CN105658653A - 可用作pim激酶抑制剂的呋喃并-和噻吩并-吡啶甲酰胺化合物 - Google Patents

可用作pim激酶抑制剂的呋喃并-和噻吩并-吡啶甲酰胺化合物 Download PDF

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Publication number
CN105658653A
CN105658653A CN201480057613.7A CN201480057613A CN105658653A CN 105658653 A CN105658653 A CN 105658653A CN 201480057613 A CN201480057613 A CN 201480057613A CN 105658653 A CN105658653 A CN 105658653A
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Prior art keywords
amino
pyridine
pyridin
carboxamide
methyl
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Pending
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CN201480057613.7A
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Chinese (zh)
Inventor
Y-L·李
D·M·伯恩斯
H·冯
T·黄
S·梅
J·潘
O·维克尔金
H·F·叶
W·朱
M·拉法尔斯基
A·王
C-B·薛
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Insight Inc
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Insight Inc
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201480057613.7A 2013-08-23 2014-08-22 可用作pim激酶抑制剂的呋喃并-和噻吩并-吡啶甲酰胺化合物 Pending CN105658653A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361869442P 2013-08-23 2013-08-23
US61/869,442 2013-08-23
PCT/US2014/052214 WO2015027124A1 (en) 2013-08-23 2014-08-22 Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors

Publications (1)

Publication Number Publication Date
CN105658653A true CN105658653A (zh) 2016-06-08

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CN201480057613.7A Pending CN105658653A (zh) 2013-08-23 2014-08-22 可用作pim激酶抑制剂的呋喃并-和噻吩并-吡啶甲酰胺化合物

Country Status (18)

Country Link
US (2) US9556197B2 (https=)
EP (1) EP3036238A1 (https=)
JP (1) JP2016528298A (https=)
KR (1) KR20160056896A (https=)
CN (1) CN105658653A (https=)
AR (1) AR097431A1 (https=)
AU (2) AU2014308703A1 (https=)
CA (1) CA2921959A1 (https=)
CL (1) CL2016000398A1 (https=)
CR (1) CR20160135A (https=)
EA (1) EA201690458A1 (https=)
IL (1) IL244224A0 (https=)
MX (1) MX2016002367A (https=)
PE (1) PE20160532A1 (https=)
PH (1) PH12016500359A1 (https=)
SG (1) SG11201601259YA (https=)
TW (1) TW201605866A (https=)
WO (1) WO2015027124A1 (https=)

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CN106977483A (zh) * 2017-06-02 2017-07-25 遵义医学院 一种二氟烷基取代的黄酮醇、异黄酮醇和香豆素类化合物的合成方法
CN116102549A (zh) * 2021-11-09 2023-05-12 暨南大学 5-醛基杂环酰胺类化合物及其应用
WO2023082044A1 (zh) * 2021-11-09 2023-05-19 暨南大学 5-醛基杂环酰胺类化合物及其应用

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JP2021521170A (ja) 2018-04-13 2021-08-26 スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド 骨髄増殖性新生物およびがんに関連する線維症の処置のためのｐｉｍキナーゼ阻害剤
KR20260008165A (ko) 2019-02-12 2026-01-15 스미토모 파마 아메리카, 인크. 헤테로시클릭 단백질 키나제 억제제를 포함하는 제제
KR20220003018A (ko) * 2019-04-30 2022-01-07 웨스팅하우스 일렉트릭 컴퍼니 엘엘씨 적층 제조된 지르코늄 합금의 개선된 내식성
CN120302975A (zh) 2022-10-31 2025-07-11 住友制药美国公司 治疗骨髓增生性肿瘤的pim1抑制剂

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