CN102781396A - 具备通气式瓶适配器的药液输送装置 - Google Patents
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- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
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Abstract
一种包括通气式瓶适配器的药液输送装置,所述通气式瓶适配器具有上盘、向下悬垂的裙缘以及双管腔穿刺钉。所述上盘包括与下面的空气过滤器流连通的通气孔以及用于遮盖所述通气孔以阻挡溅落的防护罩。所述类似于罩的罩优选为四分之一球形且具有径向朝外的罩孔。
Description
技术领域
本发明大体涉及药液输送装置,特别是包括通气式瓶适配器(vented vial adapter)的药液输送装置。
背景技术
小尼德斯皮尔(Niedospial,Jr.)等人的第6,139,534号美国专利说明并描述了由通气式瓶适配器构成的药液输送装置,所述通气式瓶适配器具有纵向瓶轴线且包括具备一系列轴向通气孔的上盘(顶壁)(top wall)、位于所述一系列通气孔的下方的环形空气过滤器、用于以套叠方式将小瓶容纳在里面的向下悬垂(依靠)裙缘(downward dependingskirt)、向下悬垂中心双管腔穿刺钉(downward depending central dual lumen puncturingspike)以及指向相反的中心液体输送(转移)孔口(central liquid transfer port)。所述双管腔穿刺钉包括一对轴向相邻管腔,即,液体输送管腔和通气管腔。所述液体输送孔口与液体输送管腔流(体)连通。所述通气孔经由空气过滤器与通气管腔流(体)连通。通气式瓶适配器包括用于使瓶内容物维持在无菌状态的弹性预分裂隔片(elastomericpre-split septum)。使用所述通气式瓶适配器可能导致药液内容物在无意间排入一个或多个通气孔,或者药液内容物溅落至一个或多个通气孔,因而弄湿下面的空气过滤器以致对其操作产生不利。
此外,具备通气式瓶适配器的药液输送装置还在以下文献中得到说明和描述:瑞特森(Ritson)的第4,834,744号美国专利,同样是小尼德斯皮尔(Niedospial,Jr)等人申请的第6,503,240号、第6,544,246号、第6,655,246号、第6,997,917号以及第7,799,009号美国专利,黄(Wong)的第7,192,423号美国专利,长谷川(Hasegawa)的第7,452,348号美国专利,沃尔什(Walsh)的第US 2007/0156112号美国专利申请公开案以及优(Yow)的第US 2008/0172024号美国专利申请公开案。
发明内容
本发明是针对包括到目前为止所述的通气式瓶适配器的药液输送装置。本发明是针对提供这种通气式瓶适配器:其具备单独防护罩(protective hoods),以便遮盖通气式瓶适配器的通气孔,从而避免药液内容物因排放、溅落或类似情况而进入通气孔并弄湿通气孔下面的空气过滤器以致对其操作产生不利。本发明可包括手动扣合盖(manuallyplaced cap),其用于扣合在液体进入孔口上,从而使内容物维持在无菌状态。或者,本发明可包括用于使瓶内容物维持在无菌状态的弹性预分裂隔片。
本发明同样可适用于包括通气式瓶适配器的多种药液输送装置,所述通气式瓶适配器用于与大小不同(即,13mm、20mm以及类似大小)的小瓶一起使用。所述药液输送装置可由瓶适配器构成,所述瓶适配器本身包括母瓶适配器(female vial adapters)、公瓶适配器(male vial adapters)以及类似瓶适配器。其它药液输送装置包括,例如,在为辛格(Zinger)等人共有的第6,558,365号美国专利中说明并描述的药液输送装置、在共有的第WO 2005/105014号PCT国际公开案中说明并描述的同轴药液输送装置(in-lineliquid drug transfer device),以及类似药液输送装置。
附图说明
为理解本发明并了解本发明在实践中的实施方式,现在将参考附图,并仅通过非限制性实例来描述优选实施例,其中附图中的相同部分编号相同,且其中:
图1是注射器、小瓶以及具有纵向瓶轴线的通气式母瓶适配器的图示;
图2是沿纵向瓶轴线的通气式瓶适配器的顶部平面图;
图3是图1中的通气式瓶适配器沿图2中的线A-A截得的纵向截面图;
图4是图1中的通气式瓶适配器沿图2中的线B-B截得的纵向截面图;以及
图5是具备可拆卸通气式瓶适配器的药液输送装置的图示。
具体实施方式
图1所示为构成生理性液体的来源的注射器10、小药瓶20以及由通气式母瓶适配器构成的药液输送装置30,其中所述通气式母瓶适配器用于与注射器10和小瓶20一起使用。注射器10包括具备柱塞12的筒管11和公鲁尔锁接头(male Luer lock connector)13。注射器10可具备其它类型的公接头。所述小瓶20包括由瓶塞22密封的顶部开口式瓶(open topped bottle)21,所述瓶塞22被金属镶边23覆盖。小瓶20在负压下容纳粉末状或液体药物24。所述注射器10通常容纳用于重新构成小瓶内容物24的稀释剂。
图1至图4所示为通气式母瓶适配器30,其具有纵向瓶轴线31且包括具有向下悬垂裙缘33的横向上盘32,所述向下悬垂裙缘33具备用于扣入配合在小瓶20上的柔韧部件34。所述瓶适配器30包括向下悬垂的双管腔穿刺钉36,其用于在将裙缘33扣入配合在小瓶20上时刺穿瓶塞22。所述穿刺钉36包括朝向上盘32的基座36A且以钉尖36B的形式终止。穿刺钉36包括一对轴向管腔,即,液体输送管腔37和通气管腔38。所述液体输送管腔37包括朝向钉尖36B的孔口37A。所述通气管腔38具有朝向钉尖36B的孔口38A。
瓶适配器30还包括与穿刺钉36指向相反且与液体输送管腔37流连通的中心轴向液体输送孔口39。所述液体输送孔口39以母鲁尔接头(female Luer connector)41的形式终止,以便与注射器的公鲁尔锁接头(male Luer connector)13进行螺纹啮合。瓶适配器30包括用于密封母鲁尔接头41的手动扣合盖42。
上盘32包括一对沿直径方向相对的轴向通气孔43。环形空气过滤器44安置在上盘32之下。通气孔43经由空气过滤器44与通气管腔38流连通。空气过滤器44对在刺穿瓶塞22时吸入瓶20的空气进行过滤。
在图2的顶部平面图中,上盘32具备一对防护罩46,其安装在通气孔43上方,以便遮盖通气孔43。防护罩46优选为四分之一球形。防护罩46各自具有罩孔47,所述罩孔47位于上盘32之上且相对于纵向瓶轴线31径向朝外。在使用瓶适配器30的过程中,防护罩46能避免药液内容物在无意间经由通气孔43弄湿空气过滤器44。
图5所示为第6,558,365号美国专利的药液输送装置50,所述药液输送装置50具备类似于通气式瓶适配器30的可拆卸通气式瓶适配器51。
虽然已结合有限数量的实施例对本发明进行了描述,但应了解,可在附属权利要求书的范围内对本发明做出许多变化、修改以及其它应用。
Claims (3)
1.一种用于与小药瓶一起使用的药液输送装置,所述小药瓶包括含有药剂的瓶、由瓶塞塞住的瓶开口以及位于所述瓶与所述瓶开口之间的窄颈,
所述药液输送装置包含通气式瓶适配器,所述通气式瓶适配器具有纵向瓶轴线且包括:横截于所述纵向轴线的上盘;实质上为圆柱形的裙缘,其具有弹性地附接至所述上盘并从所述上盘向下悬垂的柔韧部件,所述柔韧部件用于以套叠方式将所述瓶开口滑动地容纳在其内部;安置在所述上盘之下的环形空气过滤器,
用于刺穿所述瓶塞以与所述瓶的内部建立流连通的向下悬垂的双管腔穿刺钉,所述穿刺钉具有与所述上盘相邻的基座以及穿刺尖,所述穿刺尖包括从所述基座延伸至所述穿刺尖的一对轴向管腔,所述对轴向管腔包括液体输送管腔和通气管腔,
与所述液体输送管腔流连通的液体输送孔口,
在所述上盘中形成且经由所述空气过滤器与所述通气管腔流连通的至少一个轴向通气孔,
在使所述小瓶滑动地容纳在所述瓶适配器中时所述液体输送孔口和所述至少一个通气孔与所述瓶流连通,
其特征在于,
在所述通气式瓶适配器的沿所述纵向瓶轴线的顶部平面图中,所述上盘具备与所述至少一个通气孔对应的数目的至少一个防护罩,从而使所述至少一个通气孔中的每个通气孔由所述对应数目的至少一个防护罩中的一个防护罩个别地遮盖,以及
每个所述防护罩具有相对于所述纵向瓶轴线径向朝外的罩孔。
2.根据权利要求1所述的装置,其中每个所述防护罩具有四分之一球形形状。
