CN1043640C - 制备噁唑基衍生物的方法 - Google Patents

制备噁唑基衍生物的方法 Download PDF

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Publication number
CN1043640C
CN1043640C CN91104902A CN91104902A CN1043640C CN 1043640 C CN1043640 C CN 1043640C CN 91104902 A CN91104902 A CN 91104902A CN 91104902 A CN91104902 A CN 91104902A CN 1043640 C CN1043640 C CN 1043640C
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China
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formula
alkyl
compound
randomly
group
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Expired - Fee Related
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CN91104902A
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English (en)
Chinese (zh)
Other versions
CN1058215A (zh
Inventor
F·E·扬森斯
F·M·索门
A·C·J·迪耶克斯
L·P·库曼斯
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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Publication of CN1058215A publication Critical patent/CN1058215A/zh
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Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN91104902A 1990-07-19 1991-07-19 制备噁唑基衍生物的方法 Expired - Fee Related CN1043640C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55432690A 1990-07-19 1990-07-19
US554,326 1990-07-19

Publications (2)

Publication Number Publication Date
CN1058215A CN1058215A (zh) 1992-01-29
CN1043640C true CN1043640C (zh) 1999-06-16

Family

ID=24212929

Family Applications (1)

Application Number Title Priority Date Filing Date
CN91104902A Expired - Fee Related CN1043640C (zh) 1990-07-19 1991-07-19 制备噁唑基衍生物的方法

Country Status (31)

Country Link
EP (1) EP0539421B1 (OSRAM)
JP (1) JP3070951B2 (OSRAM)
KR (1) KR100190299B1 (OSRAM)
CN (1) CN1043640C (OSRAM)
AP (1) AP267A (OSRAM)
AT (1) ATE171449T1 (OSRAM)
AU (1) AU644202B2 (OSRAM)
BG (1) BG61342B1 (OSRAM)
CA (1) CA2086545A1 (OSRAM)
CZ (1) CZ279344B6 (OSRAM)
DE (1) DE69130255T2 (OSRAM)
ES (1) ES2121784T3 (OSRAM)
FI (1) FI930198A7 (OSRAM)
HU (1) HUT64340A (OSRAM)
IE (1) IE912532A1 (OSRAM)
IL (1) IL98864A (OSRAM)
MA (1) MA22226A1 (OSRAM)
MX (1) MX9100312A (OSRAM)
MY (1) MY107973A (OSRAM)
NO (1) NO300459B1 (OSRAM)
NZ (1) NZ238864A (OSRAM)
PL (1) PL169361B1 (OSRAM)
PT (1) PT98365B (OSRAM)
RO (1) RO111768B1 (OSRAM)
RU (1) RU2059636C1 (OSRAM)
SK (1) SK278133B6 (OSRAM)
TN (1) TNSN91062A1 (OSRAM)
TW (1) TW235964B (OSRAM)
WO (1) WO1992001687A1 (OSRAM)
YU (1) YU126391A (OSRAM)
ZA (1) ZA915653B (OSRAM)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3258293A (en) * 1992-01-09 1993-08-03 Janssen Pharmaceutica N.V. Antihistaminic piperazinyl derivatives
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) * 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
SK18942001A3 (sk) * 1999-06-28 2002-10-08 Janssen Pharmaceutica N. V. Inhibítory replikácie respiračného syncytiálneho vírusu
DK1196409T3 (da) 1999-06-28 2004-06-07 Janssen Pharmaceutica Nv Respiratoriske syncytilvirusreplikationsinhibitorer
HRP20010934A2 (en) 1999-06-28 2003-06-30 Janssen Pharmaceutica Nv Respiratory syncytial virus replication inhibitors
EP1479676A1 (en) * 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH Benzimidazole-derivatives as factor xa inhibitors
GB0315203D0 (en) * 2003-06-28 2003-08-06 Celltech R&D Ltd Chemical compounds
MY142783A (en) 2003-12-18 2010-12-31 Tibotec Pharm Ltd 5-or 6-substituted benzimidazole derivatives as inhibitors of respiratory syncytial virus replication
RU2379302C2 (ru) 2003-12-18 2010-01-20 Тиботек Фармасьютикалз Лтд. Аминобензимидазолы и бензимидазолы в качестве ингибиторов репликации респираторно-синцитиального вируса
EP1723136B1 (en) 2003-12-18 2011-03-09 Tibotec Pharmaceuticals Piperidine-amino-benzimidazole derivatives as inhibitors of respiratory syncytial virus replication
US7855194B2 (en) 2006-03-27 2010-12-21 Hoffmann-La Roche Inc. Pyrimidine, quinazoline, pteridine and triazine derivatives
TWI377511B (en) 2008-12-05 2012-11-21 Ind Tech Res Inst Flame detecting method and system
RU2417995C1 (ru) * 2009-09-21 2011-05-10 Государственное образовательное учреждение высшего профессионального образования "Кубанский государственный технологический университет" (ГОУ ВПО "КубГТУ") Способ получения 3-(2-замещенных-1,3-оксазол-4-ил)пиридин-2(1н)-онов
CN104098609B (zh) * 2014-07-28 2016-08-17 陕西科技大学 含二茂铁的咪唑并[2,1-b]-1,3,4-噻二唑、制备方法及其应用
EP3233799B1 (en) 2014-12-19 2021-05-19 The Broad Institute, Inc. Dopamine d2 receptor ligands
EP3233077A4 (en) 2014-12-19 2018-08-08 The Broad Institute Inc. Dopamine d2 receptor ligands

