UY34342A - ?derivados de pirrolopirimidina y purina?. - Google Patents
?derivados de pirrolopirimidina y purina?.Info
- Publication number
- UY34342A UY34342A UY34342A UY34342A UY34342A UY 34342 A UY34342 A UY 34342A UY 34342 A UY34342 A UY 34342A UY 34342 A UY34342 A UY 34342A UY 34342 A UY34342 A UY 34342A
- Authority
- UY
- Uruguay
- Prior art keywords
- pirrolopirimidina
- purina
- derivatives
- reivindicación
- pág
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Compuestos de Fórmula (I) o sales farmacéuticamente aceptables de los mismos, composiciones farmacéuticas que los contienen y métodos de aplicación de dichos compuestos y composiciones en el tratamiento del crecimiento celular anormal en mamíferos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161538103P | 2011-09-22 | 2011-09-22 | |
US201261639639P | 2012-04-27 | 2012-04-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY34342A true UY34342A (es) | 2013-04-30 |
Family
ID=47116127
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY34342A UY34342A (es) | 2011-09-22 | 2012-09-21 | ?derivados de pirrolopirimidina y purina?. |
Country Status (28)
Country | Link |
---|---|
US (2) | US9040547B2 (es) |
EP (1) | EP2758402B9 (es) |
JP (1) | JP5914667B2 (es) |
KR (1) | KR20140059246A (es) |
CN (1) | CN103814030A (es) |
AP (1) | AP2014007475A0 (es) |
AR (1) | AR088760A1 (es) |
AU (1) | AU2012311184A1 (es) |
BR (1) | BR112014006840A2 (es) |
CA (1) | CA2847540C (es) |
CL (2) | CL2014002726A1 (es) |
CO (1) | CO6910196A2 (es) |
CR (1) | CR20140132A (es) |
DO (1) | DOP2014000055A (es) |
EA (1) | EA201490673A1 (es) |
ES (1) | ES2575710T3 (es) |
IL (1) | IL231592A0 (es) |
MA (1) | MA35451B1 (es) |
MD (1) | MD20140023A2 (es) |
MX (1) | MX2014003501A (es) |
NI (1) | NI201400023A (es) |
PE (1) | PE20141228A1 (es) |
SG (1) | SG2014014450A (es) |
TN (1) | TN2014000115A1 (es) |
TW (1) | TWI492946B (es) |
UA (1) | UA110259C2 (es) |
UY (1) | UY34342A (es) |
WO (1) | WO2013042006A1 (es) |
Families Citing this family (49)
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BR112014007788A2 (pt) * | 2011-10-03 | 2017-04-18 | Univ North Carolina Chapel Hill | compostos de pirrolopirimidina para tratamento do câncer |
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AU2013266438B2 (en) | 2012-05-22 | 2017-09-07 | The University Of North Carolina At Chapel Hill | Pyrimidine compounds for the treatment of cancer |
EP2909211A4 (en) | 2012-10-17 | 2016-06-22 | Univ North Carolina | PYRAZOLOPYRIMIDINE COMPOUNDS FOR CANCER TREATMENT |
US9771330B2 (en) | 2012-11-27 | 2017-09-26 | The University Of North Carolina At Chapel Hill | Pyrimidine compounds for the treatment of cancer |
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AU2014207641A1 (en) * | 2013-01-16 | 2015-08-06 | Signal Pharmaceuticals, Llc | Substituted Pyrrolopyrimidine Compounds, compositions thereof, and methods of treatment therewith |
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KR101657616B1 (ko) * | 2013-05-24 | 2016-09-19 | 주식회사유한양행 | 피리미딘 고리를 포함하는 바이사이클릭 유도체 및 그의 제조방법 |
CA2924362C (en) * | 2013-09-18 | 2018-12-18 | Beijing Hanmi Pharmaceutical Co., Ltd. | Compound inhibiting activities of btk and/or jak3 kinases |
