CN103814030A - 吡咯并嘧啶及嘌呤衍生物 - Google Patents

吡咯并嘧啶及嘌呤衍生物 Download PDF

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Publication number
CN103814030A
CN103814030A CN201280045991.4A CN201280045991A CN103814030A CN 103814030 A CN103814030 A CN 103814030A CN 201280045991 A CN201280045991 A CN 201280045991A CN 103814030 A CN103814030 A CN 103814030A
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Prior art keywords
methyl
alkyl
formula
pharmaceutically acceptable
compound
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CN201280045991.4A
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English (en)
Chinese (zh)
Inventor
程恒淼
T·O·小约翰逊
J·C·凯思
K·K·刘
E·A·伦尼
永田麻子
S·K·奈尔
S·P·普兰肯
S·C·萨顿
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SmithKline Beecham Ltd
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SmithKline Beecham Ltd
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Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of CN103814030A publication Critical patent/CN103814030A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN201280045991.4A 2011-09-22 2012-09-10 吡咯并嘧啶及嘌呤衍生物 Pending CN103814030A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161538103P 2011-09-22 2011-09-22
US61/538,103 2011-09-22
US201261639639P 2012-04-27 2012-04-27
US61/639,639 2012-04-27
PCT/IB2012/054702 WO2013042006A1 (en) 2011-09-22 2012-09-10 Pyrrolopyrimidine and purine derivatives

Publications (1)

Publication Number Publication Date
CN103814030A true CN103814030A (zh) 2014-05-21

Family

ID=47116127

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280045991.4A Pending CN103814030A (zh) 2011-09-22 2012-09-10 吡咯并嘧啶及嘌呤衍生物

Country Status (29)

Country Link
US (2) US9040547B2 (enExample)
EP (1) EP2758402B9 (enExample)
JP (1) JP5914667B2 (enExample)
KR (1) KR20140059246A (enExample)
CN (1) CN103814030A (enExample)
AP (1) AP2014007475A0 (enExample)
AR (1) AR088760A1 (enExample)
AU (1) AU2012311184A1 (enExample)
BR (1) BR112014006840A2 (enExample)
CA (1) CA2847540C (enExample)
CL (2) CL2014000566A1 (enExample)
CO (1) CO6910196A2 (enExample)
CR (1) CR20140132A (enExample)
DO (1) DOP2014000055A (enExample)
EA (1) EA201490673A1 (enExample)
ES (1) ES2575710T3 (enExample)
IL (1) IL231592A0 (enExample)
MA (1) MA35451B1 (enExample)
MD (1) MD20140023A2 (enExample)
MX (1) MX2014003501A (enExample)
NI (1) NI201400023A (enExample)
PE (1) PE20141228A1 (enExample)
PH (1) PH12014500638A1 (enExample)
SG (1) SG2014014450A (enExample)
TN (1) TN2014000115A1 (enExample)
TW (1) TWI492946B (enExample)
UA (1) UA110259C2 (enExample)
UY (1) UY34342A (enExample)
WO (1) WO2013042006A1 (enExample)

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CN108495563A (zh) * 2015-11-25 2018-09-04 R.J.雷诺兹烟草公司 烟碱盐、共晶体和盐共晶体配合物
CN111491934A (zh) * 2017-12-28 2020-08-04 株式会社大熊制药 作为激酶抑制剂的氨基-氟哌啶衍生物
CN111527088A (zh) * 2017-12-28 2020-08-11 株式会社大熊制药 作为激酶抑制剂的氨基-甲基哌啶衍生物
CN111527091A (zh) * 2017-12-28 2020-08-11 株式会社大熊制药 作为激酶抑制剂的氧基-氟哌啶衍生物
WO2021147952A1 (zh) * 2020-01-21 2021-07-29 江苏先声药业有限公司 嘧啶并吡咯类化合物
WO2021147953A1 (zh) * 2020-01-21 2021-07-29 江苏先声药业有限公司 嘧啶并五元环类衍生物及其应用
WO2022062601A1 (zh) * 2020-09-22 2022-03-31 江苏先声药业有限公司 嘧啶并吡咯类化合物
CN114315838A (zh) * 2020-09-30 2022-04-12 江苏先声药业有限公司 嘧啶并吡咯类化合物
CN114907357A (zh) * 2021-02-07 2022-08-16 江苏先声药业有限公司 嘧啶并吡咯类化合物
WO2023041071A1 (zh) * 2021-09-18 2023-03-23 山东新时代药业有限公司 一种egfr抑制剂及其制备方法和用途

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CN105188704B (zh) 2013-01-16 2017-09-19 西格诺药品有限公司 被取代的吡咯并嘧啶化合物、其组合物和使用其的治疗方法
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