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556660A (en) * 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
US4695569A (en) * 1983-11-30 1987-09-22 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB8515934D0 (en) * 1985-06-24 1985-07-24 Janssen Pharmaceutica Nv (4-piperidinomethyl and-hetero)purines
US4835161A (en) * 1986-02-03 1989-05-30 Janssen Pharmaceutica N.V. Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines
US4897401A (en) * 1987-06-19 1990-01-30 Janssen Pharmaceutical N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases
CA1317939C (en) * 1987-07-01 1993-05-18 Janssen Pharmaceutica Naamloze Vennootschap ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines

Also Published As

Publication number Publication date
DE69130255D1 (de) 1998-10-29
TW235964B (OSRAM) 1994-12-11
MY107973A (en) 1996-07-15
EP0539421B1 (en) 1998-09-23
PL169361B1 (pl) 1996-07-31
IL98864A0 (en) 1992-07-15
AP267A (en) 1993-06-16
TNSN91062A1 (fr) 1992-10-25
AP9100298A0 (en) 1991-07-31
NZ238864A (en) 1993-08-26
CZ279344B6 (cs) 1995-04-12
CN1058215A (zh) 1992-01-29
MX9100312A (es) 1992-02-28
AU644202B2 (en) 1993-12-02
FI930198A0 (fi) 1993-01-18
EP0539421A1 (en) 1993-05-05
NO930156D0 (no) 1993-01-18
PT98365B (pt) 1999-01-29
IL98864A (en) 1995-12-08
IE912532A1 (en) 1992-01-29
ZA915653B (en) 1993-03-31
RO111768B1 (ro) 1997-01-30
ATE171449T1 (de) 1998-10-15
NO300459B1 (no) 1997-06-02
CS224091A3 (en) 1992-02-19
ES2121784T3 (es) 1998-12-16
JP3070951B2 (ja) 2000-07-31
PL297611A1 (OSRAM) 1992-07-13
SK278133B6 (en) 1996-02-07
NO930156L (no) 1993-01-18
CA2086545A1 (en) 1992-01-20
HU9300097D0 (en) 1993-04-28
FI930198A7 (fi) 1993-01-18
BG61342B1 (en) 1997-06-30
MA22226A1 (fr) 1992-04-01
JPH05508839A (ja) 1993-12-09
WO1992001687A1 (en) 1992-02-06
PT98365A (pt) 1992-05-29
DE69130255T2 (de) 1999-04-08
HUT64340A (en) 1993-12-28
YU126391A (sh) 1994-06-10
BG97314A (bg) 1994-01-24
KR100190299B1 (ko) 1999-06-01
RU2059636C1 (ru) 1996-05-10
AU8214191A (en) 1992-02-18

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