CN108752263B - 一种高纯度硝苯地平结晶的制备方法 - Google Patents
一种高纯度硝苯地平结晶的制备方法 Download PDFInfo
- Publication number
- CN108752263B CN108752263B CN201810583892.0A CN201810583892A CN108752263B CN 108752263 B CN108752263 B CN 108752263B CN 201810583892 A CN201810583892 A CN 201810583892A CN 108752263 B CN108752263 B CN 108752263B
- Authority
- CN
- China
- Prior art keywords
- nifedipine
- crystals
- purity
- minutes
- less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810583892.0A CN108752263B (zh) | 2018-06-08 | 2018-06-08 | 一种高纯度硝苯地平结晶的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810583892.0A CN108752263B (zh) | 2018-06-08 | 2018-06-08 | 一种高纯度硝苯地平结晶的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN108752263A CN108752263A (zh) | 2018-11-06 |
CN108752263B true CN108752263B (zh) | 2021-10-26 |
Family
ID=63999476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810583892.0A Active CN108752263B (zh) | 2018-06-08 | 2018-06-08 | 一种高纯度硝苯地平结晶的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108752263B (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110526879B (zh) * | 2019-08-28 | 2022-06-21 | 迪嘉药业集团有限公司 | 一种小粒度非布司他的结晶制备方法 |
CN110747511A (zh) * | 2019-10-23 | 2020-02-04 | 中山大学 | 化合物单晶及其制备方法 |
CN112592311B (zh) * | 2021-01-03 | 2023-01-31 | 迪沙药业集团有限公司 | 一种硝苯地平a晶块状晶习及其控释片组合物 |
CN113582913B (zh) * | 2021-08-18 | 2023-01-03 | 河北广祥制药有限公司 | 一种连续精制硝苯地平的方法 |
CN115353485B (zh) * | 2022-07-26 | 2024-04-19 | 山西双雁药业有限公司 | 从硝苯地平母液中回收硝苯地平的方法及应用 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1421434A (zh) * | 2001-11-22 | 2003-06-04 | 天津市河北制药厂第一分厂 | 硝苯地平的制备方法 |
EP2386544A1 (en) * | 2010-05-07 | 2011-11-16 | Laboratorios Lesvi, S.L. | Preparation of dihydropyridines |
CN102382040A (zh) * | 2010-09-02 | 2012-03-21 | 常州市第四制药厂有限公司 | 硝苯地平的制备及其杂质分离方法与应用 |
CN103613584A (zh) * | 2013-11-27 | 2014-03-05 | 沈阳药科大学 | 一种伊拉地平合成产物后处理的方法 |
CN107325043A (zh) * | 2017-08-15 | 2017-11-07 | 江苏德源药业股份有限公司 | 一种左旋阿雷地平的晶型及其制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20021445A1 (it) * | 2002-07-01 | 2004-01-02 | Erregierre Spa | Processo di sintesi industriale del isobutil metil 1,4-diidro-2,6-dimetil-4-(2-nitrofenil)piridin-3,5-dicarbossilato (nisoldipina) |
-
2018
- 2018-06-08 CN CN201810583892.0A patent/CN108752263B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1421434A (zh) * | 2001-11-22 | 2003-06-04 | 天津市河北制药厂第一分厂 | 硝苯地平的制备方法 |
EP2386544A1 (en) * | 2010-05-07 | 2011-11-16 | Laboratorios Lesvi, S.L. | Preparation of dihydropyridines |
CN102382040A (zh) * | 2010-09-02 | 2012-03-21 | 常州市第四制药厂有限公司 | 硝苯地平的制备及其杂质分离方法与应用 |
CN103613584A (zh) * | 2013-11-27 | 2014-03-05 | 沈阳药科大学 | 一种伊拉地平合成产物后处理的方法 |
CN107325043A (zh) * | 2017-08-15 | 2017-11-07 | 江苏德源药业股份有限公司 | 一种左旋阿雷地平的晶型及其制备方法 |
Non-Patent Citations (2)
Title |
---|
Synthesis, Structure, and Pharmacological Evaluation of the Stereoisomers of Furnidipine;Ramon Alajarin等;《Journal of Medicinal Chemistry》;19950701;第38卷(第15期);2830-2841 * |
