PE20142433A1 - Proceso para la elaboracion de undecapeptidos ciclicos - Google Patents
Proceso para la elaboracion de undecapeptidos ciclicosInfo
- Publication number
- PE20142433A1 PE20142433A1 PE2014001983A PE2014001983A PE20142433A1 PE 20142433 A1 PE20142433 A1 PE 20142433A1 PE 2014001983 A PE2014001983 A PE 2014001983A PE 2014001983 A PE2014001983 A PE 2014001983A PE 20142433 A1 PE20142433 A1 PE 20142433A1
- Authority
- PE
- Peru
- Prior art keywords
- deecapeptides
- elaboration
- cyclic
- cyclosporin
- ethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE REFIERE A UN PROCESO PARA LA PREPARACION DE UN COMPUESTO DE FORMULA 3, DONDE: R ES METILO, ETILO, PROPILO, ENTRE OTROS; R' ES METILO O ETILO; DICHO PROCESO COMPRENDE: ACILAR LA CICLOSPORINA A PARA FORMAR ACETIL-CICLOSPORINA A; ABRIR EL ANILLO DE LA ACETIL-CICLOSPORINA A; CRISTALIZAR DICHO ANILLO ABIERTO PARA OBTENER UN COMPUESTO DE FORMULA 3.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261644616P | 2012-05-09 | 2012-05-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20142433A1 true PE20142433A1 (es) | 2015-02-02 |
Family
ID=48444372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2014001983A PE20142433A1 (es) | 2012-05-09 | 2013-05-08 | Proceso para la elaboracion de undecapeptidos ciclicos |
Country Status (24)
Country | Link |
---|---|
US (2) | US20150087808A1 (es) |
EP (1) | EP2847211A1 (es) |
JP (3) | JP2015517481A (es) |
KR (1) | KR20150006435A (es) |
CN (2) | CN108715606A (es) |
AR (1) | AR090964A1 (es) |
AU (2) | AU2013257989A1 (es) |
BR (1) | BR112014027648A2 (es) |
CA (1) | CA2868940A1 (es) |
CL (1) | CL2014003014A1 (es) |
CO (1) | CO7141428A2 (es) |
EA (1) | EA024903B1 (es) |
EC (1) | ECSP14030537A (es) |
HK (1) | HK1202555A1 (es) |
IL (1) | IL235428A0 (es) |
IN (1) | IN2014DN08483A (es) |
MA (1) | MA20150231A1 (es) |
MX (1) | MX2014013613A (es) |
PE (1) | PE20142433A1 (es) |
PH (1) | PH12014502499A1 (es) |
SG (1) | SG11201406303XA (es) |
TN (1) | TN2014000411A1 (es) |
TW (1) | TW201350508A (es) |
WO (1) | WO2013167703A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105693820A (zh) * | 2014-11-27 | 2016-06-22 | 武汉药明康德新药开发有限公司 | 一种降解环孢菌素a的方法 |
WO2018207904A1 (ja) | 2017-05-12 | 2018-11-15 | 中外製薬株式会社 | 環状有機化合物の製造方法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT401177B (de) * | 1993-10-22 | 1996-07-25 | Biochemie Gmbh | Verfahren zur herstellung von 7-amino-3-cephem-4-carbonsäure-derivaten |
JP4350898B2 (ja) * | 1998-07-01 | 2009-10-21 | デビオファーム・ソシエテ・アノニム | 活性の特徴が改善された新規のシクロスポリン |
EP1150999B1 (fr) * | 1999-02-05 | 2006-06-21 | Debiopharm S.A. | Derives de cyclosporine et procede de preparation desdits derives |
CA2444278C (en) * | 2001-04-20 | 2011-11-22 | Debiopharm S.A. | Modified cyclosporine which can be used as a pro-drug and use thereof |
