CN103154014B - 修饰核苷、其类似物以及由它们制备的寡聚化合物 - Google Patents

修饰核苷、其类似物以及由它们制备的寡聚化合物 Download PDF

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CN103154014B
CN103154014B CN201180021008.0A CN201180021008A CN103154014B CN 103154014 B CN103154014 B CN 103154014B CN 201180021008 A CN201180021008 A CN 201180021008A CN 103154014 B CN103154014 B CN 103154014B
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alkyl
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replacement
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CN103154014A (zh
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撒扎·P·普拉卡什
普内特·P·塞思
埃里克·E·斯威兹
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Ionis Pharmaceuticals Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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CN201180021008.0A 2010-04-28 2011-04-26 修饰核苷、其类似物以及由它们制备的寡聚化合物 Active CN103154014B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US32899010P 2010-04-28 2010-04-28
US61/328,990 2010-04-28
US39310010P 2010-10-14 2010-10-14
US61/393,100 2010-10-14
US40968410P 2010-11-03 2010-11-03
US61/409,684 2010-11-03
PCT/US2011/033968 WO2011139702A2 (en) 2010-04-28 2011-04-26 Modified nucleosides and oligomeric compounds prepared therefrom

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CN103154014A CN103154014A (zh) 2013-06-12
CN103154014B true CN103154014B (zh) 2015-03-25

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US (4) US8993738B2 (enExample)
EP (2) EP3173419A1 (enExample)
JP (2) JP6005628B2 (enExample)
KR (1) KR101869570B1 (enExample)
CN (1) CN103154014B (enExample)
WO (1) WO2011139702A2 (enExample)

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