CU20120136A7 - Hidrato del hidrobromuro de agomelatina y preparación de éste - Google Patents
Hidrato del hidrobromuro de agomelatina y preparación de ésteInfo
- Publication number
- CU20120136A7 CU20120136A7 CU2012000136A CU20120136A CU20120136A7 CU 20120136 A7 CU20120136 A7 CU 20120136A7 CU 2012000136 A CU2012000136 A CU 2012000136A CU 20120136 A CU20120136 A CU 20120136A CU 20120136 A7 CU20120136 A7 CU 20120136A7
- Authority
- CU
- Cuba
- Prior art keywords
- hydrobromide
- preparation
- present method
- agomelatine
- hydrate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Se proporciona un hidrato del hidrobromuro de agomelatina de fórmula(I), en la que X es Br, preparación, uso y composición farmacéutica del mismo. Dicho hidrato obtenido mediante el presente método tiene una solubilidad significativamente aumentada que la agomelatina, y por ello es más adecuada para fabricar formulaciones farmacéuticas. Usando el presente método, se puede obtener una pureza elevada mediante de un proceso simple, sin ninguna etapa complicada.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101262639A CN102190595A (zh) | 2010-03-17 | 2010-03-17 | 阿戈美拉汀溴化氢水合物及其制备方法 |
| PCT/CN2011/071912 WO2011113363A1 (en) | 2010-03-17 | 2011-03-17 | Agomelatine hydrobromide hydrate and preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CU20120136A7 true CU20120136A7 (es) | 2012-12-17 |
Family
ID=44599557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CU2012000136A CU20120136A7 (es) | 2010-03-17 | 2012-09-17 | Hidrato del hidrobromuro de agomelatina y preparación de éste |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US8729132B2 (es) |
| EP (1) | EP2547650B1 (es) |
| JP (1) | JP5634533B2 (es) |
| KR (1) | KR101406736B1 (es) |
| CN (2) | CN102190595A (es) |
| AP (1) | AP3199A (es) |
| AU (1) | AU2011229619B2 (es) |
| BR (1) | BR112012023173B1 (es) |
| CA (1) | CA2792430C (es) |
| CL (1) | CL2012002541A1 (es) |
| CR (1) | CR20120461A (es) |
| CU (1) | CU20120136A7 (es) |
| CY (1) | CY1117134T1 (es) |
| DK (1) | DK2547650T3 (es) |
| EA (1) | EA022066B1 (es) |
| EC (1) | ECSP12012156A (es) |
| ES (1) | ES2572427T3 (es) |
| GE (1) | GEP20156232B (es) |
| GT (1) | GT201200260A (es) |
| HK (1) | HK1177732A1 (es) |
| HN (1) | HN2012001923A (es) |
| HR (1) | HRP20151343T1 (es) |
| HU (1) | HUE026673T2 (es) |
| IL (1) | IL221783A (es) |
| MA (1) | MA34054B1 (es) |
| ME (1) | ME02309B (es) |
| MX (1) | MX2012010594A (es) |
| MY (1) | MY160337A (es) |
| NI (1) | NI201200141A (es) |
| NZ (1) | NZ602451A (es) |
| PE (1) | PE20130014A1 (es) |
| PL (1) | PL2547650T3 (es) |
| PT (1) | PT2547650E (es) |
| RS (1) | RS54449B1 (es) |
| SG (1) | SG183869A1 (es) |
| SI (1) | SI2547650T1 (es) |
| TN (1) | TN2012000436A1 (es) |
| UA (1) | UA105424C2 (es) |
| WO (1) | WO2011113363A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2978916B1 (fr) | 2011-08-10 | 2013-07-26 | Servier Lab | Composition pharmaceutique solide pour administration buccale d'agomelatine |
| US9409857B2 (en) * | 2012-05-14 | 2016-08-09 | Shanghai Righthand Pharmtech, Co., Ltd. | Agomelatine sulfuric acid complex, and preparation method and application thereof |
| CN102718675B (zh) * | 2012-06-07 | 2015-03-25 | 上海右手医药科技开发有限公司 | 阿戈美拉汀甲磺酸复合物及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2658818B1 (fr) * | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| MXPA03003761A (es) * | 2000-10-30 | 2003-07-28 | Teva Pharma | Formas de cristales y solvatos de clorhidrato de ondansetron y procesos para su preparacion. |
