TNSN91062A1 - Derives nouveaux d'oxazolyle - Google Patents

Derives nouveaux d'oxazolyle

Info

Publication number
TNSN91062A1
TNSN91062A1 TNTNSN91062A TNSN91062A TNSN91062A1 TN SN91062 A1 TNSN91062 A1 TN SN91062A1 TN TNSN91062 A TNTNSN91062 A TN TNSN91062A TN SN91062 A TNSN91062 A TN SN91062A TN SN91062 A1 TNSN91062 A1 TN SN91062A1
Authority
TN
Tunisia
Prior art keywords
alk
alkyl
formula
new
oxazolyl derivatives
Prior art date
Application number
TNTNSN91062A
Other languages
English (en)
Inventor
Eduard Janssens Frans
Maria Sommen Francois
Christina Joannes Dierckx Ann
Paul Cooymans Ludwig
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of TNSN91062A1 publication Critical patent/TNSN91062A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

DERIVES D'OXAZOLYLE DE FORMULE I DANS LAQUELLE -A1 = A2 - A3 = A4 - REPRESENTE UN RADICAL DIVALENT DE FORMULE -CH=CH-CH=CH- (A-1), -N= CH-CH=CH- (A-2), -CH=N-CH=CH- (A-3), -CH=CH-N=CH- (A-4), -CH=CH-CH=N- (A-5), -N=CH-N=CH- (A-6) OU -CH=N-CH=N- (A-7) ; R REPRESENTE H OU ALKYLE EN C1-4, R1 REPRESENTE H OU ALKYLE OU HYDROXYALKYLE EN C1-6, M = 1 OU 2, D = ALCANEDIYLE EN C1-4, B REPRESENTE NR2, CH2, O, S, SO OU SO2, R2 ETANT H OU ALKYLE EN C1-4 ; N = 0, 1 OU 2 ; L EST H ; ALKYLE EN C1-12, CYCLOALKYLE EN C3-6 ; ALCENYLE EN C3-6, FACULTATIVEMENT SUBSTITUE PAR ARYLE ; ALKYLCARBONYLE EN C1-6 ; ALKYLOXYCARBONYLE EN C1-6 ; ARYLCARBONYLE ; ARYLALKYLOXY-CARBONYLE EN C1-6 ; OU UN RADICAL DE FORMULE -ALK-R3 (b-1) ; -ALK-Y-R4 (b-2) ; -ALK-Z1-C(=X)-Z2-R5 (b-3) OU - CH2-CHOH-CH2-O-R6 (b-4) ; LEURS SELS ET ISOMERES STEREOCHIMIQUES PHARMACEUTIQUEMENT ACCEPTABLES POSSEDANT DES PROPRIETES ANTI-ALLERGIQUES. COMPOSITIONS CONTENANT CES DERNIERS ET PROCEDES DE TRAITEMENT DE MAMMIFERES A SANG CHAUD SOUFFRANT D'AFFECTIONS ALLERGIQUES
TNTNSN91062A 1990-07-19 1991-07-19 Derives nouveaux d'oxazolyle TNSN91062A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55432690A 1990-07-19 1990-07-19

Publications (1)

Publication Number Publication Date
TNSN91062A1 true TNSN91062A1 (fr) 1992-10-25

Family

ID=24212929

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN91062A TNSN91062A1 (fr) 1990-07-19 1991-07-19 Derives nouveaux d'oxazolyle

Country Status (31)

Country Link
EP (1) EP0539421B1 (fr)
JP (1) JP3070951B2 (fr)
KR (1) KR100190299B1 (fr)
CN (1) CN1043640C (fr)
AP (1) AP267A (fr)
AT (1) ATE171449T1 (fr)
AU (1) AU644202B2 (fr)
BG (1) BG61342B1 (fr)
CA (1) CA2086545A1 (fr)
CZ (1) CZ279344B6 (fr)
DE (1) DE69130255T2 (fr)
ES (1) ES2121784T3 (fr)
FI (1) FI930198A (fr)
HU (1) HUT64340A (fr)
IE (1) IE912532A1 (fr)
IL (1) IL98864A (fr)
MA (1) MA22226A1 (fr)
MX (1) MX9100312A (fr)
MY (1) MY107973A (fr)
NO (1) NO300459B1 (fr)
NZ (1) NZ238864A (fr)
PL (1) PL169361B1 (fr)
PT (1) PT98365B (fr)
RO (1) RO111768B1 (fr)
RU (1) RU2059636C1 (fr)
SK (1) SK278133B6 (fr)
TN (1) TNSN91062A1 (fr)
TW (1) TW235964B (fr)
WO (1) WO1992001687A1 (fr)
YU (1) YU126391A (fr)
ZA (1) ZA915653B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3258293A (en) * 1992-01-09 1993-08-03 Janssen Pharmaceutica N.V. Antihistaminic piperazinyl derivatives
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) * 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
ATE258928T1 (de) 1999-06-28 2004-02-15 Janssen Pharmaceutica Nv Respiratorisches syncytialvirus replikation inhibitoren
SK18952001A3 (sk) 1999-06-28 2002-11-06 Janssen Pharmaceutica N. V. Inhibítory replikácie respiračného syncyciálneho vírusu
SG122814A1 (en) 1999-06-28 2006-06-29 Janssen Pharmaceutica Nv Respiratory syncytial virus replication inhibitors
GB0315203D0 (en) * 2003-06-28 2003-08-06 Celltech R&D Ltd Chemical compounds
AR046971A1 (es) 2003-12-18 2006-01-04 Tibotec Pharm Ltd Aminobenzoimidazoles y benzoimidazoles como inhibidores de la replicacion del virus sincitial respiratorio
DE602004031555D1 (de) 2003-12-18 2011-04-07 Little Island Co Cork 5- oder 6-substituierte benzimidazolderivate als inhibitoren der replikation des respiratory syncytial virus
AR046771A1 (es) 2003-12-18 2005-12-21 Tibotec Pharm Ltd Derivados piperidina-amino-bencimidazol como inhibidores de la replicacion del virus sincitial respiratorio
US7855194B2 (en) * 2006-03-27 2010-12-21 Hoffmann-La Roche Inc. Pyrimidine, quinazoline, pteridine and triazine derivatives
TWI377511B (en) 2008-12-05 2012-11-21 Ind Tech Res Inst Flame detecting method and system
CN104098609B (zh) * 2014-07-28 2016-08-17 陕西科技大学 含二茂铁的咪唑并[2,1-b]-1,3,4-噻二唑、制备方法及其应用
US10633336B2 (en) 2014-12-19 2020-04-28 The Broad Institute, Inc. Dopamine D2 receptor ligands
US10752588B2 (en) 2014-12-19 2020-08-25 The Broad Institute, Inc. Dopamine D2 receptor ligands

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556660A (en) * 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
US4695569A (en) * 1983-11-30 1987-09-22 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB8515934D0 (en) * 1985-06-24 1985-07-24 Janssen Pharmaceutica Nv (4-piperidinomethyl and-hetero)purines
US4835161A (en) * 1986-02-03 1989-05-30 Janssen Pharmaceutica N.V. Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines
US4897401A (en) * 1987-06-19 1990-01-30 Janssen Pharmaceutical N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases
CA1317939C (fr) * 1987-07-01 1993-05-18 Janssen Pharmaceutica Naamloze Vennootschap Hexahydro-1h-azepines et pyrrolidines a substitution par des ((heterocyclyle bicyclique) methyle et -hetero

Also Published As

Publication number Publication date
JP3070951B2 (ja) 2000-07-31
CZ279344B6 (cs) 1995-04-12
RO111768B1 (ro) 1997-01-30
HUT64340A (en) 1993-12-28
JPH05508839A (ja) 1993-12-09
EP0539421A1 (fr) 1993-05-05
MX9100312A (es) 1992-02-28
IL98864A0 (en) 1992-07-15
AU644202B2 (en) 1993-12-02
MA22226A1 (fr) 1992-04-01
BG97314A (bg) 1994-01-24
ZA915653B (en) 1993-03-31
PL169361B1 (pl) 1996-07-31
ATE171449T1 (de) 1998-10-15
PT98365A (pt) 1992-05-29
IE912532A1 (en) 1992-01-29
EP0539421B1 (fr) 1998-09-23
PL297611A1 (fr) 1992-07-13
CN1058215A (zh) 1992-01-29
TW235964B (fr) 1994-12-11
IL98864A (en) 1995-12-08
CS224091A3 (en) 1992-02-19
PT98365B (pt) 1999-01-29
AU8214191A (en) 1992-02-18
AP9100298A0 (en) 1991-07-31
BG61342B1 (en) 1997-06-30
MY107973A (en) 1996-07-15
KR100190299B1 (ko) 1999-06-01
YU126391A (sh) 1994-06-10
NO930156D0 (no) 1993-01-18
CN1043640C (zh) 1999-06-16
DE69130255T2 (de) 1999-04-08
DE69130255D1 (de) 1998-10-29
FI930198A0 (fi) 1993-01-18
NO300459B1 (no) 1997-06-02
WO1992001687A1 (fr) 1992-02-06
NZ238864A (en) 1993-08-26
ES2121784T3 (es) 1998-12-16
FI930198A (fi) 1993-01-18
RU2059636C1 (ru) 1996-05-10
CA2086545A1 (fr) 1992-01-20
NO930156L (no) 1993-01-18
SK278133B6 (en) 1996-02-07
HU9300097D0 (en) 1993-04-28
AP267A (en) 1993-06-16

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