PE20142433A1 - Proceso para la elaboracion de undecapeptidos ciclicos - Google Patents

Proceso para la elaboracion de undecapeptidos ciclicos

Info

Publication number
PE20142433A1
PE20142433A1 PE2014001983A PE2014001983A PE20142433A1 PE 20142433 A1 PE20142433 A1 PE 20142433A1 PE 2014001983 A PE2014001983 A PE 2014001983A PE 2014001983 A PE2014001983 A PE 2014001983A PE 20142433 A1 PE20142433 A1 PE 20142433A1
Authority
PE
Peru
Prior art keywords
deecapeptides
elaboration
cyclic
cyclosporin
ethyl
Prior art date
Application number
PE2014001983A
Other languages
English (en)
Inventor
Fabrice Gallou
Bernard Riss
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48444372&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20142433(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20142433A1 publication Critical patent/PE20142433A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

SE REFIERE A UN PROCESO PARA LA PREPARACION DE UN COMPUESTO DE FORMULA 3, DONDE: R ES METILO, ETILO, PROPILO, ENTRE OTROS; R' ES METILO O ETILO; DICHO PROCESO COMPRENDE: ACILAR LA CICLOSPORINA A PARA FORMAR ACETIL-CICLOSPORINA A; ABRIR EL ANILLO DE LA ACETIL-CICLOSPORINA A; CRISTALIZAR DICHO ANILLO ABIERTO PARA OBTENER UN COMPUESTO DE FORMULA 3.
PE2014001983A 2012-05-09 2013-05-08 Proceso para la elaboracion de undecapeptidos ciclicos PE20142433A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261644616P 2012-05-09 2012-05-09

Publications (1)

Publication Number Publication Date
PE20142433A1 true PE20142433A1 (es) 2015-02-02

Family

ID=48444372

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2014001983A PE20142433A1 (es) 2012-05-09 2013-05-08 Proceso para la elaboracion de undecapeptidos ciclicos

Country Status (24)

