ME02309B - Agomelatin hidrobromid hidrat i njegova priprema - Google Patents
Agomelatin hidrobromid hidrat i njegova pripremaInfo
- Publication number
- ME02309B ME02309B MEP-2016-9A MEP916A ME02309B ME 02309 B ME02309 B ME 02309B ME P916 A MEP916 A ME P916A ME 02309 B ME02309 B ME 02309B
- Authority
- ME
- Montenegro
- Prior art keywords
- hydrobromide hydrate
- agomelatine
- agomelatine hydrobromide
- obtaining
- accordance
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (12)
1. Agomelatin hidrobromid hidrat formule I: naznačen time, da je X Br.
2. Agomelatin hidrobromid hidrat formule I u skladu s patentnim zahtjevom 1, u kristalnom obliku, naznačen time, da ima sljedeće kristalne parametre: prostorna grupa P21/c, parametri rešetke a = 7,5943 (7), b = 23,4046 (19), c = 9,6438 (8) Å , b = 1613,9 (2) °.
3. Postupak za dobivanje agomelatin hidrobromid hidrata u skladu s patentnim zahtjevom 1 ili 2, naznačen time, da agomelatin reagira s HBr u vodenom organskom otapalu kako bi se proizveo agomelatin hidrobromid hidrat.
4. Postupak za dobivanje agomelatin hidrobromid hidrata u skladu s patentnim zahtjevom 3, naznačen time, da se agomelatin otopi u organskom otapalu prije dodavanja vodene otopine HBr kako bi se istaložio kristal proizvoda.
5. Postupak za dobivanje agomelatin hidrobromid hidrata u skladu s patentnim zahtjevom 4, naznačen time, da se vodena otopina HBr dodaje kap po kap.
6. Postupak za dobivanje agomelatin hidrobromid hidrata u skladu s patentnim zahtjevom 3, naznačen time, da se agomelatin dodaje vodenom organskom otapalu koje sadržava HBr kako bi se istaložio kristal proizvoda.
7. Postupak za dobivanje agomelatin hidrobromid hidrata u skladu s patentnim zahtjevom 4 ili 6, naznačen time, da nadalje uključuje ispiranje i sušenje krutine nakon kristalizacije.
8. Postupak za dobivanje agomelatin hidrobromid hidrata u skladu s patentnim zahtjevom 4 ili 6, naznačen time, da je temperatura reakcije od 0 do 20 °C.
9. Postupak za dobivanje agomelatin hidrobromid hidrata u skladu s patentnim zahtjevom 4 ili 6, naznačen time, da je navedeno organsko otapalo etil acetat, metil acetat, n-butil acetat, aceton ili acetonitril.
10. Postupak za dobivanje agomelatin hidrobromid hidrata u skladu s patentnim zahtjevom 9, naznačen time, da je navedeno organsko otapalo etil acetat.
11. Farmaceutska kapsula koja sadržava agomelatin hidrobromid hidrat u skladu s patentnim zahtjevom 1 ili 2, naznačena time, da je u kombinaciji s farmaceutski prihvatljivim pomoćnim tvarima ili ekscipijensima.
