ES2571043T3 - Preparación de dihidropiridinas - Google Patents
Preparación de dihidropiridinasInfo
- Publication number
- ES2571043T3 ES2571043T3 ES10162298T ES10162298T ES2571043T3 ES 2571043 T3 ES2571043 T3 ES 2571043T3 ES 10162298 T ES10162298 T ES 10162298T ES 10162298 T ES10162298 T ES 10162298T ES 2571043 T3 ES2571043 T3 ES 2571043T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- preparation
- organic solvent
- dihydropyridine preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Un proceso para la preparación de butirato de clevidipina que comprende la etapa: (i) hacer reaccionar un compuesto de fórmula (I): **Fórmula** con 3-amino-crotonato de metilo para obtener butirato de clevidipina, en el que la etapa (i) se realiza en presencia de al menos un disolvente orgánico o una mezcla de disolventes que comprende un disolvente orgánico; y en el que el compuesto de fórmula (I) se prepara mediante la esterificación de un compuesto de fórmula (II) o una sal del mismo: **Fórmula** con un compuesto de fórmula L-CH2-OCO-n-Pr, en la que L es un grupo saliente.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10162298.3A EP2386544B1 (en) | 2010-05-07 | 2010-05-07 | Preparation of dihydropyridines |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2571043T3 true ES2571043T3 (es) | 2016-05-23 |
Family
ID=42734845
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES10162298T Active ES2571043T3 (es) | 2010-05-07 | 2010-05-07 | Preparación de dihidropiridinas |
Country Status (2)
Country | Link |
---|---|
EP (2) | EP3020704A3 (es) |
ES (1) | ES2571043T3 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103781479A (zh) * | 2011-04-01 | 2014-05-07 | 医药公司 | 用于减轻中风损害的短效二氢吡啶(氯维地平) |
CN103242220B (zh) * | 2012-02-08 | 2016-03-09 | 上海医药工业研究院 | 丁酸氯维地平的制备方法 |
CN103373956B (zh) * | 2012-04-23 | 2015-07-01 | 黑龙江省格润药业有限责任公司 | 一种制备丁酸氯维地平的方法 |
CN103450076A (zh) * | 2013-09-13 | 2013-12-18 | 朱从敏 | 一种制备丁酸氯维地平的方法 |
CN104072404A (zh) * | 2014-06-06 | 2014-10-01 | 北京哈三联科技有限责任公司 | 一种丁酸氯维地平的制备方法 |
CN105198797B (zh) * | 2015-11-12 | 2017-12-08 | 华仁药业股份有限公司 | 丁酸氯维地平的纯化方法 |
CN108752263B (zh) * | 2018-06-08 | 2021-10-26 | 迪嘉药业集团有限公司 | 一种高纯度硝苯地平结晶的制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9303657D0 (sv) | 1993-11-05 | 1993-11-05 | Astra Ab | Short-acting dihydropyridines |
SE9804002D0 (sv) | 1998-11-23 | 1998-11-23 | Astra Ab | New manufacturing process |
-
2010
- 2010-05-07 ES ES10162298T patent/ES2571043T3/es active Active
- 2010-05-07 EP EP15200796.9A patent/EP3020704A3/en not_active Withdrawn
- 2010-05-07 EP EP10162298.3A patent/EP2386544B1/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP2386544A1 (en) | 2011-11-16 |
EP2386544B1 (en) | 2016-02-10 |
EP3020704A3 (en) | 2016-11-09 |
EP3020704A2 (en) | 2016-05-18 |
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