ES2112470T3 - Derivados de piridazinona, procedimientos de produccion y utilizacion. - Google Patents

Derivados de piridazinona, procedimientos de produccion y utilizacion.

Info

Publication number
ES2112470T3
ES2112470T3 ES94119888T ES94119888T ES2112470T3 ES 2112470 T3 ES2112470 T3 ES 2112470T3 ES 94119888 T ES94119888 T ES 94119888T ES 94119888 T ES94119888 T ES 94119888T ES 2112470 T3 ES2112470 T3 ES 2112470T3
Authority
ES
Spain
Prior art keywords
group
carbon atoms
integer
derivatives
piridazinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94119888T
Other languages
English (en)
Inventor
Takashi Kagawa
Takuya Motokawa
Masanori Yoshida
Yoshitami Oshita
Kazuo Kanai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nihon Nohyaku Co Ltd
Original Assignee
Nihon Nohyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Nohyaku Co Ltd filed Critical Nihon Nohyaku Co Ltd
Application granted granted Critical
Publication of ES2112470T3 publication Critical patent/ES2112470T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/22—Nitrogen and oxygen atoms

Abstract

DERIVADOS DE PIRIDAZINONA DE FORMULA (I): EN LA QUE R1 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO DE METILO, QUE PUEDE SER SUSTITUIDO POR UN GRUPO AMINO CICLICO ALIFATICO, CONTENIENDO OPCIONALMENTE UN HETERO ATOMO EN EL ANILLO DEL MISMO; CADA UNO DE X1 Y X2 INDEPENDIENTEMENTE REPRESENTA UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN GRUPO ALQUILO, TENIENDO DE 1 A 6 ATOMOS DE CARBONO, UN GRUPO ALCOXI, TENIENDO DE 1 A 6 ATOMOS DE CARBONO, UN GRUPO CIANO, UN GRUPO NITRO O UN GRUPO REPRESENTADO POR - CO - NR2R3 (EN LA QUE CADA UNO DE R2 Y R3 INDEPENDIENTEMENTE REPRESENTA UN GRUPO ALQUILO, TENIENDO DE 1 A 6 ATOMOS DE CARBONO); Y REPRESENTA UN ATOMO HALOGENO; Z REPRESENTA UN GRUPO ALCOXI, TENIENDO DE 1 A 6 ATOMOS DE CARBONO; REPRESENTA O O UN NUMERO ENTERO DE 1 A 3; A REPRESENTA XH O N; M REPRESENTA O O UN NUMERO ENTERO DE 1 A 2; Y N REPRESENTA UN NUMERO ENTERO DE 1 A 8, EXHIBEN UNA AGREGACION DE PLAQUETAS INHIBIENDO ACTIVIDAD, Y SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS CIRCULATORIOS TALESCOMO INFARTACION CEREBRAL.
ES94119888T 1993-12-16 1994-12-15 Derivados de piridazinona, procedimientos de produccion y utilizacion. Expired - Lifetime ES2112470T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP34340593 1993-12-16

Publications (1)

Publication Number Publication Date
ES2112470T3 true ES2112470T3 (es) 1998-04-01

Family

ID=18361263

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94119888T Expired - Lifetime ES2112470T3 (es) 1993-12-16 1994-12-15 Derivados de piridazinona, procedimientos de produccion y utilizacion.

Country Status (13)

Country Link
US (1) US5604226A (es)
EP (1) EP0658555B1 (es)
KR (1) KR950017967A (es)
CN (1) CN1109878A (es)
AT (1) ATE160144T1 (es)
AU (1) AU675889B2 (es)
CA (1) CA2138224A1 (es)
DE (1) DE69406763T2 (es)
DK (1) DK0658555T3 (es)
ES (1) ES2112470T3 (es)
GR (1) GR3026006T3 (es)
NZ (1) NZ270130A (es)
TW (1) TW326041B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9514160D0 (en) * 1994-07-25 1995-09-13 Zeneca Ltd Aromatic compounds
AU768825B2 (en) * 1998-12-07 2004-01-08 Nissan Chemical Industries Ltd. Remedial agent for erectile dysfunction
KR100811865B1 (ko) * 2006-12-08 2008-03-10 주식회사 레고켐 바이오사이언스 인자 Ⅶａ 억제 활성을 갖는 피리미디논 또는 피리다지논유도체

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU198696B (en) * 1987-01-20 1989-11-28 Nissan Chemical Ind Ltd Process for producing 3/2h/-pyridazinon derivatives and pharmaceutical compositions containing them as active components
JPH02256668A (ja) * 1988-12-20 1990-10-17 Nissan Chem Ind Ltd ピリダジノン誘導体
EP0482208B1 (en) * 1990-04-25 2000-07-19 Nissan Chemical Industries Ltd. Pyridazinone derivative
JPH05112454A (ja) * 1991-10-18 1993-05-07 Nissan Chem Ind Ltd 抗血小板剤

Also Published As

Publication number Publication date
DE69406763T2 (de) 1998-03-12
TW326041B (en) 1998-02-01
US5604226A (en) 1997-02-18
AU8041394A (en) 1995-06-22
CN1109878A (zh) 1995-10-11
DE69406763D1 (de) 1997-12-18
EP0658555A1 (en) 1995-06-21
DK0658555T3 (da) 1997-12-22
EP0658555B1 (en) 1997-11-12
CA2138224A1 (en) 1995-06-17
NZ270130A (en) 1995-12-21
ATE160144T1 (de) 1997-11-15
KR950017967A (ko) 1995-07-22
AU675889B2 (en) 1997-02-20
GR3026006T3 (en) 1998-04-30

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