CN103484485A - 葡聚糖酶,编码它们的核酸以及制备和使用它们的方法 - Google Patents
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Abstract
Description
SEQ ID NO: | 类型 | 最佳pH | 最佳温度 |
409,410 | 碱性内切葡聚糖酶/纤维素酶 | 5 | NA |
343,344 | 碱性内切葡聚糖酶/纤维素酶 | 6 | 60 |
319,320 | 碱性内切葡聚糖酶/纤维素酶 | 6 | 70 |
383,384 | 碱性内切葡聚糖酶/纤维素酶 | 7 | 60 |
301,302 | 碱性内切葡聚糖酶/纤维素酶 | 7 | 60 |
257,258 | 碱性内切葡聚糖酶/纤维素酶 | 8 | 42 |
419,420 | 碱性内切葡聚糖酶/纤维素酶 | 8 | 70 |
421,422 | 碱性内切葡聚糖酶/纤维素酶 | 9 | 60 |
405,406 | 碱性内切葡聚糖酶/纤维素酶 | 9 | 50 |
329,330 | 碱性内切葡聚糖酶/纤维素酶 | 9 | 50 |
325,326 | 碱性内切葡聚糖酶/纤维素酶 | (5-7)* | 70 |
415,416 | 碱性内切葡聚糖酶/纤维素酶 | (6-10)* | 70 |
303,304 | 碱性内切葡聚糖酶/纤维素酶 | (6-10)* | 60 |
271,272 | 碱性内切葡聚糖酶/纤维素酶 | (6-7)* | 60 |
175,176 | 碱性内切葡聚糖酶/纤维素酶 | (6-7)* | 70 |
9,10 | 碱性内切葡聚糖酶/纤维素酶 | (6-7)* | 70 |
297,298 | 碱性内切葡聚糖酶/纤维素酶 | (6-8)* | 50 |
109,110 | 碱性内切葡聚糖酶/纤维素酶 | (6-8)* | 60 |
267,268 | 碱性内切葡聚糖酶/纤维素酶 | (6-8)* | 70 |
107,108 | 碱性内切葡聚糖酶/纤维素酶 | (6-8)* | 70 |
305,306 | 碱性内切葡聚糖酶/纤维素酶 | (7-10)* | 60 |
417,418 | 碱性内切葡聚糖酶/纤维素酶 | (7-8.5)* | NA |
227,228 | 碱性内切葡聚糖酶/纤维素酶 | (7-9)* | 60 |
375,376 | 碱性内切葡聚糖酶/纤维素酶 | (7-9)* | 70 |
335,336 | 碱性内切葡聚糖酶/纤维素酶 | (7-9)* | 50 |
155,156 | 碱性内切葡聚糖酶/纤维素酶 | (7-9)* | 60 |
445,446 | 碱性内切葡聚糖酶/纤维素酶 | (7-9)* | 60 |
259,260 | 碱性内切葡聚糖酶/纤维素酶 | (8-10)* | 50 |
423,424 | 碱性内切葡聚糖酶/纤维素酶 | (8-10)* | 50 |
345,346 | 碱性内切葡聚糖酶/纤维素酶 | (8-9)* | 25 |
285,286 | 碱性内切葡聚糖酶/纤维素酶 | (8-9)* | 50 |
351,352 | 碱性内切葡聚糖酶/纤维素酶 | (9-10)* | 80 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111057694A (zh) * | 2019-12-17 | 2020-04-24 | 云南农业大学 | 一种来源于大额牛瘤胃的高活性纤维素酶及其基因 |
Families Citing this family (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1641910B1 (en) | 2003-07-02 | 2013-02-20 | Verenium Corporation | Glucanases, nucleic acids encoding them and methods for making and using them |
US7024800B2 (en) | 2004-07-19 | 2006-04-11 | Earthrenew, Inc. | Process and system for drying and heat treating materials |
US7685737B2 (en) | 2004-07-19 | 2010-03-30 | Earthrenew, Inc. | Process and system for drying and heat treating materials |
CA2861310A1 (en) | 2005-03-15 | 2006-09-28 | Bp Corporation North America Inc. | Cellulases, nucleic acids encoding them and methods for making and using them |
US20150328347A1 (en) | 2005-03-24 | 2015-11-19 | Xyleco, Inc. | Fibrous materials and composites |
US7708214B2 (en) | 2005-08-24 | 2010-05-04 | Xyleco, Inc. | Fibrous materials and composites |
EP1752533A1 (en) * | 2005-08-12 | 2007-02-14 | Institut National de la Recherche Agronomique | Fusion proteins between plant cell-wall degrading enzymes, and their uses |
US7610692B2 (en) | 2006-01-18 | 2009-11-03 | Earthrenew, Inc. | Systems for prevention of HAP emissions and for efficient drying/dehydration processes |
EP2444489B1 (en) | 2006-02-10 | 2014-02-12 | Verenium Corporation | Cellucloytic enzymes, nucleic acids encoding them and methods for making and using them |
WO2009020459A2 (en) * | 2006-08-04 | 2009-02-12 | Verenium Corporation | Glucanases, nucleic acids encoding them and methods for making and using them |
CN101210237B (zh) * | 2006-12-30 | 2010-09-29 | 中国科学院上海生命科学研究院 | 动物内源性的内切-β-1,4-葡聚糖酶及其应用 |
EP2074136A4 (en) * | 2007-01-30 | 2012-11-07 | Verenium Corp | ENZYMES FOR TREATING LIGNOCELLULOSE, FOR SUCH CODING NUCLEIC ACIDS, AND METHOD FOR THE PRODUCTION AND USE THEREOF |
CN101157897B (zh) * | 2007-08-03 | 2011-04-27 | 吉林农业大学 | 一种具有大豆MnSOD基因的粟酒裂殖酵母工程菌及其构建方法 |
CN101173226B (zh) * | 2007-10-22 | 2010-08-11 | 中国农业大学 | 一种巴斯德毕赤酵母重组菌及其应用 |
US9896642B2 (en) | 2008-10-14 | 2018-02-20 | Corbion Biotech, Inc. | Methods of microbial oil extraction and separation |
EP2346894A4 (en) * | 2008-10-24 | 2012-04-18 | C5 6 Technologies Inc | TERMOSTABLE CELLULASE AND USE METHOD |
AU2010236412B2 (en) * | 2009-04-14 | 2015-10-01 | Corbion Biotech, Inc. | Methods of microbial oil extraction and separation |
MX2011012543A (es) | 2009-05-26 | 2012-04-02 | Solazyme Inc | Fraccionamiento de la biomasa microbiana que contiene aceite. |
CN101591622B (zh) * | 2009-06-30 | 2011-01-19 | 重庆大学 | 蜂毒肽基因裂殖酵母工程菌及其构建方法和应用 |
JP2013516500A (ja) * | 2010-01-11 | 2013-05-13 | ヒールオア・リミテッド | 炎症性疾患および障害を治療するための方法 |
US9024111B1 (en) * | 2011-03-31 | 2015-05-05 | Sandia Corporation | Methods and materials for deconstruction of biomass for biofuels production |
WO2012151214A1 (en) * | 2011-05-02 | 2012-11-08 | The Regents Of The University Of California | Glycoside hydrolases having multiple hydrolase activities |
WO2013037933A2 (en) | 2011-09-14 | 2013-03-21 | Dupont Nutrition Biosciences Aps | Enzymes |
WO2013043864A1 (en) * | 2011-09-23 | 2013-03-28 | The Board Of Regents Of The University Of Texas System | Compositions and methods related to endothelial targeting |
CN102363774B (zh) * | 2011-10-26 | 2013-03-20 | 山东隆科特酶制剂有限公司 | 一种具有宽pH范围的β-甘露聚糖酶BA-Man5A及其基因和应用 |
JP5977029B2 (ja) * | 2012-01-11 | 2016-08-24 | 花王株式会社 | 変異グリコシドハイドロラーゼ |
AU2013240368A1 (en) * | 2012-03-30 | 2014-11-13 | Basf Enzymes Llc | Genes encoding cellulase for hydrolyzing guar fracturing fluids under extreme well conditions |
EA028648B1 (ru) * | 2012-03-30 | 2017-12-29 | Басф Энзаймс Ллк | Ген, кодирующий целлюлазу (варианты) |
US20150337247A1 (en) | 2012-08-03 | 2015-11-26 | Dupont Nutrition Biosciences Aps | Enzymes |
JP6081172B2 (ja) * | 2012-12-05 | 2017-02-15 | 花王株式会社 | 変異グリコシドハイドロラーゼ |
JP6144483B2 (ja) * | 2012-12-05 | 2017-06-07 | 花王株式会社 | 変異グリコシドハイドロラーゼ |
EP2935573A1 (en) * | 2012-12-19 | 2015-10-28 | Danisco US Inc. | Novel mannanase, compositions and methods of use thereof |
US9850512B2 (en) | 2013-03-15 | 2017-12-26 | The Research Foundation For The State University Of New York | Hydrolysis of cellulosic fines in primary clarified sludge of paper mills and the addition of a surfactant to increase the yield |
US9573980B2 (en) | 2013-03-15 | 2017-02-21 | Spogen Biotech Inc. | Fusion proteins and methods for stimulating plant growth, protecting plants from pathogens, and immobilizing Bacillus spores on plant roots |
CN103642778B (zh) * | 2013-12-18 | 2015-08-05 | 青岛蔚蓝生物集团有限公司 | 一种β-内切葡聚糖酶突变体及其应用 |
CN103966188B (zh) * | 2014-02-12 | 2016-04-20 | 华南农业大学 | 可在动物细胞表达分泌的重组葡聚糖酶及其重组方法和应用 |