12. Uporaba agomelatin hidrobromid hidrata u skladu s patentnim zahtjevom 1 ili 2, naznačena time, da se koristi za liječenje poremećaja melatonergičkog sustava, poremećaja spavanja, stresa, anksioznosti, sezonskih depresija, velike depresije, kardiovaskularnih bolesti, bolesti probavnog sustava, nesanice i umora uslijed preleta više vremenskih zona, shizofrenije, fobije ili depresivnih poremećaja.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101262639A CN102190595A (zh) | 2010-03-17 | 2010-03-17 | 阿戈美拉汀溴化氢水合物及其制备方法 |
| PCT/CN2011/071912 WO2011113363A1 (en) | 2010-03-17 | 2011-03-17 | Agomelatine hydrobromide hydrate and preparation thereof |
| EP11755680.3A EP2547650B1 (en) | 2010-03-17 | 2011-03-17 | Agomelatine hydrobromide hydrate and preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02309B true ME02309B (me) | 2016-06-20 |
Family
ID=44599557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2016-9A ME02309B (me) | 2010-03-17 | 2011-03-17 | Agomelatin hidrobromid hidrat i njegova priprema |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US8729132B2 (me) |
| EP (1) | EP2547650B1 (me) |
| JP (1) | JP5634533B2 (me) |
| KR (1) | KR101406736B1 (me) |
| CN (2) | CN102190595A (me) |
| AP (1) | AP3199A (me) |
| AU (1) | AU2011229619B2 (me) |
| BR (1) | BR112012023173B1 (me) |
| CA (1) | CA2792430C (me) |
| CL (1) | CL2012002541A1 (me) |
| CR (1) | CR20120461A (me) |
| CU (1) | CU20120136A7 (me) |
| CY (1) | CY1117134T1 (me) |
| DK (1) | DK2547650T3 (me) |
| EA (1) | EA022066B1 (me) |
| EC (1) | ECSP12012156A (me) |
| ES (1) | ES2572427T3 (me) |
| GE (1) | GEP20156232B (me) |
| GT (1) | GT201200260A (me) |
| HN (1) | HN2012001923A (me) |
| HR (1) | HRP20151343T1 (me) |
| HU (1) | HUE026673T2 (me) |
| IL (1) | IL221783A (me) |
| MA (1) | MA34054B1 (me) |
| ME (1) | ME02309B (me) |
| MX (1) | MX2012010594A (me) |
| MY (1) | MY160337A (me) |
| NI (1) | NI201200141A (me) |
| NZ (1) | NZ602451A (me) |
| PE (1) | PE20130014A1 (me) |
| PH (1) | PH12012501756A1 (me) |
| PL (1) | PL2547650T3 (me) |
| PT (1) | PT2547650E (me) |
| RS (1) | RS54449B1 (me) |
| SG (1) | SG183869A1 (me) |
| SI (1) | SI2547650T1 (me) |
| TN (1) | TN2012000436A1 (me) |
| UA (1) | UA105424C2 (me) |
| WO (1) | WO2011113363A1 (me) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07115742B2 (ja) | 1986-03-19 | 1995-12-13 | 株式会社石田衡器製作所 | 多方向仕分け装置 |
| JPH07115739B2 (ja) | 1986-03-19 | 1995-12-13 | 株式会社石田衡器製作所 | 多方向仕分け装置 |
| JPH07115740B2 (ja) | 1986-03-19 | 1995-12-13 | 株式会社石田衡器製作所 | 多方向仕分け装置 |
| JPH07115741B2 (ja) | 1986-03-19 | 1995-12-13 | 株式会社石田衡器製作所 | 多方向仕分け装置 |
| FR2978916B1 (fr) | 2011-08-10 | 2013-07-26 | Servier Lab | Composition pharmaceutique solide pour administration buccale d'agomelatine |
| EP2851363B1 (en) * | 2012-05-14 | 2018-01-03 | Shanghai Righthand Pharmtech. Co., Ltd. | Agomelatine acid radical composite, and preparation method and application thereof |
| CN102718675B (zh) * | 2012-06-07 | 2015-03-25 | 上海右手医药科技开发有限公司 | 阿戈美拉汀甲磺酸复合物及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2658818B1 (fr) * | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US20020107275A1 (en) * | 2000-10-30 | 2002-08-08 | Ramy Lidor-Hadas | Novel crystal and solvate forms of ondansetron hydrochloride and processes for their preparation |
