CN102292338B - 酪氨酸激酶蛋白受体拮抗剂 - Google Patents
酪氨酸激酶蛋白受体拮抗剂 Download PDFInfo
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- CN102292338B CN102292338B CN200980150091.4A CN200980150091A CN102292338B CN 102292338 B CN102292338 B CN 102292338B CN 200980150091 A CN200980150091 A CN 200980150091A CN 102292338 B CN102292338 B CN 102292338B
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- 0 B*(C)C1=NC=*CC(C)=C1C(C)C Chemical compound B*(C)C1=NC=*CC(C)=C1C(C)C 0.000 description 11
- HQXTWLUIYYBNTA-UHFFFAOYSA-N CC(C(C1)N(CCCC2CCCCC2)CCC=C)C(C(c2ccccc2C2O)ON)C2=C1NC1=CC=C(C)CC1 Chemical compound CC(C(C1)N(CCCC2CCCCC2)CCC=C)C(C(c2ccccc2C2O)ON)C2=C1NC1=CC=C(C)CC1 HQXTWLUIYYBNTA-UHFFFAOYSA-N 0.000 description 1
- JCHSLOAORPEWPA-UHFFFAOYSA-N CC(CC(CCCN1CCCC1)C(C12)=COC1c1c3cc(C4)c4c1)=C2C3=O Chemical compound CC(CC(CCCN1CCCC1)C(C12)=COC1c1c3cc(C4)c4c1)=C2C3=O JCHSLOAORPEWPA-UHFFFAOYSA-N 0.000 description 1
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- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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Priority Applications (1)
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| CN201610710315.4A CN106336400A (zh) | 2008-12-08 | 2009-12-08 | 酪氨酸激酶蛋白受体拮抗剂 |
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| US12082708P | 2008-12-08 | 2008-12-08 | |
| US61/120,827 | 2008-12-08 | ||
| PCT/US2009/067197 WO2010077680A2 (en) | 2008-12-08 | 2009-12-08 | Compositions of protein receptor tyrosine kinase inhibitors |
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