CY1117134T1 - Ενυδρη υδροβρωμικη αγομελατινη και παρασκευη αυτης - Google Patents

Ενυδρη υδροβρωμικη αγομελατινη και παρασκευη αυτης

Info

Publication number
CY1117134T1
CY1117134T1 CY20161100041T CY161100041T CY1117134T1 CY 1117134 T1 CY1117134 T1 CY 1117134T1 CY 20161100041 T CY20161100041 T CY 20161100041T CY 161100041 T CY161100041 T CY 161100041T CY 1117134 T1 CY1117134 T1 CY 1117134T1
Authority
CY
Cyprus
Prior art keywords
agomelatin
preparation
hybromomatic
aromatic
product
Prior art date
Application number
CY20161100041T
Other languages
English (en)
Inventor
Hanbin Shan
Zhedong Yuan
Xueyan Zhu
Peng Zhang
Hongjuan Pan
Xiong Yu
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44599557&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1117134(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of CY1117134T1 publication Critical patent/CY1117134T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Anesthesiology (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Παρέχονται, ένυδρη υδροβρωμική αγομελατίνη του τύπου (I), όπου το X είναι Br, μέθοδος παρασκευής και χρήση αυτής, καθώς επίσης φαρμακευτική σύνθεση που περιέχει αυτή. Η διαλυτότητα της ένυδρου υδροβρωμικής αγομελατίνης που λαμβάνεται με την παρούσα μέθοδο είναι σημαντικά μεγαλύτερη από ότι εκείνη της αγομελατίνης. Συνεπώς, είναι καταλληλότερη για την βιομηχανική κατασκευή φαρμακευτικών συνταγοποιήσεων. Επιπλέον, το προϊόν έχει μεγαλύτερη σταθερότητα και καθαρότητα. Το παρόν προϊόν υψηλής καθαρότητας μπορεί να ληφθεί μέσω μιας απλής μεθόδου μάλλον, παρά μεθόδου με πολύπλοκα στάδια.
CY20161100041T 2010-03-17 2016-01-18 Ενυδρη υδροβρωμικη αγομελατινη και παρασκευη αυτης CY1117134T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2010101262639A CN102190595A (zh) 2010-03-17 2010-03-17 阿戈美拉汀溴化氢水合物及其制备方法
EP11755680.3A EP2547650B1 (en) 2010-03-17 2011-03-17 Agomelatine hydrobromide hydrate and preparation thereof

Publications (1)

Publication Number Publication Date
CY1117134T1 true CY1117134T1 (el) 2017-04-05

Family

ID=44599557

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161100041T CY1117134T1 (el) 2010-03-17 2016-01-18 Ενυδρη υδροβρωμικη αγομελατινη και παρασκευη αυτης

Country Status (39)

Country Link
US (1) US8729132B2 (el)
EP (1) EP2547650B1 (el)
JP (1) JP5634533B2 (el)
KR (1) KR101406736B1 (el)
CN (2) CN102190595A (el)
AP (1) AP3199A (el)
AU (1) AU2011229619B2 (el)
BR (1) BR112012023173B1 (el)
CA (1) CA2792430C (el)
CL (1) CL2012002541A1 (el)
CR (1) CR20120461A (el)
CU (1) CU20120136A7 (el)
CY (1) CY1117134T1 (el)
DK (1) DK2547650T3 (el)
EA (1) EA022066B1 (el)
EC (1) ECSP12012156A (el)
ES (1) ES2572427T3 (el)
GE (1) GEP20156232B (el)
GT (1) GT201200260A (el)
HK (1) HK1177732A1 (el)
HN (1) HN2012001923A (el)
HR (1) HRP20151343T1 (el)
HU (1) HUE026673T2 (el)
IL (1) IL221783A (el)
MA (1) MA34054B1 (el)
ME (1) ME02309B (el)
MX (1) MX2012010594A (el)
MY (1) MY160337A (el)
NI (1) NI201200141A (el)
NZ (1) NZ602451A (el)
PE (1) PE20130014A1 (el)
PL (1) PL2547650T3 (el)
PT (1) PT2547650E (el)
RS (1) RS54449B1 (el)
SG (1) SG183869A1 (el)
SI (1) SI2547650T1 (el)
TN (1) TN2012000436A1 (el)
UA (1) UA105424C2 (el)
WO (1) WO2011113363A1 (el)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2978916B1 (fr) 2011-08-10 2013-07-26 Servier Lab Composition pharmaceutique solide pour administration buccale d'agomelatine
CN102718675B (zh) * 2012-06-07 2015-03-25 上海右手医药科技开发有限公司 阿戈美拉汀甲磺酸复合物及其制备方法
KR20150020191A (ko) * 2012-05-14 2015-02-25 상하이 라이트핸드 팜테크 주식회사 아고멜라틴 산기 복합체와 그의 제조방법 및 용도

