CN103649079B - 丙型肝炎抑制剂及其用途 - Google Patents

丙型肝炎抑制剂及其用途 Download PDF

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Publication number
CN103649079B
CN103649079B CN201180068128.6A CN201180068128A CN103649079B CN 103649079 B CN103649079 B CN 103649079B CN 201180068128 A CN201180068128 A CN 201180068128A CN 103649079 B CN103649079 B CN 103649079B
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China
Prior art keywords
benzofuran
cyclopropyl
fluorophenyl
imidazol
methanesulfonamide
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Expired - Fee Related
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CN201180068128.6A
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English (en)
Chinese (zh)
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CN103649079A (zh
Inventor
C.J.梅林
J.K.普拉特
W.A.卡罗尔
刘大春
D.A.德贝本纳
D.K.哈钦森
M.D.塔法诺
T.W.罗克维
U.谢恩
A.帕尔
A.维特
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Abbott Products LLC
AbbVie Inc
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Abbott Products LLC
AbbVie Inc
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Priority to CN201610903761.7A priority Critical patent/CN106986862A/zh
Publication of CN103649079A publication Critical patent/CN103649079A/zh
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    • C07—ORGANIC CHEMISTRY
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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CN201180068128.6A 2010-12-22 2011-12-16 丙型肝炎抑制剂及其用途 Expired - Fee Related CN103649079B (zh)

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US9303020B2 (en) * 2012-02-08 2016-04-05 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
EP2984080B1 (en) 2013-04-12 2017-08-30 Bayer CropScience Aktiengesellschaft Novel triazolinthione derivatives
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