| FR2890562B1 (fr) * | 2005-09-09 | 2012-10-12 | Servier Lab | Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement des troubles du sommeil chez le patient deprime |
| FR2899472B1 (fr) * | 2006-04-07 | 2008-09-12 | Servier Lab | Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement du trouble anxiete generalisee |
| CN101481321B (zh) * | 2009-02-27 | 2012-04-18 | 上海医药工业研究院 | 阿戈美拉汀卤化氢复合物及其制备方法 |
| CN101585779B (zh) * | 2009-03-10 | 2014-04-02 | 上海医药工业研究院 | 阿戈美拉汀的晶型vi及其制备方法和应用 |
-
2010
- 2010-03-17 CN CN2010101262639A patent/CN102190595A/zh active Pending
-
2011
- 2011-03-17 UA UAA201211719A patent/UA105424C2/uk unknown
- 2011-03-17 US US13/635,087 patent/US8729132B2/en active Active
- 2011-03-17 SI SI201130723T patent/SI2547650T1/sl unknown
- 2011-03-17 WO PCT/CN2011/071912 patent/WO2011113363A1/en not_active Ceased
- 2011-03-17 PL PL11755680T patent/PL2547650T3/pl unknown
- 2011-03-17 CN CN201180024413.8A patent/CN102892749B/zh not_active Expired - Fee Related
- 2011-03-17 MX MX2012010594A patent/MX2012010594A/es active IP Right Grant
- 2011-03-17 ES ES11755680T patent/ES2572427T3/es active Active
- 2011-03-17 HR HRP20151343TT patent/HRP20151343T1/hr unknown
- 2011-03-17 KR KR1020127026897A patent/KR101406736B1/ko not_active Expired - Fee Related
- 2011-03-17 BR BR112012023173-1A patent/BR112012023173B1/pt not_active IP Right Cessation
- 2011-03-17 PE PE2012001449A patent/PE20130014A1/es active IP Right Grant
- 2011-03-17 SG SG2012065017A patent/SG183869A1/en unknown
- 2011-03-17 MA MA35191A patent/MA34054B1/fr unknown
- 2011-03-17 PT PT117556803T patent/PT2547650E/pt unknown
- 2011-03-17 EP EP11755680.3A patent/EP2547650B1/en active Active
- 2011-03-17 AP AP2012006493A patent/AP3199A/xx active
- 2011-03-17 DK DK11755680.3T patent/DK2547650T3/en active
- 2011-03-17 AU AU2011229619A patent/AU2011229619B2/en not_active Ceased
- 2011-03-17 RS RS20150831A patent/RS54449B1/sr unknown
- 2011-03-17 CA CA2792430A patent/CA2792430C/en active Active
- 2011-03-17 MY MYPI2012700614A patent/MY160337A/en unknown
- 2011-03-17 ME MEP-2016-9A patent/ME02309B/me unknown
- 2011-03-17 JP JP2012557393A patent/JP5634533B2/ja not_active Expired - Fee Related
- 2011-03-17 NZ NZ602451A patent/NZ602451A/en not_active IP Right Cessation
- 2011-03-17 GE GEAP201112870A patent/GEP20156232B/en unknown
- 2011-03-17 EA EA201201293A patent/EA022066B1/ru unknown
- 2011-03-17 PH PH1/2012/501756A patent/PH12012501756A1/en unknown
- 2011-03-17 HU HUE11755680A patent/HUE026673T2/en unknown
-
2012
- 2012-08-31 TN TNP2012000436A patent/TN2012000436A1/en unknown
- 2012-09-04 IL IL221783A patent/IL221783A/en not_active IP Right Cessation
- 2012-09-11 CR CR20120461A patent/CR20120461A/es unknown
- 2012-09-12 NI NI201200141A patent/NI201200141A/es unknown
- 2012-09-13 CL CL2012002541A patent/CL2012002541A1/es unknown
- 2012-09-14 HN HN2012001923A patent/HN2012001923A/es unknown
- 2012-09-14 EC ECSP12012156 patent/ECSP12012156A/es unknown
- 2012-09-17 GT GT201200260A patent/GT201200260A/es unknown
- 2012-09-17 CU CU2012000136A patent/CU20120136A7/es unknown
-
2016
- 2016-01-18 CY CY20161100041T patent/CY1117134T1/el unknown
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