DE69130255D1 - Oxadolderivate - Google Patents

Oxadolderivate

Info

Publication number
DE69130255D1
DE69130255D1 DE69130255T DE69130255T DE69130255D1 DE 69130255 D1 DE69130255 D1 DE 69130255D1 DE 69130255 T DE69130255 T DE 69130255T DE 69130255 T DE69130255 T DE 69130255T DE 69130255 D1 DE69130255 D1 DE 69130255D1
Authority
DE
Germany
Prior art keywords
oxadol
derivatives
oxadol derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69130255T
Other languages
English (en)
Other versions
DE69130255T2 (de
Inventor
Frans Janssens
Francois Maria Sommen
Ann Dierckx
Ludwig Cooymans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE69130255D1 publication Critical patent/DE69130255D1/de
Application granted granted Critical
Publication of DE69130255T2 publication Critical patent/DE69130255T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/26Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32Nitrogen atom
    • C07D473/34Nitrogen atom attached in position 6, e.g. adenine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE69130255T 1990-07-19 1991-07-09 Oxadolderivate Expired - Lifetime DE69130255T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55432690A 1990-07-19 1990-07-19
PCT/EP1991/001291 WO1992001687A1 (en) 1990-07-19 1991-07-09 Novel oxazolyl derivatives

Publications (2)

Publication Number Publication Date
DE69130255D1 true DE69130255D1 (de) 1998-10-29
DE69130255T2 DE69130255T2 (de) 1999-04-08

Family

ID=24212929

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69130255T Expired - Lifetime DE69130255T2 (de) 1990-07-19 1991-07-09 Oxadolderivate

Country Status (31)

Country Link
EP (1) EP0539421B1 (de)
JP (1) JP3070951B2 (de)
KR (1) KR100190299B1 (de)
CN (1) CN1043640C (de)
AP (1) AP267A (de)
AT (1) ATE171449T1 (de)
AU (1) AU644202B2 (de)
BG (1) BG61342B1 (de)
CA (1) CA2086545A1 (de)
CZ (1) CZ279344B6 (de)
DE (1) DE69130255T2 (de)
ES (1) ES2121784T3 (de)
FI (1) FI930198A (de)
HU (1) HUT64340A (de)
IE (1) IE912532A1 (de)
IL (1) IL98864A (de)
MA (1) MA22226A1 (de)
MX (1) MX9100312A (de)
MY (1) MY107973A (de)
NO (1) NO300459B1 (de)
NZ (1) NZ238864A (de)
PL (1) PL169361B1 (de)
PT (1) PT98365B (de)
RO (1) RO111768B1 (de)
RU (1) RU2059636C1 (de)
SK (1) SK278133B6 (de)
TN (1) TNSN91062A1 (de)
TW (1) TW235964B (de)
WO (1) WO1992001687A1 (de)
YU (1) YU126391A (de)
ZA (1) ZA915653B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3258293A (en) * 1992-01-09 1993-08-03 Janssen Pharmaceutica N.V. Antihistaminic piperazinyl derivatives
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) * 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
EP1418175A1 (de) 1999-06-28 2004-05-12 Janssen Pharmaceutica N.V. Replikationsinhibitoren des respiratorischen Synzytialvirus
PT1196410E (pt) 1999-06-28 2004-07-30 Janssen Pharmaceutica Nv Inibidores da replicacao de virus sincicial respiratorio
AU778218B2 (en) 1999-06-28 2004-11-25 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
GB0315203D0 (en) * 2003-06-28 2003-08-06 Celltech R&D Ltd Chemical compounds
RU2381224C2 (ru) * 2003-12-18 2010-02-10 Тиботек Фармасьютикалз Лтд. Пиперидинаминобензимидазольные производные как ингибиторы репликации респираторного синцитиального вируса
EP1697347B1 (de) 2003-12-18 2011-02-23 Tibotec Pharmaceuticals 5- oder 6-substituierte benzimidazolderivate als inhibitoren der replikation des respiratory syncytial virus
AU2004298457B2 (en) 2003-12-18 2010-05-27 Tibotec Pharmaceuticals Ltd. Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication
US7855194B2 (en) * 2006-03-27 2010-12-21 Hoffmann-La Roche Inc. Pyrimidine, quinazoline, pteridine and triazine derivatives
TWI377511B (en) 2008-12-05 2012-11-21 Ind Tech Res Inst Flame detecting method and system
CN104098609B (zh) * 2014-07-28 2016-08-17 陕西科技大学 含二茂铁的咪唑并[2,1-b]-1,3,4-噻二唑、制备方法及其应用
WO2016100940A1 (en) 2014-12-19 2016-06-23 The Broad Institute, Inc. Dopamine d2 receptor ligands
EP3233799B1 (de) 2014-12-19 2021-05-19 The Broad Institute, Inc. Dopamin-d2-rezeptor-liganden

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556660A (en) * 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
US4695569A (en) * 1983-11-30 1987-09-22 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB8515934D0 (en) * 1985-06-24 1985-07-24 Janssen Pharmaceutica Nv (4-piperidinomethyl and-hetero)purines
US4835161A (en) * 1986-02-03 1989-05-30 Janssen Pharmaceutica N.V. Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines
US4897401A (en) * 1987-06-19 1990-01-30 Janssen Pharmaceutical N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases
CA1317939C (en) * 1987-07-01 1993-05-18 Janssen Pharmaceutica Naamloze Vennootschap ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines

Also Published As

Publication number Publication date
MY107973A (en) 1996-07-15
WO1992001687A1 (en) 1992-02-06
ATE171449T1 (de) 1998-10-15
AP267A (en) 1993-06-16
AP9100298A0 (en) 1991-07-31
YU126391A (sh) 1994-06-10
PL297611A1 (de) 1992-07-13
CS224091A3 (en) 1992-02-19
ES2121784T3 (es) 1998-12-16
JP3070951B2 (ja) 2000-07-31
EP0539421A1 (de) 1993-05-05
MA22226A1 (fr) 1992-04-01
NZ238864A (en) 1993-08-26
IE912532A1 (en) 1992-01-29
SK278133B6 (en) 1996-02-07
CN1043640C (zh) 1999-06-16
HUT64340A (en) 1993-12-28
NO930156D0 (no) 1993-01-18
PT98365A (pt) 1992-05-29
CA2086545A1 (en) 1992-01-20
ZA915653B (en) 1993-03-31
PT98365B (pt) 1999-01-29
EP0539421B1 (de) 1998-09-23
PL169361B1 (pl) 1996-07-31
AU644202B2 (en) 1993-12-02
CN1058215A (zh) 1992-01-29
TNSN91062A1 (fr) 1992-10-25
MX9100312A (es) 1992-02-28
IL98864A (en) 1995-12-08
FI930198A0 (fi) 1993-01-18
AU8214191A (en) 1992-02-18
RU2059636C1 (ru) 1996-05-10
NO930156L (no) 1993-01-18
HU9300097D0 (en) 1993-04-28
JPH05508839A (ja) 1993-12-09
FI930198A (fi) 1993-01-18
IL98864A0 (en) 1992-07-15
RO111768B1 (ro) 1997-01-30
DE69130255T2 (de) 1999-04-08
KR100190299B1 (ko) 1999-06-01
TW235964B (de) 1994-12-11
NO300459B1 (no) 1997-06-02
CZ279344B6 (cs) 1995-04-12
BG61342B1 (en) 1997-06-30
BG97314A (bg) 1994-01-24

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Legal Events

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8364 No opposition during term of opposition