US9951363B2 (en) | 2014-03-14 | 2018-04-24 | The Research Foundation for the State University of New York College of Environmental Science and Forestry | Enzymatic hydrolysis of old corrugated cardboard (OCC) fines from recycled linerboard mill waste rejects |
WO2015144824A1 (en) * | 2014-03-27 | 2015-10-01 | Novozymes A/S | Beta-glucanase variants and polynucleotides encoding same |
JP2017518076A (ja) * | 2014-05-29 | 2017-07-06 | オハイオ ソイビーン カウンシル | 植物性ミールの栄養阻害物質の軽減 |
WO2015200354A2 (en) * | 2014-06-24 | 2015-12-30 | Tethys Research Llc | Enzymes that cleave non-glycosidic ether bonds between lignins or derivatives thereof and saccharides |
DK3167055T3 (da) * | 2014-07-10 | 2019-11-18 | Novozymes As | Polypeptider med xylanaseaktivitet og polynukleotider, som koder for dem |
US20170114371A1 (en) * | 2014-07-10 | 2017-04-27 | Novozymes A/S | Process For Producing Ethanol From Starch Using A GH5 Xylanase |
JP6315807B2 (ja) | 2014-08-04 | 2018-04-25 | 本田技研工業株式会社 | Ghファミリー12に属する超耐熱性エンドグルカナーゼ |
JP6268486B2 (ja) | 2014-08-04 | 2018-01-31 | 本田技研工業株式会社 | Ghファミリー12に属する超耐熱性エンドグルカナーゼ |
BR122023020869A2 (pt) | 2014-09-17 | 2024-01-30 | Spogen Biotech Inc | Métodos para a remoção de exosporium a partir de esporos de uma bactéria de bacillus recombinante, para estimular o crescimento e proteger uma planta de um agente patogênico, bem como para aumentar resistência a stress em uma planta |
AR101957A1 (es) | 2014-09-17 | 2017-01-25 | Bayer Cropscience Lp | Composiciones que comprenden células recombinantes de bacillus y un insecticida |
WO2016044548A1 (en) | 2014-09-17 | 2016-03-24 | Bayer Cropscience Lp | Compositions comprising recombinant bacillus cells and another biological control agent |
AR101960A1 (es) | 2014-09-17 | 2017-01-25 | Bayer Cropscience Lp | Composiciones que comprenden células recombinantes de bacillus y un fungicida |
AR101959A1 (es) | 2014-09-17 | 2017-01-25 | Bayer Cropscience Lp | Composiciones que comprenden células recombinantes de bacillus y un insecticida |
EP3017706A1 (en) | 2014-11-05 | 2016-05-11 | Dupont Nutrition Biosciences ApS | Enzymes for malting |
US10266863B2 (en) * | 2015-03-11 | 2019-04-23 | Genencor International B.V. | Enzymatic activity of lytic polysaccharide monooxygenase |
GB201509149D0 (en) | 2015-05-28 | 2015-07-15 | Sintef | Thermostatable Cellulases |
EP3429347A4 (en) | 2016-03-16 | 2020-07-29 | Spogen Biotech Inc. | PROCESSES FOR PROMOTING PLANT HEALTH USING FREE ENZYMES AND MICRO-ORGANISMS OVEREXPRESSING ENZYMES |
AR108694A1 (es) * | 2016-06-10 | 2018-09-19 | Cargill Inc | Suspensión de biopolímero bombeable y/o fluida |
CN106198952A (zh) * | 2016-07-01 | 2016-12-07 | 清华大学 | 一种抑制核酸分子对传感界面非特异性吸附的封闭方法 |
JP2019534391A (ja) | 2016-09-16 | 2019-11-28 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | セルラーゼ酵素を含有するパルプの変性方法及びそれらの製品 |
WO2018094322A1 (en) * | 2016-11-21 | 2018-05-24 | Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center | Novel fungal toxins and methods related to the same |
CN112368375A (zh) | 2018-04-26 | 2021-02-12 | 巴斯夫欧洲公司 | 脂肪酶 |
EP3788145A1 (en) | 2018-05-03 | 2021-03-10 | Basf Se | Amylase enzymes |
CN109295031B (zh) * | 2018-10-23 | 2020-06-19 | 南京工业大学 | 一种抗真菌蛋白β-1,3-葡聚糖酶和含有该基因的工程菌及其应用 |
CN114127256A (zh) | 2019-02-20 | 2022-03-01 | 巴斯夫欧洲公司 | 用确定成分培养基和微量元素补料的芽孢杆菌工业发酵工艺 |
US20220186177A1 (en) | 2019-02-20 | 2022-06-16 | Basf Se | Industrial fermentation process for bacillus using defined medium and magnesium feed |
JP6646266B1 (ja) * | 2019-03-06 | 2020-02-14 | 不二製油グループ本社株式会社 | 新規固定化酵素 |
WO2020186030A1 (en) | 2019-03-14 | 2020-09-17 | The Procter & Gamble Company | Cleaning compositions comprising enzymes |
WO2020186028A1 (en) | 2019-03-14 | 2020-09-17 | The Procter & Gamble Company | Cleaning compositions comprising enzymes |
MX2021011106A (es) * | 2019-03-14 | 2021-10-22 | Procter & Gamble | Metodo para tratar el algodon. |
EP3947665A2 (en) | 2019-03-25 | 2022-02-09 | Basf Se | Amylase enzymes |
US20220170001A1 (en) | 2019-03-25 | 2022-06-02 | Basf Se | Amylase Enzymes |
WO2020193532A1 (en) | 2019-03-25 | 2020-10-01 | Basf Se | Cleaning composition having amylase enzymes |
MX2021011981A (es) * | 2019-04-03 | 2021-11-03 | Novozymes As | Polipeptidos que tienen actividad de beta-glucanasa, polinucleotidos que los codifican y usos de los mismos en composiciones de limpieza y de detergente. |
WO2020249546A1 (en) | 2019-06-13 | 2020-12-17 | Basf Se | Method of recovering a protein from fermentation broth using a divalent cation |
PL3959326T3 (pl) | 2019-07-05 | 2023-10-09 | Basf Se | Przemysłowy sposób fermentacji dla komórek bakteryjnych z wykorzystaniem kultury wstępnej okresowej z zasilaniem |
JPWO2021015158A1 (zh) * | 2019-07-23 | 2021-01-28 | ||
CN110501983B (zh) * | 2019-07-31 | 2021-03-26 | 农业农村部南京农业机械化研究所 | 基于批次式包衣机的专家控制系统及控制方法 |
BR112022000573A2 (pt) | 2019-08-22 | 2022-03-15 | Basf Se | Polipeptídeo isolado, sintético ou recombinante com atividade alfa-amilase, ácido nucleico isolado, sintético ou recombinante, construto de ácido nucleico, vetor de expressão, célula hospedeira, composição, método para produzir polipeptídeo isolado, sintético ou recombinante, método para preparar uma massa ou um produto de panificação, e, métodos para usar o polipeptídeo isolado, sintético ou recombinante e um domínio c de uma primeira amilase |
AU2020335238A1 (en) * | 2019-08-30 | 2022-03-24 | Ab Enzymes Gmbh | Use of GH12 cellulases in preparing bakery products comprising rye-flour |
US20230220308A1 (en) * | 2019-09-23 | 2023-07-13 | Basf Se | Mannanase for formulations having ph 5-12 |
JP2022549264A (ja) * | 2019-09-23 | 2022-11-24 | ビーエーエスエフ ソシエタス・ヨーロピア | pH5~12を有する配合物のためのマンナナーゼ |
CN110819610A (zh) * | 2019-10-16 | 2020-02-21 | 江苏大学 | 一种极耐热甘露聚糖酶及其制备方法与应用 |
EP4045625A1 (en) | 2019-10-18 | 2022-08-24 | Basf Se | Storage-stable hydrolase containing liquids |
JP2021101622A (ja) * | 2019-12-24 | 2021-07-15 | 株式会社日立製作所 | タンパク質を耐熱化するための方法 |
US20230081929A1 (en) * | 2020-02-14 | 2023-03-16 | Basf Se | Mannanase variants |
EP4103708A1 (en) * | 2020-02-14 | 2022-12-21 | Basf Se | Mannanase variants |
BR112022015928A2 (pt) * | 2020-02-14 | 2022-10-04 | Basf Se | Variante de mananase, polinucleotídeo que codifica a mananase, construto de expressão, célula hospedeira, métodos para expressar uma variante de mananase, para aumentar a estabilidade no tensoativo de uma mananase, para prover uma formulação de detergente e para lavagem ou limpeza, preparação enzimática líquida, formulação, e, uso de pelo menos uma mananase |
WO2022063698A1 (en) | 2020-09-22 | 2022-03-31 | Basf Se | Liquid composition comprising peptide aldehyde |
CN114279952B (zh) * | 2020-09-27 | 2024-03-12 | 瑞辰星生物技术(广州)有限公司 | 用于造纸系统控制有机污染物沉积的生物酶酶活力的测定方法 |
WO2022063697A1 (en) | 2020-09-28 | 2022-03-31 | Basf Se | Anti-greying composition for laundry |
EP4015629A1 (en) | 2020-12-18 | 2022-06-22 | Basf Se | Polymer mixtures for increasing stability and performance of hydrolase-containing detergents |
CN112725302B (zh) * | 2021-01-15 | 2023-06-13 | 江南大学 | 一种融合蛋白的构建及其降解聚合物的方法和应用 |
CN113504344B (zh) * | 2021-08-18 | 2022-04-26 | 中国科学院南京土壤研究所 | 一种评估酸性土壤改良剂长效性的方法及装置 |
WO2023225459A2 (en) | 2022-05-14 | 2023-11-23 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
CN116497004A (zh) * | 2022-07-12 | 2023-07-28 | 佛山科学技术学院 | 一种来源于牛瘤胃的高活性纤维素酶及其基因 |
WO2024012894A1 (en) | 2022-07-15 | 2024-01-18 | Basf Se | Alkanolamine formates for enzyme stabilization in liquid formulations |
CN115191404B (zh) * | 2022-07-28 | 2023-04-21 | 四川省畜牧科学研究院 | 提高黄羽肉鸡后代公鸡比例的新品种选育方法 |
KR20240029583A (ko) * | 2022-08-24 | 2024-03-06 | 씨제이제일제당 (주) | 글루카나제 활성을 갖는 변이체 폴리펩티드 |
CN115918818B (zh) * | 2022-11-30 | 2024-02-09 | 广西壮族自治区亚热带作物研究所(广西亚热带农产品加工研究所) | 一种黄皮果果汁的增香方法 |
CN117296994B (zh) * | 2023-11-30 | 2024-03-22 | 潍坊新希望六和饲料科技有限公司 | 一种鸡胃微生物源纤维素酶在制备鸡饲料添加剂中的应用 |
Family Cites Families (278)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US624546A (en) * | 1899-05-09 | Frank l | ||
US642033A (en) | 1899-08-23 | 1900-01-23 | Gothard Wyss | Compound for preserving ropes, & c. |
US3762991A (en) | 1970-11-30 | 1973-10-02 | Beloit Corp | Paper machine foil support having controlled deflection |
US3830732A (en) | 1972-09-18 | 1974-08-20 | Universal Oil Prod Co | Solvent deasphalting process |
US3856174A (en) | 1972-11-10 | 1974-12-24 | Cota Spedition Int Container T | Large-volume container |
FR2324899A1 (fr) | 1974-01-14 | 1977-04-15 | Poclain Sa | Installation hydraulique permettant un stockage d'energie aux faibles puissances d'utilisation |
JPS5832575B2 (ja) | 1976-02-12 | 1983-07-14 | 協和醗酵工業株式会社 | 畜乳の乳量、乳質の改善用飼料および改善方法 |
US4261868A (en) * | 1979-08-08 | 1981-04-14 | Lever Brothers Company | Stabilized enzymatic liquid detergent composition containing a polyalkanolamine and a boron compound |
JPS56501231A (zh) | 1979-09-28 | 1981-09-03 | ||
US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
US4404128A (en) * | 1981-05-29 | 1983-09-13 | The Procter & Gamble Company | Enzyme detergent composition |
US5021246A (en) | 1984-03-30 | 1991-06-04 | Anheuser-Busch, Incorporated | Step mashing process for producing low alcohol beer |
US5204015A (en) * | 1984-05-29 | 1993-04-20 | Genencor International, Inc. | Subtilisin mutants |
US5087571A (en) | 1984-06-22 | 1992-02-11 | President And Fellows Of Harvard College | Method for providing a cell culture from a transgenic non-human mammal |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
DE3546807C2 (zh) | 1985-03-30 | 1991-03-28 | Marc Genf/Geneve Ch Ballivet | |
FI87577C (fi) | 1985-12-03 | 1993-01-25 | Gist Brocades Nv | Foerfarande foer framstaellning av voert och oel med foerbaettrad filtrerbarhet och/eller laegre viskositet |
FI93859C (fi) | 1985-12-03 | 1995-06-12 | Gist Brocades Nv | Menetelmä glukoosisiirappien ja puhdistettujen tärkkelysten tuottamiseksi vehnän ja muiden viljakasvien pentosaaneja sisältävistä tärkkelyksistä |
US4725544A (en) * | 1986-04-25 | 1988-02-16 | Tan Larry U | Method for purifying xylanase |
US5780292A (en) | 1987-04-29 | 1998-07-14 | Alko Group Ltd. | Production of phytate degrading enzymes in trichoderma |
DE3621220A1 (de) | 1986-06-25 | 1988-01-07 | Roehm Gmbh | Verfahren zur filtration von dick-gluten |
US4962028A (en) | 1986-07-09 | 1990-10-09 | Dna Plant Technology Corporation | Plant promotors |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
US5015580A (en) | 1987-07-29 | 1991-05-14 | Agracetus | Particle-mediated transformation of soybean plants and lines |
US5573933A (en) | 1987-04-14 | 1996-11-12 | Luminis Pty, Ltd. | Transgenic pigs |
US4788066A (en) * | 1987-12-14 | 1988-11-29 | Grain Processing Corporation | Preparation of low alcohol beer |
US5116746A (en) | 1988-03-04 | 1992-05-26 | Institut Armand Frappier | Cellulase-free endo-xylanase enzyme of use in pulp delignification |
US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
US6054270A (en) | 1988-05-03 | 2000-04-25 | Oxford Gene Technology Limited | Analying polynucleotide sequences |
US5217879A (en) | 1989-01-12 | 1993-06-08 | Washington University | Infectious Sindbis virus vectors |
US5179021A (en) | 1989-02-10 | 1993-01-12 | Gil Inc. (Now Ici Canada Inc.) | Pulp bleaching process comprising oxygen delignification and xylanase enzyme treatment |
GB8906837D0 (en) | 1989-03-23 | 1989-05-10 | Unilever Plc | Bread improvers |
US5622738A (en) * | 1989-05-16 | 1997-04-22 | Nihon Shokuhin Kako Co., Ltd. | Method of preparing water-soluble dietary fiber |
US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US5527681A (en) | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
SE465320B (sv) | 1990-01-10 | 1991-08-26 | Korsnaes Ab | Preparat som uppvisar enzymatisk delignifieringsaktivitet, saett att framstaella detsamma och tillaempningar daerav |
US5589583A (en) | 1990-01-11 | 1996-12-31 | Monsanto Company | Plant promoter |
AU7791991A (en) | 1990-04-24 | 1991-11-11 | Stratagene | Methods for phenotype creation from multiple gene populations |
US5326477A (en) | 1990-05-07 | 1994-07-05 | Bio-Sep, Inc. | Process for digesting solid waste |
CA2082279C (en) * | 1990-05-09 | 2007-09-04 | Grethe Rasmussen | Cellulase preparation comprising an endoglucanase enzyme |
ATE161395T1 (de) | 1990-05-29 | 1998-01-15 | Chemgen Corp | Hemicellulasezusatz geeignet zum erhöhen des energiewirkungsgrads von hemicellulose enthaltenden nahrungsmitteln und tierfutter |
ES2217250T3 (es) | 1990-06-15 | 2004-11-01 | Scios Inc. | Mamifero transgenico, no humano que muestra la patologia de formacion amiloides de la enfermedad de alzheimer. |
NL9001388A (nl) | 1990-06-19 | 1992-01-16 | Unilever Nv | Recombinant dna, cel die daarvan afgeleid dna bevat, enzym waarvoor het recombinant dna codeert en toepassingen daarvan. |
GB9018426D0 (en) | 1990-08-22 | 1990-10-03 | Sandoz Ltd | Improvements in or relating to novel compounds |
DK30991D0 (da) * | 1991-02-22 | 1991-02-22 | Novo Nordisk As | Hidtil ukendte enzymer |
FI904214A (fi) | 1990-08-27 | 1992-02-28 | Valtion Teknillinen | Hydrolyseringsfoerfarande foer hemicellulosa. |
US5641664A (en) | 1990-11-23 | 1997-06-24 | Plant Genetic Systems, N.V. | Process for transforming monocotyledonous plants |
ATE423207T1 (de) * | 1990-12-10 | 2009-03-15 | Genencor Int | Verbesserte saccharifizierung von zellulose durch klonierung und vervielfältigung des beta- glukosidase genes aus trichoderma |
GB9027303D0 (en) | 1990-12-17 | 1991-02-06 | Enzymatix Ltd | Enzyme formulation |
ATE177782T1 (de) | 1990-12-20 | 1999-04-15 | Ixsys Inc | Optimierung von bindenden proteinen |
NL9100050A (nl) | 1991-01-11 | 1992-08-03 | Heineken Technische Beheer Bv | Werkwijze voor het continu bereiden van wort. |
US5405624A (en) | 1991-02-14 | 1995-04-11 | Bio-Technical Resources | Process for producing a product with an intensified beer flavor |
US6110700A (en) | 1991-03-11 | 2000-08-29 | The General Hospital Corporation | PRAD1 cyclin and its cDNA |
FI108800B (fi) | 1991-05-07 | 2002-03-28 | Iogen Corp | Menetelmä ja laitteisto entsyymin käyttämiseksi paperimassan valmistuksessa ja valkaisussa |
CA2075135A1 (en) | 1991-08-02 | 1993-02-03 | David E. Ellis | Particle-mediated transformation of gymnosperms |
CA2048322A1 (en) | 1991-08-08 | 1993-02-09 | Dieter Kluepfel | Xylanase for biobleaching |
DK175391D0 (da) * | 1991-10-18 | 1991-10-18 | Novo Nordisk As | Nye enzymer |
US5632957A (en) | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
JPH05236997A (ja) | 1992-02-28 | 1993-09-17 | Hitachi Ltd | ポリヌクレオチド捕捉用チップ |
US5369024A (en) | 1992-03-25 | 1994-11-29 | The United States Of America As Represented By The Secretary Of Agriculture | Xylanase from streptomyces roseiscleroticus NRRL-11019 for removing color from kraft wood pulps |
US5498534A (en) | 1992-03-25 | 1996-03-12 | The United States Of America As Represented By The Secretary Of Agriculture | Method of removing color from wood pulp using xylanase from streptomyces roseiscleroticus NRRL B-11019 |
US5550046A (en) * | 1992-03-27 | 1996-08-27 | Toyo Boseki Kabushiki Kaisha | DNA encoding α-glucosidase and method of producing same by genetic engineering |
FI931193A0 (fi) * | 1992-05-22 | 1993-03-17 | Valtion Teknillinen | Mannanasenzymer, gener som kodar foer dem och foerfaranden foer isoleringav generna samt foerfarande foer blekning av lignocellulosahaltig massa |
DE4226528A1 (de) * | 1992-08-11 | 1994-02-17 | Roehm Gmbh | Batterien-Xylanase, Verfahren zu ihrer Herstellung sowie dafür geeigneter Bakterienstamm, Plasmid mit zugehörigem Strukturgen, sowie Backmittel und Backverfahren zur Herstellung von Brot und Backwaren unter Verwendung der Xylanase |
CA2127807A1 (en) | 1992-11-20 | 1994-06-09 | John Maliyakal | Transgenic cotton plants producing heterologous bioplastic |
AU697766B2 (en) | 1992-12-31 | 1998-10-15 | Metallgesellschaft Aktiengesellschaft | Process of producing beer |
US6021536A (en) | 1993-03-04 | 2000-02-08 | Wasinger; Eric | Mechanical desizing and abrading device |
DE69433499T2 (de) | 1993-03-10 | 2004-12-02 | Novozymes A/S | Enzyme mit xylanaseaktivität aus aspergillus aculeatus |
US5405769A (en) * | 1993-04-08 | 1995-04-11 | National Research Council Of Canada | Construction of thermostable mutants of a low molecular mass xylanase |
DK48693D0 (da) | 1993-04-30 | 1993-04-30 | Novo Nordisk As | Enzym |
FR2705686B1 (fr) * | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
CA2169456A1 (en) | 1993-08-13 | 1995-02-23 | J. Wesley Fox | Biocatalytic methods for synthesizing and identifying biologically active compounds |
JPH08509871A (ja) | 1993-09-30 | 1996-10-22 | アグラシータス インコーポレイテッド | 異種ペルオキシダーゼを生産するトランスジェニック綿植物 |
BE1007651A3 (fr) | 1993-10-22 | 1995-09-05 | Solvay Interox | Procede pour le blanchiment d'une pate a papier chimique. |
US6045996A (en) | 1993-10-26 | 2000-04-04 | Affymetrix, Inc. | Hybridization assays on oligonucleotide arrays |
US6468742B2 (en) | 1993-11-01 | 2002-10-22 | Nanogen, Inc. | Methods for determination of single nucleic acid polymorphisms using bioelectronic microchip |
US5965452A (en) | 1996-07-09 | 1999-10-12 | Nanogen, Inc. | Multiplexed active biologic array |
DK0686193T3 (da) | 1993-12-24 | 2010-10-25 | Dsm Ip Assets Bv | Alkalitolerante xylanaser |
JP3081434B2 (ja) * | 1994-01-24 | 2000-08-28 | 花王株式会社 | アルカリセルラーゼ |
US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US5834252A (en) | 1995-04-18 | 1998-11-10 | Glaxo Group Limited | End-complementary polymerase reaction |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
EP0746206B1 (en) | 1994-03-02 | 2004-09-08 | Novozymes A/S | Processing plant material with xylanase |
US5639940A (en) | 1994-03-03 | 1997-06-17 | Pharmaceutical Proteins Ltd. | Production of fibrinogen in transgenic animals |
MX198456B (es) | 1994-03-09 | 2000-09-05 | Abbott Lab | Animales trangenicos que producen oligosacaridos y glucoconjugados. |
NZ279676A (en) | 1994-03-09 | 1998-04-27 | Abbott Lab | Humanized milk produced by non-human transgenic mammal transformed with a heterologous gene coding for human enzyme producing human oligosaccharides and glycoconjugates |
CA2186592C (en) | 1994-03-29 | 2008-02-19 | Helle Outtrup | Alkaline bacillus amylase |
US5437992A (en) * | 1994-04-28 | 1995-08-01 | Genencor International, Inc. | Five thermostable xylanases from microtetraspora flexuosa for use in delignification and/or bleaching of pulp |
GB9409336D0 (en) | 1994-05-10 | 1994-06-29 | Finnfeeds Int Ltd | Use of an enzyme for manufacturing an agent for the treatment and/or prophylaxis of coccidiosis |
EP0716702B1 (en) * | 1994-06-14 | 2002-08-28 | Genencor International, Inc. | Thermostable xylanases |
US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US5750870A (en) | 1994-06-17 | 1998-05-12 | Agritope, Inc. | Plant genetic transformation methods and transgenic plants |
US5582681A (en) | 1994-06-29 | 1996-12-10 | Kimberly-Clark Corporation | Production of soft paper products from old newspaper |
US5830732A (en) * | 1994-07-05 | 1998-11-03 | Mitsui Toatsu Chemicals, Inc. | Phytase |
US5486534A (en) * | 1994-07-21 | 1996-01-23 | G. D. Searle & Co. | 3,4-substituted pyrazoles for the treatment of inflammation |
BE1008751A3 (fr) | 1994-07-26 | 1996-07-02 | Solvay | Xylanase, microorganismes la produisant, molecules d'adn, procedes de preparation de cette xylanase et utilisations de celle-ci. |
US5871730A (en) | 1994-07-29 | 1999-02-16 | Universite De Sherbrooke | Thermostable xylanase DNA, protein and methods of use |
US5959171A (en) | 1994-08-17 | 1999-09-28 | Pharming B.V. | Method for the production of biologically active polypeptides in a mammal's |
GB9416841D0 (en) | 1994-08-19 | 1994-10-12 | Finnfeeds Int Ltd | An enzyme feed additive and animal feed including it |
US6099844A (en) | 1994-08-22 | 2000-08-08 | Triarco Industries, Inc. | Increasing yield of extractable substances from botanicals with an enzyme composition |
WO1996006927A1 (en) | 1994-09-01 | 1996-03-07 | Merck & Co., Inc. | Transgenic animal expressing a familial form of human amyloid precursor protein |
US6111166A (en) | 1994-09-19 | 2000-08-29 | Medarex, Incorporated | Transgenic mice expressing human Fcα and β receptors |
US5795737A (en) | 1994-09-19 | 1998-08-18 | The General Hospital Corporation | High level expression of proteins |
US5880327A (en) | 1994-09-21 | 1999-03-09 | American National Red Cross | Transgenic mammals expressing human coagulation factor VIII |
US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
AUPM900894A0 (en) | 1994-10-26 | 1994-11-17 | Biotech International Limited | Bacterial xylanase |
US5786316A (en) | 1994-10-27 | 1998-07-28 | The Procter & Gamble Company | Cleaning compositions comprising xylanases |
EP0709452A1 (en) | 1994-10-27 | 1996-05-01 | The Procter & Gamble Company | Cleaning compositions comprising xylanases |
US5725732A (en) | 1994-11-18 | 1998-03-10 | P. H. Glatfelter Company | Process for treating hardwood pulp with an enzyme mixture to reduce vessel element picking |
US5770012A (en) | 1994-11-18 | 1998-06-23 | P. H. Glatfelter Co. | Process for treating paper machine stock containing bleached hardwood pulp with an enzyme mixture to reduce vessel element picking |
FR2727689A1 (fr) * | 1994-12-01 | 1996-06-07 | Transgene Sa | Nouveau procede de preparation d'un vecteur viral |
US6187992B1 (en) | 1994-12-05 | 2001-02-13 | Merck & Co., Inc. | Transgenic mouse having a disrupted amyloid precursor protein gene |
US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
US5633440A (en) | 1994-12-20 | 1997-05-27 | Dna Plant Technology Corporation | P119 promoters and their uses |
US5705369A (en) * | 1994-12-27 | 1998-01-06 | Midwest Research Institute | Prehydrolysis of lignocellulose |
CN1165614C (zh) | 1995-01-26 | 2004-09-08 | 诺沃奇梅兹有限公司 | 含有木聚糖酶的动物饲料添加剂 |
DE19503060A1 (de) | 1995-02-01 | 1996-08-08 | Henkel Ecolab Gmbh & Co Ohg | Reinigungsverfahren für Membranfilter |
US6093562A (en) | 1996-02-05 | 2000-07-25 | Novo Nordisk A/S | Amylase variants |
US5959098A (en) | 1996-04-17 | 1999-09-28 | Affymetrix, Inc. | Substrate preparation process |
MX9706974A (es) | 1995-03-17 | 1997-11-29 | Novo Nordisk As | Endoglucanasas novedosas. |
WO1996039154A1 (en) | 1995-06-06 | 1996-12-12 | Isis Pharmaceuticals, Inc. | Oligonucleotides having phosphorothioate linkages of high chiral purity |
US5709971A (en) * | 1995-06-20 | 1998-01-20 | Eastman Kodak Company | Dye imbibition printing blanks with antistatic layer |
WO1997001629A1 (en) | 1995-06-28 | 1997-01-16 | Novo Nordisk A/S | A cellulase with reduced mobility |
US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
US5720971A (en) | 1995-07-05 | 1998-02-24 | Her Majesty The Queen In Right Of Canada, As Represented By The Department Of Agriculture And Agri-Food Canada | Enzyme additives for ruminant feeds |
FR2736359B1 (fr) * | 1995-07-06 | 1997-10-03 | Agronomique Inst Nat Rech | Beta-glucosidase de champignons filamenteaux, et ses utilisations |
US5985662A (en) | 1995-07-13 | 1999-11-16 | Isis Pharmaceuticals Inc. | Antisense inhibition of hepatitis B virus replication |
US6057103A (en) | 1995-07-18 | 2000-05-02 | Diversa Corporation | Screening for novel bioactivities |
US6030779A (en) | 1995-07-18 | 2000-02-29 | Diversa Corporation | Screening for novel bioactivities |
US5958672A (en) | 1995-07-18 | 1999-09-28 | Diversa Corporation | Protein activity screening of clones having DNA from uncultivated microorganisms |
AU6513096A (en) | 1995-07-19 | 1997-02-18 | Novo Nordisk A/S | Treatment of fabrics |
US6036981A (en) | 1995-09-22 | 2000-03-14 | Novo Nordisk A/S | Process for the improvement of gel formation or viscosity increase |
WO1997016533A1 (en) | 1995-10-31 | 1997-05-09 | The Regents Of The University Of California | Mammalian artificial chromosomes and methods of using same |
JP3626203B2 (ja) | 1995-11-15 | 2005-03-02 | ノボザイムス アクティーゼルスカブ | 染色されたデニムの複合糊抜及び「ストーンウォッシュ」方法 |
US5965408A (en) | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
US5939250A (en) | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
US5830696A (en) | 1996-12-05 | 1998-11-03 | Diversa Corporation | Directed evolution of thermophilic enzymes |
US6368798B1 (en) | 1995-12-07 | 2002-04-09 | Diversa Corporation | Screening for novel bioactivities |
US6361974B1 (en) | 1995-12-07 | 2002-03-26 | Diversa Corporation | Exonuclease-mediated nucleic acid reassembly in directed evolution |
US6344328B1 (en) | 1995-12-07 | 2002-02-05 | Diversa Corporation | Method for screening for enzyme activity |
US20030215798A1 (en) | 1997-06-16 | 2003-11-20 | Diversa Corporation | High throughput fluorescence-based screening for novel enzymes |
US6022963A (en) | 1995-12-15 | 2000-02-08 | Affymetrix, Inc. | Synthesis of oligonucleotide arrays using photocleavable protecting groups |
WO1997028256A1 (en) | 1996-01-29 | 1997-08-07 | Novo Nordisk A/S | Process for desizing cellulosic fabric |
BR9707836A (pt) | 1996-03-06 | 1999-07-27 | Novo Nordisk | Processos para inibir microorganismo presentes na lavagem de roupas e crescimento microbiano sobre uma superfície dura e para exterminar células microbianas presentes na pele de seres humanos ou de animais nas membranas mucosas nos dentes em ferimentos nas contusoes ou nos olhos ou para inibir o seu crescimento |
US6013440A (en) | 1996-03-11 | 2000-01-11 | Affymetrix, Inc. | Nucleic acid affinity columns |
DE69736389T8 (de) * | 1996-03-14 | 2007-11-22 | Meiji Seika Kaisha Ltd. | Proteine mit zellulase-aktivitäten und prozess für ihre herstellung |
US6096548A (en) | 1996-03-25 | 2000-08-01 | Maxygen, Inc. | Method for directing evolution of a virus |
US6025155A (en) | 1996-04-10 | 2000-02-15 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
BR9709175A (pt) * | 1996-05-03 | 1999-08-03 | Gist Brocades Bv | Método para a fabricação de mosto tendo aperfeiçoada filtrabilidade e/ou maior rendimento |
US6197070B1 (en) | 1996-05-15 | 2001-03-06 | The Procter & Gamble Company | Detergent compositions comprising alpha combination of α-amylases for malodor stripping |
US5789228A (en) * | 1996-05-22 | 1998-08-04 | Diversa Corporation | Endoglucanases |
AU3568897A (en) | 1996-06-07 | 1998-01-05 | Eos Biotechnology, Inc. | Immobilised linear oligonucleotide arrays |
US5833857A (en) * | 1996-06-07 | 1998-11-10 | Lytal Family Trust | Mobile Bioreactor and Biogenerator |
DE19628263A1 (de) | 1996-07-12 | 1998-01-15 | Fraunhofer Ges Forschung | Verfahren zur Herstellung von Celluloselösungen in wasserhaltigem Aminoxid |
US5747320A (en) * | 1996-08-02 | 1998-05-05 | The United States Of America, As Represented By The Secretary Of Agriculture | Glucose and cellobiose tolerant β-glucosidase from Candida peltata |
WO1998006892A1 (en) * | 1996-08-16 | 1998-02-19 | International Paper Company | Enzymatic freeness enhancement |
US5759840A (en) | 1996-09-09 | 1998-06-02 | National Research Council Of Canada | Modification of xylanase to improve thermophilicity, alkalophilicity and thermostability |
US6326341B1 (en) | 1996-09-11 | 2001-12-04 | The Procter & Gamble Company | Low foaming automatic dishwashing compositions |
CN1552849B (zh) * | 1996-09-12 | 2013-08-14 | 辛根塔参与股份公司 | 表达纤维素分解酶的转基因植物 |
US6057438A (en) | 1996-10-11 | 2000-05-02 | Eastman Chemical Company | Process for the co-production of dissolving-grade pulp and xylan |
AU4550997A (en) * | 1996-10-11 | 1998-05-11 | Novo Nordisk A/S | Cellulose binding domains (cbds) for oral care products |
US5948667A (en) | 1996-11-13 | 1999-09-07 | Her Majesty The Queen In Right Of Canada, As Represented By The Department Of Agriculture And Agri-Food | Xylanase obtained from an anaerobic fungus |
EP1027367B1 (en) * | 1996-12-06 | 2005-05-18 | Diversa Corporation | Glycosidase enzymes |
JP2001505440A (ja) * | 1996-12-06 | 2001-04-24 | ディベルサ コーポレーション | グリコシダーゼ酵素 |
AU5465498A (en) | 1996-12-13 | 1998-07-03 | Michael Kunitani | Analysis and separation of platelet-derived growth factor proteins |
US6069122A (en) | 1997-06-16 | 2000-05-30 | The Procter & Gamble Company | Dishwashing detergent compositions containing organic diamines for improved grease cleaning, sudsing, low temperature stability and dissolution |
US5989885A (en) * | 1997-01-10 | 1999-11-23 | Myriad Genetics, Inc. | Specific mutations of map kinase 4 (MKK4) in human tumor cell lines identify it as a tumor suppressor in various types of cancer |
US6326204B1 (en) | 1997-01-17 | 2001-12-04 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
EP1007732B1 (en) | 1997-01-17 | 2006-07-26 | Maxygen, Inc. | EVOLUTION OF procaryotic WHOLE CELLS BY RECURSIVE SEQUENCE RECOMBINATION |
DE19703364A1 (de) | 1997-01-30 | 1998-08-06 | Henkel Ecolab Gmbh & Co Ohg | Pastenförmiges Wasch- und Reinigungsmittel |
US6023065A (en) | 1997-03-10 | 2000-02-08 | Alberta Research Council | Method and apparatus for monitoring and controlling characteristics of process effluents |
NZ337900A (en) | 1997-03-18 | 2001-05-25 | Novo Nordisk As | DNA shuffling for randomised heterologous and homogenous 3' and 5' primers for construction of DNA libraries for generation of more desirable mutants |
ATE418608T1 (de) | 1997-03-18 | 2009-01-15 | Novozymes As | Methode zur herstellung einer bibliothek mittels dna-shuffling |
NZ337615A (en) * | 1997-03-18 | 2000-10-27 | 2B Ag | Processing of vegetable biomass in screw press with axially separated chambers |
US5948653A (en) | 1997-03-21 | 1999-09-07 | Pati; Sushma | Sequence alterations using homologous recombination |
US6153410A (en) | 1997-03-25 | 2000-11-28 | California Institute Of Technology | Recombination of polynucleotide sequences using random or defined primers |
RU2127760C1 (ru) | 1997-04-22 | 1999-03-20 | Акционерное общество открытого типа "Туласпирт" спиртоводочный завод "Лужковский" | Способ производства этилового спирта из зернового сырья |
US5916780A (en) * | 1997-06-09 | 1999-06-29 | Iogen Corporation | Pretreatment process for conversion of cellulose to fuel ethanol |
US7019827B2 (en) | 1997-06-16 | 2006-03-28 | Diversa Corporation | GigaMatrix holding tray having through-hole wells |
GB2327345B (en) | 1997-07-18 | 1999-06-23 | Finnfeeds Int Ltd | Use of an enzyme for manufacturing an agent for controlling bacterial infection |
NZ328434A (en) * | 1997-07-24 | 1998-05-27 | Univ British Columbia Substitu | Coniferin beta-glucosidase cdna for modifying lignin content in plants |
US6826296B2 (en) | 1997-07-25 | 2004-11-30 | Affymetrix, Inc. | Method and system for providing a probe array chip design database |
US5958758A (en) * | 1997-08-04 | 1999-09-28 | Biosun Systems Corporation | Treatment of animal waste |
EP0896998A1 (en) * | 1997-08-14 | 1999-02-17 | The Procter & Gamble Company | Laundry detergent compositions comprising a saccharide gum degrading enzyme |
US6376445B1 (en) | 1997-08-14 | 2002-04-23 | Procter & Gamble Company | Detergent compositions comprising a mannanase and a protease |
EP1012335A4 (en) | 1997-08-15 | 2004-06-09 | Hyseq Inc | METHODS AND COMPOSITIONS FOR DETECTION OR QUANTIFICATION OF NUCLEIC ACID SPECIES |
US5981233A (en) | 1997-08-21 | 1999-11-09 | Roche Vitamins Inc. | Process for manufacturing a xylanase enzyme complex from pre-treated thin stillage of rye |
ATE319986T1 (de) | 1997-09-11 | 2006-03-15 | Bioventures Inc | Verfahren zur herstellung von arrays hoher dichte |
US6465178B2 (en) | 1997-09-30 | 2002-10-15 | Surmodics, Inc. | Target molecule attachment to surfaces |
AU1124499A (en) | 1997-10-28 | 1999-05-17 | Maxygen, Inc. | Human papillomavirus vectors |
BRPI9813328B1 (pt) | 1997-10-30 | 2016-04-12 | Novo Nordisk As | variante de uma alfa-amilase, vetor de expressão recombinante, uso de uma variante de alfa-amilase, aditivo detergente, composição detergente, e, composição para lavagem de roupas manual ou automática |
EP1690868A1 (en) | 1997-10-31 | 2006-08-16 | Maxygen, Inc. | Modification of virus tropism and host range by viral genome shuffling |
EP1032644B1 (en) | 1997-11-10 | 2003-03-19 | The Procter & Gamble Company | Process for preparing a detergent tablet |
CA2251263A1 (en) | 1997-11-14 | 1999-05-14 | Hajime Karasuyama | Transgenic animal allergy models and methods for their use |
US6187580B1 (en) | 1997-11-24 | 2001-02-13 | Novo Nordisk A/S | Pectate lyases |
AU746786B2 (en) | 1997-12-08 | 2002-05-02 | California Institute Of Technology | Method for creating polynucleotide and polypeptide sequences |
US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
EP1054973A1 (en) | 1998-02-11 | 2000-11-29 | Maxygen, Inc. | Antigen library immunization |
JP2002503461A (ja) | 1998-02-11 | 2002-02-05 | マキシジェン, インコーポレイテッド | 遺伝子ワクチンベクター工学 |
US6015703A (en) | 1998-03-10 | 2000-01-18 | Iogen Corporation | Genetic constructs and genetically modified microbes for enhanced production of beta-glucosidase |
JP2002510505A (ja) | 1998-04-03 | 2002-04-09 | フィロス インク. | 位置特定可能な蛋白質アレイ |
US6156952A (en) | 1998-04-09 | 2000-12-05 | Constituent Institution Of The University Of Maryland System | HIV transgenic animals and uses therefor |
JP2003527450A (ja) | 1998-05-01 | 2003-09-16 | ノボ ノルディスク アクティーゼルスカブ | N−ヒドロキシアセトアニリドの様な増強剤 |
US6048695A (en) | 1998-05-04 | 2000-04-11 | Baylor College Of Medicine | Chemically modified nucleic acids and methods for coupling nucleic acids to solid support |
EP1080204A2 (en) * | 1998-05-06 | 2001-03-07 | University of Georgia Research Foundation, Inc. | Beta-glucosidase coding sequences and protein from orpinomyces pc-2 |
EP0976838A1 (en) | 1998-05-06 | 2000-02-02 | Rhone-Poulenc Nutrition Animale | Enzymes mixture |
DE19824705A1 (de) | 1998-06-03 | 1999-12-09 | Henkel Kgaa | Amylase und Protease enthaltende Wasch- und Reinigungsmittel |
US6420331B1 (en) | 1998-06-10 | 2002-07-16 | Procter & Gamble Company | Detergent compositions comprising a mannanase and a bleach system |
ES2381824T3 (es) | 1998-06-29 | 2012-05-31 | Bristol-Myers Squibb Company | Procedimientos para generar genotecas muy diversas |
JP4335995B2 (ja) | 1998-07-22 | 2009-09-30 | 昭 神谷 | 環境保全型粒状洗浄用組成物 |
FR2782323B1 (fr) | 1998-08-12 | 2002-01-11 | Proteus | Procede de production in vitro de sequences polynucleotidiques recombinees, banques de sequences et sequences ainsi obtenues |
US6602700B1 (en) * | 1998-09-04 | 2003-08-05 | University Of Georgia Research Foundation, Inc. | Phenolic acid esterases, coding sequences and methods |
US5980581A (en) | 1998-09-08 | 1999-11-09 | The Virkler Company | Process for desizing and cleaning woven fabrics and garments |
JP2002525445A (ja) * | 1998-09-17 | 2002-08-13 | ノボザイムス ノース アメリカ,インコーポレイティド | 印刷紙を脱インク及び脱色するための方法 |
US6277628B1 (en) | 1998-10-02 | 2001-08-21 | Incyte Genomics, Inc. | Linear microarrays |
CA2346691A1 (en) * | 1998-10-23 | 2000-05-04 | The Procter & Gamble Company | Fabric care composition and method |
US6921655B1 (en) * | 1998-10-23 | 2005-07-26 | Meiji Seika Kaisha, Ltd. | Endoglucanases and cellulase preparations containing the same |
US6277489B1 (en) | 1998-12-04 | 2001-08-21 | The Regents Of The University Of California | Support for high performance affinity chromatography and other uses |
US7220542B2 (en) * | 2000-07-17 | 2007-05-22 | Van Den Brink Johannes Maarten | Expression cloning in filamentous fungi |
EP1142992A4 (en) * | 1998-12-24 | 2003-05-14 | Takara Bio Inc | POLYPEPTIDES |
US6368861B1 (en) | 1999-01-19 | 2002-04-09 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
US6436675B1 (en) | 1999-09-28 | 2002-08-20 | Maxygen, Inc. | Use of codon-varied oligonucleotide synthesis for synthetic shuffling |
US6376246B1 (en) | 1999-02-05 | 2002-04-23 | Maxygen, Inc. | Oligonucleotide mediated nucleic acid recombination |
FR2788782B1 (fr) | 1999-01-25 | 2003-01-31 | Gie Agro Ind | Produit multienzymatique a activites glucoamylasique, proteolytique et xylanasique et procede pour sa production par fermentation a l'etat solide de son de ble avec aspergillus niger |
US6024766A (en) | 1999-01-27 | 2000-02-15 | Wasinger; Eric M. | Process for enzymatic desizing of garments and enzyme deactivation |
JP2000245356A (ja) | 1999-02-26 | 2000-09-12 | Fuji Oil Co Ltd | マンノース含有コプラミール組成物 |
US6511824B1 (en) | 1999-03-17 | 2003-01-28 | Exelixis, Inc. | Nucleic acids and polypeptides of invertebrate TWIK channels and methods of use |
US6309871B1 (en) | 1999-03-31 | 2001-10-30 | Novozymes A/S | Polypeptides having alkaline α-amylase activity |
US6221653B1 (en) | 1999-04-27 | 2001-04-24 | Agilent Technologies, Inc. | Method of performing array-based hybridization assays using thermal inkjet deposition of sample fluids |
US6682923B1 (en) | 1999-05-12 | 2004-01-27 | Xencor | Thermostable alkaliphilic xylanase |
WO2000078341A1 (en) * | 1999-06-21 | 2000-12-28 | Murdoch Childrens Research Institute | A method for the prophylaxis and/or treatment of medical disorders |
US6653151B2 (en) | 1999-07-30 | 2003-11-25 | Large Scale Proteomics Corporation | Dry deposition of materials for microarrays using matrix displacement |
AU6346699A (en) | 1999-10-25 | 2001-05-08 | Giten Groupe S.A. | Method for stimulating the natural defences of plants |
US6409841B1 (en) * | 1999-11-02 | 2002-06-25 | Waste Energy Integrated Systems, Llc. | Process for the production of organic products from diverse biomass sources |
US20010008765A1 (en) | 1999-12-06 | 2001-07-19 | Fuji Photo Film Co., Ltd. | DNA chip and reactive solid carrier |
US6531644B1 (en) | 2000-01-14 | 2003-03-11 | Exelixis, Inc. | Methods for identifying anti-cancer drug targets |
US6368147B1 (en) * | 2000-03-02 | 2002-04-09 | Microhelix, Inc. | Zero insertion force percutaneous connector and flexible brain probe assembly |
BE1013340A6 (fr) | 2000-03-03 | 2001-12-04 | Robert Stiernon S A Nv Ets | Procede pour la fabrication de tanins oenologiques. |
EP1272643B2 (en) * | 2000-03-20 | 2014-02-26 | Basf Se | Talaromyces emersonii beta-glucanases |
US6399123B1 (en) | 2000-05-25 | 2002-06-04 | University Of Missouri Board Of Curators | Oligosaccharide removal from animal feed |
AU2001275389A1 (en) | 2000-06-08 | 2001-12-17 | Christopher M. Easton | Nucleic acid sequences encoding type iii tenebrio antifreeze proteins and method for assaying activity |
CA2413022A1 (en) | 2000-06-14 | 2001-12-20 | Diversa Corporation | Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating |
US6423145B1 (en) | 2000-08-09 | 2002-07-23 | Midwest Research Institute | Dilute acid/metal salt hydrolysis of lignocellulosics |
CA2422558C (en) | 2000-09-25 | 2012-02-14 | Iogen Energy Corporation | Method for glucose production with a modified cellulase mixture |
WO2002029032A2 (en) | 2000-09-30 | 2002-04-11 | Diversa Corporation | Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating |
MXPA02005717A (es) | 2000-10-10 | 2003-10-14 | Diversa Corp | Analisis de alto rendimiento o a base de capilares para bioactividad o biomoleuclas. |
AU1166502A (en) | 2000-10-12 | 2002-04-22 | Exelixis Inc | Human ect2 and methods of use |
US6309872B1 (en) | 2000-11-01 | 2001-10-30 | Novozymes Biotech, Inc | Polypeptides having glucoamylase activity and nucleic acids encoding same |
US7459172B2 (en) | 2000-11-30 | 2008-12-02 | Verenium Corporation | Method of making a protein polymer and uses of the polymer |
WO2002072815A1 (fr) * | 2001-03-12 | 2002-09-19 | Kukita, Takeshi | Procede d'alignement de clones genomiques |
US20030104410A1 (en) * | 2001-03-16 | 2003-06-05 | Affymetrix, Inc. | Human microarray |
ATE527376T1 (de) * | 2001-05-18 | 2011-10-15 | Boston Probes Inc | Pna-sonden, sondensätze, verfahren und kits im zusammenhang mit dem nachweis von candida |
AU2002311012A1 (en) * | 2001-06-06 | 2002-12-16 | Novozymes A/S | Endo-beta-1,4-glucanase from bacillus |
EP2298868B1 (en) | 2001-06-26 | 2015-01-07 | Novozymes A/S | Polypeptides having cellobiohydrolase I activity and polynucleotides encoding same |
US7112429B2 (en) | 2001-07-28 | 2006-09-26 | Midwest Research Institute | Thermal tolerant mannanase from acidothermus cellulolyticus |
WO2003012109A1 (en) | 2001-07-28 | 2003-02-13 | Midwest Research Institute | Thermal tolerant cellulase from acidothermus cellulolyticus |
US7393673B2 (en) * | 2001-07-28 | 2008-07-01 | Midwest Research Institute | Thermal tolerant exoglucanase from Acidothermus cellulolyticus |
WO2003012126A2 (en) | 2001-08-03 | 2003-02-13 | Diversa Corporation | Epoxide hydrolases, nucleic acids encoding them and methods for making and using them |
US7314974B2 (en) | 2002-02-21 | 2008-01-01 | Monsanto Technology, Llc | Expression of microbial proteins in plants for production of plants with improved properties |
ATE399869T1 (de) * | 2002-04-10 | 2008-07-15 | Novozymes As | Verbesserte bacillus-wirtszelle |
US20040005674A1 (en) | 2002-04-30 | 2004-01-08 | Athenix Corporation | Methods for enzymatic hydrolysis of lignocellulose |
US20030215812A1 (en) | 2002-05-17 | 2003-11-20 | Yan-He Ma | Gene encoding beta-mannanase, enzyme preparation and uses thereof |
DK2295559T3 (en) | 2002-08-16 | 2015-12-14 | Danisco Us Inc | Hitherto UNKNOWN HYPROCREA JECORINA CBH1 CELLULASE VARIETY WITH INCREASED THERMAL STABILITY COMPREHENSIVE SUBSTITUTION OR DELETION AT POSITION T255 |
AU2003219956A1 (en) | 2003-02-27 | 2004-09-28 | Midwest Research Institute | Superactive cellulase formulation using cellobiohydrolase-1 from penicillium funiculosum |
US20040231060A1 (en) | 2003-03-07 | 2004-11-25 | Athenix Corporation | Methods to enhance the activity of lignocellulose-degrading enzymes |
EP1620112A4 (en) * | 2003-04-17 | 2007-04-25 | Univ Columbia | DESMOGLEIN 4 IS A NEW GENUS INVOLVED IN HAIR GROWTH |
EP1641910B1 (en) | 2003-07-02 | 2013-02-20 | Verenium Corporation | Glucanases, nucleic acids encoding them and methods for making and using them |
ES2340390T3 (es) | 2003-10-28 | 2010-06-02 | Novozymes North America, Inc. | Enzimas hibridas. |
US20060147581A1 (en) * | 2004-12-22 | 2006-07-06 | Novozymes A/S | Hybrid enzymes |
CA2861310A1 (en) | 2005-03-15 | 2006-09-28 | Bp Corporation North America Inc. | Cellulases, nucleic acids encoding them and methods for making and using them |
EP3011302B1 (en) | 2013-06-21 | 2019-11-27 | Bio-Rad Laboratories, Inc. | Microfluidic system with fluid pickups |
US9618579B2 (en) | 2015-04-28 | 2017-04-11 | Lattice Semiconductor Corporation | Programmable circuits for correcting scan-test circuitry defects in integrated circuit designs |
-
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111057694A (zh) * | 2019-12-17 | 2020-04-24 | 云南农业大学 | 一种来源于大额牛瘤胃的高活性纤维素酶及其基因 |
CN111057694B (zh) * | 2019-12-17 | 2022-05-03 | 云南农业大学 | 一种来源于大额牛瘤胃的高活性纤维素酶及其基因 |
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