PL210795B1 (pl) * | 2001-10-19 | 2012-03-30 | Isotechnika Inc | Sposób wytwarzania mieszaniny ISATX247 wzbogaconej w izomer (E), sposób wytwarzania mieszaniny ISATX247 wzbogaconej w izomer (Z), sposób stereoselektywnej syntezy izomeru (E) ISATX247, sposób stereoselektywnej syntezy izomeru (Z) ISATX247 i sposób wytwarzania mieszaniny izomerów ISATX247 |
TW200505946A (en) | 2003-04-08 | 2005-02-16 | Hoffmann La Roche | Process for preparation of cyclosporin a analog |
BRPI0515494A (pt) * | 2004-10-01 | 2008-07-29 | Debiopharm Sa | uso de [d-meala] 3-[etval] 4-ciclosporina para o tratamento de infecção por hepatite c e composição farmacêutica compreendendo a referida [d-meala] 3-[etval] 4-ciclosporina |
BRPI0517207A (pt) * | 2004-12-17 | 2008-09-30 | Isotechnika Inc | composto isolado, metabólito isolado de ciclo {{(e)- e (z)- (2s,3r,4r)-3-hidróxi-4-metil-2-(metilamino)-6,8-nonadien oil}-l-2-aminobutiril-n-metil-glicil-n-metil-l-leucil-l-v alil-n-metil-l-leucil-l-alanil-d-alanil-n-metil-l-leucil- n-metil-l-leucil-n-metil-l-valil} (isa247) e os sais e solvatos farmaceuticamente aceitáveis dos mesmos, método de preparação de metabólitos de isa247 in vitro, método de produção de um metabólito hidroxilado de isa247, metabólito hidroxilado isolado de isa247, metabólito hidroxilado isolado, método de produção de um metabólito de epóxido de isa247 in vitro, metabólito isolado de epóxido de isa247, metabólito isolado de epóxido, método de produção de um metabólito de diol de isa247 in vitro, metabólito de diol isolado de isa247, metabólito de diol isolado, método de produção de um metabólito de diol de isa247, método de produção de um metabólito de diol de isa247 e composição farmacêutica |
MX2009007045A (es) | 2007-01-04 | 2009-10-07 | Debiopharm Sa | Ciclosporina no inmunosupresora para el tratamiento de distrofia muscular congenita de ullrich. |
AU2008304313B2 (en) | 2007-09-26 | 2013-01-10 | Oregon Health & Science University | Cyclic undecapeptides and derivatives as multiple sclerosis therapies |
US7910378B2 (en) * | 2007-12-14 | 2011-03-22 | Siemens Healthcare Diagnostics Inc. | Methods for detection of hydrophobic drugs |
WO2009098533A1 (en) | 2008-02-08 | 2009-08-13 | Debiopharm Sa | Non -immunosuppressive cyclosporin for the treatment of muscular dystrophy |
UA102414C2 (ru) | 2008-11-06 | 2013-07-10 | Дебио Решерш Фармасьютик С.А. | Циклоундекадепсипептидные соединения для лечения инфекций, вызванных вирусом гепатита с |
US8536114B2 (en) * | 2008-12-31 | 2013-09-17 | Scynexis, Inc. | Macrocycles |
WO2010088573A1 (en) * | 2009-01-30 | 2010-08-05 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues for preventing or treating hepatitis c infection |
US9573978B2 (en) * | 2010-08-12 | 2017-02-21 | S&T Global, Inc. | Cyclosporin derivatives for the treatment and prevention of a viral infection |
-
2013
- 2013-05-07 AR ARP130101557A patent/AR090964A1/es unknown
- 2013-05-08 PE PE2014001983A patent/PE20142433A1/es not_active Application Discontinuation
- 2013-05-08 EA EA201492036A patent/EA024903B1/ru not_active IP Right Cessation
- 2013-05-08 AU AU2013257989A patent/AU2013257989A1/en not_active Abandoned