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
CZ20031397A3 (cs) * 2000-10-30 2003-11-12 Teva Pharmaceutical Industries Ltd. Nové krystalické a solvatované formy ondansetron hydrochloridu a způsoby jejich přípravy
FR2890562B1 (fr) * 2005-09-09 2012-10-12 Servier Lab Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement des troubles du sommeil chez le patient deprime
FR2899472B1 (fr) * 2006-04-07 2008-09-12 Servier Lab Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement du trouble anxiete generalisee
CN101481321B (zh) * 2009-02-27 2012-04-18 上海医药工业研究院 阿戈美拉汀卤化氢复合物及其制备方法
CN101585779B (zh) * 2009-03-10 2014-04-02 上海医药工业研究院 阿戈美拉汀的晶型vi及其制备方法和应用

Also Published As

Publication number Publication date
IL221783A (en) 2017-11-30
CN102892749B (zh) 2014-11-05
ES2572427T3 (es) 2016-05-31
PT2547650E (pt) 2015-11-30
HN2012001923A (es) 2015-09-14
EP2547650A1 (en) 2013-01-23
GEP20156232B (en) 2015-01-26
CN102190595A (zh) 2011-09-21
JP5634533B2 (ja) 2014-12-03
KR20120128713A (ko) 2012-11-27
ECSP12012156A (es) 2012-12-28
HK1177732A1 (en) 2013-08-30
MA34054B1 (fr) 2013-03-05
PE20130014A1 (es) 2013-01-26
EP2547650B1 (en) 2015-11-04
CL2012002541A1 (es) 2013-01-11
SI2547650T1 (sl) 2016-02-29
US8729132B2 (en) 2014-05-20
WO2011113363A1 (en) 2011-09-22
CU20120136A7 (es) 2012-12-17
JP2013522242A (ja) 2013-06-13
CN102892749A (zh) 2013-01-23
MY160337A (en) 2017-02-28
AU2011229619A1 (en) 2012-09-27
MX2012010594A (es) 2012-10-03
US20130012592A1 (en) 2013-01-10
CA2792430A1 (en) 2011-09-22
PL2547650T3 (pl) 2016-06-30
NZ602451A (en) 2014-10-31
DK2547650T3 (en) 2016-02-15
TN2012000436A1 (en) 2014-01-30
EA201201293A1 (ru) 2013-04-30
CA2792430C (en) 2015-12-08
CR20120461A (es) 2012-11-29
RS54449B1 (en) 2016-06-30
GT201200260A (es) 2013-11-18
BR112012023173B1 (pt) 2021-08-24
SG183869A1 (en) 2012-10-30
AU2011229619B2 (en) 2014-05-22
KR101406736B1 (ko) 2014-06-12
EP2547650A4 (en) 2013-09-18
BR112012023173A2 (pt) 2016-05-17
HRP20151343T1 (hr) 2016-01-01
AP3199A (en) 2015-03-31
ME02309B (me) 2016-06-20
HUE026673T2 (en) 2016-07-28
EA022066B1 (ru) 2015-10-30
NI201200141A (es) 2012-11-09
UA105424C2 (uk) 2014-05-12
AP2012006493A0 (en) 2012-10-31

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