CN1051313C - 5－芳基吲哚衍生物及其用途、含有它们的药物组合物以及制备它们的中间体 - Google Patents

5－芳基吲哚衍生物及其用途、含有它们的药物组合物以及制备它们的中间体 Download PDF

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Publication number
CN1051313C
CN1051313C CN93120716A CN93120716A CN1051313C CN 1051313 C CN1051313 C CN 1051313C CN 93120716 A CN93120716 A CN 93120716A CN 93120716 A CN93120716 A CN 93120716A CN 1051313 C CN1051313 C CN 1051313C
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CN
China
Prior art keywords
ylmethyl
indoles
compound
methylpyrrolidin
benzoglyoxaline
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Expired - Fee Related
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CN93120716A
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English (en)
Chinese (zh)
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CN1094727A (zh
Inventor
J·E·梅卡
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Pfizer Inc
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Pfizer Inc
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Publication of CN1051313C publication Critical patent/CN1051313C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
CN93120716A 1992-11-02 1993-11-01 5－芳基吲哚衍生物及其用途、含有它们的药物组合物以及制备它们的中间体 Expired - Fee Related CN1051313C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97075892A 1992-11-02 1992-11-02
US970,758 1992-11-02

Publications (2)

Publication Number Publication Date
CN1094727A CN1094727A (zh) 1994-11-09
CN1051313C true CN1051313C (zh) 2000-04-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN93120716A Expired - Fee Related CN1051313C (zh) 1992-11-02 1993-11-01 5－芳基吲哚衍生物及其用途、含有它们的药物组合物以及制备它们的中间体

Country Status (27)

Country Link
US (1) US5886008A (https=)
EP (2) EP0666858B1 (https=)
JP (1) JP2788551B2 (https=)
KR (1) KR0163371B1 (https=)
CN (1) CN1051313C (https=)
AT (1) ATE202102T1 (https=)
AU (1) AU685066B2 (https=)
BR (1) BR9307348A (https=)
CA (2) CA2340999C (https=)
CZ (1) CZ283001B6 (https=)
DE (1) DE69330351T2 (https=)
DK (1) DK0666858T3 (https=)
EG (1) EG20396A (https=)
ES (1) ES2157224T3 (https=)
FI (2) FI111257B (https=)
GR (1) GR3036579T3 (https=)
HU (1) HU222235B1 (https=)
IL (1) IL107386A (https=)
MY (1) MY109696A (https=)
NO (1) NO309652B1 (https=)
NZ (1) NZ257059A (https=)
PL (1) PL176091B1 (https=)
PT (1) PT666858E (https=)
RU (1) RU2134266C1 (https=)
TW (1) TW251284B (https=)
WO (1) WO1994010171A1 (https=)
ZA (1) ZA938137B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
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CN107835814A (zh) * 2015-04-29 2018-03-23 詹森药业有限公司 氮杂苯并咪唑及其作为ampa受体调节剂的用途

