CN1049428C - 短效的二氢吡啶类化合物及其制备方法和用途 - Google Patents

短效的二氢吡啶类化合物及其制备方法和用途 Download PDF

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Publication number
CN1049428C
CN1049428C CN94194500A CN94194500A CN1049428C CN 1049428 C CN1049428 C CN 1049428C CN 94194500 A CN94194500 A CN 94194500A CN 94194500 A CN94194500 A CN 94194500A CN 1049428 C CN1049428 C CN 1049428C
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CN
China
Prior art keywords
general formula
compound
dimethyl
dichlorophenyl
dihydropyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CN94194500A
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English (en)
Chinese (zh)
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CN1137269A (zh
Inventor
K·安德逊
M·诺兰达
R·C·韦斯特隆
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Astra AB
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Publication date
Application filed by Astra AB filed Critical Astra AB
Publication of CN1137269A publication Critical patent/CN1137269A/zh
Application granted granted Critical
Publication of CN1049428C publication Critical patent/CN1049428C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
CN94194500A 1993-11-05 1994-11-03 短效的二氢吡啶类化合物及其制备方法和用途 Expired - Lifetime CN1049428C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9303657A SE9303657D0 (sv) 1993-11-05 1993-11-05 Short-acting dihydropyridines
SE93036572 1993-11-05
SE9303657-2 1993-11-05

Publications (2)

Publication Number Publication Date
CN1137269A CN1137269A (zh) 1996-12-04
CN1049428C true CN1049428C (zh) 2000-02-16

Family

ID=20391655

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94194500A Expired - Lifetime CN1049428C (zh) 1993-11-05 1994-11-03 短效的二氢吡啶类化合物及其制备方法和用途

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US (1) US5856346A (enExample)
EP (1) EP0726894B1 (enExample)
JP (1) JP3712209B2 (enExample)
KR (1) KR100331663B1 (enExample)
CN (1) CN1049428C (enExample)
AT (1) ATE194330T1 (enExample)
AU (1) AU685532B2 (enExample)
BR (1) BR9407946A (enExample)
CA (1) CA2174969C (enExample)
CZ (1) CZ285691B6 (enExample)
DE (1) DE69425152T2 (enExample)
DK (1) DK0726894T3 (enExample)
EE (1) EE03230B1 (enExample)
EG (1) EG20539A (enExample)
ES (1) ES2150544T3 (enExample)
FI (1) FI110429B (enExample)
FR (1) FR12C0053I2 (enExample)
GR (1) GR3034469T3 (enExample)
HU (1) HU215591B (enExample)
IL (1) IL111127A (enExample)
IS (1) IS1674B (enExample)
LU (1) LU92209I2 (enExample)
MY (1) MY111770A (enExample)
NO (1) NO305656B1 (enExample)
NZ (1) NZ275915A (enExample)
PL (1) PL185099B1 (enExample)
PT (1) PT726894E (enExample)
RU (1) RU2139278C1 (enExample)
SA (1) SA94150250B1 (enExample)
SE (1) SE9303657D0 (enExample)
SK (1) SK281467B6 (enExample)
TW (1) TW279859B (enExample)
UA (1) UA45959C2 (enExample)
WO (1) WO1995012578A1 (enExample)
ZA (1) ZA947570B (enExample)

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SE9804002D0 (sv) * 1998-11-23 1998-11-23 Astra Ab New manufacturing process
EP1455804A4 (en) * 2001-12-21 2005-01-05 Alcon Inc USE OF NANOTEILES AS CARRIERS OF BIOCIDES IN OPHTHALMIC COMPOSITIONS
FR2922439B1 (fr) * 2007-10-18 2010-12-10 Hill Rom Ind Sa Procede de gonflage alterne d'un dispositif de support a cellules gonflables et dispositif pour sa mise en oeuvre
KR101772602B1 (ko) 2008-08-01 2017-08-29 치에시 파마슈티시 에스.피.아. 약제학적 조성물 및 그의 저 불순물 농축물을 제조하는 방법
CA2775061A1 (en) * 2009-09-30 2011-04-07 Microdose Therapeutx, Inc. Methods and compositions for treatment of raynaud's phenomenon
CN101780036B (zh) * 2010-03-30 2011-11-16 武汉武药科技有限公司 丁酸氯维地平脂微球注射液及其制备方法
CA2701087A1 (en) * 2010-04-12 2011-10-12 Alphora Research Inc. Preparation of clevidipine butyrate ring the same
US8455655B2 (en) 2010-05-07 2013-06-04 Laboratorios Lesvi, S.L. Preparation of dihydropyridines
EP2386544B1 (en) 2010-05-07 2016-02-10 Laboratorios Lesvi, S.L. Preparation of dihydropyridines
US8658676B2 (en) 2010-10-12 2014-02-25 The Medicines Company Clevidipine emulsion formulations containing antimicrobial agents
JP6040437B2 (ja) 2010-10-12 2016-12-07 チエシイ ファルマセウティシ ソシエタ ペル アチオニＣｈｉｅｓｉ Ｆａｒｍａｃｅｕｔｉｃｉ Ｓ．Ｐ．Ａ． 抗菌剤を含むクレビジピン乳化製剤
BR112013025368A8 (pt) * 2011-04-01 2018-06-12 The Medicines Co Medicamento, método para preparar um medicamento útil para reduzir danos por derrame em um sujeito com derrame, método para preparar um medicamento útil para reduzir a pressão sanguínea e reduzir danos por derrame em um sujeito com derrame
AU2012303683B2 (en) 2011-08-26 2016-09-08 Wockhardt Limited Methods for treating cardiovascular disorders
CN103420899B (zh) * 2012-05-25 2016-01-27 四川科伦药物研究有限公司 一种丁酸氯维地平的纯化方法
KR102299073B1 (ko) 2012-10-26 2021-09-09 치에시 파마슈티시 에스.피.아. 심부전에서 혈압을 조절하고 호흡곤란을 감소시키는 방법
CN103073485B (zh) * 2013-01-17 2015-09-02 北京嘉林药业股份有限公司 一种丁酸氯维地平的制备方法
CN103086956B (zh) * 2013-01-17 2015-11-04 北京嘉林药业股份有限公司 一种丁酸氯维地平中间体的纯化方法
KR102380701B1 (ko) 2014-05-19 2022-03-31 치에시 파마슈티시 에스.피.아. 클레비디핀 나노입자 및 그의 제약적 조성물
CN105367487A (zh) * 2014-08-23 2016-03-02 南京海纳医药科技有限公司 一种丁酸氯维地平重要中间体新的合成方法
CN104370802A (zh) * 2014-09-24 2015-02-25 北京蓝丹医药科技有限公司 氯维地平衍生物及其制备方法
DK3298027T3 (da) 2015-05-20 2021-08-09 Boehringer Ingelheim Animal Health Usa Inc Anthelmintiske depsipeptidforbindelser
JP6943859B2 (ja) 2015-12-28 2021-10-06 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド 駆虫性デプシペプチド化合物
MX2019005628A (es) 2016-11-16 2019-12-18 Boehringer Ingelheim Animal Health Usa Inc Compuestos depsipeptidos antihelminticos.
RU2755349C1 (ru) * 2021-02-16 2021-09-15 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Применение бензил 6-({ 2-[(3,4-диметилфенил)амино]-2-оксоэтил} тио)-2-метил-4-(4-хлорфенил)-5-циано-1,4-дигидропиридин-3-карбоксилата в качестве гепатопротекторного средства