- 2013-05-08 TW TW102116414A patent/TW201350508A/zh unknown
- 2013-05-08 CA CA2868940A patent/CA2868940A1/en not_active Abandoned
- 2013-05-08 BR BR112014027648A patent/BR112014027648A2/pt not_active IP Right Cessation
- 2013-05-08 EP EP13722740.1A patent/EP2847211A1/en not_active Withdrawn
- 2013-05-08 JP JP2015510823A patent/JP2015517481A/ja not_active Withdrawn
- 2013-05-08 MX MX2014013613A patent/MX2014013613A/es unknown
- 2013-05-08 MA MA37498A patent/MA20150231A1/fr unknown
- 2013-05-08 US US14/399,261 patent/US20150087808A1/en not_active Abandoned
- 2013-05-08 IN IN8483DEN2014 patent/IN2014DN08483A/en unknown
- 2013-05-08 KR KR1020147031112A patent/KR20150006435A/ko not_active Application Discontinuation
- 2013-05-08 WO PCT/EP2013/059672 patent/WO2013167703A1/en active Application Filing
- 2013-05-08 CN CN201810575515.2A patent/CN108715606A/zh active Pending
- 2013-05-08 SG SG11201406303XA patent/SG11201406303XA/en unknown
- 2013-05-08 CN CN201380023760.8A patent/CN104284902A/zh active Pending
-
2014
- 2014-09-30 TN TNP2014000411A patent/TN2014000411A1/fr unknown
- 2014-10-30 IL IL235428A patent/IL235428A0/en unknown
- 2014-11-07 CL CL2014003014A patent/CL2014003014A1/es unknown
- 2014-11-10 CO CO14248207A patent/CO7141428A2/es unknown
- 2014-11-10 PH PH12014502499A patent/PH12014502499A1/en unknown
- 2014-12-08 EC ECIEPI201430537A patent/ECSP14030537A/es unknown
-
2015
- 2015-03-20 HK HK15102858.0A patent/HK1202555A1/xx unknown
-
2016
- 2016-06-30 US US15/198,152 patent/US9840534B2/en not_active Expired - Fee Related
- 2016-08-31 AU AU2016222370A patent/AU2016222370B2/en not_active Ceased
-
2017
- 2017-08-29 JP JP2017164867A patent/JP2018035154A/ja not_active Withdrawn
-
2019
- 2019-09-30 JP JP2019179311A patent/JP2020033349A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
TW201350508A (zh) | 2013-12-16 |
WO2013167703A1 (en) | 2013-11-14 |
IN2014DN08483A (es) | 2015-05-08 |
BR112014027648A2 (pt) | 2017-06-27 |
ECSP14030537A (es) | 2015-09-30 |
PH12014502499A1 (en) | 2014-12-22 |
EA201492036A1 (ru) | 2015-02-27 |
TN2014000411A1 (en) | 2015-12-21 |
AU2013257989A1 (en) | 2014-10-23 |
EA024903B1 (ru) | 2016-10-31 |
MX2014013613A (es) | 2015-02-12 |
CL2014003014A1 (es) | 2015-03-06 |
US9840534B2 (en) | 2017-12-12 |
JP2015517481A (ja) | 2015-06-22 |
US20160304554A1 (en) | 2016-10-20 |
AU2016222370A1 (en) | 2016-09-15 |
SG11201406303XA (en) | 2014-11-27 |
AU2016222370B2 (en) | 2017-10-05 |
JP2018035154A (ja) | 2018-03-08 |
CA2868940A1 (en) | 2013-11-14 |
CO7141428A2 (es) | 2014-12-12 |
KR20150006435A (ko) | 2015-01-16 |
US20150087808A1 (en) | 2015-03-26 |
WO2013167703A9 (en) | 2014-11-20 |
CN108715606A (zh) | 2018-10-30 |
AR090964A1 (es) | 2014-12-17 |
IL235428A0 (en) | 2014-12-31 |
CN104284902A (zh) | 2015-01-14 |
JP2020033349A (ja) | 2020-03-05 |
HK1202555A1 (en) | 2015-10-02 |
MA20150231A1 (fr) | 2015-07-31 |
EP2847211A1 (en) | 2015-03-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |