CN102603895B - 新颖抗原结合多肽和其用途 - Google Patents

新颖抗原结合多肽和其用途 Download PDF

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Publication number
CN102603895B
CN102603895B CN201210053815.7A CN201210053815A CN102603895B CN 102603895 B CN102603895 B CN 102603895B CN 201210053815 A CN201210053815 A CN 201210053815A CN 102603895 B CN102603895 B CN 102603895B
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China
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amino acids
amino acid
antigen
abp
limited
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Expired - Lifetime
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CN201210053815.7A
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English (en)
Chinese (zh)
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CN102603895A (zh
Inventor
丘霍松
托马斯·O·丹尼尔
特洛伊·E·威尔逊
托马斯·P·丘杰克
芬·蒂昂
安娜-玛丽亚·A.·海斯·普特南
布鲁斯·E·基梅尔
莉莲·霍
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Ambrx Inc
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Ambrx Inc
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Priority claimed from CN2005800199550A external-priority patent/CN1968712B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201210053815.7A 2004-06-18 2005-06-17 新颖抗原结合多肽和其用途 Expired - Lifetime CN102603895B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US58133404P 2004-06-18 2004-06-18
US60/581,334 2004-06-18
US64822205P 2005-01-28 2005-01-28
US60/648,222 2005-01-28
US65401805P 2005-02-17 2005-02-17
US60/654,018 2005-02-17
CN2005800199550A CN1968712B (zh) 2004-06-18 2005-06-17 新颖抗原结合多肽和其用途

Related Parent Applications (1)

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CN2005800199550A Division CN1968712B (zh) 2004-06-18 2005-06-17 新颖抗原结合多肽和其用途

Publications (2)

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CN102603895A CN102603895A (zh) 2012-07-25
CN102603895B true CN102603895B (zh) 2016-09-28

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CN201210054276.9A Expired - Lifetime CN102532321B (zh) 2004-06-18 2005-06-17 新颖抗原结合多肽和其用途
CN201210053815.7A Expired - Lifetime CN102603895B (zh) 2004-06-18 2005-06-17 新颖抗原结合多肽和其用途

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US (4) US7632924B2 (https=)
EP (1) EP1771205B1 (https=)
JP (1) JP2008503217A (https=)
KR (2) KR20070034512A (https=)
CN (2) CN102532321B (https=)
AU (1) AU2005265163B2 (https=)
BR (1) BRPI0512235A (https=)
CA (1) CA2568952C (https=)
GB (1) GB2430677A (https=)
IL (1) IL179300B (https=)
MX (1) MXPA06014684A (https=)
NZ (2) NZ551335A (https=)
WO (1) WO2006009901A2 (https=)

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NZ551335A (en) 2010-03-26
MXPA06014684A (es) 2007-02-12
CN102603895A (zh) 2012-07-25
EP1771205B1 (en) 2016-10-26
US20080050374A1 (en) 2008-02-28
NZ582684A (en) 2011-05-27
CN102532321B (zh) 2018-10-12
CA2568952C (en) 2019-05-21
EP1771205A2 (en) 2007-04-11
GB2430677A (en) 2007-04-04
US9175083B2 (en) 2015-11-03
GB2430677A8 (en) 2007-06-12
IL179300B (en) 2018-01-31
BRPI0512235A (pt) 2008-02-19
JP2008503217A (ja) 2008-02-07
AU2005265163B2 (en) 2009-10-01
EP1771205A4 (en) 2008-10-01
US7632924B2 (en) 2009-12-15
KR101699142B1 (ko) 2017-01-23
US20060153860A1 (en) 2006-07-13
IL179300A0 (en) 2007-03-08
KR20150005973A (ko) 2015-01-15
CN102532321A (zh) 2012-07-04
CA2568952A1 (en) 2006-01-26
WO2006009901A3 (en) 2006-10-05
GB0700909D0 (en) 2007-02-28
US20080085277A1 (en) 2008-04-10
US20080081038A1 (en) 2008-04-03
WO2006009901A2 (en) 2006-01-26
AU2005265163A1 (en) 2006-01-26

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