CN104513229A (zh) | 2013-09-28 | 2015-04-15 | 正大天晴药业集团股份有限公司 | 喹唑啉衍生物及其制备方法 |
UA115388C2 (uk) | 2013-11-21 | 2017-10-25 | Пфайзер Інк. | 2,6-заміщені пуринові похідні та їх застосування в лікуванні проліферативних захворювань |
MA39219B1 (fr) | 2014-01-29 | 2018-11-30 | Glaxosmithkline Ip Dev Ltd | Nouveaux composés inhibiteurs de la kinase lrrk2 utilisés pour le traitement du parkinson, de l’alzheimer et de la sclérose latérale amyotrophique |
ES2717757T3 (es) | 2014-01-29 | 2019-06-25 | Glaxosmithkline Ip Dev Ltd | Compuestos |
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WO2015157123A1 (en) | 2014-04-11 | 2015-10-15 | The University Of North Carolina At Chapel Hill | Mertk-specific pyrrolopyrimidine compounds |
EP3145512B1 (en) * | 2014-05-19 | 2019-07-17 | Jiangsu Hengrui Medicine Co., Ltd. | Substituted ethynyl heterobicyclic compounds as tyrosine kinase inhibitors |
JP2017520603A (ja) | 2014-07-14 | 2017-07-27 | シグナル ファーマシューティカルズ,エルエルシー | 置換ピロロピリミジン化合物を使用するがんの治療方法及びその組成物 |
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CN105524068B (zh) | 2014-09-30 | 2017-11-24 | 上海海雁医药科技有限公司 | 氮杂双环衍生物、其制法与医药上的用途 |
CN111170998B (zh) * | 2014-11-05 | 2023-04-11 | 益方生物科技(上海)股份有限公司 | 嘧啶或吡啶类化合物、其制备方法和医药用途 |
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JP6861166B2 (ja) * | 2015-03-27 | 2021-04-21 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | サイクリン依存性キナーゼの阻害剤 |
CN106236060B (zh) | 2015-06-04 | 2021-04-09 | 松下知识产权经营株式会社 | 生物体信息检测装置 |
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CN114656446A (zh) * | 2015-11-25 | 2022-06-24 | R.J.雷诺兹烟草公司 | 烟碱盐、共晶体和盐共晶体配合物 |
US10709708B2 (en) | 2016-03-17 | 2020-07-14 | The University Of North Carolina At Chapel Hill | Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor |
PT3472153T (pt) | 2016-06-16 | 2021-12-31 | Denali Therapeutics Inc | Pirimidin-2-ilamino-1h-pirazóis como inibidores de lrrk2 para uso no tratamento de distúrbios neurodegenerativos |
WO2018155916A2 (ko) * | 2017-02-22 | 2018-08-30 | 재단법인 대구경북첨단의료산업진흥재단 | 피롤로-피리미딘 유도체 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 단백질 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물 |
KR102398659B1 (ko) * | 2017-03-17 | 2022-05-16 | 주식회사 대웅제약 | 카이네이즈 저해제로서의 피롤로트리아진 유도체 |
EP3694528A4 (en) | 2017-10-13 | 2021-07-28 | The Regents of the University of California | MTORC1 MODULATORS |
WO2019112269A1 (ko) * | 2017-12-05 | 2019-06-13 | 주식회사 오스코텍 | Lrrk2 억제제로서의 피롤로(피라졸로)피리미딘 유도체 |
KR102577241B1 (ko) * | 2017-12-28 | 2023-09-11 | 주식회사 대웅제약 | 카이네이즈 저해제로서의 아미노-플루오로피페리딘 유도체 |
KR102577242B1 (ko) * | 2017-12-28 | 2023-09-11 | 주식회사 대웅제약 | 카이네이즈 저해제로서의 아미노-메틸피페리딘 유도체 |
TN2020000082A1 (en) * | 2017-12-28 | 2022-01-06 | Dae Woong Pharma | Oxy-fluoropiperidine derivative as kinase inhibitor |
KR102377007B1 (ko) * | 2018-09-20 | 2022-03-22 | 한미약품 주식회사 | 상피세포 성장인자 수용체 돌연변이 저해 효과를 갖는 신규 융합 피리미딘 골격 설폰아마이드 유도체 |
WO2020060268A1 (ko) * | 2018-09-20 | 2020-03-26 | 한미약품 주식회사 | 상피세포 성장인자 수용체 돌연변이 저해 효과를 갖는 신규 융합 피리미딘 골격 설폰아마이드 유도체 |
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WO2021147952A1 (zh) * | 2020-01-21 | 2021-07-29 | 江苏先声药业有限公司 | 嘧啶并吡咯类化合物 |
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