CN103458850A - 液体药物转移套件 - Google Patents
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Abstract
供药瓶（20）使用的液体药物转移套件（100A），该药瓶具有由药瓶瓶塞（24）封住的药瓶开口（23）。该液体药物转移套件（100A）包括用来刺穿药瓶瓶塞（24）的药瓶瓶塞刺穿部件（110）。该液体药物转移套件（100A）还包括药瓶适配器（120），其具有药瓶适配器裙（122）、直立的药瓶适配器口（124）、以及与直立的药瓶适配器口（124）反向向下延伸的并与其相流通的药瓶适配器衬套（131）。药瓶适配器（120）滑动的设置在药瓶瓶塞刺穿部件（110）上，使得当把液体药物转移套件（100A）安装到药瓶（20）上时，药瓶瓶塞刺穿部件（110）刺穿药瓶瓶塞（24）以形成贯通的刺穿孔P且药瓶适配器衬套（131）划定出刺穿孔P。
Description
技术领域
本发明涉及用于液体药物重构（reconstitution）和给药目的的液体药物转移套件。
背景技术
两端结尾的双腔线性转移针典型的用于出于给药目的的液体因重力从含有液体组分的液瓶转移到含有药物组分的药瓶从而在药瓶中形成液体药物内含物，同时出于压力均衡目的空气从药瓶向液瓶的转移。转移针使得药瓶瓶塞和液瓶瓶塞刺穿部件曝露，而液瓶瓶塞刺穿部件带有的锋利的瓶塞刺穿尖通常对用户尤其是家庭用户构成威胁。此外，很难使转移针准确地定位于瓶塞的中心并在其上正确的插入转移针以确保转移针正确地刺穿瓶塞而实现与瓶内部的流通。此外，用户不得不手动地移去转移针并使用其他工具例如针来取出液体药物内含物，这动作可能是繁琐的并会导致卡针损坏和污染液体药物内含物。
发明内容
本发明涉及供药瓶使用的液体药物转移套件，该药瓶包括含有药物组分并且具有被药瓶瓶塞封住的药瓶开口的药瓶瓶体。该药物组分典型的是粉状药物组分但同样可以是不同粘度的液体药物组分。液体药物转移套件包括药瓶瓶塞刺穿部件和药瓶适配器，该药瓶适配器具有基本上圆柱形的带有药瓶适配器顶面的药瓶适配器裙、用以可伸缩地滑动接收药瓶开口于其内的药瓶适配器本体部分、以及药瓶适配器裙缘。药瓶适配器顶面形成有直立的药瓶适配器口和与药瓶适配器口反向向下延伸并与其相流通的药瓶适配器衬套。药瓶适配器裙可选的形成有至少两个的多数量的药瓶适配器褶曲部件。药瓶适配器裙可选的包括向内导向的用以卡扣配合到药瓶开口上的突出。药瓶适配器裙缘可选的相对于药瓶适配器本体部分向外伸展以协助引导药瓶适配器到药瓶上。药瓶适配器滑动的设置在药瓶瓶塞刺穿部件上，使得液体药物转移套件处于安装位置时药瓶瓶塞刺穿部件伸出超过药瓶适配器衬套。
液体药物转移套件被安装到药瓶上，使得药瓶瓶塞刺穿部件刺穿药瓶瓶塞以形成贯通的刺穿孔且药瓶适配器衬套穿过药瓶瓶塞而划定出刺穿孔。当药瓶瓶塞刺穿部件从药瓶瓶塞退去时，药瓶适配器衬套阻止药瓶瓶塞将自己封住，从而维持药瓶瓶体和药瓶适配器口之间的连续流通。药瓶适配器衬套还防止药瓶瓶塞的残余物污染药瓶中的液体药物内含物。合适的医药装置可以容易的安装到药瓶适配器口上以实现与药瓶瓶体的流通。合适的医药装置，除其他以外，尤其包括无针注射器、给药管线等等。
药瓶瓶塞刺穿部件可以设置为两端结尾的双腔线性转移针的一端，该两端结尾的双腔线性转移针包括与药瓶瓶塞刺穿部件相反的用以刺穿含有液体组分的液瓶的液瓶瓶塞的液瓶瓶塞刺穿部件。液体组分典型的为稀释剂但同样可以包含活性药物组分。这样的两端结尾的双腔线性转移针允许作为给药目的的液体因重力从液瓶转移到药瓶从而在药瓶中形成液体药物内含物，同时允许作为压力均衡目的的空气从药瓶向液瓶的转移。
两端结尾的双腔线性转移针可以整体形成有用以安装到液瓶上的液瓶适配器。或者，两端结尾的双腔线性转移针可以整体形成有供分离的液瓶适配器使用的液体药物转移装置，用以安装到液瓶上从而形成包括药瓶适配器在内的三组件液体药物转移套件。液体药物转移装置包括横向定位的位于沿两端结尾的双腔线性转移针的中间位置的间隔圈，至少两个纵向定位的药瓶腿和与这至少两个纵向定位的药瓶腿反向的至少两个纵向定位的液瓶腿。药瓶腿和液瓶腿用来定位他们对应的药瓶瓶塞刺穿尖和液瓶瓶塞刺穿尖相对于他们各自的瓶塞的中心位置。
附图说明
为了理解本发明以及了解发明是如何实际实施的，现通过非限制性实例并参考所附的图描述优选的实施方式，附图中相同的部分使用相同的编号，其中：
图1图示了液体药物转移套件的第一优选实施方式，该套件包括药瓶瓶塞刺穿部件和药瓶适配器，用于长期保存套件的薄膜包装，无针的注射器，以及药瓶；
图2是图1的液体药物转移套件的分解图；
图3是图1的液体药物转移套件在其最初的即用状态下沿图1中的线A-A的纵截面；
图4A是图1的液体药物转移套件的纵截面，该套件处于安装位置并与药瓶同轴设置以准备在其上卡扣配合；
图4B是图1的液体药物转移套件按照最初的朝着药瓶向下按压情形下的纵截面；
图4C是图1的液体药物转移套件按照药瓶适配器完全卡扣配合到药瓶上的纵截面；
图4D是图1的液体药物转移套件按照移去药瓶瓶塞刺穿部件情形下的纵截面；
图5是图1的液体药物转移套件的另一实施方式的纵截面，其包括具有液体药物入口和管线内滤器的药瓶刺穿防止部件；
图6显示了图1的药瓶适配器的又一实施方式，其包括装在药瓶适配器顶面上的药瓶适配器衬套部件；
图7图示了液体物转移套件的第二优选实施方式，该套件包括液瓶适配器和药瓶适配器，用于长期保存套件的薄膜包装，无针注射器，以及液瓶；
图8是图7的液体药物转移套件的分解图；
图9是图7的液体药物转移套件在其最初的即用状态下沿图7中的线B-B的纵截面；
图10A显示图7的液体药物转移套件共轴于药瓶并准备卡扣配合在药瓶上；
图10B显示图7的液体药物转移套件卡扣配合到药瓶上；
图10C显示了图10B的装配的倒置形态，以准备卡扣配合到液瓶上；
图10D显示图10B的装配卡扣配合到液瓶上；
图10E显示了倒置位置的图10D的装配，用以允许液体从液瓶到药瓶的重力转移，从而在药瓶中形成液体药物内含物，以及允许从药瓶向液瓶排气；
图10F显示了在移去液瓶适配器连同附接的空液瓶后的安装到含有液体药物内含物的药瓶上的药瓶适配器；以及
图10G显示了使用无针注射器将液体药物内含物从药瓶中吸出以用于给药目的；
图11图示了液体物转移套件的第三优选实施方式的图示，该套件包括液体药物转移装置，药瓶适配器，以及在其最初即可使用状态的液瓶适配器，用于长期保存套件的薄膜包装，无针注射器，药瓶，以及液瓶；
图12图11的液体药物转移套件的透视图；
图13是图11的液体药物转移套件的分解图，以及液体药物转移装置的两端结尾的双腔线性转移针的放大的横截面；
图14是图11的液体药物转移套件在其最初的即用状态下沿图11中的线C-C的纵截面；
图15A是图11的液体药物转移套件准备卡扣安装在与其共轴的药瓶上的纵截面；
图15B是图11的液体药物转移套件按照液体药物转移套件最初朝着药瓶向下按压情形下的纵截面；
图15C是图11的液体药物转移套件按照液体药物转移套件朝着药瓶进一步向下按压情形下的纵截面；
图15D是图11的液体药物转移套件按照液体药物转移套件朝着药瓶更进一步向下按压情形下的纵截面；
图15E是图11的液体药物转移套件按照药瓶适配器完全卡扣配合到药瓶上的纵截面；
图15F是图11的液体药物转移套件的纵截面，其显示完全卡扣配合到药瓶和液瓶，包括液体药物转移装置与液瓶适配器的卡扣配合；
图16A显示图11的液体药物转移套件共轴于药瓶并准备卡扣配合在药瓶上；
图16B显示图11的液体药物转移套件卡扣配合到药瓶上；
图16C显示了图16B的装配的倒置形态，以准备卡扣配合到液瓶上；
图16D显示图16B的装配卡扣配合到液瓶上；
图16E显示了倒置位置的图16D的装配，用以允许液体从液瓶到药瓶的重力转移，从而在药瓶中形成液体药物内含物，以及允许从药瓶向液瓶排气；
图16F显示了在移去液体药物转移装置以及液体药物适配器连同与其附接的空液瓶后的安装到含有液体药物内含物的药瓶上的药瓶适配器；以及
图16G显示了使用无针注射器将液体药物内含物从药瓶中吸出以用于给药目的。
具体实施方式
图1显示了供无针注射器10和药瓶20使用的液体药物转移套件100A。注射器10包括带有柱塞12的管体11和凸鲁尔锁紧接头13。注射器10可以形成为与其他类型的凸插头配合。注射器10装有液体组分14。液体组分14可以仅仅是稀释剂。或者，液体组分14可以包括活性组分。药瓶20具有纵向药瓶轴20A并且包括具有药瓶瓶肩22的药瓶瓶体21和被药瓶瓶塞24封住的药瓶瓶口23。药瓶瓶口23具有最上最外的药瓶缘26。药瓶20包含药物组分27。液体药物转移套件100A优选封装于具有内表面102和保护封口103的薄膜包装101A内。
图1-3显示的液体药物转移套件100A包括药瓶瓶塞刺穿部件110和药瓶适配器120，药瓶瓶塞刺穿部件110具有纵向的药瓶瓶塞刺穿部件轴111。薄膜包装101A的形状和尺寸使得刚好将液体药物转移套件100A装入其内，并可以用来将套件装到药瓶20上。药瓶瓶塞刺穿部件110具有用来刺穿药瓶瓶塞24的药瓶瓶塞刺穿尖112和横向定位的头113。
药瓶适配器120具有纵向的药瓶适配器轴121并且包括药瓶适配器裙122，药瓶适配器裙122具有横向定位的药瓶适配器顶面123和与其形成的直立的药瓶适配器口124和6个随向下延伸的药瓶适配器褶曲部件126。药瓶适配器褶曲部件126具备有用来在药瓶瓶口23下方卡扣配合的向内定位的突出127，褶曲部件126限定出用以刚好容纳药瓶瓶口23的药瓶适配器本体部分128。药瓶适配器褶曲部件126限定出相对于药瓶适配器本体部分128向外扩展的药瓶适配器裙缘129，用以协助将药瓶适配器120引导至药瓶20上。药瓶适配器口124优选采用凹鲁尔连接器，用来与其上的无针注射器10螺纹配合。或者，药瓶适配器口124可以形成为例如宽直径，以允许粘性液体药物从药瓶20自流出。
药瓶适配器120还包括与药瓶适配器口124相反的向下延伸的药瓶适配器衬套131作为此处的流动通道。包括药瓶适配器口124和药瓶适配器衬套131的药瓶适配器120可以以单个注塑制模单元形成，其由同一种适合的塑料例如聚碳酸酯等制成。在液体药物转移套件100A最初的安装位置下，药瓶适配器衬套131在短于药瓶瓶塞刺穿尖112处停止，使得药瓶瓶塞刺穿尖112超过那里伸出。如此，当把液体药物转移套件100A装到药瓶20上时，药瓶瓶塞刺穿尖112先于药瓶适配器衬套131与药瓶塞24接触。
图4A和4D显示了用于液体药物重构和给药的使用，如下：
图4A显示了液体药物转移套件100A在其最初的即可使用状态下通过将100A朝向药瓶20向下按压来卡扣配合到药瓶20上。
图4B显示了最初液体药物转移套件100A朝向药瓶20向下按压，同时导致药瓶适配器裙缘129将药瓶适配器120与药瓶20共轴定位并使得药瓶瓶塞刺穿尖112开始刺穿药瓶瓶塞24。
图4C显示了液体药物转移套件100A完全卡扣配合到药瓶20上，包括药瓶瓶塞刺穿部件110完全刺穿通过药瓶瓶塞24而形成穿刺孔P。
图4D显示了从药瓶20上移去药瓶瓶塞刺穿部件110而只留下药瓶适配器120在那里。药瓶适配器衬套131划定了穿刺孔P的边界以防止药瓶瓶塞24将其自身封住。药瓶适配器衬套131还可以防止药瓶瓶塞的任何残余物落入药瓶中对瓶中内含物造成污染。可以容易的将无针注射器10装到凹鲁尔连接器124以将其内含物注入药瓶瓶体21中以达到重构或稀释的目的。
图5显示了包括药瓶瓶塞刺穿部件110的液体药物转移套件100A，药瓶瓶塞刺穿部件110具有带有纵向内腔116的液体药物进入孔114，以允许液流因药瓶塞24被刺穿而通向药瓶瓶体21。液体药物进入孔114可以可选的形成为凹鲁尔连接器。液体药物进入孔114和/或纵向内腔116可以可选的形成有管线过滤器117。
图6显示了药瓶适配器120的另一实施方式，其包括装在药瓶适配器120的顶面123上的药瓶适配器衬套部件133。药瓶适配器衬套部件133可以由不同于药瓶适配器120其余部分的材料形成。除其他之外，适合的材料包括弹性材料、金属、氯丁橡胶织物、橡胶、硅树脂、玻璃等等。
图7显示了供空的注射器10、药瓶20和液瓶30使用的液体药物转移套件100B。液瓶30具有纵轴30A并且包括具有液瓶瓶肩32和被液瓶瓶塞34封住的液瓶瓶口33的液瓶瓶体31。液瓶瓶口33具有最上最外的液瓶瓶缘36。液瓶30包含用以加到药物组分27的液体组分37。液体药物转移套件100B优选封装在薄膜包装101B中，该薄膜包装的形状和尺寸刚好能将液体药物转移套件100B装入其内并用来对套件进行操作。
图7-图9显示了包括药瓶适配器120和液瓶适配器140的液体药物转移套件100B。液瓶适配器140具有纵向的液瓶适配器轴141并且包括液瓶适配器裙142，液瓶适配器裙142具有横向定位的液瓶适配器顶面143和与其形成的6个随着向下的液瓶适配器褶曲部件144。液瓶适配器褶曲部件144具备有用来在液瓶瓶口33下方卡扣配合的向内定位的突出146，褶曲部件144限定出用以刚好容纳液瓶瓶口33的液瓶适配器本体部分147。液瓶适配器褶曲部件144限定出相对于液瓶适配器本体部分147向外扩展的液瓶适配器裙缘148，用以协助将液瓶适配器140引导至液瓶30上。
液瓶适配器140还包括两端结尾的双腔线性转移针151，该转移针具有用以刺穿药瓶塞24的药瓶瓶塞刺穿部件152和与其反向的用以刺穿液瓶瓶塞34的液瓶瓶塞刺穿部件153。药瓶瓶塞刺穿部件152从液瓶适配器顶面143朝远离液瓶适配器裙142的方向延伸。药瓶瓶塞刺穿部件152在药瓶瓶塞刺穿尖端154处结尾，当液瓶适配器140安装至药瓶适配器120上时，该尖端延伸超过药瓶适配器衬套131。液瓶瓶塞刺穿部件153从液瓶适配器顶面143延伸进入液瓶适配器裙142。液瓶瓶塞刺穿部件153在液瓶瓶塞刺穿尖端156处结尾。两端结尾的双腔线性转移针151包括将液体从液瓶30转移至药瓶20的液体转移腔157和用于压力均衡目的的将空气从药瓶20转移至液瓶30的空气转移腔158。
图10A-图10G显示了用于液体药物重构和给药的液体药物转移套件100B的使用，如下：
图10A显示了液体药物转移套件100B在其最初的即可使用状态下通过将100朝向药瓶20向下按压来卡扣配合到药瓶20上。
图10B显示了液体药物转移套件100B的完全卡扣配合，包括药瓶瓶塞刺穿部件152完全刺穿通过药瓶塞24而形成穿刺孔P。
图10C显示了图10B的装配的倒置形态，用以准备将液瓶适配器140卡扣配合到液瓶30上。
图4D显示了包括药瓶20的液体药物转移套件100B完全卡扣配合到液瓶30上。
图10E显示了图10D装配的倒置形态，用以允许液体从液瓶30到药瓶20的重力转移，从而在药瓶20中形成液体药物内含物LD，以及允许从药瓶20向液瓶30排气。用户可以轻轻地搅动反转的图10D的装配以根据药物组分和液体组分促进重构或稀释。
图10F显示了移去液瓶适配器140和与其相连的空液瓶30而留下的具有液体药物内含物LD的药瓶20。药瓶适配器衬套131划定了穿刺孔P的边界以防止药瓶塞将其自身封住。药瓶适配器衬套131还可以防止药瓶瓶塞的任何残余物落入药瓶中而污染内含物。
图10G显示了使用无针注射器10将液体药物内含物LD从药瓶20中吸出以用于给药目的。
图11-图14显示了供空的注射器10、药瓶20和液瓶30使用的液体药物转移套件100C。液体药物转移套件100C具有三组件结构，包括药瓶适配器160、液瓶适配器170以及具有纵向液体药物转移装置轴181的液体药物转移装置180。液体药物转移套件100C优选封装在薄膜包装101C中，该薄膜包装的形状和尺寸刚好能将液体药物转移套件100C装入其内并用来对套件进行操作。
药瓶适配器160具有与药瓶适配器120相同的结构，因此对相同的部分以相同的编号。药瓶适配器160不同于药瓶适配器120在于，前者160包括一对相反的药瓶适配器褶曲部件161，其在药瓶适配器本体部分128区域形成有药瓶腿尖穿孔162。还有，药瓶适配器褶曲部件161在药瓶适配器裙缘129的区域具有平滑的外表面163，与药瓶适配器褶曲部件126的脊状表面相反。
液瓶适配器170具有与液瓶适配器140相同的结构，因此对相同的部分以相同的编号。液瓶适配器170不同于液瓶适配器140在于，前者170包括一对相反的液瓶适配器褶曲部件171，其在液瓶适配器本体部分147区域形成有液瓶腿尖穿孔172。还有，液瓶适配器褶曲部件171在液瓶适配器裙缘148的区域具有平滑的外表面173，与液瓶适配器褶曲部件144的脊状表面相反。
此外，液瓶适配器170不具有两端结尾的双腔线性转移针151，取而代之的是直立的从液瓶适配器顶面143远离液瓶适配器裙142延伸的管形构件174。管形构件174包括横向定位的凸缘176。
液体药物转移装置180具有与两端结尾的双腔线性转移针151相同的结构，因此对相同的部分以相同的编号。液体药物转移装置180包括在药瓶瓶塞刺穿尖端154处结尾的药瓶瓶塞刺穿部件152和相反向的在液瓶瓶塞刺穿尖端156处结尾的液瓶瓶塞刺穿部件153。液体药物转移装置180包括液体转移腔157和空气转移腔158。液体转移腔157比空气转移腔158具有更大的腔体横截面积。液体转移腔157具有大概新月形的横截面，其部分的将空气转移腔158环绕，从而减少总的转移针横截面积以有助于刺穿药瓶瓶塞24和液瓶瓶塞34。
液体药物转移装置180另外形成有横向定位的牢固安装在其中间位置的间隔圈182，一对纵向定位的药瓶腿183铰接在间隔圈182上并与药瓶瓶塞刺穿部件152相间隔且同向延伸，以及一对纵向定位的液瓶腿184铰接在间隔圈182上并与液瓶瓶塞刺穿部件153相间隔且同向延伸。药瓶腿183在药瓶腿尖端186处结尾，与药瓶瓶塞刺穿尖端154共延伸且朝向药瓶瓶塞刺穿尖端154向内突出。药瓶腿尖端186用来最初插入到穿透孔162中。液瓶腿184在液瓶腿尖端187处结尾，与液瓶瓶塞刺穿尖端156共延伸且朝向液瓶瓶塞刺穿尖端156向内突出。液瓶腿尖端187用来最初插入到穿透孔172中。
液瓶腿184优选各自形成有一对向外导向的液瓶腿突起188用来与薄膜包装101C的内表面102相抵，以便协助液体药物转移套件100C卡扣配合到药瓶20上。
液体药物转移套件100C包括卡扣配合配置190，在将液瓶适配器140卡扣配合到液瓶30上时，用来机械地将液瓶适配器140附接到间隔圈182上。卡扣配合配置190由管形构件174和间隔圈182构成，间隔圈182具有一对用来卡扣配合到横向定位的凸缘176上的卡扣部件191。
图15A-图15E显示了用以卡扣配合到药瓶20上的液体药物转移套件100C的操作。
图15A显示了与药瓶20共轴的即可卡扣配合到其上的液体药物转移套件100C。
图15B显示了最初液体药物转移套件100C朝向药瓶20向下按压。药瓶腿尖端186推动药瓶适配器裙缘129而将药瓶适配器120与药瓶20共轴定位、以及使得药瓶瓶塞刺穿尖156开始刺穿药瓶瓶塞24。
图15C显示了液体药物转移套件100C进一步朝着药瓶20向下按压导致药瓶适配器120完全卡扣配合到药瓶20上以及完全刺穿药瓶瓶塞24以形成刺穿孔P。药瓶适配器衬套131划定出刺穿孔P。药瓶缘26开始推动药瓶腿尖端186从他们各自的药瓶腿尖端孔162向外移动。
图15D显示了液体药物转移套件100C朝着药瓶20更进一步向下按压导致药瓶腿尖端186离开他们各自的药瓶腿尖端孔162使得液体药物转移装置180被释放以产生相对于药瓶适配器120向下滑动的效果。药瓶腿尖端186开始向下滑过他们各自的褶曲部件161的光滑外表面163。
图15E显示了液体药物转移套件100C朝着药瓶20仍旧更进一步向下按压导致药瓶腿尖端186停止于药瓶适配器裙缘129。
液体药物转移套件100C以类似于其卡扣配合在药瓶20上的方式卡扣配合在液瓶30上。液体药物转移装置180此外还卡扣配合到液瓶适配器140上以允许在药瓶20内形成液体药物内含物之后可以方便的移去两个组分和空的液瓶30。
图15F显示了卡扣配合配置190的操作，也就是，卡扣配合部件191卡扣到管形构件174的凸缘176上。
图16A-图16G显示了用于液体药物重构和给药的液体药物转移套件100C的使用，如下：
图16A显示了液体药物转移套件100C在其最初的即可使用状态下通过将100朝向药瓶20向下按压来卡扣配合到药瓶20上。
图16B显示了液体药物转移套件100C朝向药瓶20向下按压，导致液体药物转移装置180推动药瓶适配器120向下卡扣配合到药瓶20上，使得药瓶刺穿部件152刺穿药瓶瓶塞24，以及使得药瓶适配器衬套131划定出刺穿孔P。此外，液体药物转移装置180的向下运动导致药瓶腿尖端186从药瓶适配器120处被向外推动并坐落在药瓶适配器裙缘129上。
图16C显示了图6B的装配的倒置形态，用以卡扣配合到液瓶30上。
图16D显示了液体液体物转移套件100C朝向药瓶30向下按压，导致液体液体物转移装置180推动液瓶适配器140向下卡扣配合到液瓶30上，并使得液瓶刺穿部件153刺穿液瓶瓶塞24。此外，液体药物转移装置180的向下运动导致液瓶腿尖端187从液瓶适配器140处被向外推动并坐落在液瓶适配器裙缘148上。该向下运动还导致卡扣配合配置190在液体药物转移装置180和液体药物适配器140之间的传动。
图16E显示了图16D装配的倒置形态，用以允许液体从液瓶30到药瓶20的重力转移，从而在药瓶20中形成液体药物内含物LD，以及允许从药瓶20向液瓶30排气。用户可以轻轻地搅动反转的图16D的装配以促进液体药物内含物LD的重构或稀释。
图16F显示了在移去了液体药物转移装置180连同液体药物适配器140和附接于其上的空液瓶30后的安装到含有液体药物内含物LD的药瓶20上的药瓶适配器120。
图16G显示了使用无针注射器10将液体药物内含物LD从药瓶20中吸出以用于给药目的。
尽管根据有限的实施方式对本发明做了描述，但是应当理解的是在所附权利要求书的范围内可以对本发明做出许多变型、改变以及其他应用。
Claims (12)
1.一种供药瓶使用的液体药物转移套件，该药瓶包括含有药物组分的药瓶瓶体并带有被药瓶瓶塞封住的药瓶开口，该液体药物转移套件包含：
（a）药瓶瓶塞刺穿部件，其具有用以刺穿药瓶瓶塞的药瓶瓶塞刺穿尖；以及
（b）药瓶适配器，其具有纵向药瓶适配器轴并且包括具有横向定位的药瓶适配器顶面的药瓶适配器裙，该药瓶适配器顶面形成有直立的药瓶适配器口；用以刚好容纳药瓶开口的药瓶适配器本体部分以及远离所述药瓶适配器顶面的药瓶适配器裙缘；以及从所述药瓶适配器顶面向下与所述直立药瓶适配器口反向延伸并与其流通的药瓶适配器衬套，
所述药瓶适配器滑动的设置在所述药瓶瓶塞刺穿部件上，使得所述药瓶瓶塞刺穿尖突出超过所述药瓶适配器衬套，
该配置使得当把液体药物转移套件装到药瓶上时，所述药瓶瓶塞刺穿部件刺穿药瓶瓶塞以形成贯通的刺穿孔以及所述药瓶适配器衬套由此划定出所述刺穿孔，而当所述药瓶瓶塞刺穿部件从所述刺穿孔退出时，所述药瓶适配器衬套防止药瓶瓶塞将其自身封住从而允许所述药瓶适配器口与药瓶瓶体之间的流通。
2.如权利要求1所述的套件，其特征在于，所述药瓶适配器裙、所述药瓶适配器口以及所述药瓶适配器衬套以单个注塑制模单元、由相同塑料材料形成。
3.如权利要求1所述的套件，其特征在于，所述药瓶适配器衬套装在所述药瓶适配器裙上并由与其不同的材料形成。
4.如权利要求1至3中任一项所述的套件，其特征在于，所述药瓶瓶塞刺穿部件包括液体药物入口和纵向内腔，当刺穿所述药瓶瓶塞时，该纵向内腔允许与药瓶瓶体的流通。
5.如权利要求4所述的套件，其特征在于，所述药瓶瓶塞刺穿部件包括管线内滤器。
6.如权利要求1至3任一项所述的套件，还可以供液瓶使用，该液瓶包括含有液体组分并具有被液瓶瓶塞封住的液瓶瓶口的液瓶瓶体，该液体组分用于加入到药物组分以形成液体药物内含物，
其特征在于，所述药瓶瓶塞刺穿部件形成为整体上形成有液瓶适配器的两端结尾的双腔线性转移针，该液瓶适配器包括具有横向定位的液瓶适配器顶面的液瓶适配器裙和用以刚好在其内容纳液瓶瓶口的液瓶适配器本体部分，
所述两端结尾的双腔线性转移针包括与所述药瓶瓶塞刺穿部件相反的液瓶瓶塞刺穿部件，所述液瓶瓶塞刺穿部件具有用来在把液瓶适配器装到液瓶上时刺穿所述液瓶瓶塞的液瓶瓶塞刺穿尖，从而当组成最上面是液瓶、最下面是药瓶的直立装配时，使得液体组分从液瓶因重力流向药瓶的同时气流从药瓶流向液瓶，当把液瓶适配器从药瓶适配器移去时，可以在药瓶内形成用于给药目的的液体药物内含物。
7.如权利要求1至3任一项所述的套件，还可以供液瓶使用，该液瓶包括含有液体组分并具有被液瓶瓶塞封住的液瓶瓶口的液瓶瓶体，该液体组分用于加入到药物组分以形成液体药物内含物，
其特征在于，所述药瓶瓶塞刺穿部件形成为具有纵轴的两端结尾的双腔线性转移针的一端，该转移针包括：
i)反向定位的液瓶瓶塞刺穿部件，其具有用以刺穿液瓶瓶塞的液瓶瓶塞刺穿尖，
ii)刚性地安装在所述线性转移针上的横向定位的间隔圈，
iii)至少两个纵向定位的药瓶腿，其安装在所述间隔圈上并与所述药瓶瓶塞刺穿部件同向延伸且相间隔，
所述至少两个药瓶腿在药瓶腿尖端处结尾，并且与所述药瓶瓶塞刺穿尖共延伸且朝向所述药瓶瓶塞刺穿尖向内突出，
iv)至少两个纵向定位的液瓶腿，其安装在所述间隔圈上并与所述液瓶瓶塞刺穿部件同向延伸且相间隔，
所述至少两个液瓶腿在液瓶腿尖端处结尾，并且与所述液瓶瓶塞刺穿尖共延伸且朝向所述液瓶瓶塞刺穿尖向内突出，
所述药瓶适配器以所述药瓶适配器顶面朝向所述间隔圈而所述药瓶适配器裙缘远离所述间隔圈的形式可滑动的安装在所述药瓶瓶塞刺穿部件上，
所述药瓶适配器裙具有用以最初接收所述药瓶腿尖端的药瓶腿尖端孔，所述药瓶腿尖端用来最初使所述药瓶适配器与所述间隔圈相间隔，由此使得所述药瓶适配器裙缘相比所述药瓶瓶塞刺穿尖更远离所述间隔圈，当所述药瓶适配器滑向所述间隔圈时，所述药瓶适配器裙安装到药瓶开口上用以将药瓶开口装入所述药瓶适配器本体部分内，所述药瓶瓶塞刺穿部件刺穿药瓶瓶塞以实现与药瓶瓶体的流通，而所述药瓶腿尖端沿着所述药瓶适配器裙滑向所述药瓶适配器裙缘；以及
(c)液瓶适配器包括具有横向定位的液瓶适配器顶面和液瓶适配器裙缘的液瓶适配器裙，该液瓶适配器顶面形成有用以刚好接收液瓶瓶口的液瓶适配器本体部分，
所述液瓶适配器以所述液瓶适配器顶面朝着所述间隔圈而所述液瓶适配器裙缘远离所述间隔圈的形式可滑动的设置在所述液瓶瓶塞刺穿部件上，
所述液瓶适配器裙具有用以最初接收所述液瓶腿尖端的液瓶腿尖端孔，所述液瓶腿尖端用来最初使所述液瓶适配器与所述间隔圈相间隔，由此使得所述液瓶适配器裙缘相比所述液瓶瓶塞刺穿尖更远离所述间隔圈，当所述液瓶适配器滑向所述间隔圈时，所述液瓶适配器裙安装到液瓶瓶口上用以将液瓶瓶口装入所述液瓶适配器本体部分内，所述液瓶瓶塞刺穿部件刺穿液瓶瓶塞以实现与液瓶瓶体的流通，而所述液瓶腿尖端沿着所述液瓶适配器裙滑向所述液瓶适配器裙缘。
8.如权利要求7所述的套件，其特征在于，所述液体药物转移装置和所述液瓶适配器具有卡扣配合配置，当把所述液瓶适配器安装到液瓶上时，用来机械地将所述液体药物转移装置附接至所述液瓶适配器。
9.如权利要求8所述的套件，其特征在于，所述卡扣配合配置由所述液瓶适配器端口构成，该液瓶适配器端口具有纵向定位的朝向所述间隔圈的管形构件，所述间隔圈具有至少一个卡扣部件用以卡扣配合到所述管形构件上。
10.如权利要求7至9中任一项所述的套件，其特征在于，所述药瓶适配器裙缘相对于所述药瓶适配器本体部分向外伸展并且包括用以促进所述药瓶腿尖端滑向所述药瓶适配器裙缘的光滑外表面。
11.如权利要求7至10中任一项所述的套件，其特征在于，所述液瓶适配器裙缘相对于所述液瓶适配器本体部分向外伸展并且包括用以促进所述液瓶腿尖端滑向所述液瓶适配器裙缘的光滑外表面。
12.如权利要求7至11中任一项所述的套件，其特征在于，所述液体药物转移套件封装于薄膜包装内，每个液瓶腿具有至少一个向外导向的液瓶腿突起用来与所述薄膜包装的内表面相抵。
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| Application Number | Priority Date | Filing Date | Title |
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| IL212420A IL212420A0 (en) | 2011-04-17 | 2011-04-17 | Liquid drug transfer assembly |
| IL212420 | 2011-04-17 | ||
| PCT/IL2012/000164 WO2012143921A1 (en) | 2011-04-17 | 2012-04-17 | Liquid drug transfer assembly |
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| Publication Number | Publication Date |
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| CN103458850A true CN103458850A (zh) | 2013-12-18 |
| CN103458850B CN103458850B (zh) | 2015-04-29 |
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| CN201280018180.5A Active CN103458850B (zh) | 2011-04-17 | 2012-04-17 | 液体药物转移套件 |
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| Country | Link |
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| US (1) | US8752598B2 (zh) |
| EP (1) | EP2680806B1 (zh) |
| JP (1) | JP5681834B2 (zh) |
| CN (1) | CN103458850B (zh) |
| BR (1) | BR112013024788B1 (zh) |
| DK (1) | DK2680806T3 (zh) |
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| BR112013024788B1 (pt) | 2021-02-17 |
| DK2680806T3 (en) | 2015-06-29 |
| EP2680806B1 (en) | 2015-04-15 |
| CN103458850B (zh) | 2015-04-29 |
| IL228452A0 (en) | 2013-12-31 |
| US20140020793A1 (en) | 2014-01-23 |
| WO2012143921A1 (en) | 2012-10-26 |
| EP2680806A1 (en) | 2014-01-08 |
| IL228452B (en) | 2018-02-28 |
| IL212420A0 (en) | 2011-06-30 |
| JP2014514114A (ja) | 2014-06-19 |
| US8752598B2 (en) | 2014-06-17 |
| JP5681834B2 (ja) | 2015-03-11 |
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