JP5918264B2 - Ｃ型肝炎阻害剤およびその使用 - Google Patents

Ｃ型肝炎阻害剤およびその使用 Download PDF

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Publication number
JP5918264B2
JP5918264B2 JP2013546262A JP2013546262A JP5918264B2 JP 5918264 B2 JP5918264 B2 JP 5918264B2 JP 2013546262 A JP2013546262 A JP 2013546262A JP 2013546262 A JP2013546262 A JP 2013546262A JP 5918264 B2 JP5918264 B2 JP 5918264B2
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JP
Japan
Prior art keywords
benzofuran
cyclopropyl
fluorophenyl
methanesulfonamide
imidazol
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Expired - Fee Related
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JP2013546262A
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Japanese (ja)
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JP2014500322A (ja
JP2014500322A5 (enExample
Inventor
マーリング，クラレンス・ジエイ
プラツト，ジヨン・ケイ
キヤロル，ウイリアム・エイ
リウ，ダーチユン
ベテベナー，デイビツド・エイ
ハツチンソン，ダグラス・ケイ
テユフアノ，マイケル・デイー
ロツクウエイ，トツド・ダブリユ
シエーン，ウーベ
パール，アクセル
ビツテ，アドレアス
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Abbott Products GmbH
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Abbott Products GmbH
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Publication of JP2014500322A5 publication Critical patent/JP2014500322A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D88/00—Large containers
    • B65D88/54—Large containers characterised by means facilitating filling or emptying
    • B65D88/64—Large containers characterised by means facilitating filling or emptying preventing bridge formation
    • B65D88/70—Large containers characterised by means facilitating filling or emptying preventing bridge formation using fluid jets
    • B65D88/703—Air blowing devices, i.e. devices for the sudden introduction of compressed air into the container
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  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Mechanical Engineering (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013546262A 2010-12-22 2011-12-16 Ｃ型肝炎阻害剤およびその使用 Expired - Fee Related JP5918264B2 (ja)

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US201061426312P 2010-12-22 2010-12-22
US61/426,312 2010-12-22
PCT/US2011/065558 WO2012087833A1 (en) 2010-12-22 2011-12-16 Hepatitis c inhibitors and uses thereof

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JP2014500322A JP2014500322A (ja) 2014-01-09
JP2014500322A5 JP2014500322A5 (enExample) 2015-02-12
JP5918264B2 true JP5918264B2 (ja) 2016-05-18

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US (3) US9173887B2 (enExample)
EP (1) EP2655362A1 (enExample)
JP (1) JP5918264B2 (enExample)
CN (2) CN106986862A (enExample)
CA (1) CA2822357A1 (enExample)
WO (1) WO2012087833A1 (enExample)

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US9303020B2 (en) 2012-02-08 2016-04-05 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
JP2016522800A (ja) 2013-04-12 2016-08-04 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 新規トリアゾリンチオン誘導体
CN105308032B (zh) 2013-04-12 2017-05-24 拜耳作物科学股份公司 新的三唑衍生物
EA030024B1 (ru) 2013-04-12 2018-06-29 Байер Кропсайенс Акциенгезельшафт Новые производные триазола для борьбы с фитопатогенными вредоносными грибами
DK3043803T3 (da) 2013-09-11 2022-08-01 Univ Emory Nukleotid- og nucleosidsammensætninger og deres anvendelse
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