JP6005628B2 - 修飾ヌクレオシド、その類似体、およびこれらから調製されるオリゴマー化合物 - Google Patents

修飾ヌクレオシド、その類似体、およびこれらから調製されるオリゴマー化合物 Download PDF

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JP6005628B2
JP6005628B2 JP2013508162A JP2013508162A JP6005628B2 JP 6005628 B2 JP6005628 B2 JP 6005628B2 JP 2013508162 A JP2013508162 A JP 2013508162A JP 2013508162 A JP2013508162 A JP 2013508162A JP 6005628 B2 JP6005628 B2 JP 6005628B2
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substituted
alkyl
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independently
alkoxy
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JP2013532122A5 (enExample
JP2013532122A (ja
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プラカシュ，タジャ・ピー
セス，プニット・ピー
スウェイジ，エリック・イー
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Ionis Pharmaceuticals Inc
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2013508162A 2010-04-28 2011-04-26 修飾ヌクレオシド、その類似体、およびこれらから調製されるオリゴマー化合物 Active JP6005628B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US32899010P 2010-04-28 2010-04-28
US61/328,990 2010-04-28
US39310010P 2010-10-14 2010-10-14
US61/393,100 2010-10-14
US40968410P 2010-11-03 2010-11-03
US61/409,684 2010-11-03
PCT/US2011/033968 WO2011139702A2 (en) 2010-04-28 2011-04-26 Modified nucleosides and oligomeric compounds prepared therefrom

Related Child Applications (1)

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JP2016078844A Division JP2016166222A (ja) 2010-04-28 2016-04-11 修飾ヌクレオシド、その類似体、およびこれらから調製されるオリゴマー化合物

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JP2013532122A JP2013532122A (ja) 2013-08-15
JP2013532122A5 JP2013532122A5 (enExample) 2014-06-19
JP6005628B2 true JP6005628B2 (ja) 2016-10-12

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JP2013508162A Active JP6005628B2 (ja) 2010-04-28 2011-04-26 修飾ヌクレオシド、その類似体、およびこれらから調製されるオリゴマー化合物
JP2016078844A Withdrawn JP2016166222A (ja) 2010-04-28 2016-04-11 修飾ヌクレオシド、その類似体、およびこれらから調製されるオリゴマー化合物

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US (4) US8993738B2 (enExample)
EP (2) EP3173419A1 (enExample)
JP (2) JP6005628B2 (enExample)
KR (1) KR101869570B1 (enExample)
CN (1) CN103154014B (enExample)
WO (1) WO2011139702A2 (enExample)

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EP2451461A4 (en) 2009-07-06 2013-05-29 Ontorii Inc NOVEL NUCLEIC ACID PRODRUGS AND METHOD OF USE THEREOF
ES2733708T3 (es) 2010-02-08 2019-12-02 Ionis Pharmaceuticals Inc Reducción selectiva de variantes alélicas
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WO2011139702A2 (en) * 2010-04-28 2011-11-10 Isis Pharmaceuticals, Inc. Modified nucleosides and oligomeric compounds prepared therefrom
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US9175291B2 (en) 2012-10-11 2015-11-03 Isis Pharmaceuticals Inc. Modulation of androgen receptor expression
EP4086347A3 (en) 2012-10-12 2023-01-11 Ionis Pharmaceuticals, Inc. Selective antisense compounds and uses thereof
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