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012180A1 (de) * 1978-10-31 1980-06-25 Bayer Ag Neue 1,4-Dihydropyridinverbindungen, Verfahren zu ihrer Herstellung, die genannten Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
EP0366548A1 (en) * 1988-10-27 1990-05-02 Yuhan Corporation Ltd. Dihydropyridine derivatives
EP0416479A1 (en) * 1989-08-31 1991-03-13 Tanabe Seiyaku Co., Ltd. 1,5-Benzothiazepine derivatives and preparation thereof
EP0474129A2 (en) * 1990-09-01 1992-03-11 Kazuo Achiwa 1,4-Dihydropyridine derivatives and process for preparing the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US4154839A (en) * 1975-11-05 1979-05-15 Bayer Aktiengesellschaft 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012180A1 (de) * 1978-10-31 1980-06-25 Bayer Ag Neue 1,4-Dihydropyridinverbindungen, Verfahren zu ihrer Herstellung, die genannten Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
EP0366548A1 (en) * 1988-10-27 1990-05-02 Yuhan Corporation Ltd. Dihydropyridine derivatives
EP0416479A1 (en) * 1989-08-31 1991-03-13 Tanabe Seiyaku Co., Ltd. 1,5-Benzothiazepine derivatives and preparation thereof
EP0474129A2 (en) * 1990-09-01 1992-03-11 Kazuo Achiwa 1,4-Dihydropyridine derivatives and process for preparing the same

Also Published As

Publication number Publication date
HU215591B (hu) 1999-01-28
CA2174969A1 (en) 1995-05-11
BR9407946A (pt) 1996-11-26
NO961776D0 (no) 1996-05-02
SA94150250B1 (ar) 2006-03-01
UA45959C2 (uk) 2002-05-15
JPH09504542A (ja) 1997-05-06
SK281467B6 (sk) 2001-04-09
FI961914L (fi) 1996-05-06
HUT75316A (en) 1997-05-28
DK0726894T3 (da) 2000-10-23
ATE194330T1 (de) 2000-07-15
IL111127A (en) 2000-11-21
PT726894E (pt) 2000-10-31
EE03230B1 (et) 1999-10-15
LU92209I2 (fr) 2013-08-23
AU685532B2 (en) 1998-01-22
FR12C0053I1 (enExample) 2012-02-11
HK1013292A1 (en) 1999-08-20
DE69425152D1 (de) 2000-08-10
EG20539A (en) 1999-07-31
IS1674B (is) 1997-12-31
NO961776L (no) 1996-05-02
RU2139278C1 (ru) 1999-10-10
CN1137269A (zh) 1996-12-04
FI110429B (fi) 2003-01-31
SK55996A3 (en) 1996-12-04
IL111127A0 (en) 1994-12-29
EP0726894A1 (en) 1996-08-21
SE9303657D0 (sv) 1993-11-05
TW279859B (enExample) 1996-07-01
CZ285691B6 (cs) 1999-10-13
HU9601187D0 (en) 1996-07-29
NZ275915A (en) 1997-04-24
MY111770A (en) 2000-12-30
US5856346A (en) 1999-01-05
FR12C0053I2 (fr) 2013-08-16
CZ127396A3 (en) 1996-09-11
NO305656B1 (no) 1999-07-05
PL185099B1 (pl) 2003-02-28
CA2174969C (en) 2005-05-17
GR3034469T3 (en) 2000-12-29
EP0726894B1 (en) 2000-07-05
ES2150544T3 (es) 2000-12-01
JP3712209B2 (ja) 2005-11-02
WO1995012578A1 (en) 1995-05-11
DE69425152T2 (de) 2001-03-22
FI961914A0 (fi) 1996-05-06
AU8119694A (en) 1995-05-23
PL314128A1 (en) 1996-08-19
IS4218A (is) 1995-05-06
ZA947570B (en) 1995-05-29
KR100331663B1 (ko) 2002-09-26

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Address after: Swedish Sodertalje

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Expiration termination date: 20141103

Granted publication date: 20000216