CN104975020B - 经修饰的RNAi多核苷酸及其用途 - Google Patents
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- CN104975020B CN104975020B CN201510113335.9A CN201510113335A CN104975020B CN 104975020 B CN104975020 B CN 104975020B CN 201510113335 A CN201510113335 A CN 201510113335A CN 104975020 B CN104975020 B CN 104975020B
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6533508P | 2008-02-11 | 2008-02-11 | |
| US61/065,335 | 2008-02-11 | ||
| CN200980112313.3A CN102016036B (zh) | 2008-02-11 | 2009-02-11 | 经修饰的RNAi多核苷酸及其用途 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980112313.3A Division CN102016036B (zh) | 2008-02-11 | 2009-02-11 | 经修饰的RNAi多核苷酸及其用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104975020A CN104975020A (zh) | 2015-10-14 |
| CN104975020B true CN104975020B (zh) | 2020-01-17 |
Family
ID=40843376
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510113335.9A Expired - Fee Related CN104975020B (zh) | 2008-02-11 | 2009-02-11 | 经修饰的RNAi多核苷酸及其用途 |
| CN200980112313.3A Expired - Fee Related CN102016036B (zh) | 2008-02-11 | 2009-02-11 | 经修饰的RNAi多核苷酸及其用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980112313.3A Expired - Fee Related CN102016036B (zh) | 2008-02-11 | 2009-02-11 | 经修饰的RNAi多核苷酸及其用途 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10131904B2 (https=) |
| EP (2) | EP2247729B1 (https=) |
| JP (3) | JP5697993B2 (https=) |
| CN (2) | CN104975020B (https=) |
| AU (1) | AU2009213147A1 (https=) |
| CA (1) | CA2715289C (https=) |
| IL (1) | IL207548A0 (https=) |
| WO (1) | WO2009102427A2 (https=) |
Families Citing this family (130)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US10131904B2 (en) | 2008-02-11 | 2018-11-20 | Rxi Pharmaceuticals Corporation | Modified RNAi polynucleotides and uses thereof |
| TWI455944B (zh) | 2008-07-01 | 2014-10-11 | Daiichi Sankyo Co Ltd | 雙股多核苷酸 |
| US8815818B2 (en) | 2008-07-18 | 2014-08-26 | Rxi Pharmaceuticals Corporation | Phagocytic cell delivery of RNAI |
| CA2746527A1 (en) | 2008-09-22 | 2010-03-25 | Rxi Pharmaceuticals Corporation | Rna interference in skin indications |
| WO2010059226A2 (en) * | 2008-11-19 | 2010-05-27 | Rxi Pharmaceuticals Corporation | Inhibition of map4k4 through rnai |
| US9493774B2 (en) | 2009-01-05 | 2016-11-15 | Rxi Pharmaceuticals Corporation | Inhibition of PCSK9 through RNAi |
| US9745574B2 (en) | 2009-02-04 | 2017-08-29 | Rxi Pharmaceuticals Corporation | RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality |
| US8871730B2 (en) | 2009-07-13 | 2014-10-28 | Somagenics Inc. | Chemical modification of short small hairpin RNAs for inhibition of gene expression |
| WO2011109248A1 (en) | 2010-03-02 | 2011-09-09 | Hapten Pharmaceuticals, Llc | Effective sensitizing dose of a gelled immunomodulating topical composition |
| WO2011112516A1 (en) | 2010-03-08 | 2011-09-15 | Ico Therapeutics Inc. | Treating and preventing hepatitis c virus infection using c-raf kinase antisense oligonucleotides |
| BR112012024049A2 (pt) | 2010-03-24 | 2017-03-01 | Rxi Pharmaceuticals Corp | interferência de rna em indicações dérmicas e fibróticas |
| US9080171B2 (en) | 2010-03-24 | 2015-07-14 | RXi Parmaceuticals Corporation | Reduced size self-delivering RNAi compounds |
| CN106074591B (zh) | 2010-03-24 | 2020-01-14 | 菲奥医药公司 | 眼部症候中的rna干扰 |
| JO3756B1 (ar) | 2010-11-23 | 2021-01-31 | Regeneron Pharma | اجسام مضادة بشرية لمستقبلات الجلوكاجون |
| US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
| AU2013315007A1 (en) | 2012-09-17 | 2015-04-09 | The Research Institute At Nationwide Children's Hospital | Compositions and methods for treating amyotrophic lateral sclerosis |
| EP2927320B1 (en) | 2012-11-29 | 2019-09-04 | Gifu University | Rna interference agent, method for producing same, and use thereof |
| LT3702466T (lt) * | 2013-08-27 | 2023-02-27 | Research Institute At Nationwide Children's Hospital | Produktai ir būdai, skirti šoninės amiotrofinės sklerozės gydymui |
