ATE202102T1 - 5-arylindol-derivate und ihre verwendung als serotonin (5-ht1)-agonisten - Google Patents

5-arylindol-derivate und ihre verwendung als serotonin (5-ht1)-agonisten

Info

Publication number
ATE202102T1
ATE202102T1 AT93923389T AT93923389T ATE202102T1 AT E202102 T1 ATE202102 T1 AT E202102T1 AT 93923389 T AT93923389 T AT 93923389T AT 93923389 T AT93923389 T AT 93923389T AT E202102 T1 ATE202102 T1 AT E202102T1
Authority
AT
Austria
Prior art keywords
alkyl
aryl
hydrogen
ring
membered
Prior art date
Application number
AT93923389T
Other languages
English (en)
Inventor
John Eugene Macor
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE202102T1 publication Critical patent/ATE202102T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
AT93923389T 1992-11-02 1993-10-19 5-arylindol-derivate und ihre verwendung als serotonin (5-ht1)-agonisten ATE202102T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97075892A 1992-11-02 1992-11-02
PCT/US1993/009790 WO1994010171A1 (en) 1992-11-02 1993-10-19 5-arylindole derivatives and their use as serotonin (5-ht1) agonists

Publications (1)

Publication Number Publication Date
ATE202102T1 true ATE202102T1 (de) 2001-06-15

Family

ID=25517470

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93923389T ATE202102T1 (de) 1992-11-02 1993-10-19 5-arylindol-derivate und ihre verwendung als serotonin (5-ht1)-agonisten

Country Status (27)

Country Link
US (1) US5886008A (de)
EP (2) EP0666858B1 (de)
JP (1) JP2788551B2 (de)
KR (1) KR0163371B1 (de)
CN (1) CN1051313C (de)
AT (1) ATE202102T1 (de)
AU (1) AU685066B2 (de)
BR (1) BR9307348A (de)
CA (2) CA2340999C (de)
CZ (1) CZ283001B6 (de)
DE (1) DE69330351T2 (de)
DK (1) DK0666858T3 (de)
EG (1) EG20396A (de)
ES (1) ES2157224T3 (de)
FI (2) FI111257B (de)
GR (1) GR3036579T3 (de)
HU (1) HU222235B1 (de)
IL (1) IL107386A (de)
MY (1) MY109696A (de)
NO (1) NO309652B1 (de)
NZ (1) NZ257059A (de)
PL (1) PL176091B1 (de)
PT (1) PT666858E (de)
RU (1) RU2134266C1 (de)
TW (1) TW251284B (de)
WO (1) WO1994010171A1 (de)
ZA (1) ZA938137B (de)

