CN101909610B - 口服给药组合物 - Google Patents
口服给药组合物 Download PDFInfo
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- CN101909610B CN101909610B CN2008801230944A CN200880123094A CN101909610B CN 101909610 B CN101909610 B CN 101909610B CN 2008801230944 A CN2008801230944 A CN 2008801230944A CN 200880123094 A CN200880123094 A CN 200880123094A CN 101909610 B CN101909610 B CN 101909610B
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- fat
- cryptoxanthin
- citrus
- carotenoid
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
Description
Claims (7)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-339460 | 2007-12-28 | ||
JP2007339460A JP5577019B2 (ja) | 2007-12-28 | 2007-12-28 | 経口投与組成物 |
JP2008-022784 | 2008-02-01 | ||
JP2008022784A JP5830214B2 (ja) | 2008-02-01 | 2008-02-01 | 経口投与組成物 |
PCT/JP2008/065466 WO2009084275A1 (ja) | 2007-12-28 | 2008-08-28 | 経口投与組成物 |
Publications (2)
Publication Number | Publication Date |
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CN101909610A CN101909610A (zh) | 2010-12-08 |
CN101909610B true CN101909610B (zh) | 2013-12-04 |
Family
ID=40824003
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN2008801230944A Expired - Fee Related CN101909610B (zh) | 2007-12-28 | 2008-08-28 | 口服给药组合物 |
Country Status (5)
Country | Link |
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US (2) | US20100273727A1 (zh) |
EP (1) | EP2226071B1 (zh) |
KR (1) | KR101449976B1 (zh) |
CN (1) | CN101909610B (zh) |
WO (1) | WO2009084275A1 (zh) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5564330B2 (ja) * | 2010-05-24 | 2014-07-30 | ハウスウェルネスフーズ株式会社 | メタボリックシンドロームの予防、改善または治療用組成物 |
CN101947215A (zh) * | 2010-06-21 | 2011-01-19 | 澳门大学 | 陈皮中黄酮类化合物在制备抑制血管新生药物中的应用 |
GB201120772D0 (en) | 2011-12-02 | 2012-01-11 | Ip Science Ltd | Cocoa-based food products |
JP5749300B2 (ja) | 2013-07-30 | 2015-07-15 | 日本甜菜製糖株式会社 | 粉末セラミドの製造方法 |
EP3277269A4 (en) * | 2015-04-02 | 2018-11-14 | Omniactive Health Technologies Ltd. | Methods for prevention and treatment of cardiometabolic syndrome and compositions used therein |
TWI736755B (zh) | 2017-04-03 | 2021-08-21 | 大江生醫股份有限公司 | 包含植物萃取物的組成物及其減少紫外線所致皮膚損傷之用途 |
WO2020092905A1 (en) * | 2018-11-01 | 2020-05-07 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Synergy for increasing energy expenditure and insulin sensitivity |
CN109480114A (zh) * | 2018-12-18 | 2019-03-19 | 山东汉欧生物科技有限公司 | 一种预防宠物肥胖的食品及制备方法 |
CN109938301B (zh) * | 2019-03-19 | 2022-02-01 | 重庆市中药研究院 | 一种具有降血糖作用的发酵柚皮口含片及其制备方法 |
KR102279861B1 (ko) | 2019-04-26 | 2021-07-20 | 박재규 | 청귤류로부터 5-o-디메틸노빌레틴의 추출/분리 및 만성 알코올성 지방간 손상보호 조성물 |
CN111011642A (zh) * | 2019-12-25 | 2020-04-17 | 昭通市众生农业开发有限公司 | 一种无抗生态饲料及其生产工艺 |
CN111631324A (zh) * | 2020-06-29 | 2020-09-08 | 长沙昆博生物科技有限公司 | 一种基于柑桔幼果提取物的蛋鸡饲料添加剂及其应用 |
IT202100020369A1 (it) * | 2021-07-30 | 2023-01-30 | Wavemed S R L | Composizione somministrabile per via orale e parenterale, per la prevenzione o trattamento della cellulite. |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004112776A2 (en) * | 2003-06-23 | 2004-12-29 | Advanced Bionutrition (Europe) Limited | Inflammatory disease treatment |