| WO2015069647A1 (en) * | 2013-11-05 | 2015-05-14 | The Research Institute At Nationwide Children's Hospital | COMPOSITIONS AND METHODS FOR INHIBITING NF- kB AND SOD-1 TO TREAT AMYOTROPHIC LATERAL SCLEROSIS |
| WO2015084897A2 (en) | 2013-12-02 | 2015-06-11 | Mirimmune, Llc | Immunotherapy of cancer |
| EP3077050B1 (en) | 2013-12-04 | 2020-10-21 | Phio Pharmaceuticals Corp. | Methods for treatment of wound healing utilizing chemically modified oligonucleotides |
| EP4410805A3 (en) | 2014-03-18 | 2024-11-27 | University of Massachusetts | Raav-based compositions and methods for treating amyotrophic lateral sclerosis |
| RS60707B1 (sr) * | 2014-04-01 | 2020-09-30 | Biogen Ma Inc | Kompozicije za modulaciju ekspresije sod-1 |
| EP3733856A1 (en) | 2014-04-18 | 2020-11-04 | University of Massachusetts | Exosomal loading using hydrophobically modified oligonucleotides |
| US11279934B2 (en) | 2014-04-28 | 2022-03-22 | Phio Pharmaceuticals Corp. | Methods for treating cancer using nucleic acids targeting MDM2 or MYCN |
| WO2015168605A1 (en) | 2014-05-01 | 2015-11-05 | Rxi Pharmaceuticals Corporation | Methods for treatment of disorders in the front of the eye utilizing nucleic acid molecules |
| IL316808A (en) | 2014-08-20 | 2025-01-01 | Alnylam Pharmaceuticals Inc | Modified double-stranded RNA materials and their uses |
| KR102506169B1 (ko) | 2014-09-05 | 2023-03-08 | 피오 파마슈티칼스 코프. | Tyr 또는 mmp1을 표적화하는 핵산을 사용한 노화 및 피부 장애의 치료 방법 |
| KR20170062466A (ko) | 2014-09-16 | 2017-06-07 | 리제너론 파마슈티칼스 인코포레이티드 | 항-글루카곤 항체 및 그것의 사용 |
| CN119876138A (zh) | 2014-11-14 | 2025-04-25 | 沃雅戈治疗公司 | 调节性多核苷酸 |
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| CN108135923B (zh) * | 2015-07-06 | 2021-03-02 | 菲奥医药公司 | 靶向超氧化物歧化酶1(sod1)的核酸分子 |
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| WO2017132669A1 (en) | 2016-01-31 | 2017-08-03 | University Of Massachusetts | Branched oligonucleotides |
| JP2019513371A (ja) | 2016-04-01 | 2019-05-30 | アビディティー バイオサイエンシーズ エルエルシー | 核酸ポリペプチド組成物とその使用 |
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| WO2017173297A1 (en) | 2016-04-01 | 2017-10-05 | Avidity Biosciences Llc | Beta-catenin nucleic acids and uses thereof |
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| US10876116B2 (en) * | 2016-07-15 | 2020-12-29 | The Board Of Regents Of The University Of Oklahoma | Anti-ARID3a treatments for inflammatory disorders |
| CA3033368A1 (en) | 2016-08-12 | 2018-02-15 | University Of Massachusetts | Conjugated oligonucleotides |
| CN106244590B (zh) * | 2016-08-18 | 2019-10-01 | 广州市锐博生物科技有限公司 | 经修饰的siRNA分子、RNAi分子混合物及其应用 |
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- 2009-02-11 EP EP19169047.8A patent/EP3643782A1/en not_active Withdrawn
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2010
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2015
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2018
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Also Published As
| Publication number | Publication date |
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| CN104975020A (zh) | 2015-10-14 |
| EP2247729B1 (en) | 2019-05-01 |
| JP6170954B2 (ja) | 2017-07-26 |
| US20190169608A1 (en) | 2019-06-06 |
| CA2715289A1 (en) | 2009-08-20 |
| JP5697993B2 (ja) | 2015-04-08 |
| CN102016036A (zh) | 2011-04-13 |
| IL207548A0 (en) | 2010-12-30 |
| WO2009102427A2 (en) | 2009-08-20 |
| JP2015133968A (ja) | 2015-07-27 |
| US20110039914A1 (en) | 2011-02-17 |
| JP2018007663A (ja) | 2018-01-18 |
| WO2009102427A3 (en) | 2009-12-23 |
| JP2011511636A (ja) | 2011-04-14 |
| CA2715289C (en) | 2019-12-24 |
| US10131904B2 (en) | 2018-11-20 |
| CN102016036B (zh) | 2015-04-08 |
| US10633654B2 (en) | 2020-04-28 |
| EP3643782A1 (en) | 2020-04-29 |
| AU2009213147A1 (en) | 2009-08-20 |
| EP2247729A2 (en) | 2010-11-10 |
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