Country Link
US (2) US20150087808A1 (es)
EP (1) EP2847211A1 (es)
JP (3) JP2015517481A (es)
KR (1) KR20150006435A (es)
CN (2) CN108715606A (es)
AR (1) AR090964A1 (es)
AU (2) AU2013257989A1 (es)
BR (1) BR112014027648A2 (es)
CA (1) CA2868940A1 (es)
CL (1) CL2014003014A1 (es)
CO (1) CO7141428A2 (es)
EA (1) EA024903B1 (es)
EC (1) ECSP14030537A (es)
HK (1) HK1202555A1 (es)
IL (1) IL235428A0 (es)
IN (1) IN2014DN08483A (es)
MA (1) MA20150231A1 (es)
MX (1) MX2014013613A (es)
PE (1) PE20142433A1 (es)
PH (1) PH12014502499A1 (es)
SG (1) SG11201406303XA (es)
TN (1) TN2014000411A1 (es)
TW (1) TW201350508A (es)
WO (1) WO2013167703A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105693820A (zh) * 2014-11-27 2016-06-22 武汉药明康德新药开发有限公司 一种降解环孢菌素a的方法
WO2018207904A1 (ja) 2017-05-12 2018-11-15 中外製薬株式会社 環状有機化合物の製造方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT401177B (de) * 1993-10-22 1996-07-25 Biochemie Gmbh Verfahren zur herstellung von 7-amino-3-cephem-4-carbonsäure-derivaten
JP4350898B2 (ja) * 1998-07-01 2009-10-21 デビオファーム・ソシエテ・アノニム 活性の特徴が改善された新規のシクロスポリン
EP1150999B1 (fr) * 1999-02-05 2006-06-21 Debiopharm S.A. Derives de cyclosporine et procede de preparation desdits derives
CA2444278C (en) * 2001-04-20 2011-11-22 Debiopharm S.A. Modified cyclosporine which can be used as a pro-drug and use thereof
PL210795B1 (pl) * 2001-10-19 2012-03-30 Isotechnika Inc Sposób wytwarzania mieszaniny ISATX247 wzbogaconej w izomer (E), sposób wytwarzania mieszaniny ISATX247 wzbogaconej w izomer (Z), sposób stereoselektywnej syntezy izomeru (E) ISATX247, sposób stereoselektywnej syntezy izomeru (Z) ISATX247 i sposób wytwarzania mieszaniny izomerów ISATX247
TW200505946A (en) 2003-04-08 2005-02-16 Hoffmann La Roche Process for preparation of cyclosporin a analog
BRPI0515494A (pt) * 2004-10-01 2008-07-29 Debiopharm Sa uso de [d-meala] 3-[etval] 4-ciclosporina para o tratamento de infecção por hepatite c e composição farmacêutica compreendendo a referida [d-meala] 3-[etval] 4-ciclosporina
BRPI0517207A (pt) * 2004-12-17 2008-09-30 Isotechnika Inc composto isolado, metabólito isolado de ciclo {{(e)- e (z)- (2s,3r,4r)-3-hidróxi-4-metil-2-(metilamino)-6,8-nonadien oil}-l-2-aminobutiril-n-metil-glicil-n-metil-l-leucil-l-v alil-n-metil-l-leucil-l-alanil-d-alanil-n-metil-l-leucil- n-metil-l-leucil-n-metil-l-valil} (isa247) e os sais e solvatos farmaceuticamente aceitáveis dos mesmos, método de preparação de metabólitos de isa247 in vitro, método de produção de um metabólito hidroxilado de isa247, metabólito hidroxilado isolado de isa247, metabólito hidroxilado isolado, método de produção de um metabólito de epóxido de isa247 in vitro, metabólito isolado de epóxido de isa247, metabólito isolado de epóxido, método de produção de um metabólito de diol de isa247 in vitro, metabólito de diol isolado de isa247, metabólito de diol isolado, método de produção de um metabólito de diol de isa247, método de produção de um metabólito de diol de isa247 e composição farmacêutica
MX2009007045A (es) 2007-01-04 2009-10-07 Debiopharm Sa Ciclosporina no inmunosupresora para el tratamiento de distrofia muscular congenita de ullrich.
AU2008304313B2 (en) 2007-09-26 2013-01-10 Oregon Health & Science University Cyclic undecapeptides and derivatives as multiple sclerosis therapies
US7910378B2 (en) * 2007-12-14 2011-03-22 Siemens Healthcare Diagnostics Inc. Methods for detection of hydrophobic drugs
WO2009098533A1 (en) 2008-02-08 2009-08-13 Debiopharm Sa Non -immunosuppressive cyclosporin for the treatment of muscular dystrophy
UA102414C2 (ru) 2008-11-06 2013-07-10 Дебио Решерш Фармасьютик С.А. Циклоундекадепсипептидные соединения для лечения инфекций, вызванных вирусом гепатита с
US8536114B2 (en) * 2008-12-31 2013-09-17 Scynexis, Inc. Macrocycles
WO2010088573A1 (en) * 2009-01-30 2010-08-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis c infection
US9573978B2 (en) * 2010-08-12 2017-02-21 S&T Global, Inc. Cyclosporin derivatives for the treatment and prevention of a viral infection

Also Published As

Publication number Publication date
TW201350508A (zh) 2013-12-16
WO2013167703A1 (en) 2013-11-14
IN2014DN08483A (es) 2015-05-08
BR112014027648A2 (pt) 2017-06-27
ECSP14030537A (es) 2015-09-30
PH12014502499A1 (en) 2014-12-22
EA201492036A1 (ru) 2015-02-27
TN2014000411A1 (en) 2015-12-21
AU2013257989A1 (en) 2014-10-23
EA024903B1 (ru) 2016-10-31
MX2014013613A (es) 2015-02-12
CL2014003014A1 (es) 2015-03-06
US9840534B2 (en) 2017-12-12
JP2015517481A (ja) 2015-06-22
US20160304554A1 (en) 2016-10-20
AU2016222370A1 (en) 2016-09-15
SG11201406303XA (en) 2014-11-27
AU2016222370B2 (en) 2017-10-05
JP2018035154A (ja) 2018-03-08
CA2868940A1 (en) 2013-11-14
CO7141428A2 (es) 2014-12-12
KR20150006435A (ko) 2015-01-16
US20150087808A1 (en) 2015-03-26
WO2013167703A9 (en) 2014-11-20
CN108715606A (zh) 2018-10-30
AR090964A1 (es) 2014-12-17
IL235428A0 (en) 2014-12-31
CN104284902A (zh) 2015-01-14
JP2020033349A (ja) 2020-03-05
HK1202555A1 (en) 2015-10-02
MA20150231A1 (fr) 2015-07-31
EP2847211A1 (en) 2015-03-18

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