CN101878031A - 用于治疗骨髓增生性疾病和其他增生性疾病的激酶抑制剂 - Google Patents
用于治疗骨髓增生性疾病和其他增生性疾病的激酶抑制剂 Download PDFInfo
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- CN101878031A CN101878031A CN2008800085252A CN200880008525A CN101878031A CN 101878031 A CN101878031 A CN 101878031A CN 2008800085252 A CN2008800085252 A CN 2008800085252A CN 200880008525 A CN200880008525 A CN 200880008525A CN 101878031 A CN101878031 A CN 101878031A
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- 229960001367 tartaric acid Drugs 0.000 description 1
- 238000003419 tautomerization reaction Methods 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
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- SEDZOYHHAIAQIW-UHFFFAOYSA-N trimethylsilyl azide Chemical compound C[Si](C)(C)N=[N+]=[N-] SEDZOYHHAIAQIW-UHFFFAOYSA-N 0.000 description 1
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- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical class C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
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- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US91321607P | 2007-04-20 | 2007-04-20 | |
| US60/913,216 | 2007-04-20 | ||
| PCT/US2008/060896 WO2008131276A1 (en) | 2007-04-20 | 2008-04-18 | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
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| CN101878031A true CN101878031A (zh) | 2010-11-03 |
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| CN200880020714A Pending CN101801383A (zh) | 2007-04-20 | 2008-04-18 | 用于治疗骨髓增生性疾病和其他增生性疾病的激酶抑制剂 |
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| CN200880020714A Pending CN101801383A (zh) | 2007-04-20 | 2008-04-18 | 用于治疗骨髓增生性疾病和其他增生性疾病的激酶抑制剂 |
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| EP (5) | EP2481736A1 (enExample) |
| JP (2) | JP2010524970A (enExample) |
| KR (2) | KR20100017184A (enExample) |
| CN (2) | CN101878031A (enExample) |
| AU (4) | AU2008242720A1 (enExample) |
| BR (2) | BRPI0810094A2 (enExample) |
| CA (4) | CA2684950A1 (enExample) |
| EA (1) | EA200970700A1 (enExample) |
| IL (1) | IL201650A0 (enExample) |
| MX (2) | MX2009011343A (enExample) |
| RU (1) | RU2009142851A (enExample) |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106866623A (zh) * | 2014-04-08 | 2017-06-20 | 北大方正集团有限公司 | 多取代的吡啶化合物、制备方法、用途及药物组合物 |
| CN112830936A (zh) * | 2021-01-08 | 2021-05-25 | 广西师范大学 | 新型核黄素化合物、其制备方法及应用 |
| CN115772167A (zh) * | 2021-09-08 | 2023-03-10 | 暨南大学 | 含脲结构的化合物及其应用 |
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| EP2481736A1 (en) * | 2007-04-20 | 2012-08-01 | Deciphera Pharmaceuticals, LLC. | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| US20110189167A1 (en) * | 2007-04-20 | 2011-08-04 | Flynn Daniel L | Methods and Compositions for the Treatment of Myeloproliferative Diseases and other Proliferative Diseases |
| KR20110099687A (ko) * | 2008-10-29 | 2011-09-08 | 데시페라 파마슈티칼스, 엘엘씨. | 항-암과 항-증식성 활성을 나타내는 시클로프로판 아미드와 유사체 |
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| US8609663B2 (en) * | 2009-11-18 | 2013-12-17 | University Of Massachusetts | Compounds for modulating TLR2 |
| BR112012015868A2 (pt) | 2009-12-11 | 2017-06-20 | Autifony Therapeutics Ltd | derivados de imidazolidinadiona |
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| JP2013536806A (ja) * | 2010-09-01 | 2013-09-26 | アスセピオン ファーマスーティカル、インコーポレイテッド | キナーゼ阻害剤としての重水素化複素環式化合物 |
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- 2008-04-18 WO PCT/US2008/060867 patent/WO2008131253A1/en not_active Ceased
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- 2008-04-18 SG SG2012053559A patent/SG183054A1/en unknown
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- 2008-04-18 US US12/105,408 patent/US8143293B2/en not_active Expired - Fee Related
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106866623A (zh) * | 2014-04-08 | 2017-06-20 | 北大方正集团有限公司 | 多取代的吡啶化合物、制备方法、用途及药物组合物 |
| CN112830936A (zh) * | 2021-01-08 | 2021-05-25 | 广西师范大学 | 新型核黄素化合物、其制备方法及应用 |
| CN115772167A (zh) * | 2021-09-08 | 2023-03-10 | 暨南大学 | 含脲结构的化合物及其应用 |
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