WO2006068041A1 (ja) * | 2004-12-20 | 2006-06-29 | Okayasu Shoten Co., Ltd. | 体内脂肪の分解促進作用を有する組成物及びそれを含有する食品又は食品配合剤 |
WO2007116981A1 (ja) * | 2006-04-07 | 2007-10-18 | Snow Brand Milk Products Co., Ltd. | 脂肪蓄積抑制剤 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2700788A (en) * | 1987-12-18 | 1989-06-22 | City Of Hope | Inhibition of lipogenesis |
JP3359298B2 (ja) * | 1998-05-06 | 2002-12-24 | 株式会社愛媛柑橘資源開発研究所 | かんきつ果汁由来のカロチノイド高含有粉末の製造方法 |
JP3756438B2 (ja) | 2001-03-02 | 2006-03-15 | 花王株式会社 | 容器詰飲料 |
JP2006325602A (ja) * | 2002-10-25 | 2006-12-07 | Ehime Inryo:Kk | β−クリプトキサンチンを有効成分とする骨形成促進剤 |
US8148431B2 (en) * | 2002-10-25 | 2012-04-03 | Kemin Health, L.C. | Osteogenesis promoter containing β-cryptoxanthin as the active ingredient |
EP1772143A4 (en) * | 2004-05-20 | 2009-12-30 | Arkray Inc | ACTIVATOR OF PPAR (PEROXISOMEPROLIFERATORACTIVATED RECEPTOR) AND MEDICAMENTS, ADDITIVES, FUNCTIONAL FOODS AND FOOD ADDITIVES USING THIS |
JP2006083151A (ja) * | 2004-09-16 | 2006-03-30 | Oriza Yuka Kk | 骨粗鬆症予防、改善用組成物 |
JP2006089452A (ja) * | 2004-09-27 | 2006-04-06 | Oriza Yuka Kk | 美白・美容用組成物 |
JP4845363B2 (ja) * | 2004-10-01 | 2011-12-28 | ユニチカ株式会社 | 経口投与組成物及び美白剤 |
JP4799895B2 (ja) * | 2004-12-15 | 2011-10-26 | 電源開発株式会社 | カロチノイド色素、スフィンゴ糖脂質、ユビキノンq−10の生産方法 |
JP5613953B2 (ja) * | 2005-02-08 | 2014-10-29 | 学校法人中村学園 | 温州ミカンパルプ含有機能性材料の用途 |
JP2007091693A (ja) * | 2005-09-30 | 2007-04-12 | Oriza Yuka Kk | 保湿用組成物 |
JP2007153845A (ja) | 2005-12-07 | 2007-06-21 | Yamaha Motor Co Ltd | 脂肪蓄積抑制剤 |
JP2007223914A (ja) * | 2006-02-21 | 2007-09-06 | Unitika Ltd | 経口投与組成物 |
-
2008
- 2008-08-28 KR KR1020107014211A patent/KR101449976B1/ko active IP Right Grant
- 2008-08-28 CN CN2008801230944A patent/CN101909610B/zh not_active Expired - Fee Related
- 2008-08-28 US US12/810,543 patent/US20100273727A1/en not_active Abandoned
- 2008-08-28 WO PCT/JP2008/065466 patent/WO2009084275A1/ja active Application Filing
- 2008-08-28 EP EP08867917.0A patent/EP2226071B1/en not_active Not-in-force
-
2012
- 2012-07-17 US US13/551,129 patent/US20120282358A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004112776A2 (en) * | 2003-06-23 | 2004-12-29 | Advanced Bionutrition (Europe) Limited | Inflammatory disease treatment |
WO2006068041A1 (ja) * | 2004-12-20 | 2006-06-29 | Okayasu Shoten Co., Ltd. | 体内脂肪の分解促進作用を有する組成物及びそれを含有する食品又は食品配合剤 |
WO2007116981A1 (ja) * | 2006-04-07 | 2007-10-18 | Snow Brand Milk Products Co., Ltd. | 脂肪蓄積抑制剤 |
Non-Patent Citations (1)
Title |
---|
JP特开200683151A 2006.03.30 |
Also Published As
Publication number | Publication date |
---|---|
US20100273727A1 (en) | 2010-10-28 |
EP2226071A4 (en) | 2011-06-01 |
KR20100102624A (ko) | 2010-09-24 |
KR101449976B1 (ko) | 2014-10-14 |
WO2009084275A1 (ja) | 2009-07-09 |
US20120282358A1 (en) | 2012-11-08 |
EP2226071B1 (en) | 2016-04-13 |
CN101909610A (zh) | 2010-12-08 |
EP2226071A1 (en) | 2010-09-08 |
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