3.根据权利要求1或2所述的装置,其进一步包含用于密封所述液体进入孔口的手动扣合盖。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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IL20414110 | 2010-02-24 | ||
IL204141 | 2010-02-24 | ||
IL209101A IL209101A0 (en) | 2010-11-04 | 2010-11-04 | Vented vial adapter |
IL209101 | 2010-11-04 | ||
PCT/IL2011/000187 WO2011104712A1 (en) | 2010-02-24 | 2011-02-23 | Liquid drug transfer device with vented vial adapter |
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CN102781396B CN102781396B (zh) | 2015-01-07 |
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US (1) | US8753325B2 (zh) |
EP (1) | EP2512398B1 (zh) |
JP (1) | JP5709905B2 (zh) |
CN (1) | CN102781396B (zh) |
BR (1) | BR112012020829B1 (zh) |
DK (1) | DK2512398T3 (zh) |
IL (1) | IL219793A (zh) |
WO (1) | WO2011104712A1 (zh) |
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CN104884028A (zh) * | 2012-12-17 | 2015-09-02 | 尤尼特拉克特注射器公司 | 瓶适配器 |
CN104884028B (zh) * | 2012-12-17 | 2018-04-27 | 尤尼特拉克特注射器公司 | 瓶适配器 |
CN105934229A (zh) * | 2013-11-22 | 2016-09-07 | Icu医学有限公司 | 流体传输装置及使用方法 |
CN109152699A (zh) * | 2016-05-24 | 2019-01-04 | 西部制药服务以色列有限公司 | 包括相同的成对的小瓶转接器的双瓶转接器组合件 |
CN109152699B (zh) * | 2016-05-24 | 2020-03-10 | 西部制药服务以色列有限公司 | 包括相同的成对的小瓶转接器的双瓶转接器组合件 |
CN114340580A (zh) * | 2019-07-30 | 2022-04-12 | 伊奎希尔德医疗有限公司 | 开放液体药物转移系统的组件以及采用所述组件的机器人系统 |
Also Published As
Publication number | Publication date |
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IL219793A (en) | 2015-01-29 |
JP5709905B2 (ja) | 2015-04-30 |
DK2512398T3 (da) | 2014-10-13 |
IL219793A0 (en) | 2012-07-31 |
BR112012020829A2 (pt) | 2016-06-28 |
US8753325B2 (en) | 2014-06-17 |
US20130046269A1 (en) | 2013-02-21 |
EP2512398B1 (en) | 2014-08-27 |
BR112012020829B1 (pt) | 2020-04-14 |
JP2013520273A (ja) | 2013-06-06 |
WO2011104712A1 (en) | 2011-09-01 |
EP2512398A1 (en) | 2012-10-24 |
CN102781396B (zh) | 2015-01-07 |
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