JP6005628B2 - 修飾ヌクレオシド、その類似体、およびこれらから調製されるオリゴマー化合物 - Google Patents

修飾ヌクレオシド、その類似体、およびこれらから調製されるオリゴマー化合物 Download PDF

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JP6005628B2
JP6005628B2 JP2013508162A JP2013508162A JP6005628B2 JP 6005628 B2 JP6005628 B2 JP 6005628B2 JP 2013508162 A JP2013508162 A JP 2013508162A JP 2013508162 A JP2013508162 A JP 2013508162A JP 6005628 B2 JP6005628 B2 JP 6005628B2
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substituted
alkyl
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independently
alkoxy
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JP2013532122A5 (enExample
JP2013532122A (ja
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プラカシュ，タジャ・ピー
セス，プニット・ピー
スウェイジ，エリック・イー
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Ionis Pharmaceuticals Inc
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013508162A 2010-04-28 2011-04-26 修飾ヌクレオシド、その類似体、およびこれらから調製されるオリゴマー化合物 Active JP6005628B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US32899010P 2010-04-28 2010-04-28
US61/328,990 2010-04-28
US39310010P 2010-10-14 2010-10-14
US61/393,100 2010-10-14
US40968410P 2010-11-03 2010-11-03
US61/409,684 2010-11-03
PCT/US2011/033968 WO2011139702A2 (en) 2010-04-28 2011-04-26 Modified nucleosides and oligomeric compounds prepared therefrom

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JP2016078844A Division JP2016166222A (ja) 2010-04-28 2016-04-11 修飾ヌクレオシド、その類似体、およびこれらから調製されるオリゴマー化合物

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JP2013532122A JP2013532122A (ja) 2013-08-15
JP2013532122A5 JP2013532122A5 (enExample) 2014-06-19
JP6005628B2 true JP6005628B2 (ja) 2016-10-12

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JP2013508162A Active JP6005628B2 (ja) 2010-04-28 2011-04-26 修飾ヌクレオシド、その類似体、およびこれらから調製されるオリゴマー化合物
JP2016078844A Withdrawn JP2016166222A (ja) 2010-04-28 2016-04-11 修飾ヌクレオシド、その類似体、およびこれらから調製されるオリゴマー化合物

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US (4) US8993738B2 (enExample)
EP (2) EP2601204B1 (enExample)
JP (2) JP6005628B2 (enExample)
KR (1) KR101869570B1 (enExample)
CN (1) CN103154014B (enExample)
WO (1) WO2011139702A2 (enExample)

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MX347361B (es) 2011-07-19 2017-04-12 Wave Life Sciences Ltd Metodos para la sintesis de acidos nucleicos funcionalizados.
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WO2013177248A2 (en) 2012-05-22 2013-11-28 Isis Pharmaceuticals, Inc. Modulation of enhancer rna mediated gene expression
EP4458361A3 (en) 2012-06-25 2025-01-22 Ionis Pharmaceuticals, Inc. Modulation of ube3a-ats expression
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US9175291B2 (en) 2012-10-11 2015-11-03 Isis Pharmaceuticals Inc. Modulation of androgen receptor expression
WO2014059364A1 (en) 2012-10-11 2014-04-17 Isis Pharmaceuticals, Inc. Methods of treating kennedy's disease
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WO2014120861A2 (en) * 2013-01-31 2014-08-07 Isis Pharmaceuticals, Inc. Method of preparing oligomeric compounds using modified coupling protocols
ES2680599T3 (es) 2013-02-14 2018-09-10 Ionis Pharmaceuticals, Inc. Modulación de la expresión de apolipoproteína C-III (ApoCIII) en poblaciones deficientes en lipoproteína lipasa (LPLD)
JP6613143B2 (ja) 2013-02-22 2019-11-27 サーナ・セラピューティクス・インコーポレイテッド ２’ヌクレオシド間結合を含有する低分子干渉核酸（ｓｉＮＡ）分子
MX2015012621A (es) 2013-03-14 2016-05-31 Ionis Pharmaceuticals Inc Composiciones y metodos para modular la expresion de tau.
PL2992098T3 (pl) 2013-05-01 2019-09-30 Ionis Pharmaceuticals, Inc. Kompozycje i sposoby modulowania ekspresji hbv i ttr
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