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GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
NZ305166A (en) * 1995-03-20 1998-12-23 Lilly Co Eli 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles; preparation and medicaments
JPH11513666A (ja) * 1995-10-10 1999-11-24 イーライ・リリー・アンド・カンパニー Ｎ−［２−置換−３−（２−アミノエチル）−１ｈ−インドール−５−イル］−アミド：新規５−ｈｔ▲下１ｆ▼作動剤
NZ502642A (en) 1997-07-03 2002-06-28 Du Pont Pharm Co Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders
US6465484B1 (en) 1997-09-26 2002-10-15 Merck & Co., Inc. Angiogenesis inhibitors
WO2000000196A1 (en) * 1998-06-30 2000-01-06 Eli Lilly And Company Pyrrolidine and pyrroline derivatives having effects on serotonin related systems
US6365589B1 (en) 1998-07-02 2002-04-02 Bristol-Myers Squibb Pharma Company Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
PE20030008A1 (es) 2001-06-19 2003-01-22 Bristol Myers Squibb Co Inhibidores duales de pde 7 y pde 4
US20040102360A1 (en) * 2002-10-30 2004-05-27 Barnett Stanley F. Combination therapy
ATE503483T1 (de) 2002-10-30 2011-04-15 Merck Sharp & Dohme Hemmer der akt aktivität
US7332508B2 (en) * 2002-12-18 2008-02-19 Novo Nordisk A/S Substituted homopiperidine, piperidine or pyrrolidine derivatives
CA2522430A1 (en) 2003-04-24 2004-11-11 Merck & Co., Inc. Inhibitors of akt activity
DE10337184A1 (de) 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituierte 3-Pyrrolidin-Indol-Derivate
CN1839132A (zh) * 2003-08-21 2006-09-27 Osi制药公司 作为c－kit抑制剂的n3－取代的咪唑并吡啶衍生物
US7442709B2 (en) * 2003-08-21 2008-10-28 Osi Pharmaceuticals, Inc. N3-substituted imidazopyridine c-Kit inhibitors
AU2004278014B2 (en) 2003-10-03 2011-04-28 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
MXPA06005910A (es) 2003-11-25 2006-08-23 3M Innovative Properties Co Sistemas de anillo imidazo sustituido y metodos.
DE102004014304A1 (de) 2004-03-22 2005-10-06 Grünenthal GmbH Substituierte 1,4,8- Triazaspiro[4,5]decan-2-on-Verbindungen
CA2597092A1 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune reponse modifiers
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN105142623A (zh) 2013-03-15 2015-12-09 艾吉因生物股份有限公司 用于改善认知功能的方法和组合物
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
EP4144736A1 (de) * 2015-04-29 2023-03-08 JANSSEN Pharmaceutica NV Azabenzimidazole und ihre verwendung als ampa-rezeptor-modulatoren
KR20170141767A (ko) 2015-04-29 2017-12-26 얀센 파마슈티카 엔.브이. 벤즈이미다졸론 및 벤조티아졸론 화합물 및 ampa 수용체 조절제로서의 이들의 용도
JP6811187B2 (ja) 2015-04-29 2021-01-13 ヤンセン ファーマシューティカ エヌ．ベー． インドロン化合物、及びａｍｐａ受容体調節因子としてのそれらの使用
EP3288945B1 (de) 2015-04-29 2019-09-18 Janssen Pharmaceutica NV Imidazopyrazine und pyrazolopyrimidine und ihre verwendung als ampa-rezeptormodulatoren
NZ738682A (en) 2015-05-22 2022-01-28 Agenebio Inc Extended release pharmaceutical compositions of levetiracetam
MY197370A (en) 2015-11-06 2023-06-14 Hoffmann La Roche Indolin-2-one derivatives
WO2017076932A1 (en) 2015-11-06 2017-05-11 F. Hoffmann-La Roche Ag Indolin-2-one derivatives useful in the treatment of cns diseases
WO2017076931A1 (en) 2015-11-06 2017-05-11 F. Hoffmann-La Roche Ag Indolin-2-one derivatives for use in the treatment of cns and related disorders
EP3371174B1 (de) 2015-11-06 2021-03-17 H. Hoffnabb-La Roche Ag Indolin-2-on-derivate
CN111822047B (zh) * 2020-07-17 2022-05-27 曲阜师范大学 一种磁性介孔聚合离子液体负载催化合成吲哚类衍生物的方法

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Also Published As

Publication number Publication date
JP2788551B2 (ja) 1998-08-20
BR9307348A (pt) 1999-05-11
IL107386A (en) 1999-03-12
MY109696A (en) 1997-04-30
CZ283001B6 (cs) 1997-12-17
US5886008A (en) 1999-03-23
KR0163371B1 (ko) 1998-12-01
DK0666858T3 (da) 2001-08-27
EP0666858A1 (de) 1995-08-16
CA2340999C (en) 2005-01-04
CA2148380C (en) 2001-08-14
WO1994010171A1 (en) 1994-05-11
HU222235B1 (hu) 2003-05-28
RU95109927A (ru) 1997-01-10
CN1094727A (zh) 1994-11-09
CA2340999A1 (en) 1994-05-11
CZ110895A3 (en) 1995-11-15
HUT66011A (en) 1994-08-29
EP0666858B1 (de) 2001-06-13
FI20002505A (fi) 2000-11-15
NO951633L (no) 1995-04-28
JPH07508759A (ja) 1995-09-28
AU685066B2 (en) 1998-01-15
PT666858E (pt) 2001-09-28
ES2157224T3 (es) 2001-08-16
FI111257B (fi) 2003-06-30
EG20396A (en) 1999-02-28
GR3036579T3 (en) 2001-12-31
PL176091B1 (pl) 1999-04-30
KR950704313A (ko) 1995-11-17
NO951633D0 (no) 1995-04-28
TW251284B (de) 1995-07-11
CN1051313C (zh) 2000-04-12
EP1094064A1 (de) 2001-04-25
NZ257059A (en) 1997-07-27
IL107386A0 (en) 1994-01-25
DE69330351D1 (de) 2001-07-19
AU5329494A (en) 1994-05-24
DE69330351T2 (de) 2001-09-20
PL308669A1 (en) 1995-08-21
FI934825A (fi) 1994-05-03
NO309652B1 (no) 2001-03-05
RU2134266C1 (ru) 1999-08-10
FI934825A0 (fi) 1993-11-01
ZA938137B (en) 1995-05-02
CA2148380A1 (en) 1994-05-11

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee