CN103154014B - 修饰核苷、其类似物以及由它们制备的寡聚化合物 - Google Patents

修饰核苷、其类似物以及由它们制备的寡聚化合物 Download PDF

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CN103154014B
CN103154014B CN201180021008.0A CN201180021008A CN103154014B CN 103154014 B CN103154014 B CN 103154014B CN 201180021008 A CN201180021008 A CN 201180021008A CN 103154014 B CN103154014 B CN 103154014B
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alkyl
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replacement
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CN103154014A (zh
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撒扎·P·普拉卡什
普内特·P·塞思
埃里克·E·斯威兹
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Ionis Pharmaceuticals Inc
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Isis Pharmaceuticals Inc
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201180021008.0A 2010-04-28 2011-04-26 修饰核苷、其类似物以及由它们制备的寡聚化合物 Active CN103154014B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US32899010P 2010-04-28 2010-04-28
US61/328,990 2010-04-28
US39310010P 2010-10-14 2010-10-14
US61/393,100 2010-10-14
US40968410P 2010-11-03 2010-11-03
US61/409,684 2010-11-03
PCT/US2011/033968 WO2011139702A2 (en) 2010-04-28 2011-04-26 Modified nucleosides and oligomeric compounds prepared therefrom

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CN103154014A CN103154014A (zh) 2013-06-12
CN103154014B true CN103154014B (zh) 2015-03-25

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US (4) US8993738B2 (enExample)
EP (2) EP2601204B1 (enExample)
JP (2) JP6005628B2 (enExample)
KR (1) KR101869570B1 (enExample)
CN (1) CN103154014B (enExample)
WO (1) WO2011139702A2 (enExample)

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JP6280045B2 (ja) 2011-12-22 2018-02-14 アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 肺腺癌内転移関連性転写物１（ｍｅｔａｓｔａｓｉｓ−ａｓｓｏｃｉａｔｅｄ−ｉｎ−ｌｕｎｇ−ａｄｅｎｏｃａｒｃｉｎｏｍａ−ｔｒａｎｓｃｒｉｐｔ−１：ｍａｌａｔ−１）の発現調節法
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JP6294876B2 (ja) 2012-06-25 2018-03-14 アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． Ｕｂｅ３ａ−ａｔｓ発現の調節
CN112007045B (zh) 2012-07-13 2026-01-06 波涛生命科学有限公司 手性控制
JP6246121B2 (ja) 2012-07-13 2017-12-13 株式会社新日本科学 キラル核酸アジュバント
DK2872485T3 (da) 2012-07-13 2021-03-08 Wave Life Sciences Ltd Asymmetrisk hjælpegruppe
EP4052709A1 (en) 2012-10-11 2022-09-07 Ionis Pharmaceuticals, Inc. Methods of treating kennedy's disease
AR092982A1 (es) 2012-10-11 2015-05-13 Isis Pharmaceuticals Inc Modulacion de la expresion de receptores androgenicos
US20150275208A1 (en) 2012-10-12 2015-10-01 Isis Pharmaceuticals, Inc. Selective antisense compounds and uses thereof
US9701708B2 (en) 2013-01-31 2017-07-11 Ionis Pharmaceuticals, Inc. Method of preparing oligomeric compounds using modified coupling protocols
KR102169899B1 (ko) 2013-02-14 2020-10-26 아이오니스 파마수티컬즈, 인코포레이티드 지질단백질 리파제 결핍 (lpld) 모집단에서 아포지질단백질 c-iii (apociii) 발현의 조절
DK2958998T3 (en) * 2013-02-22 2018-04-16 Sirna Therapeutics Inc SHORT INTERFERATING NUCLEIC ACID (SINA) MOLECULES CONTAINING A 2'-INTERNUCLEOSIDE BOND
CN111254145A (zh) 2013-03-14 2020-06-09 Ionis制药公司 用于调节tau表达的组合物和方法
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