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JP2829788B2 (ja) * 1994-02-10 1998-12-02 ファイザー インク． ベンゾジアゼピン受容体部位アゴニスト及びアンタゴニストとしての５−ヘテロアリールインドール誘導体
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WO1997013512A1 (en) * 1995-10-10 1997-04-17 Eli Lilly And Company N-[2-substituted-3-(2-aminoethyl)-1h-indol-5-yl]-amides: new 5-ht1f agonists
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US6465484B1 (en) 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
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US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
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US7442709B2 (en) * 2003-08-21 2008-10-28 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine c-Kit inhibitors
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CA2547020C (en) 2003-11-25 2014-03-25 3M Innovative Properties Company 1h-imidazo[4,5-c]pyridine-4-amine derivatives as immune response modifier
DE102004014304A1 (de) * 2004-03-22 2005-10-06 Grünenthal GmbH Substituierte 1,4,8- Triazaspiro[4,5]decan-2-on-Verbindungen
AU2006210392A1 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune response modifiers
ES2346157T3 (es) * 2006-03-22 2010-10-11 Janssen Pharmaceutica N.V. Derivados de alquilaminas ciclicas como inhibidores de la interaccion entre mdm2 y p53.
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
JP6433482B2 (ja) 2013-03-15 2018-12-05 エージンバイオ， インコーポレイテッド 認知機能を改善するための方法および組成物
KR20170141769A (ko) 2015-04-29 2017-12-26 얀센 파마슈티카 엔.브이. 인돌론 화합물 및 ampa 수용체 조절제로서의 이의 용도
JP6804469B2 (ja) 2015-04-29 2020-12-23 ヤンセン ファーマシューティカ エヌ．ベー． ベンゾイミダゾロン及びベンゾチアゾロン化合物並びにａｍｐａ受容体調節因子としてのそれらの使用
MX373652B (es) 2015-04-29 2020-04-02 Janssen Pharmaceutica Nv Imidazopirazinas y pirazolopirimidinas y su uso como moduladores del receptor de ampa.
WO2016191288A1 (en) 2015-05-22 2016-12-01 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam
EP3371170B1 (en) 2015-11-06 2019-07-31 H. Hoffnabb-La Roche Ag Indolin-2-one derivatives useful in the treatment of cns diseases
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CN108137561B (zh) 2015-11-06 2021-03-26 豪夫迈·罗氏有限公司 二氢吲哚-2-酮衍生物
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CN111822047B (zh) * 2020-07-17 2022-05-27 曲阜师范大学 一种磁性介孔聚合离子液体负载催化合成吲哚类衍生物的方法
WO2025104491A1 (en) * 2023-11-14 2025-05-22 Mindset Pharma Inc. Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto
WO2025104490A1 (en) * 2023-11-14 2025-05-22 Mindset Pharma Inc. Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto

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WO1992006973A1 (en) * 1990-10-15 1992-04-30 Pfizer Inc. Indole derivatives

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Publication number Priority date Publication date Assignee Title
CN107835814A (zh) * 2015-04-29 2018-03-23 詹森药业有限公司 氮杂苯并咪唑及其作为ampa受体调节剂的用途
US12304908B2 (en) 2015-04-29 2025-05-20 Rapport Therapeutics, Inc. Azabenzimidazoles and their use as AMPA receptor modulators

Also Published As

Publication number Publication date
DE69330351D1 (de) 2001-07-19
CA2148380A1 (en) 1994-05-11
CA2148380C (en) 2001-08-14
EP1094064A1 (en) 2001-04-25
HUT66011A (en) 1994-08-29
FI20002505L (fi) 2000-11-15
CA2340999A1 (en) 1994-05-11
PT666858E (pt) 2001-09-28
KR0163371B1 (ko) 1998-12-01
DK0666858T3 (da) 2001-08-27
ES2157224T3 (es) 2001-08-16
FI20002505A7 (fi) 2000-11-15
US5886008A (en) 1999-03-23
CZ283001B6 (cs) 1997-12-17
NO309652B1 (no) 2001-03-05
CA2340999C (en) 2005-01-04
FI934825A0 (fi) 1993-11-01
DE69330351T2 (de) 2001-09-20
RU95109927A (ru) 1997-01-10
NO951633D0 (no) 1995-04-28
IL107386A0 (en) 1994-01-25
GR3036579T3 (en) 2001-12-31
ATE202102T1 (de) 2001-06-15
FI111257B (fi) 2003-06-30
WO1994010171A1 (en) 1994-05-11
AU5329494A (en) 1994-05-24
PL308669A1 (en) 1995-08-21
TW251284B (https=) 1995-07-11
FI934825L (fi) 1994-05-03
EP0666858B1 (en) 2001-06-13
KR950704313A (ko) 1995-11-17
EG20396A (en) 1999-02-28
JP2788551B2 (ja) 1998-08-20
CN1094727A (zh) 1994-11-09
AU685066B2 (en) 1998-01-15
BR9307348A (pt) 1999-05-11
CZ110895A3 (en) 1995-11-15
HU222235B1 (hu) 2003-05-28
JPH07508759A (ja) 1995-09-28
PL176091B1 (pl) 1999-04-30
NZ257059A (en) 1997-07-27
NO951633L (no) 1995-04-28
IL107386A (en) 1999-03-12
RU2134266C1 (ru) 1999-08-10
ZA938137B (en) 1995-05-02
MY109696A (en) 1997-04-30
EP0666858A1 (en) 1995-08-16

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