CL2014003014A1 - Proceso para la preparacion de un compuesto derivado de undecapeptidos ciclicos que comprende los pasos de: acilar la ciclosporina a, abrir el anillo de la acetil-ciclosporina a formada y cristalizar el anillo abierto para obtener un compuesto de formula 3 o de formula 4; compuesto undecapeptido ciclico de formula 3 y de formula 4. - Google Patents

Proceso para la preparacion de un compuesto derivado de undecapeptidos ciclicos que comprende los pasos de: acilar la ciclosporina a, abrir el anillo de la acetil-ciclosporina a formada y cristalizar el anillo abierto para obtener un compuesto de formula 3 o de formula 4; compuesto undecapeptido ciclico de formula 3 y de formula 4.

Info

Publication number
CL2014003014A1
CL2014003014A1 CL2014003014A CL2014003014A CL2014003014A1 CL 2014003014 A1 CL2014003014 A1 CL 2014003014A1 CL 2014003014 A CL2014003014 A CL 2014003014A CL 2014003014 A CL2014003014 A CL 2014003014A CL 2014003014 A1 CL2014003014 A1 CL 2014003014A1
Authority
CL
Chile
Prior art keywords
formula
compound
cyclosporine
cyclic
ring
Prior art date
Application number
CL2014003014A
Other languages
English (en)
Inventor
Fabrice Gallou
Bernard Riss
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48444372&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2014003014(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2014003014A1 publication Critical patent/CL2014003014A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
CL2014003014A 2012-05-09 2014-11-07 Proceso para la preparacion de un compuesto derivado de undecapeptidos ciclicos que comprende los pasos de: acilar la ciclosporina a, abrir el anillo de la acetil-ciclosporina a formada y cristalizar el anillo abierto para obtener un compuesto de formula 3 o de formula 4; compuesto undecapeptido ciclico de formula 3 y de formula 4. CL2014003014A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261644616P 2012-05-09 2012-05-09

Publications (1)

Publication Number Publication Date
CL2014003014A1 true CL2014003014A1 (es) 2015-03-06

Family

ID=48444372

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014003014A CL2014003014A1 (es) 2012-05-09 2014-11-07 Proceso para la preparacion de un compuesto derivado de undecapeptidos ciclicos que comprende los pasos de: acilar la ciclosporina a, abrir el anillo de la acetil-ciclosporina a formada y cristalizar el anillo abierto para obtener un compuesto de formula 3 o de formula 4; compuesto undecapeptido ciclico de formula 3 y de formula 4.

Country Status (24)