| FR2890562B1 (fr) * | 2005-09-09 | 2012-10-12 | Servier Lab | Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement des troubles du sommeil chez le patient deprime |
| FR2899472B1 (fr) * | 2006-04-07 | 2008-09-12 | Servier Lab | Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement du trouble anxiete generalisee |
| CN101481321B (zh) * | 2009-02-27 | 2012-04-18 | 上海医药工业研究院 | 阿戈美拉汀卤化氢复合物及其制备方法 |
| CN101585779B (zh) * | 2009-03-10 | 2014-04-02 | 上海医药工业研究院 | 阿戈美拉汀的晶型vi及其制备方法和应用 |
-
2010
- 2010-03-17 CN CN2010101262639A patent/CN102190595A/zh active Pending
-
2011
- 2011-03-17 BR BR112012023173-1A patent/BR112012023173B1/pt not_active IP Right Cessation
- 2011-03-17 SG SG2012065017A patent/SG183869A1/en unknown
- 2011-03-17 HU HUE11755680A patent/HUE026673T2/en unknown
- 2011-03-17 RS RS20150831A patent/RS54449B1/en unknown
- 2011-03-17 JP JP2012557393A patent/JP5634533B2/ja active Active
- 2011-03-17 GE GEAP201112870A patent/GEP20156232B/en unknown
- 2011-03-17 NZ NZ602451A patent/NZ602451A/en not_active IP Right Cessation
- 2011-03-17 AU AU2011229619A patent/AU2011229619B2/en not_active Ceased
- 2011-03-17 EA EA201201293A patent/EA022066B1/ru unknown
- 2011-03-17 WO PCT/CN2011/071912 patent/WO2011113363A1/en active Application Filing
- 2011-03-17 EP EP11755680.3A patent/EP2547650B1/en active Active
- 2011-03-17 SI SI201130723T patent/SI2547650T1/sl unknown
- 2011-03-17 AP AP2012006493A patent/AP3199A/xx active
- 2011-03-17 UA UAA201211719A patent/UA105424C2/uk unknown
- 2011-03-17 PL PL11755680T patent/PL2547650T3/pl unknown
- 2011-03-17 KR KR1020127026897A patent/KR101406736B1/ko active IP Right Grant
- 2011-03-17 MA MA35191A patent/MA34054B1/fr unknown
- 2011-03-17 MX MX2012010594A patent/MX2012010594A/es active IP Right Grant
- 2011-03-17 MY MYPI2012700614A patent/MY160337A/en unknown
- 2011-03-17 CN CN201180024413.8A patent/CN102892749B/zh not_active Expired - Fee Related
- 2011-03-17 PE PE2012001449A patent/PE20130014A1/es active IP Right Grant
- 2011-03-17 PT PT117556803T patent/PT2547650E/pt unknown
- 2011-03-17 ME MEP-2016-9A patent/ME02309B/me unknown
- 2011-03-17 ES ES11755680T patent/ES2572427T3/es active Active
- 2011-03-17 DK DK11755680.3T patent/DK2547650T3/en active
- 2011-03-17 US US13/635,087 patent/US8729132B2/en active Active
- 2011-03-17 CA CA2792430A patent/CA2792430C/en active Active
-
2012
- 2012-08-31 TN TNP2012000436A patent/TN2012000436A1/en unknown
- 2012-09-04 IL IL221783A patent/IL221783A/en not_active IP Right Cessation
- 2012-09-11 CR CR20120461A patent/CR20120461A/es unknown
- 2012-09-12 NI NI201200141A patent/NI201200141A/es unknown
- 2012-09-13 CL CL2012002541A patent/CL2012002541A1/es unknown
- 2012-09-14 HN HN2012001923A patent/HN2012001923A/es unknown
- 2012-09-14 EC ECSP12012156 patent/ECSP12012156A/es unknown
- 2012-09-17 CU CU2012000136A patent/CU20120136A7/es unknown
- 2012-09-17 GT GT201200260A patent/GT201200260A/es unknown
-
2013
- 2013-04-23 HK HK13104895.3A patent/HK1177732A1/xx not_active IP Right Cessation
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2015
- 2015-12-08 HR HRP20151343TT patent/HRP20151343T1/hr unknown
-
2016
- 2016-01-18 CY CY20161100041T patent/CY1117134T1/el unknown
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