 1988-01-18 AT AT88300354T patent/ATE96174T1/de not_active IP Right Cessation
- 1988-01-18 DE DE88300354T patent/DE3884973T2/de not_active Expired - Lifetime
- 1988-01-18 IL IL85118A patent/IL85118A/xx not_active IP Right Cessation
- 1988-01-18 ES ES88300354T patent/ES2059498T3/es not_active Expired - Lifetime
- 1988-01-18 EP EP88300354A patent/EP0276103B1/en not_active Expired - Lifetime
- 1988-01-19 MA MA21397A patent/MA21160A1/fr unknown
- 1988-01-19 MY MYPI88000037A patent/MY103514A/en unknown
- 1988-01-20 DE DE8888300426T patent/DE3879975T2/de not_active Expired - Lifetime
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- 1988-01-20 AT AT88300426T patent/ATE87927T1/de not_active IP Right Cessation
- 1988-01-20 EP EP88300426A patent/EP0276131B1/en not_active Expired - Lifetime
- 1988-01-21 PL PL1988270239A patent/PL156764B1/pl unknown
- 1988-01-21 IL IL85165A patent/IL85165A/xx not_active IP Right Cessation
- 1988-01-21 PT PT86584A patent/PT86584B/pt unknown
- 1988-01-21 EG EG3588A patent/EG18797A/xx active
- 1988-01-21 PT PT86583A patent/PT86583B/pt unknown
- 1988-01-21 CZ CS88407A patent/CZ279782B6/cs unknown
- 1988-01-21 PL PL1988270238A patent/PL156763B1/pl unknown
- 1988-01-21 SK SK407-88A patent/SK279351B6/sk unknown
- 1988-01-22 ZA ZA88449A patent/ZA88449B/xx unknown
- 1988-01-22 IE IE16188A patent/IE61066B1/en not_active IP Right Cessation
- 1988-01-22 DK DK028988A patent/DK28988A/da not_active Application Discontinuation
- 1988-01-22 HU HU88261A patent/HU200487B/hu unknown
- 1988-01-22 HU HU88260D patent/HU201973B/hu unknown
- 1988-01-22 FI FI880281A patent/FI90088C/fi not_active IP Right Cessation
- 1988-01-22 CN CN88100649A patent/CN1056883C/zh not_active Expired - Lifetime
- 1988-01-22 ZA ZA88448A patent/ZA88448B/xx unknown
- 1988-01-22 DD DD88312393A patent/DD290214A5/de unknown
- 1988-01-22 KR KR1019880000470A patent/KR900004419B1/ko not_active Expired
- 1988-01-22 NZ NZ223271A patent/NZ223271A/en unknown
- 1988-01-22 JP JP63012462A patent/JPH0681757B2/ja not_active Expired - Lifetime
- 1988-01-22 ZA ZA88447A patent/ZA88447B/xx unknown
- 1988-01-22 AU AU10696/88A patent/AU595673B2/en not_active Expired
- 1988-01-22 DD DD88312394A patent/DD267512A5/de unknown
- 1988-01-22 RU SU884355079A patent/RU1806198C/ru active
- 1988-01-22 IE IE16088A patent/IE61483B1/en not_active IP Right Cessation
- 1988-01-22 FI FI880280A patent/FI90091C/fi not_active IP Right Cessation
- 1988-01-22 YU YU11988A patent/YU47878B/sh unknown
- 1988-01-22 DK DK198800290A patent/DK175720B1/da not_active IP Right Cessation
- 1988-01-22 NZ NZ223272A patent/NZ223272A/xx unknown
- 1988-01-22 AR AR88309888A patent/AR241798A1/es active
- 1988-01-23 JP JP63011881A patent/JPH0817693B2/ja not_active Expired - Lifetime
- 1988-01-23 KR KR1019880000506A patent/KR910002225B1/ko not_active Expired
- 1988-01-25 BR BRPI8800271-3A patent/BR8800271A/pt not_active IP Right Cessation
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1991
- 1991-02-15 AU AU71110/91A patent/AU631298B2/en not_active Expired
-
1993
- 1993-04-08 GR GR930400638T patent/GR3007586T3/el unknown
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