Country Link
US (2) US20150087808A1 (es)
EP (1) EP2847211A1 (es)
JP (3) JP2015517481A (es)
KR (1) KR20150006435A (es)
CN (2) CN104284902A (es)
AR (1) AR090964A1 (es)
AU (2) AU2013257989A1 (es)
BR (1) BR112014027648A2 (es)
CA (1) CA2868940A1 (es)
CL (1) CL2014003014A1 (es)
CO (1) CO7141428A2 (es)
EA (1) EA024903B1 (es)
EC (1) ECSP14030537A (es)
HK (1) HK1202555A1 (es)
IL (1) IL235428A0 (es)
IN (1) IN2014DN08483A (es)
MA (1) MA20150231A1 (es)
MX (1) MX2014013613A (es)
PE (1) PE20142433A1 (es)
PH (1) PH12014502499A1 (es)
SG (1) SG11201406303XA (es)
TN (1) TN2014000411A1 (es)
TW (1) TW201350508A (es)
WO (1) WO2013167703A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105693820A (zh) * 2014-11-27 2016-06-22 武汉药明康德新药开发有限公司 一种降解环孢菌素a的方法
CN117624307A (zh) 2017-05-12 2024-03-01 中外制药株式会社 用于制备环状有机化合物的方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT401177B (de) 1993-10-22 1996-07-25 Biochemie Gmbh Verfahren zur herstellung von 7-amino-3-cephem-4-carbonsäure-derivaten
DK1091975T3 (da) * 1998-07-01 2006-04-18 Debiopharm Sa Ny cyclosporin med forbedret aktivitetsprofil
PT1150999E (pt) * 1999-02-05 2006-10-31 Debiopharm Sa Derivados da ciclosporina em que a sequencia peptidica contem pelo menos um aminoacido nao natural do tipo pseudo-prolina e metodo para preparacao dos mesmos
ATE313557T1 (de) * 2001-04-20 2006-01-15 Debiopharm Sa Modifiziertes, als medikamentvorstufe anwendbares cyclosporin und dessen verwendung
BRPI0213658A8 (pt) * 2001-10-19 2016-12-06 F Hoffmann La Roche Ltd Método para preparar uma mistura isomérica predeterminada ou não dos análogos de ciclosporina a modificados no resíduo de 1-aminoácido, métodopara produzir uma mistura enriquecida com e-isômero ou com z-isômero de análogos de ciclosporina a modificados no resíduo de 1-aminoácido, mistura de (e) e (z)-isômeros, composição, método para a síntese estereoseletiva do z-isômero de isatx247, método para a preparação de aldeído do ciclosporina a
TW200505946A (en) 2003-04-08 2005-02-16 Hoffmann La Roche Process for preparation of cyclosporin a analog
DK1793844T3 (da) * 2004-10-01 2011-03-21 Debiopharm Sa Anvendelse af [D-MeAla]3-[EtVal]4-cyklosporin til behandling af hepatitis C-infektion
CN101120012A (zh) * 2004-12-17 2008-02-06 伊素制药公司 环孢菌素类似物的代谢物
CN105056207A (zh) 2007-01-04 2015-11-18 德比奥法姆国际股份有限公司 用于治疗Ullrich先天性肌营养不良的非免疫抑制性环孢霉素
US8394763B2 (en) 2007-09-26 2013-03-12 Oregon Health & Science University Cyclic undecapeptides and derivatives as multiple sclerosis therapies
US7910378B2 (en) * 2007-12-14 2011-03-22 Siemens Healthcare Diagnostics Inc. Methods for detection of hydrophobic drugs
WO2009098533A1 (en) 2008-02-08 2009-08-13 Debiopharm Sa Non -immunosuppressive cyclosporin for the treatment of muscular dystrophy
US8501683B2 (en) 2008-11-06 2013-08-06 Debio Recherche Pharmaceutique S.A. Cycloundecadepsipeptide compounds and use of said compounds as a medicament
CA2748389A1 (en) * 2008-12-31 2010-07-08 Scynexis, Inc. Derivatives of cyclosporin a
CA2751210C (en) * 2009-01-30 2015-04-21 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis c infection
WO2012021796A2 (en) * 2010-08-12 2012-02-16 S&T Global, Inc. Novel cyclosporin derivatives for the treatment and prevention of a viral infection

Also Published As

Publication number Publication date
TW201350508A (zh) 2013-12-16
SG11201406303XA (en) 2014-11-27
US20150087808A1 (en) 2015-03-26
AR090964A1 (es) 2014-12-17
WO2013167703A9 (en) 2014-11-20
HK1202555A1 (en) 2015-10-02
CN104284902A (zh) 2015-01-14
CN108715606A (zh) 2018-10-30
EA024903B1 (ru) 2016-10-31
MA20150231A1 (fr) 2015-07-31
PH12014502499A1 (en) 2014-12-22
JP2020033349A (ja) 2020-03-05
US9840534B2 (en) 2017-12-12
KR20150006435A (ko) 2015-01-16
BR112014027648A2 (pt) 2017-06-27
MX2014013613A (es) 2015-02-12
IN2014DN08483A (es) 2015-05-08
AU2016222370A1 (en) 2016-09-15
JP2015517481A (ja) 2015-06-22
US20160304554A1 (en) 2016-10-20
AU2016222370B2 (en) 2017-10-05
TN2014000411A1 (en) 2015-12-21
CO7141428A2 (es) 2014-12-12
CA2868940A1 (en) 2013-11-14
ECSP14030537A (es) 2015-09-30
EP2847211A1 (en) 2015-03-18
AU2013257989A1 (en) 2014-10-23
PE20142433A1 (es) 2015-02-02
EA201492036A1 (ru) 2015-02-27
JP2018035154A (ja) 2018-03-08
WO2013167703A1 (en) 2013-11-14
IL235428A0 (en) 2014-12-31

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