硝苯地平缓控释制剂的质量分析;吴秋云;《南京农业大学硕士学位论文》;20170612;1-41 * |
Also Published As
Publication number | Publication date |
---|---|
CN108752263A (zh) | 2018-11-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN108752263B (zh) | 一种高纯度硝苯地平结晶的制备方法 | |
US6218574B1 (en) | Process for purifying long-chain dicarboxylic acid | |
EP2573070A1 (en) | Crystal form of (s)-4-hydroxy-2-oxo-1-pyrrolidine acetamide, preparation method and use thereof | |
JPH0643400B2 (ja) | トラセミドの安定な変態の製法 | |
CN107216289B (zh) | 一种依达拉奉的制备方法 | |
CN109503585B (zh) | 一种己酮可可碱回收品的精制方法 | |
CN101717365B (zh) | 托拉塞米的纯化方法 | |
CN109232389B (zh) | 一种小粒度硝苯地平的结晶制备方法 | |
CN112645912A (zh) | 一种高纯度m2晶型麦考酚钠的制备方法 | |
CN109232574B (zh) | 一种有效的叶酸纯化方法 | |
CN110627637B (zh) | 一步法制备消旋酮异亮氨酸钙 | |
EP2138499A1 (de) | Verfahren zum Herstellen von hochreinen Benzazepinderivaten | |
CN108546278A (zh) | 甲钴胺的精制方法 | |
CA2239313C (en) | Solid compound, its preparation and use in medicine | |
CN108440324B (zh) | 一种门冬氨酸鸟氨酸及其结晶方法 | |
KR102595725B1 (ko) | 아트로핀의 제조방법 | |
CN108395466B (zh) | 一种提高非那雄胺纯度的重结晶方法 | |
CN106905192A (zh) | 一种沙库必曲中间体的纯化方法 | |
CN112745246A (zh) | 一种沙库必曲中间体的纯化方法 | |
CN112480037B (zh) | 一种盐酸苯海索的合成方法 | |
CN115353485B (zh) | 从硝苯地平母液中回收硝苯地平的方法及应用 | |
US4055648A (en) | Papaverine thienyl-carboxylates and medicaments containing them | |
CN109553573B (zh) | 一种减少维生素b6精制过程中活性炭用量的方法 | |
CN114437026A (zh) | 一种低组合物杂质的苹果酸奈诺沙星原料药及其制备方法 | |
CN111303226B (zh) | 利用索非布韦晶型i制备索非布韦晶型vi的方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20210903 Address after: 264205 Wendeng economic and Technological Development Zone, Weihai City, Shandong Province Applicant after: Dijia Pharmaceutical Group Co.,Ltd. Applicant after: DISHA PHARMACEUTICAL GROUP Co.,Ltd. Address before: 266440 No.268, Tianrun Road, Wendeng economic and Technological Development Zone, Weihai City, Shandong Province Applicant before: WEIHAI DISU PHARMACEUTICAL Co.,Ltd. Applicant before: DISHA PHARMACEUTICAL GROUP Co.,Ltd. Effective date of registration: 20210903 Address after: 264205 268 Tianrun Road, Wendeng economic and Technological Development Zone, Weihai, Shandong Applicant after: Dijia Pharmaceutical Group Co.,Ltd. Address before: 264205 Wendeng economic and Technological Development Zone, Weihai City, Shandong Province Applicant before: Dijia Pharmaceutical Group Co.,Ltd. Applicant before: DISHA PHARMACEUTICAL GROUP Co.,Ltd. |
|
TA01 | Transfer of patent application right | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP03 | Change of name, title or address |
Address after: No. 268, Tianrun Road, Wendeng Economic and Technological Development Zone, Weihai City, Shandong Province, 264200 Patentee after: Dijia Pharmaceutical Group Co.,Ltd. Address before: 264205 268 Tianrun Road, Wendeng economic and Technological Development Zone, Weihai, Shandong Patentee before: Dijia Pharmaceutical Group Co.,Ltd. |
|
CP03 | Change of name, title or address |