CN104053672A - Trop-2特异性抗体及其用途 - Google Patents

Trop-2特异性抗体及其用途 Download PDF

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Publication number
CN104053672A
CN104053672A CN201280055208.2A CN201280055208A CN104053672A CN 104053672 A CN104053672 A CN 104053672A CN 201280055208 A CN201280055208 A CN 201280055208A CN 104053672 A CN104053672 A CN 104053672A
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China
Prior art keywords
antibody
seq
trop
sequence
antibodies
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Pending
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CN201280055208.2A
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English (en)
Chinese (zh)
Inventor
S-H·刘
W-H·胡
P·施特罗普
M·G·多里沃尔斯卡
A·拉吉帕尔
D·L·谢尔顿
T·T·德兰
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Rinat Neuroscience Corp
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Rinat Neuroscience Corp
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Publication of CN104053672A publication Critical patent/CN104053672A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • A61K47/6859—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from liver or pancreas cancer cell
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C07K16/3046—Stomach, Intestines
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201280055208.2A 2011-11-11 2012-11-07 Trop-2特异性抗体及其用途 Pending CN104053672A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161559015P 2011-11-11 2011-11-11
US61/559,015 2011-11-11
US201261640641P 2012-04-30 2012-04-30
US61/640,641 2012-04-30
US201261717288P 2012-10-23 2012-10-23
US61/717,288 2012-10-23
PCT/IB2012/056234 WO2013068946A2 (en) 2011-11-11 2012-11-07 Antibodies specific for trop-2 and their uses

Publications (1)

Publication Number Publication Date
CN104053672A true CN104053672A (zh) 2014-09-17

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CN201280055208.2A Pending CN104053672A (zh) 2011-11-11 2012-11-07 Trop-2特异性抗体及其用途

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US (4) US8871908B2 (https=)
EP (1) EP2776470A2 (https=)
JP (3) JP5936702B2 (https=)
KR (1) KR20140091040A (https=)
CN (1) CN104053672A (https=)
AR (1) AR088693A1 (https=)
AU (1) AU2012335205A1 (https=)
BR (1) BR112014011331A2 (https=)
CA (2) CA2954166A1 (https=)
CO (1) CO7010785A2 (https=)
HK (1) HK1201851A1 (https=)
IL (1) IL232426A0 (https=)
MX (1) MX2014005728A (https=)
PH (1) PH12014500932A1 (https=)
RU (1) RU2014116406A (https=)
SA (1) SA112330988B1 (https=)
SG (1) SG11201401699WA (https=)
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